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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January-2018 Volume 41 Issue 1

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review

Inhibitors targeting the SUMOylation pathway: A patent review 2012‑2015 (Review)

Yanjun Zhou, Chunmei Ji, Mengda Cao, Miao Guo, Wen Huang, Weiwei Ni, Ling Meng, Haiwei Yang, Ji‑Fu Wei
Pages: 3-12
Published online on: 01 November 2017

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Article Open Access

Connexin 43 in splenic lymphocytes is involved in the regulation of CD4+CD25+ T lymphocyte proliferation and cytokine production in hypertensive inflammation

Hai-Chao Zhang, Zhong-Shuang Zhang, Liang Zhang, Ai Wang, He Zhu, Li Li, Jun-Qiang Si, Xin-Zhi Li, Ke-Tao Ma
Pages: 13-24
Published online on: 20 October 2017

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Article Open Access

Renoprotective effect of erythropoietin via modulation of the STAT6/MAPK/NF-κB pathway in ischemia/reperfusion injury after renal transplantation

Jinhua Zhang, Daqiang Zhao, Ning Na, Heng Li, Bin Miao, Liangqing Hong, Zhengyu Huang
Pages: 25-32
Published online on: 20 October 2017

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Article Open Access

Atorvastatin protects the proliferative ability of human umbilical vein endothelial cells inhibited by angiotensin II by changing mitochondrial energy metabolism

Ye Chang, Yuan Li, Ning Ye, Xiaofan Guo, Zhao Li, Guozhe Sun, Yingxian Sun
Pages: 33-42
Published online on: 19 October 2017

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Article Open Access

Proliferation of vascular smooth muscle cells under inflammation is regulated by NF-κB p65/microRNA-17/RB pathway activation

Dong Yang, Chen Sun, Jing Zhang, Shu Lin, Lin Zhao, Lun Wang, Ruoran Lin, Junyuan Lv, Shijie Xin
Pages: 43-50
Published online on: 25 October 2017

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Article Open Access

Combination treatment of adipose-derived stem cells and adiponectin attenuates pulmonary arterial hypertension in rats by inhibiting pulmonary arterial smooth muscle cell proliferation and regulating the AMPK/BMP/Smad pathway Corrigendum in /10.3892/ijmm.2021.4953

Li Luo, Wuhong Zheng, Guili Lian, Huaning Chen, Ling Li, Changsheng Xu, Liangdi Xie
Pages: 51-60
Published online on: 31 October 2017

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Article Open Access

Apolipoprotein C-III in the high-density lipoprotein proteome of cerebral lacunar infarction patients impairs its anti-inflammatory function

Pu Lv, Mingming Zhao, Yuanyuan Liu, Haiqiang Jin, Wei Cui, Chenghe Fan, Yuming Teng, Lemin Zheng, Yining Huang
Pages: 61-68
Published online on: 27 October 2017

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Article Open Access

AMPK activation serves a critical role in mitochondria quality control via modulating mitophagy in the heart under chronic hypoxia

Huagang Zhang, Bo Liu, Tianbo Li, Yun Zhu, Guiping Luo, Yunhan Jiang, Fuqin Tang, Zhao Jian, Yingbin Xiao
Pages: 69-76
Published online on: 26 October 2017

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Article Open Access

Anti-hypoglycemic and hepatocyte-protective effects of hyperoside from Zanthoxylum bungeanum leaves in mice with high-carbohydrate/high-fat diet and alloxan-induced diabetes

Yali Zhang, Mimi Wang, Huanhuan Dong, Xiaomin Yu, Jingfang Zhang
Pages: 77-86
Published online on: 25 October 2017

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Article Open Access

Generation of human-induced pluripotent stem cells from burn patient-derived skin fibroblasts using a non-integrative method

Shangfeng Fu, Jianwu Ding, Dewu Liu, Heping Huang, Min Li, Yang Liu, Longxiang Tu, Deming Liu
Pages: 87-94
Published online on: 23 October 2017

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Article Open Access

Inhibition of histone deacetylase 1 ameliorates renal tubulointerstitial fibrosis via modulation of inflammation and extracellular matrix gene transcription in mice

Tùng Nguyễn-Thanh, Dal Kim, Sik Lee, Won Kim, Sung Kwang Park, Kyung Pyo Kang
Pages: 95-106
Published online on: 27 October 2017

