Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
December-2017 Volume 40 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2017 Volume 40 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Protective effects of compounds from Garcinia mangostana L. (mangosteen) against UVB damage in HaCaT cells and hairless mice

  • Authors:
    • A-Rang Im
    • Young-Mi Kim
    • Young-Won Chin
    • Sungwook Chae
  • View Affiliations / Copyright

    Affiliations: KM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea, College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University-Seoul, Goyang‑si, Gyeonggi‑do 10326, Republic of Korea
  • Pages: 1941-1949
    |
    Published online on: October 13, 2017
       https://doi.org/10.3892/ijmm.2017.3188
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Ultraviolet B (UVB) radiation causes alterations in the skin, such as epidermal thickening, wrinkle formation and inflammation. Therefore, preventing UVB-induced skin damage can promote general health among the human population. Garcinia mangostana L. (mangosteen) is a fruit that has become a popular botanical dietary supplement because of its perceived role in promoting overall health. The present study investigated the photoprotective effects of α-, β-, γ-mangostins and gartanin against UVB radiation using the HaCaT immortalized human keratinocyte cell line as an in vitro model and hairless mice as an in vivo model. UVB radiation increased the expression of matrix metalloproteinase (MMP)‑1 and ‑9 and decreased the mRNA expression levels of involucrin, filaggrin and loricrin in HaCaT cells; however, these changes were attenuated by pretreating the cells with α-, β-, γ-mangostins and gartanin. Among these compounds, α-mangostin exhibited the greatest effects in reducing UVB-induced skin wrinkles, inhibited epidermal thickening in hairless mice in vivo. Exposure to UVB radiation increased the expression of MMPs and pro-inflammatory cytokines and activated mitogen-activated protein kinases in hairless mice, but these changes were attenuated by α-mangostin. The authors suggested that α-mangostin exerts anti-wrinkle and anti-aging properties.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Helfrich YR, Sachs DL and Voorhees JJ: Overview of skin aging and photoaging. Dermatol Nurs. 20:177–183; quiz 184. 2008.PubMed/NCBI

2 

Kammeyer A and Luiten RM: Oxidation events and skin aging. Ageing Res Rev. 21:16–29. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Dupont E, Gomez J and Bilodeau D: Beyond UV radiation: A skin under challenge. Int J Cosmet Sci. 35:224–232. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Wenk J, Brenneisen P, Meewes C, Wlaschek M, Peters T, Blaudschun R, Ma W, Kuhr L, Schneider L and Scharffetter-Kochanek K: UV-induced oxidative stress and photoaging. Curr Probl Dermatol. 29:83–94. 2001. View Article : Google Scholar : PubMed/NCBI

5 

Quan T, Qin Z, Xia W, Shao Y, Voorhees JJ and Fisher GJ: Matrix-degrading metalloproteinases in photoaging. Invest Dermatol Symp Proc. 14:20–24. 2009. View Article : Google Scholar

6 

Amano S, Ogura Y, Akutsu N, Matsunaga Y, Kadoya K, Adachi E and Nishiyama T: Protective effect of matrix metalloproteinase inhibitors against epidermal basement membrane damage: Skin equivalents partially mimic photoageing process. Br J Dermatol. 153(Suppl 2): 37–46. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Brink N, Szamel M, Young AR, Wittern KP and Bergemann J: Comparative quantification of IL-1beta, IL-10, IL-10r, TNFalpha and IL-7 mRNA levels in UV-irradiated human skin in vivo. Inflamm Res. 49:290–296. 2000. View Article : Google Scholar : PubMed/NCBI

8 

Campanini MZ, Pinho-Ribeiro FA, Ivan AL, Ferreira VS, Vilela FM, Vicentini FT, Martinez RM, Zarpelon AC, Fonseca MJ, Faria TJ, et al: Efficacy of topical formulations containing Pimenta pseudocaryophyllus extract against UVB-induced oxidative stress and inflammation in hairless mice. J Photochem Photobiol B. 127:153–160. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Son Y, Cheong YK, Kim NH, Chung HT, Kang DG and Pae HO: Mitogen-activated protein kinases and reactive oxygen species: how can ROS activate MAPK pathways? J Signal Transduct. 2011:7926392011. View Article : Google Scholar : PubMed/NCBI

10 

Bickers DR and Athar M: Oxidative stress in the pathogenesis of skin disease. J Invest Dermatol. 126:2565–2575. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Obolskiy D, Pischel I, Siriwatanametanon N and Heinrich M: Garcinia mangostana L.: A phytochemical and pharmacological review. Phytother Res. 23:1047–1065. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Kinghorn AD, Chai HB, Sung CK and Keller WJ: The classical drug discovery approach to defining bioactive constituents of botanicals. Fitoterapia. 82:71–79. 2011. View Article : Google Scholar

