Protective effects of compounds from Garcinia mangostana L. (mangosteen) against UVB damage in HaCaT cells and hairless mice

  • Authors:
    • A-Rang Im
    • Young-Mi Kim
    • Young-Won Chin
    • Sungwook Chae
  • View Affiliations

  • Published online on: October 13, 2017     https://doi.org/10.3892/ijmm.2017.3188
  • Pages:1941-1949
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Abstract

Ultraviolet B (UVB) radiation causes alterations in the skin, such as epidermal thickening, wrinkle formation and inflammation. Therefore, preventing UVB-induced skin damage can promote general health among the human population. Garcinia mangostana L. (mangosteen) is a fruit that has become a popular botanical dietary supplement because of its perceived role in promoting overall health. The present study investigated the photoprotective effects of α-, β-, γ-mangostins and gartanin against UVB radiation using the HaCaT immortalized human keratinocyte cell line as an in vitro model and hairless mice as an in vivo model. UVB radiation increased the expression of matrix metalloproteinase (MMP)‑1 and ‑9 and decreased the mRNA expression levels of involucrin, filaggrin and loricrin in HaCaT cells; however, these changes were attenuated by pretreating the cells with α-, β-, γ-mangostins and gartanin. Among these compounds, α-mangostin exhibited the greatest effects in reducing UVB-induced skin wrinkles, inhibited epidermal thickening in hairless mice in vivo. Exposure to UVB radiation increased the expression of MMPs and pro-inflammatory cytokines and activated mitogen-activated protein kinases in hairless mice, but these changes were attenuated by α-mangostin. The authors suggested that α-mangostin exerts anti-wrinkle and anti-aging properties.

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December 2017
Volume 40 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

2016 Impact Factor: 2.341
Ranked #21/128 Medicine Research and Experimental
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APA
Im, A., Kim, Y., Chin, Y., & Chae, S. (2017). Protective effects of compounds from Garcinia mangostana L. (mangosteen) against UVB damage in HaCaT cells and hairless mice. International Journal of Molecular Medicine, 40, 1941-1949. https://doi.org/10.3892/ijmm.2017.3188
MLA
Im, A., Kim, Y., Chin, Y., Chae, S."Protective effects of compounds from Garcinia mangostana L. (mangosteen) against UVB damage in HaCaT cells and hairless mice". International Journal of Molecular Medicine 40.6 (2017): 1941-1949.
Chicago
Im, A., Kim, Y., Chin, Y., Chae, S."Protective effects of compounds from Garcinia mangostana L. (mangosteen) against UVB damage in HaCaT cells and hairless mice". International Journal of Molecular Medicine 40, no. 6 (2017): 1941-1949. https://doi.org/10.3892/ijmm.2017.3188