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Article Open Access

Detection of calprotectin in inflammatory bowel disease: Fecal and serum levels and immunohistochemical localization

Shuhei Fukunaga, Kotaro Kuwaki, Keiichi Mitsuyama, Hidetoshi Takedatsu, Shinichiro Yoshioka, Hiroshi Yamasaki, Ryosuke Yamauchi, Atsushi Mori, Tatsuyuki Kakuma, Osamu Tsuruta, Takuji Torimura
Pages: 107-118
Published online on: 07 November 2017

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Article Open Access

Radical scavenging-linked anti-adipogenic activity of Alnus firma extracts

Sun-Il Choi, Jong Seok Lee, Sarah Lee, Jin-Ha Lee, Hee-Sun Yang, Joohong Yeo, Jong-Yea Kim, Boo-Yong Lee, Il-Jun Kang, Ok-Hwan Lee
Pages: 119-128
Published online on: 27 October 2017

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Article Open Access

Transforming growth factor β1 promotes migration and invasion in HepG2 cells: Epithelial‑to‑mesenchymal transition via JAK/STAT3 signaling

Xiao‑Long Lin, Mihua Liu, Yuanbo Liu, Huijun Hu, Yongquan  Pan, Weiwen Zou, Xiaojuan Fan, Xuemei Hu
Pages: 129-136
Published online on: 01 November 2017

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Article Open Access

Cryptdin-2 predicts intestinal injury during heatstroke in mice

Jingjing Ji, Zhengtao Gu, Hui Li, Lei Su, Zhifeng Liu
Pages: 137-146
Published online on: 01 November 2017

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Article Open Access

Activation of adrenergic receptor β2 promotes tumor progression and epithelial mesenchymal transition in tongue squamous cell carcinoma

Haichao Liu, Cheng Wang, Nan Xie, Zehang Zhuang, Xiqiang Liu, Jinsong Hou, Hongzhang Huang
Pages: 147-154
Published online on: 09 November 2017

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Article Open Access

Histone deacetylase 3 is associated with gastric cancer cell growth via the miR-454-mediated targeting of CHD5

Guangru Xu, Hongxing Zhu, Minghui Zhang, Jinhua Xu
Pages: 155-163
Published online on: 31 October 2017

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Article Open Access

YAP and TAZ mediate steroid-induced alterations in the trabecular meshwork cytoskeleton in human trabecular meshwork cells

Jie Peng, Hailian Wang, Xin Wang, Minghan Sun, Shaoping Deng, Yi Wang
Pages: 164-172
Published online on: 23 October 2017

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Article Open Access

Synovial fluid‑derived synovial fragments represent an improved source of synovial mesenchymal stem cells in the temporomandibular joint

Yu Yao, Zheng‑Yu Li, Hong Zhang, You‑Hua Zheng, Li‑Xiang Mai, Wen‑Jing Liu, Zhi‑Guang Zhang, Yang‑Peng Sun
Pages: 173-183
Published online on: 25 October 2017

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Article Open Access

Metabolic profiles of adipose-derived and bone marrow-derived stromal cells from elderly coronary heart disease patients by capillary liquid chromatography quadrupole time-of-flight mass spectrometry

Jian-Zhong Li, Hui Qu, Jian Wu, Fan Zhang, Zhi-Bo Jia, Jian-Yong Sun, Bo Lv, Yue Kang, Shu-Lin Jiang, Kai Kang
Pages: 184-194
Published online on: 19 October 2017

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Article Open Access

A novel method of neural differentiation of PC12 cells by using Opti-MEM as a basic induction medium

Rendong Hu, Qiaoyu Cao, Zhongqing Sun, Jinying Chen, Qing Zheng, Fei Xiao
Pages: 195-201
Published online on: 19 October 2017

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Article Open Access

Resveratrol prevents osteoporosis by upregulating FoxO1 transcriptional activity

Yan-Ling Feng, Xiao-Tong Jiang, Fang-Fang Ma, Jie Han, Xu-Lei Tang
Pages: 202-212
Published online on: 23 October 2017

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Article Open Access

Long non‑coding RNA DANCR regulates the proliferation and osteogenic differentiation of human bone-derived marrow mesenchymal stem cells via the p38 MAPK pathway

Jinlong Zhang, Zhiwen Tao, Yuli Wang
Pages: 213-219
Published online on: 27 October 2017

