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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January-2018 Volume 41 Issue 1

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review

Inhibitors targeting the SUMOylation pathway: A patent review 2012‑2015 (Review)

Yanjun Zhou, Chunmei Ji, Mengda Cao, Miao Guo, Wen Huang, Weiwei Ni, Ling Meng, Haiwei Yang, Ji‑Fu Wei
Pages: 3-12
Published online on: 01 November 2017

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Article Open Access

Connexin 43 in splenic lymphocytes is involved in the regulation of CD4+CD25+ T lymphocyte proliferation and cytokine production in hypertensive inflammation

Hai-Chao Zhang, Zhong-Shuang Zhang, Liang Zhang, Ai Wang, He Zhu, Li Li, Jun-Qiang Si, Xin-Zhi Li, Ke-Tao Ma
Pages: 13-24
Published online on: 20 October 2017

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Article Open Access

Renoprotective effect of erythropoietin via modulation of the STAT6/MAPK/NF-κB pathway in ischemia/reperfusion injury after renal transplantation

Jinhua Zhang, Daqiang Zhao, Ning Na, Heng Li, Bin Miao, Liangqing Hong, Zhengyu Huang
Pages: 25-32
Published online on: 20 October 2017

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Article Open Access

Atorvastatin protects the proliferative ability of human umbilical vein endothelial cells inhibited by angiotensin II by changing mitochondrial energy metabolism

Ye Chang, Yuan Li, Ning Ye, Xiaofan Guo, Zhao Li, Guozhe Sun, Yingxian Sun
Pages: 33-42
Published online on: 19 October 2017

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Article Open Access

Proliferation of vascular smooth muscle cells under inflammation is regulated by NF-κB p65/microRNA-17/RB pathway activation

Dong Yang, Chen Sun, Jing Zhang, Shu Lin, Lin Zhao, Lun Wang, Ruoran Lin, Junyuan Lv, Shijie Xin
Pages: 43-50
Published online on: 25 October 2017

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Article Open Access

Combination treatment of adipose-derived stem cells and adiponectin attenuates pulmonary arterial hypertension in rats by inhibiting pulmonary arterial smooth muscle cell proliferation and regulating the AMPK/BMP/Smad pathway Corrigendum in /10.3892/ijmm.2021.4953

Li Luo, Wuhong Zheng, Guili Lian, Huaning Chen, Ling Li, Changsheng Xu, Liangdi Xie
Pages: 51-60
Published online on: 31 October 2017

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Article Open Access

Apolipoprotein C-III in the high-density lipoprotein proteome of cerebral lacunar infarction patients impairs its anti-inflammatory function

Pu Lv, Mingming Zhao, Yuanyuan Liu, Haiqiang Jin, Wei Cui, Chenghe Fan, Yuming Teng, Lemin Zheng, Yining Huang
Pages: 61-68
Published online on: 27 October 2017

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Article Open Access

AMPK activation serves a critical role in mitochondria quality control via modulating mitophagy in the heart under chronic hypoxia

Huagang Zhang, Bo Liu, Tianbo Li, Yun Zhu, Guiping Luo, Yunhan Jiang, Fuqin Tang, Zhao Jian, Yingbin Xiao
Pages: 69-76
Published online on: 26 October 2017

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Article Open Access

Anti-hypoglycemic and hepatocyte-protective effects of hyperoside from Zanthoxylum bungeanum leaves in mice with high-carbohydrate/high-fat diet and alloxan-induced diabetes

Yali Zhang, Mimi Wang, Huanhuan Dong, Xiaomin Yu, Jingfang Zhang
Pages: 77-86
Published online on: 25 October 2017

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Article Open Access

Generation of human-induced pluripotent stem cells from burn patient-derived skin fibroblasts using a non-integrative method

Shangfeng Fu, Jianwu Ding, Dewu Liu, Heping Huang, Min Li, Yang Liu, Longxiang Tu, Deming Liu
Pages: 87-94
Published online on: 23 October 2017