13 

Pedraza-Chaverri J, Cárdenas-Rodríguez N, Orozco-Ibarra M and Pérez-Rojas JM: Medicinal properties of mangosteen (Garcinia mangostana). Food Chem Toxicol. 46:3227–3239. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Zadernowski R, Czaplicki S and Naczk M: Phenolic acid profiles of mangosteen fruits (Garcinia mangostana). Food Chem. 112:685–689. 2009. View Article : Google Scholar

15 

Han AR, Kim JA, Lantvit DD, Kardono LB, Riswan S, Chai H, Carcache de Blanco EJ, Farnsworth NR, Swanson SM and Kinghorn AD: Cytotoxic xanthone constituents of the stem bark of Garcinia mangostana (mangosteen). J Nat Prod. 72:2028–2031. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Gopalakrishnan C, Shankaranarayanan D, Kameswaran L and Nazimudeen SK: Effect of mangostin, a xanthone from Garcinia mangostana Linn. in immunopathological and inflammatory reactions. Indian J exp Biol. 18:843–846. 1980.PubMed/NCBI

17 

Ibrahim MY, Hashim NM, Mariod AA, Mohan S, Abdulla MA, Abdelwahab SI and Arbab IA: α-Mangostin from Garcinia mangostana Linn: An updated review of its pharmacological properties. Arab J Chem. 9:317–329. 2016. View Article : Google Scholar

18 

Liu Z, Antalek M, Nguyen L, Li X, Tian X, Le A and Zi X: The effect of gartanin, a naturally occurring xanthone in mangosteen juice, on the mTOR pathway, autophagy, apoptosis, and the growth of human urinary bladder cancer cell lines. Nutr Cancer. 65(Suppl 1): 68–77. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Pothitirat W, Chomnawang MT, Supabphol R and Gritsanapan W: Comparison of bioactive compounds content, free radical scavenging and anti-acne inducing bacteria activities of extracts from the mangosteen fruit rind at two stages of maturity. Fitoterapia. 80:442–447. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Naczk M, Towsend M, Zadernowski R and Shahidi F: Protein- binding and antioxidant potential of phenolics of mangosteen fruit (Garcinia mangostana). Food Chem. 128:292–298. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Pothitirat W, Chomnawang MT, Supabphol R and Gritsanapan W: Free radical scavenging and anti-acne activities of mangosteen fruit rind extracts prepared by different extraction methods. Pharm Biol. 48:182–186. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

23 

Fisher GJ, Kang S, Varani J, Bata-Csorgo Z, Wan Y, Datta S and Voorhees JJ: Mechanisms of photoaging and chronological skin aging. Arch Dermatol. 138:1462–1470. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Balunas MJ, Su B, Brueggemeier RW and Kinghorn AD: Xanthones from the botanical dietary supplement mangosteen (Garcinia mangostana) with aromatase inhibitory activity. J Nat Prod. 71:1161–1166. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Sakagami Y, Iinuma M, Piyasena KG and Dharmaratne HR: Antibacterial activity of alpha-mangostin against vancomycin resistant enterococci (VRe) and synergism with antibiotics. Phytomedicine. 12:203–208. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Matsuda M, Hoshino T, Yamakawa N, Tahara K, Adachi H, Sobue G, Maji D, Ihn H and Mizushima T: Suppression of UV-induced wrinkle formation by induction of HSP70 expression in mice. J Invest Dermatol. 133:919–928. 2013. View Article : Google Scholar

27 

Rittié L and Fisher GJ: UV-light-induced signal cascades and skin aging. Ageing Res Rev. 1:705–720. 2002. View Article : Google Scholar : PubMed/NCBI

28 

Gilchrest BA: Skin aging and photoaging. Dermatol Nurs. 2:79–82. 1990.PubMed/NCBI

29 

Hendi A, Brodland DG and Zitelli JA: Melanocytes in long-standing sun-exposed skin: Quantitative analysis using the MART-1 immunostain. Arch Dermatol. 142:871–876. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Lee WJ, Park KH, Cha HW, Sohn MY, Park KD, Lee SJ and Kim DW: The expression of involucrin, loricrin, and filaggrin in cultured sebocytes. Ann Dermatol. 26:134–137. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Hänel KH, Cornelissen C, Lüscher B and Baron JM: Cytokines and the skin barrier. Int J Mol Sci. 14:6720–6745. 2013. View Article : Google Scholar : PubMed/NCBI