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Article Open Access

Genome-wide DNA methylome alterations in acute coronary syndrome

Dandan Li, Jing Yan, Yunlong Yuan, Cheng Wang, Jia Wu, Qingwen Chen, Jiaxi Song, Junjun Wang
Pages: 220-232
Published online on: 27 October 2017

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Article Open Access

Luteolin inhibits multi-heavy metal mixture-induced HL7702 cell apoptosis through downregulation of ROS-activated mitochondrial pathway

Yafei Wang, Hong Su, Xin Song, Samuel Selorm Fiati Kenston, Jinshun Zhao, Yuanliang Gu
Pages: 233-241
Published online on: 27 October 2017

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Article Open Access

Neuroprotective effects of hydrogen sulfide on sodium azide-induced oxidative stress in PC12 cells

Cheng Gao, Pan Chang, Lijun Yang, Yi Wang, Shaohua Zhu, Haiyan Shan, Mingyang Zhang, Luyang Tao
Pages: 242-250
Published online on: 01 November 2017

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Article Open Access

Lychee seed extract protects against neuronal injury and improves cognitive function in rats with type II diabetes mellitus with cognitive impairment

Yong Tang, Chonglin Yu, Jianming Wu, Haixia Chen, Yuan Zeng, Xiuling Wang, Le Yang, Qibing Mei, Shousong Cao, Dalian Qin
Pages: 251-263
Published online on: 09 November 2017

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Article Open Access

Schisandrin A suppresses lipopolysaccharide-induced inflammation and oxidative stress in RAW 264.7 macrophages by suppressing the NF-κB, MAPKs and PI3K/Akt pathways and activating Nrf2/HO-1 signaling

Da Hye Kwon, Hee-Jae Cha, Eun Ok Choi, Sun-Hee Leem, Gi-Young Kim, Sung-Kwon Moon, Young-Chae Chang, Seok-Joong Yun, Hye Jin Hwang, Byung Woo Kim, Wun-Jae Kim, Yung Hyun Choi
Pages: 264-274
Published online on: 25 October 2017

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Article Open Access

Fibroblast activation protein-α promotes the growth and migration of lung cancer cells via the PI3K and sonic hedgehog pathways

Jun Jia, Tracey A. Martin, Lin Ye, Lin Meng, Nan Xia, Wen G. Jiang, Xiaodong Zhang
Pages: 275-283
Published online on: 27 October 2017

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Article Open Access

Suppression of microRNA-130b inhibits glioma cell proliferation and invasion, and induces apoptosis by PTEN/AKT signaling

Jian-Jun Gu, Kai-Chun Fan, Jian-He Zhang, Hong-Jie Chen, Shou-Sen Wang
Pages: 284-292
Published online on: 02 November 2017

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Article Open Access

Alterations of protein glycosylation in embryonic stem cells during adipogenesis

Wenguang Liu, Xingrong Yan, Wei Liu, Yangyang Wang, Yang Rao, Hanjie Yu, Jihong Cui, Xin Xie, Mei Sun, Lu Yin, Hongmin Li, Fulin Chen
Pages: 293-301
Published online on: 07 November 2017

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Article Open Access

Expression profile analysis of long non-coding RNAs involved in the metformin-inhibited gluconeogenesis of primary mouse hepatocytes

Yao Wang, Hongju Tang, Xueying Ji, Yuqing Zhang, Wan Xu, Xue Yang, Ruyuan Deng, Yun Liu, Fengying Li, Xiao Wang, Libin Zhou
Pages: 302-310
Published online on: 07 November 2017

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Article Open Access

Global gene expression analysis combined with a genomics approach for the identification of signal transduction networks involved in postnatal mouse myocardial proliferation and development

Ruoxin Wang, Chao Su, Xinting Wang, Qiang Fu, Xingjie Gao, Chunyan Zhang, Jie Yang, Xi Yang, Minxin Wei
Pages: 311-321
Published online on: 03 November 2017

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Article Open Access

Reactive oxygen species induce injury of the intestinal epithelium during hyperoxia

Min Zhao, Shimiao Tang, Junchi Xin, Yingliang Wei, Dongyan Liu
Pages: 322-330
Published online on: 09 November 2017

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Article Open Access

Hey1 functions as a positive regulator of odontogenic differentiation in odontoblast‑lineage cells