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Article Open Access

Inhibition of histone deacetylase 1 ameliorates renal tubulointerstitial fibrosis via modulation of inflammation and extracellular matrix gene transcription in mice

Tùng Nguyễn-Thanh, Dal Kim, Sik Lee, Won Kim, Sung Kwang Park, Kyung Pyo Kang
Pages: 95-106
Published online on: 27 October 2017

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Article Open Access

Detection of calprotectin in inflammatory bowel disease: Fecal and serum levels and immunohistochemical localization

Shuhei Fukunaga, Kotaro Kuwaki, Keiichi Mitsuyama, Hidetoshi Takedatsu, Shinichiro Yoshioka, Hiroshi Yamasaki, Ryosuke Yamauchi, Atsushi Mori, Tatsuyuki Kakuma, Osamu Tsuruta, Takuji Torimura
Pages: 107-118
Published online on: 07 November 2017

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Article Open Access

Radical scavenging-linked anti-adipogenic activity of Alnus firma extracts

Sun-Il Choi, Jong Seok Lee, Sarah Lee, Jin-Ha Lee, Hee-Sun Yang, Joohong Yeo, Jong-Yea Kim, Boo-Yong Lee, Il-Jun Kang, Ok-Hwan Lee
Pages: 119-128
Published online on: 27 October 2017

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Article Open Access

Transforming growth factor β1 promotes migration and invasion in HepG2 cells: Epithelial‑to‑mesenchymal transition via JAK/STAT3 signaling

Xiao‑Long Lin, Mihua Liu, Yuanbo Liu, Huijun Hu, Yongquan  Pan, Weiwen Zou, Xiaojuan Fan, Xuemei Hu
Pages: 129-136
Published online on: 01 November 2017

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Article Open Access

Cryptdin-2 predicts intestinal injury during heatstroke in mice

Jingjing Ji, Zhengtao Gu, Hui Li, Lei Su, Zhifeng Liu
Pages: 137-146
Published online on: 01 November 2017

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Article Open Access

Activation of adrenergic receptor β2 promotes tumor progression and epithelial mesenchymal transition in tongue squamous cell carcinoma

Haichao Liu, Cheng Wang, Nan Xie, Zehang Zhuang, Xiqiang Liu, Jinsong Hou, Hongzhang Huang
Pages: 147-154
Published online on: 09 November 2017

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Article Open Access

Histone deacetylase 3 is associated with gastric cancer cell growth via the miR-454-mediated targeting of CHD5

Guangru Xu, Hongxing Zhu, Minghui Zhang, Jinhua Xu
Pages: 155-163
Published online on: 31 October 2017

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Article Open Access

YAP and TAZ mediate steroid-induced alterations in the trabecular meshwork cytoskeleton in human trabecular meshwork cells

Jie Peng, Hailian Wang, Xin Wang, Minghan Sun, Shaoping Deng, Yi Wang
Pages: 164-172
Published online on: 23 October 2017

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Article Open Access

Synovial fluid‑derived synovial fragments represent an improved source of synovial mesenchymal stem cells in the temporomandibular joint

Yu Yao, Zheng‑Yu Li, Hong Zhang, You‑Hua Zheng, Li‑Xiang Mai, Wen‑Jing Liu, Zhi‑Guang Zhang, Yang‑Peng Sun
Pages: 173-183
Published online on: 25 October 2017

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Article Open Access

Metabolic profiles of adipose-derived and bone marrow-derived stromal cells from elderly coronary heart disease patients by capillary liquid chromatography quadrupole time-of-flight mass spectrometry

Jian-Zhong Li, Hui Qu, Jian Wu, Fan Zhang, Zhi-Bo Jia, Jian-Yong Sun, Bo Lv, Yue Kang, Shu-Lin Jiang, Kai Kang
Pages: 184-194
Published online on: 19 October 2017

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Article Open Access

A novel method of neural differentiation of PC12 cells by using Opti-MEM as a basic induction medium

Rendong Hu, Qiaoyu Cao, Zhongqing Sun, Jinying Chen, Qing Zheng, Fei Xiao
Pages: 195-201
Published online on: 19 October 2017

