Antinociceptive effect of Valeriana fauriei regulates BDNF signaling in an animal model of fibromyalgia

  • Authors:
    • Hwayoung Lee
    • Jiyun Im
    • Hansol Won
    • Jun Young Kim
    • Hyung‑Ki Kim
    • Jun‑Tack Kwon
    • Young Ock Kim
    • Sanghyun Lee
    • Ik‑Hyun Cho
    • Sang Won Lee
    • Hak‑Jae Kim
  • View Affiliations

  • Published online on: October 20, 2017     https://doi.org/10.3892/ijmm.2017.3203
  • Pages:485-492
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Abstract

The genus Valeriana has been widely used in popular medicine for centuries, to treat sleep disorders, anxiety, epilepsy and insomnia. Recent studies have focused on the novel pharmacological effects of Valeriana fauriei Briq. (VF) species. Previous studies have attempted to determine the pharmacological functions of Valeriana in various human diseases, particularly with regards to its neuroprotective effects, and its ability to reduce pain and stress. The present study constructed an animal model of fibromyalgia (FM), which was induced by intermittent cold stress with slight modification. Subsequently, the study aimed to determine whether VF exerts antinociceptive effects on the FM‑like model following oral administration of VF extracts. The effects of VF extracts on the FM model were investigated by analyzing behavioral activity, including pain, and detecting protein expression. In the behavioral analysis, the results of a nociception assay indicated that the pain threshold was significantly decreased in the FM group. Subsequently, western blotting and immunohistochemical analyses of the hippocampus demonstrated that the protein expression levels of brain‑derived neurotrophic factor (BDNF) and phosphorylated‑cAMP response element‑binding protein were downregulated in the FM group. Conversely, VF restored these levels. These results suggested that the effects of VF extract on a model of FM may be associated with its modulatory effects on the BDNF signaling pathway in the hippocampus and medial prefrontal cortex. In conclusion, the mechanism underlying the protective effects of VF as a therapeutic agent against FM may involve the BDNF signaling pathway.

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January 2018
Volume 41 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

2016 Impact Factor: 2.341
Ranked #21/128 Medicine Research and Experimental
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APA
Lee, H., Im, J., Won, H., Kim, J.Y., Kim, H., Kwon, J. ... Kim, H. (2018). Antinociceptive effect of Valeriana fauriei regulates BDNF signaling in an animal model of fibromyalgia. International Journal of Molecular Medicine, 41, 485-492. https://doi.org/10.3892/ijmm.2017.3203
MLA
Lee, H., Im, J., Won, H., Kim, J. Y., Kim, H., Kwon, J., Kim, Y. O., Lee, S., Cho, I., Lee, S. W., Kim, H."Antinociceptive effect of Valeriana fauriei regulates BDNF signaling in an animal model of fibromyalgia". International Journal of Molecular Medicine 41.1 (2018): 485-492.
Chicago
Lee, H., Im, J., Won, H., Kim, J. Y., Kim, H., Kwon, J., Kim, Y. O., Lee, S., Cho, I., Lee, S. W., Kim, H."Antinociceptive effect of Valeriana fauriei regulates BDNF signaling in an animal model of fibromyalgia". International Journal of Molecular Medicine 41, no. 1 (2018): 485-492. https://doi.org/10.3892/ijmm.2017.3203