Xiao Yin, Zhaobin Zeng, Jinliang Xing, Ansheng Zhang, Wenkai Jiang, Wei Wang, Hantang Sun, Longxing Ni
Pages: 331-339
Published online on: 13 November 2017

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Article Open Access

Broadleaf Mahonia attenuates granulomatous lobular mastitis‑associated inflammation by inhibiting CCL‑5 expression in macrophages

Zhiyu Wang, Neng Wang, Xiaoyan Liu, Qi Wang, Biao Xu, Pengxi Liu, Huayu Zhu, Jianping Chen, Honglin Situ, Yi Lin
Pages: 340-352
Published online on: 09 November 2017

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Article Open Access

In vitro investigation of the mechanism underlying the effect of ginsenoside on the proliferation and differentiation of neural stem cells subjected to oxygen-glucose deprivation/reperfusion

Jian Gao, Huajing Bai, Qiang Li, Jian Li, Feng Wan, Mo Tian, Yuanyuan Li, Yilun Song, Jianping Zhang, Yinchu Si
Pages: 353-363
Published online on: 13 November 2017

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Article Open Access

Vitamin D receptor activation influences the ERK pathway and protects against neurological deficits and neuronal death

Jie Yuan, Xin Guo, Zhengang Liu, Xiuqin Zhao, Yan Feng, Sixin Song, Changmeng Cui, Pei Jiang
Pages: 364-372
Published online on: 09 November 2017

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Article

Herbal prescription, Danggui-Sayuk-Ga-Osuyu-Senggang-Tang, inhibits TNF-α-induced epithelial-mesenchymal transition in HCT116 colorectal cancer cells

Kangwook Lee, Sung-Gook Cho, Youn Kyung Choi, Yu-Jeong Choi, Gyu-Ri Lee, Chan-Yong Jeon, Seong-Gyu Ko
Pages: 373-380
Published online on: 07 November 2017

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Article Open Access

CCDC134 serves a crucial role in embryonic development

Biaoyi Yu, Tianzhuo Zhang, Peng Xia, Xiaoting Gong, Xiaoyan Qiu, Jing Huang
Pages: 381-390
Published online on: 19 October 2017

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Article

Anti-inflammatory effects of a methanolic extract of Castanea seguinii Dode in LPS-induced RAW264.7 macrophage cells

Yourim Lim, Ji-Won Park, Ok-Kyoung Kwon, Jae-Won Lee, Han-Sol Lee, Sangwoo Lee, Sangho Choi, Wanyi Li, Hang Jin, Sang-Bae Han, Kyung-Seop Ahn
Pages: 391-398
Published online on: 27 October 2017

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Article

The inhibition of MyD88 and TRIF signaling serve equivalent roles in attenuating myocardial deterioration due to acute severe inflammation

Min-Zhi Ouyang, Dan Zhou, Yun Zhu, Ming Zhang, Ling Li
Pages: 399-408
Published online on: 07 November 2017

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Article

Angiotensin-converting enzyme 2-angiotensin (1-7)-Mas axis prevents pancreatic acinar cell inflammatory response via inhibition of the p38 mitogen-activated protein kinase/nuclear factor-κB pathway

Xiaozheng Yu, Lijian Cui, Fei Hou, Xiaoya Liu, Yan Wang, Yan Wen, Cheng Chi, Chunyun Li, Ruixia Liu, Chenghong Yin
Pages: 409-420
Published online on: 13 November 2017

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Article

Effect on the dopaminergic metabolism induced by oral exposure to simazine during the prepubertal period in rats

Xueting Li, Jia Yu, Yanping Wu, Baixiang Li
Pages: 421-429
Published online on: 20 October 2017

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Article

Inhibition of Rho kinase protects against colitis in mice by attenuating intestinal epithelial barrier dysfunction via MLC and the NF-κB pathway

Yanting Zou, Lili Ma, Yuan Zhao, Shuncai Zhang, Chaohui Zhou, Yu Cai
Pages: 430-438
Published online on: 19 October 2017

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Article

High glucose upregulates endothelin type B receptors in vascular smooth muscle cells via the downregulation of Sirt1

Yan Lin, Yan Zhao, Enqi Liu
Pages: 439-445
Published online on: 07 November 2017

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Article

Mechanism of long non-coding RNA MALAT1 in lipopolysaccharide-induced acute kidney injury is mediated by the miR-146a/NF-κB signaling pathway