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Article Open Access

Resveratrol prevents osteoporosis by upregulating FoxO1 transcriptional activity

Yan-Ling Feng, Xiao-Tong Jiang, Fang-Fang Ma, Jie Han, Xu-Lei Tang
Pages: 202-212
Published online on: 23 October 2017

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Article Open Access

Long non‑coding RNA DANCR regulates the proliferation and osteogenic differentiation of human bone-derived marrow mesenchymal stem cells via the p38 MAPK pathway

Jinlong Zhang, Zhiwen Tao, Yuli Wang
Pages: 213-219
Published online on: 27 October 2017

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Article Open Access

Genome-wide DNA methylome alterations in acute coronary syndrome

Dandan Li, Jing Yan, Yunlong Yuan, Cheng Wang, Jia Wu, Qingwen Chen, Jiaxi Song, Junjun Wang
Pages: 220-232
Published online on: 27 October 2017

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Article Open Access

Luteolin inhibits multi-heavy metal mixture-induced HL7702 cell apoptosis through downregulation of ROS-activated mitochondrial pathway

Yafei Wang, Hong Su, Xin Song, Samuel Selorm Fiati Kenston, Jinshun Zhao, Yuanliang Gu
Pages: 233-241
Published online on: 27 October 2017

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Article Open Access

Neuroprotective effects of hydrogen sulfide on sodium azide-induced oxidative stress in PC12 cells

Cheng Gao, Pan Chang, Lijun Yang, Yi Wang, Shaohua Zhu, Haiyan Shan, Mingyang Zhang, Luyang Tao
Pages: 242-250
Published online on: 01 November 2017

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Article Open Access

Lychee seed extract protects against neuronal injury and improves cognitive function in rats with type II diabetes mellitus with cognitive impairment

Yong Tang, Chonglin Yu, Jianming Wu, Haixia Chen, Yuan Zeng, Xiuling Wang, Le Yang, Qibing Mei, Shousong Cao, Dalian Qin
Pages: 251-263
Published online on: 09 November 2017

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Article Open Access

Schisandrin A suppresses lipopolysaccharide-induced inflammation and oxidative stress in RAW 264.7 macrophages by suppressing the NF-κB, MAPKs and PI3K/Akt pathways and activating Nrf2/HO-1 signaling

Da Hye Kwon, Hee-Jae Cha, Eun Ok Choi, Sun-Hee Leem, Gi-Young Kim, Sung-Kwon Moon, Young-Chae Chang, Seok-Joong Yun, Hye Jin Hwang, Byung Woo Kim, Wun-Jae Kim, Yung Hyun Choi
Pages: 264-274
Published online on: 25 October 2017

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Article Open Access

Fibroblast activation protein-α promotes the growth and migration of lung cancer cells via the PI3K and sonic hedgehog pathways

Jun Jia, Tracey A. Martin, Lin Ye, Lin Meng, Nan Xia, Wen G. Jiang, Xiaodong Zhang
Pages: 275-283
Published online on: 27 October 2017

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Article Open Access

Suppression of microRNA-130b inhibits glioma cell proliferation and invasion, and induces apoptosis by PTEN/AKT signaling

Jian-Jun Gu, Kai-Chun Fan, Jian-He Zhang, Hong-Jie Chen, Shou-Sen Wang
Pages: 284-292
Published online on: 02 November 2017

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Article Open Access

Alterations of protein glycosylation in embryonic stem cells during adipogenesis

Wenguang Liu, Xingrong Yan, Wei Liu, Yangyang Wang, Yang Rao, Hanjie Yu, Jihong Cui, Xin Xie, Mei Sun, Lu Yin, Hongmin Li, Fulin Chen
Pages: 293-301
Published online on: 07 November 2017

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Article Open Access

Expression profile analysis of long non-coding RNAs involved in the metformin-inhibited gluconeogenesis of primary mouse hepatocytes