32 

D'Orazio J, Jarrett S, Amaro-Ortiz A and Scott T: UV radiation and the skin. Int J Mol Sci. 14:12222–12248. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Burke KE: Photoaging: The role of oxidative stress. G Ital Dermatol Venereol. 145:445–459. 2010.PubMed/NCBI

34 

Fisher GJ, Wang ZQ, Datta SC, Varani J, Kang S and Voorhees JJ: Pathophysiology of premature skin aging induced by ultraviolet light. N Engl J Med. 337:1419–1428. 1997. View Article : Google Scholar : PubMed/NCBI

35 

Zhuang Y and Lyga J: Inflammaging in skin and other tissues - the roles of complement system and macrophage. Inflamm Allergy Drug Targets. 13:153–161. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Chung JH and Eun HC: Angiogenesis in skin aging and photoaging. J Dermatol. 34:593–600. 2007. View Article : Google Scholar : PubMed/NCBI

37 

Kondo S: The roles of cytokines in photoaging. J Dermatol Sci. 23(Suppl 1): S30–S36. 2000. View Article : Google Scholar : PubMed/NCBI

38 

Fisher GJ: The pathophysiology of photoaging of the skin. Cutis. 75(Suppl 2): 5–9. 2005.PubMed/NCBI

39 

Jung E, Lee J, Baek J, Jung K, Lee J, Huh S, Kim S, Koh J and Park D: Effect of Camellia japonica oil on human type I procollagen production and skin barrier function. J ethnopharmacol. 112:127–131. 2007. View Article : Google Scholar : PubMed/NCBI

40 

Urbanski A, Schwarz T, Neuner P, Krutmann J, Kirnbauer R, Köck A and Luger TA: Ultraviolet light induces increased circulating interleukin-6 in humans. J Invest Dermatol. 94:808–811. 1990. View Article : Google Scholar : PubMed/NCBI

41 

Peus D, Vasa RA, Beyerle A, Meves A, Krautmacher C and Pittelkow MR: UVB activates ERK1/2 and p38 signaling pathways via reactive oxygen species in cultured keratinocytes. J Invest Dermatol. 112:751–756. 1999. View Article : Google Scholar : PubMed/NCBI

42 

Roux PP and Blenis J: ERK and p38 MAPK-activated protein kinases: A family of protein kinases with diverse biological functions. Microbiol Mol Biol Rev. 68:320–344. 2004. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Im A, Kim Y, Chin Y and Chae S: Protective effects of compounds from Garcinia mangostana L. (mangosteen) against UVB damage in HaCaT cells and hairless mice. Int J Mol Med 40: 1941-1949, 2017.
APA
Im, A., Kim, Y., Chin, Y., & Chae, S. (2017). Protective effects of compounds from Garcinia mangostana L. (mangosteen) against UVB damage in HaCaT cells and hairless mice. International Journal of Molecular Medicine, 40, 1941-1949. https://doi.org/10.3892/ijmm.2017.3188
MLA
Im, A., Kim, Y., Chin, Y., Chae, S."Protective effects of compounds from Garcinia mangostana L. (mangosteen) against UVB damage in HaCaT cells and hairless mice". International Journal of Molecular Medicine 40.6 (2017): 1941-1949.
Chicago
Im, A., Kim, Y., Chin, Y., Chae, S."Protective effects of compounds from Garcinia mangostana L. (mangosteen) against UVB damage in HaCaT cells and hairless mice". International Journal of Molecular Medicine 40, no. 6 (2017): 1941-1949. https://doi.org/10.3892/ijmm.2017.3188
Copy and paste a formatted citation
x
Spandidos Publications style
Im A, Kim Y, Chin Y and Chae S: Protective effects of compounds from Garcinia mangostana L. (mangosteen) against UVB damage in HaCaT cells and hairless mice. Int J Mol Med 40: 1941-1949, 2017.
APA
Im, A., Kim, Y., Chin, Y., & Chae, S. (2017). Protective effects of compounds from Garcinia mangostana L. (mangosteen) against UVB damage in HaCaT cells and hairless mice. International Journal of Molecular Medicine, 40, 1941-1949. https://doi.org/10.3892/ijmm.2017.3188
MLA
Im, A., Kim, Y., Chin, Y., Chae, S."Protective effects of compounds from Garcinia mangostana L. (mangosteen) against UVB damage in HaCaT cells and hairless mice". International Journal of Molecular Medicine 40.6 (2017): 1941-1949.
Chicago
Im, A., Kim, Y., Chin, Y., Chae, S."Protective effects of compounds from Garcinia mangostana L. (mangosteen) against UVB damage in HaCaT cells and hairless mice". International Journal of Molecular Medicine 40, no. 6 (2017): 1941-1949. https://doi.org/10.3892/ijmm.2017.3188
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team