Ying Ding, Feng Guo, Tao Zhu, Jun Li, Danyan Gu, Weiliang Jiang, Yuying Lu, Daoyang Zhou
Pages: 446-454
Published online on: 02 November 2017

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Article

Persistent STAT5-mediated ROS production and involvement of aberrant p53 apoptotic signaling in the resistance of chronic myeloid leukemia to imatinib

Yanhong Cheng, Yingchan Hao, Aimei Zhang, Chaojie Hu, Xiaoxiao Jiang, Quan Wu, Xiucai Xu
Pages: 455-463
Published online on: 20 October 2017

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Article

Hesperidin induces apoptosis and G0/G1 arrest in human non-small cell lung cancer A549 cells

Rongmu Xia, Xin Sheng, Xianlin Xu, Chunbo Yu, Hongling Lu
Pages: 464-472
Published online on: 09 November 2017

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Article Open Access

Induced pluripotent stem cell-conditioned medium suppresses pulmonary fibroblast-to-myofibroblast differentiation via the inhibition of TGF-β1/Smad pathway

Yan Zhou, Qiang Zhang, Yuan Gao, Mingqi Tan, Rui Zheng, Li Zhao, Xiaoye Zhang
Pages: 473-484
Published online on: 19 October 2017

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Article

Antinociceptive effect of Valeriana fauriei regulates BDNF signaling in an animal model of fibromyalgia

Hwayoung Lee, Jiyun Im, Hansol Won, Jun Young Kim, Hyung‑Ki Kim, Jun‑Tack Kwon, Young Ock Kim, Sanghyun Lee, Ik‑Hyun Cho, Sang Won Lee, Hak‑Jae Kim
Pages: 485-492
Published online on: 20 October 2017

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Article

Downregulation of microRNA‑124‑3p suppresses the mTOR signaling pathway by targeting DDIT4 in males with major depressive disorder

Qiuling Wang, Gaofeng Zhao, Zhenzhen Yang, Xia Liu, Ping Xie
Pages: 493-500
Published online on: 06 November 2017

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Article

MicroRNA-142-3p relieves neuropathic pain by targeting high mobility group box 1

Yang Zhang, Junying Mou, Li Cao, Su Zhen, Hongjuan Huang, Hongguang Bao
Pages: 501-510
Published online on: 27 October 2017

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Article

Protein extracted from Porphyra yezoensis prevents cisplatin-induced nephrotoxicity by downregulating the MAPK and NF-κB pathways

In-Hye Kim, Mi-Jin Kwon, Jae-Hun Jung, Taek-Jeong Nam
Pages: 511-520
Published online on: 26 October 2017

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Article

Anti-neuroinflammatory effect of curcumin on Pam3CSK4-stimulated microglial cells

Meiling Jin, Sun Young Park, Qian Shen, Yihong Lai, Xingmei Ou, Zhuo Mao, Dongxu Lin, Yangyang Yu, Weizhen Zhang
Pages: 521-530
Published online on: 27 October 2017

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Article

Vibrio vulnificus infection induces the maturation and activation of dendritic cells with inflammatory Th17-polarizing ability

Arim Lee, Hui Xuan Lim, Myun Soo Kim, Daeho Cho, Kyung Ku Jang, Sang Ho Choi, Tae Sung Kim
Pages: 531-540
Published online on: 01 November 2017

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Article

Peanut arachidin-1 enhances Nrf2-mediated protective mechanisms against TNF-α-induced ICAM-1 expression and NF-κB activation in endothelial cells

Lih-Geeng Chen, Yu-Qi Zhang, Zhi-Zhen Wu, Chia-Wen Hsieh, Chi-Shih Chu, Being-Sun Wung
Pages: 541-547
Published online on: 07 November 2017

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Article

Low-dose irradiation inhibits proliferation of the p53null type human prostate cancer cells through the ATM/p21 pathway

Si-Jie Li, Xin-Yue Liang, Hai-Jun Li, Guo-Zi Yang, Wei Li, Zhuo Li, Lei Zhou, Xue Wen, De-Hai Yu, Jiu-Wei Cui
Pages: 548-554
Published online on: 07 November 2017

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Article

Berberine prevents the apoptosis of mouse podocytes induced by TRAF5 overexpression by suppressing NF-κB activation