Yao Wang, Hongju Tang, Xueying Ji, Yuqing Zhang, Wan Xu, Xue Yang, Ruyuan Deng, Yun Liu, Fengying Li, Xiao Wang, Libin Zhou
Pages: 302-310
Published online on: 07 November 2017

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Article Open Access

Global gene expression analysis combined with a genomics approach for the identification of signal transduction networks involved in postnatal mouse myocardial proliferation and development

Ruoxin Wang, Chao Su, Xinting Wang, Qiang Fu, Xingjie Gao, Chunyan Zhang, Jie Yang, Xi Yang, Minxin Wei
Pages: 311-321
Published online on: 03 November 2017

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Article Open Access

Reactive oxygen species induce injury of the intestinal epithelium during hyperoxia

Min Zhao, Shimiao Tang, Junchi Xin, Yingliang Wei, Dongyan Liu
Pages: 322-330
Published online on: 09 November 2017

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Article Open Access

Hey1 functions as a positive regulator of odontogenic differentiation in odontoblast‑lineage cells

Xiao Yin, Zhaobin Zeng, Jinliang Xing, Ansheng Zhang, Wenkai Jiang, Wei Wang, Hantang Sun, Longxing Ni
Pages: 331-339
Published online on: 13 November 2017

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Article Open Access

Broadleaf Mahonia attenuates granulomatous lobular mastitis‑associated inflammation by inhibiting CCL‑5 expression in macrophages

Zhiyu Wang, Neng Wang, Xiaoyan Liu, Qi Wang, Biao Xu, Pengxi Liu, Huayu Zhu, Jianping Chen, Honglin Situ, Yi Lin
Pages: 340-352
Published online on: 09 November 2017

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Article Open Access

In vitro investigation of the mechanism underlying the effect of ginsenoside on the proliferation and differentiation of neural stem cells subjected to oxygen-glucose deprivation/reperfusion

Jian Gao, Huajing Bai, Qiang Li, Jian Li, Feng Wan, Mo Tian, Yuanyuan Li, Yilun Song, Jianping Zhang, Yinchu Si
Pages: 353-363
Published online on: 13 November 2017

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Article Open Access

Vitamin D receptor activation influences the ERK pathway and protects against neurological deficits and neuronal death

Jie Yuan, Xin Guo, Zhengang Liu, Xiuqin Zhao, Yan Feng, Sixin Song, Changmeng Cui, Pei Jiang
Pages: 364-372
Published online on: 09 November 2017

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Article

Herbal prescription, Danggui-Sayuk-Ga-Osuyu-Senggang-Tang, inhibits TNF-α-induced epithelial-mesenchymal transition in HCT116 colorectal cancer cells

Kangwook Lee, Sung-Gook Cho, Youn Kyung Choi, Yu-Jeong Choi, Gyu-Ri Lee, Chan-Yong Jeon, Seong-Gyu Ko
Pages: 373-380
Published online on: 07 November 2017

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Article Open Access

CCDC134 serves a crucial role in embryonic development

Biaoyi Yu, Tianzhuo Zhang, Peng Xia, Xiaoting Gong, Xiaoyan Qiu, Jing Huang
Pages: 381-390
Published online on: 19 October 2017

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Article

Anti-inflammatory effects of a methanolic extract of Castanea seguinii Dode in LPS-induced RAW264.7 macrophage cells

Yourim Lim, Ji-Won Park, Ok-Kyoung Kwon, Jae-Won Lee, Han-Sol Lee, Sangwoo Lee, Sangho Choi, Wanyi Li, Hang Jin, Sang-Bae Han, Kyung-Seop Ahn
Pages: 391-398
Published online on: 27 October 2017

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Article

The inhibition of MyD88 and TRIF signaling serve equivalent roles in attenuating myocardial deterioration due to acute severe inflammation

Min-Zhi Ouyang, Dan Zhou, Yun Zhu, Ming Zhang, Ling Li
Pages: 399-408
Published online on: 07 November 2017