Feng Wu, Dong-Sheng Yao, Tian-Ying Lan, Chen Wang, Jian-Dong Gao, Li-Qun He, Di Huang
Pages: 555-563
Published online on: 07 November 2017

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January-2026 Volume 57 Issue 1

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Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

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FK506‑binding proteins as emerging bridges linking proteostasis to multi‑system pathogenesis and therapeutic strategies (Review)

Zhi Li, Xiaolei Liu, Hesong Zeng
Article Number: 30
Published online on: 24 November 2025

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[Retracted] Suppression of SIK1 by miR‑141 in human ovarian cancer cell lines and tissues

Jin-Long Chen, Fang Chen, Ting-Ting Zhang, Nai-Fu Liu
Article Number: 29
Published online on: 24 November 2025

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METTL3 inhibits LINC00312 to suppress osteoporosis progression in a YTHDF2‑dependent manner

Yang Wang, Yihao Tian, Gang Yao
Article Number: 28
Published online on: 20 November 2025

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Decoding structural birth defects through genomic landscapes: Innovative frameworks for diagnosis (Review)

Ruihao Xu, Haoming Ren, Zhengwei Yuan, Wanqi Huang, Hui Gu
Article Number: 27
Published online on: 20 November 2025

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MOTS‑c protects against placental injury via Nrf2 activation in hypoxia‑induced intrauterine growth restriction mice

Dan Chen, Hui-Min Zhao, Xiao-Lin Sun, Zhi-Xuan Xing, Sheng-Peng Li, Shuai-Chao Li, Ya-Xian Wu, Qing-Feng Pang, Jian-Feng Huang
Article Number: 26
Published online on: 18 November 2025

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Synergistic effects of Akebia saponin D and Semaglutide on diabetic nephropathy and osteoporosis via the Klotho‑p53 signaling axis

Qian Zhang, Dan Wang, Hongxia Jia, Zongji Zheng, Liyan Lin, Linna Li, Ling Wang, Yaoming Xue
Article Number: 25
Published online on: 18 November 2025

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[Retracted] MicroRNA‑103 modulates tumor progression by targeting KLF7 in non‑small cell lung cancer

Ke Li, Conghu Yuan
Article Number: 24
Published online on: 17 November 2025

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Article

Comparative analysis of pan MHC‑I epitopes immunoreactivity on Hantaan virus nucleocapsid protein

Zhikui Li, Weijie Ding, Yubo Sun, Chenfeng Tian, Shuaishuai Fu, Fei Shi, Zhenchi Fang, Yuanzhe Li, Jianchang Li, Sirui Cai, Haobo Kang, Baozeng Sun, Junqi Zhang, Yuanjie Sun, Shuya Yang, Yusi Zhang, Chunmei Zhang, Yun Zhang, Xiyang Zhang, Kun Yang, Dongbo Jiang
Article Number: 23
Published online on: 14 November 2025

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Human papillomavirus E7 inhibits immune responses in keratinocytes by activating HTRA1‑mediated mitophagy

Boya Zhang, Defeng Kong, Siji Chen, Xuewu Sun, Hao Cheng
Article Number: 22
Published online on: 14 November 2025

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Targeting p38 MAPK signaling pathway: 
Quercetin as a novel therapy for TMJ synovitis

Mosha Cheng, Yuhe Guan, Xiaotao Xin, Xin Yi, Yi Liu
Article Number: 21
Published online on: 13 November 2025

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Lipid droplets in astrocytes: Key organelles for CNS homeostasis and disease (Review)

Yuchen Wang, Boxuan Wang, Jinchao Hou, Xiaodong Huo, Chenlin Liu, Ruili Guan, Honggang Chen, Yang Zhou, Jianbin Zhang, Congcong Zhuang, Yuankang Zou
Article Number: 20
Published online on: 13 November 2025

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Copper dyshomeostasis and cardiovascular disease: Molecular mechanisms and new strategies for targeted intervention with cuproptosis (Review)

Peiyu Li, Yinghui Li, Qian Meng, Jie Wang, Kun Wang, Sumin Yang
Article Number: 19
Published online on: 13 November 2025

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Elevated FTO alleviates sepsis‑induced acute kidney injury by regulating macrophage inflammatory phenotypes

Xiaona Chen, Ziqi Sun, Jiabo Chen, Jinquan Zhang, Zeyu Liu, Zhengzheng Yan, Quan Li, Zhixia Chen
Article Number: 18
Published online on: 12 November 2025

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Correction Open Access

[Corrigendum]  Suppression of PAX6 promotes cell proliferation and inhibits apoptosis in human retinoblastoma cells

Bo Meng, Yisong Wang, Bin Li
Article Number: 17
Published online on: 10 November 2025

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Microbial short chain fatty acids: Effective histone deacetylase inhibitors in immune regulation (Review)

Jing Wang, Qin Zhao, Shuwan Zhang, Jia Liu, Xingyue Fan, Bin Han, Yaqin Hou, Xiaopeng Ai
Article Number: 16
Published online on: 05 November 2025

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High‑fat diet and cognitive dysfunction: Mechanistic insights into diet‑induced neurodegeneration (Review)

Min You, Fan Wu, Feng Xiong, Xue-Fei Hu, Huan Wu, Li Zhou, Hong-Xing Zhang
Article Number: 15
Published online on: 05 November 2025

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ROCK inhibition promotes axon and myelin regeneration via PI3K/Akt/GSK3β in a mouse sciatic nerve injury model

Shuang Dou, Zhijun Li, Boyao Zheng, Zhenyu Ren, Hai Wang, Qing Zuo, Fang Fang, Yuehong Zhuang
Article Number: 14
Published online on: 05 November 2025

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Mechanisms of mTORC1 and GCN2 amino acid sensing pathways in tumorigenesis and metastatic progression (Review)

Chaowei Zhang, Yuxuan Han, Weiyi Yao, Qing Hong, Na Chen
Article Number: 13
Published online on: 04 November 2025

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β‑hydroxybutyric acid as a potential therapeutic metabolite for type 2 diabetes mellitus (Review)

Xianyi Ding, Jiabin Wu, Lian Wang, Ke Li, Haoyang Gao, Mingyu Wu, Qiuyu Zhang, Ruonan Han, Wenhong Wang, Weihua Xiao
Article Number: 12
Published online on: 03 November 2025

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Review

Histone lactylation: Unveiling a novel pathway for the impact of lactate on physiological and pathological processes (Review)

Xunjie Jian, Chang Cheng, Wenjie Lu, Hui Peng, Diqi Yang
Article Number: 11
Published online on: 03 November 2025

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Interpretation of the molecular mechanism and therapeutic potential of microRNA‑155 in cardiovascular and cerebrovascular diseases (Review)

Xitong Zhao, Pengqin Wang
Article Number: 10
Published online on: 03 November 2025

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Expression of Concern Open Access

[Expression of Concern]  CDKN2A (p16INK4A) affects the anti‑tumor effect of CDK inhibitor in somatotroph adenomas

Yiyuan Chen, Zhenye Li, Qiuyue Fang, Hongyun Wang, Chuzhong Li, Hua Gao, Yazhuo Zhang
Article Number: 9
Published online on: 29 October 2025

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TWEAK modulates the characteristics of periodontal ligament stem cells via the Fn14/NF‑κB pathway

Linlin Xiao, Man Qu, Lulu Chen, Mingli Xiang, Qian Long, Jianguo Liu, Xiaoyan Guan, Chengcheng Liao
Article Number: 8
Published online on: 27 October 2025

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Harnessing copper: Innovative approaches to combat neurodegenerative diseases and cancer (Review)

Tao Duan, Hanhai Mao, Xingyue Jiang, Ying Tian, Jidong Zhang, Jun Tan
Article Number: 7
Published online on: 27 October 2025

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Retraction Open Access

[Retracted] Effects of miR‑106b‑3p on cell proliferation and epithelial‑mesenchymal transition, and targeting of ZNRF3 in esophageal squamous cell carcinoma

Guanen Qiao, Chenguang Dai, Yang He, Junjie Shi, Chunfang Xu
Article Number: 6
Published online on: 27 October 2025

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Immune and metabolic remodeling following bariatric surgery: Implications for targeted immunotherapy (Review)

Yiming Shao, Ke Song, Ruixin Yu, He Xiao, Chengjun Li, Yuling Deng, Yuan Zhang, Yixing Ren
Article Number: 5
Published online on: 24 October 2025