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Article

Angiotensin-converting enzyme 2-angiotensin (1-7)-Mas axis prevents pancreatic acinar cell inflammatory response via inhibition of the p38 mitogen-activated protein kinase/nuclear factor-κB pathway

Xiaozheng Yu, Lijian Cui, Fei Hou, Xiaoya Liu, Yan Wang, Yan Wen, Cheng Chi, Chunyun Li, Ruixia Liu, Chenghong Yin
Pages: 409-420
Published online on: 13 November 2017

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Article

Effect on the dopaminergic metabolism induced by oral exposure to simazine during the prepubertal period in rats

Xueting Li, Jia Yu, Yanping Wu, Baixiang Li
Pages: 421-429
Published online on: 20 October 2017

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Article

Inhibition of Rho kinase protects against colitis in mice by attenuating intestinal epithelial barrier dysfunction via MLC and the NF-κB pathway

Yanting Zou, Lili Ma, Yuan Zhao, Shuncai Zhang, Chaohui Zhou, Yu Cai
Pages: 430-438
Published online on: 19 October 2017

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Article

High glucose upregulates endothelin type B receptors in vascular smooth muscle cells via the downregulation of Sirt1

Yan Lin, Yan Zhao, Enqi Liu
Pages: 439-445
Published online on: 07 November 2017

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Article

Mechanism of long non-coding RNA MALAT1 in lipopolysaccharide-induced acute kidney injury is mediated by the miR-146a/NF-κB signaling pathway

Ying Ding, Feng Guo, Tao Zhu, Jun Li, Danyan Gu, Weiliang Jiang, Yuying Lu, Daoyang Zhou
Pages: 446-454
Published online on: 02 November 2017

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Article

Persistent STAT5-mediated ROS production and involvement of aberrant p53 apoptotic signaling in the resistance of chronic myeloid leukemia to imatinib

Yanhong Cheng, Yingchan Hao, Aimei Zhang, Chaojie Hu, Xiaoxiao Jiang, Quan Wu, Xiucai Xu
Pages: 455-463
Published online on: 20 October 2017

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Article

Hesperidin induces apoptosis and G0/G1 arrest in human non-small cell lung cancer A549 cells

Rongmu Xia, Xin Sheng, Xianlin Xu, Chunbo Yu, Hongling Lu
Pages: 464-472
Published online on: 09 November 2017

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Article Open Access

Induced pluripotent stem cell-conditioned medium suppresses pulmonary fibroblast-to-myofibroblast differentiation via the inhibition of TGF-β1/Smad pathway

Yan Zhou, Qiang Zhang, Yuan Gao, Mingqi Tan, Rui Zheng, Li Zhao, Xiaoye Zhang
Pages: 473-484
Published online on: 19 October 2017

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Article

Antinociceptive effect of Valeriana fauriei regulates BDNF signaling in an animal model of fibromyalgia

Hwayoung Lee, Jiyun Im, Hansol Won, Jun Young Kim, Hyung‑Ki Kim, Jun‑Tack Kwon, Young Ock Kim, Sanghyun Lee, Ik‑Hyun Cho, Sang Won Lee, Hak‑Jae Kim
Pages: 485-492
Published online on: 20 October 2017

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Article

Downregulation of microRNA‑124‑3p suppresses the mTOR signaling pathway by targeting DDIT4 in males with major depressive disorder

Qiuling Wang, Gaofeng Zhao, Zhenzhen Yang, Xia Liu, Ping Xie
Pages: 493-500
Published online on: 06 November 2017

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Article

MicroRNA-142-3p relieves neuropathic pain by targeting high mobility group box 1

Yang Zhang, Junying Mou, Li Cao, Su Zhen, Hongjuan Huang, Hongguang Bao
Pages: 501-510
Published online on: 27 October 2017

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Article

Protein extracted from Porphyra yezoensis prevents cisplatin-induced nephrotoxicity by downregulating the MAPK and NF-κB pathways

In-Hye Kim, Mi-Jin Kwon, Jae-Hun Jung, Taek-Jeong Nam
Pages: 511-520
Published online on: 26 October 2017