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Exportin 1 inhibitor KPT‑330 reverses oxaliplatin resistance via p53 nuclear retention in colorectal cancer

Chuanxi Lai, Xiya Jia, Yiyi Chen, Kangke Chen, Fei Wang, Qiqi Zhang, Xiaonan Xiang, Zhe-Sheng Chen, Lingna Xu, Sheng Dai
Article Number: 4
Published online on: 23 October 2025

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Targeting of CIRP attenuates osteoarthritis progression via suppressing TLR4/NF‑κB/NLRP3 signaling axis

Weichao Sun, Yi Liao, Jianguo Feng, Jianhui Liang, Qifei He, Yinxing Cui, Dixi Huang, Houyin Shi, Wei You, Wei Sun, Qian Yi
Article Number: 3
Published online on: 23 October 2025

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Review

Importance of B cells (Review)

Zhiyuan Liu, Haoran Dai, Xiaoyu Cui, Yeping Liu, Zhaocheng Dong
Article Number: 2
Published online on: 22 October 2025

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Retraction Open Access

[Retracted] Hypoxic preconditioned bone mesenchymal stem cells ameliorate spinal cord injury in rats via improved survival and migration

Weiheng Wang, Xiaodong Huang, Wenbo Lin, Yuanyuan Qiu, Yunfei He, Jiangming Yu, Yanhai Xi, Xiaojian Ye
Article Number: 1
Published online on: 22 October 2025

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Journal Cover
February-2026 Volume 57 Issue 2

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

FGF4 alleviates the lung cell damage caused by high glucose via AMPK‑PGC‑1 signaling axis in vitro and in vivo

Qiujuan Fu, Yongfang Ou, Qin Wu, Jue Gong, Feixia Li, Tuxing Wang, Zhitai Lin, Kejie Huang, Jianlong Xie
Article Number: 39
Published online on: 05 December 2025

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STOML2 interacts with PHB to activate the MEK/ERK signaling pathway and mediates autophagy‑related proteins in the progression of hepatocellular carcinoma

Haoyang Hu, Haozhe Zhang, Shuai Han, Jianli Chen, Ying Xie
Article Number: 38
Published online on: 04 December 2025

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HMGB1 mediates low-dose ionizing radiation-induced Wnt/β-catenin activation in SRA01/04 cells: Mechanistic clues to early cataractogenesis

Ping Wang, Chunnan Piao, Dong Yan, Yingxue He, Yaru Li, Li Fan, Mei Tian
Article Number: 37
Published online on: 04 December 2025

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FBXO22 promotes hepatocellular carcinoma progression via paracrine myo‑inositol‑induced M2‑type polarization of macrophages

Liangliang Bai, Jing Xiong, Sihai Chen, Jiahao Hu, Meixia Zhang, Bimin Li, Jing Hu, Mingyan He
Article Number: 36
Published online on: 02 December 2025

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Branched‑chain amino acid metabolism and bone metabolism: Implications for osteoporosis pathogenesis and therapeutic strategies (Review)

Qi Xiao, Haimin Zeng, Ruhui Yang, Yuxin Zhan, Fangzhen Lin, Bofan Chen, Xiang Chen
Article Number: 35
Published online on: 02 December 2025

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Mitochondria-associated endoplasmic reticulum membranes: Emerging regulators of cardiac microvascular ischemia/reperfusion injury (Review)

Yan Wang, Baowei Feng, Yanting Wu, Zongle Sun, Hao Yuan, Wei Chen, Chang Zhao, Zhi Liu
Article Number: 34
Published online on: 02 December 2025

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Role of matrix metalloproteinases in the invasion of glioblastoma and drug interventions (Review)

Bohao Zheng, Ying Han, Haiying Zhang
Article Number: 33
Published online on: 01 December 2025

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Bridging bench to bedside: Exosome‑based strategies for endometriosis diagnosis and treatment (Review)

Wanmeng Chen, Yujiu Ma, Xudong Zhang, Siwen Zhang, Shanshan Wu, Yimeng Lu, Jichun Tan
Article Number: 32
Published online on: 01 December 2025

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Retraction Open Access

[Retracted] miR‑381 functions as a tumor suppressor by targeting ETS1 in pancreatic cancer

Guanen Qiao, Jing Li, Jun Wang, Zhaoyang Wang, Wei Bian
Article Number: 31
Published online on: 01 December 2025

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