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Article

Anti-neuroinflammatory effect of curcumin on Pam3CSK4-stimulated microglial cells

Meiling Jin, Sun Young Park, Qian Shen, Yihong Lai, Xingmei Ou, Zhuo Mao, Dongxu Lin, Yangyang Yu, Weizhen Zhang
Pages: 521-530
Published online on: 27 October 2017

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Article

Vibrio vulnificus infection induces the maturation and activation of dendritic cells with inflammatory Th17-polarizing ability

Arim Lee, Hui Xuan Lim, Myun Soo Kim, Daeho Cho, Kyung Ku Jang, Sang Ho Choi, Tae Sung Kim
Pages: 531-540
Published online on: 01 November 2017

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Article

Peanut arachidin-1 enhances Nrf2-mediated protective mechanisms against TNF-α-induced ICAM-1 expression and NF-κB activation in endothelial cells

Lih-Geeng Chen, Yu-Qi Zhang, Zhi-Zhen Wu, Chia-Wen Hsieh, Chi-Shih Chu, Being-Sun Wung
Pages: 541-547
Published online on: 07 November 2017

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Article

Low-dose irradiation inhibits proliferation of the p53null type human prostate cancer cells through the ATM/p21 pathway

Si-Jie Li, Xin-Yue Liang, Hai-Jun Li, Guo-Zi Yang, Wei Li, Zhuo Li, Lei Zhou, Xue Wen, De-Hai Yu, Jiu-Wei Cui
Pages: 548-554
Published online on: 07 November 2017

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Article

Berberine prevents the apoptosis of mouse podocytes induced by TRAF5 overexpression by suppressing NF-κB activation

Feng Wu, Dong-Sheng Yao, Tian-Ying Lan, Chen Wang, Jian-Dong Gao, Li-Qun He, Di Huang
Pages: 555-563
Published online on: 07 November 2017

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August-2026 Volume 58 Issue 2

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Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Myokines in exercise‑mediated bone homeostasis: Molecular signaling mechanisms and therapeutic implications for bone disorders (Review)

Bin Tian, Xuesong Chen, Jiang Zheng, Xin Kang
Article Number: 231
Published online on: 24 June 2026

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Neutrophil extracellular traps in thrombosis of hematologic malignancies: Underlying mechanisms and therapeutic opportunities (Review)

Kebing Lv, Zijie Ma, Qiuni Chen, Yang Su, Jingjing Ma, Chunling Wang, Liang Yu
Article Number: 230
Published online on: 23 June 2026

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Recombinant myonectin ameliorates sepsis‑induced cardiomyopathy by alleviating mitochondrial dysfunction via the AdipoR1/AMPK pathway

Peipei Li, Rui Chen, Hanmo Zhang, Lihong Li, Huiling Luo, Beibei Du, Ping Yang
Article Number: 229
Published online on: 23 June 2026

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MTA2: Decoding pathogenic mechanisms, clinical implications and therapeutic frontiers across disease landscapes (Review)

Hao Xie, Ling Chen, Jing Gou, Xuehong Long, Ya Yang, Hai Hu, Ping Wu, Qibing Yan, Yongkang Wu
Article Number: 228
Published online on: 22 June 2026

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Mitochondria‑endoplasmic reticulum contact site nexus: Molecular integration, disease pathogenesis and therapeutic opportunities (Review)

Yi Liu, Xianda Che, Wei Wei, Chong Teng, Huimin Li
Article Number: 227
Published online on: 22 June 2026

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Metabolic messengers from the gut to the joint: Toward precision management of osteoarthritis (Review)

Ruipu Zhang, Liang Zhang, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 226
Published online on: 22 June 2026

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Retraction Open Access

[Retracted] Protection of telomeres 1 protein levels are associated with telomere length in gastric cancer

Kiyomu Fujii, Tomonori Sasahira, Yukiko Moriwaka, Naohide Oue, Wataru Yasui, Hiroki Kuniyasu
Article Number: 225
Published online on: 22 June 2026

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Molecular mechanism of hydromorphone preconditioning in cerebral ischemia/reperfusion‑induced inflammatory injury

Jing Yao, Zeqing Huang, Songze Li, Minghui Lun, Jianing Fan
Article Number: 224
Published online on: 18 June 2026

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Oridonin ameliorates ulcerative colitis by regulating the PI3K/AKT/mTOR signaling pathway to activate autophagy

Zhongxing Miao, Baohong Liu, Xingzhi Zhou, Mengru Lu, Ni Jia, Huamin Zhang, Ying Qi, Xiaoyu Tan, Qinggao Zhang
Article Number: 223
Published online on: 18 June 2026

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Arsenic exposure and skin cancer: Mechanisms, clinical evidence and public health implications (Review)

Dimitrios A. Andreikos, Michael Aschner, Dimitrios C. Ziogas, Aristidis Tsatsakis, Demetrios A. Spandidos
Article Number: 222
Published online on: 18 June 2026

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Targeting glutathione metabolism for tumor radiosensitization (Review)

Haonan Xu, Meng Du, Xiaowen Liang, Xilin Xiao, Zhiyi Chen
Article Number: 221
Published online on: 16 June 2026

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Effects of exercise‑derived extracellular vesicles: Epigenetic regulatory mechanisms and protective roles (Review)

Xinxin Zhang, Biao Zhang
Article Number: 220
Published online on: 15 June 2026

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Moderate downregulation of NDUFA13 promotes cardiomyocytes proliferation and heart regeneration through the glycolysis/c‑Myc/Ccnd1 axis

Ying Gao, Ningjing Qian, Junyan Jin, Jiayi Liu, Bingqi Wang, Yaping Wang
Article Number: 219
Published online on: 12 June 2026

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Correction Open Access

[Corrigendum] (‑)‑Epigallocatechin‑3‑gallate attenuates myocardial injury induced by ischemia/reperfusion in diabetic rats and in H9c2 cells under hyperglycemic conditions

Yang Wu, Zhong-Yuan Xia, Bo Zhao, Yan Leng, Juan Dou, Qing-Tao Meng, Shao-Qing Lei, Zhi-Ze Chen, Jie Zhu
Article Number: 218
Published online on: 10 June 2026

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Melatonin ameliorates circadian rhythm disruption induced erectile dysfunction by inhibiting oxidative stress mediated pyroptosis via Nrf2/HO‑1 axis

Qingtao Yang, Wei Li, Qi Yu, Jiang Shi, Lu Yang, Jun Qiao, Xi Wei, Changshi Gu, Fa Sun, Tao Li
Article Number: 217
Published online on: 09 June 2026

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Spatial architecture of immunometabolism: Mitochondrial‑organelle interfaces in immune signaling (Review)

Yaping Wu, Hao Yu, Ling Xia, Li Yang, Yu Zhou, Qian Yu
Article Number: 216
Published online on: 08 June 2026

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Urea cycle dysregulation and arginine pathways in the pathogenesis of NAFLD and NASH (Review)

Boying Zhu, Chaoyang Wang, Peng Liu, Zhifeng Qu, Ran Qi, Shengjiang Chen, Huanzhang Niu
Article Number: 215
Published online on: 08 June 2026

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Article Open Access

Withaferin A, a candidate drug for lupus nephritis, confers renal protection via Pon1‑mediated attenuation of oxidative stress

Miao Xue, Junshuai Feng, Xiaorong Mao
Article Number: 214
Published online on: 08 June 2026

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Retraction Open Access

[Retracted] Classical dendritic cells regulate acute lung inflammation and injury in mice with lipopolysaccharide‑induced acute respiratory distress syndrome

Lang Li, Liang Dong, Dan Zhao, Fei Gao, Jie Yan
Article Number: 213
Published online on: 08 June 2026

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Plant‑derived natural products alleviate dexamethasone‑induced skeletal muscle atrophy by modulating FoxO (Review)

Wei Dai, Jiabin Wu, Xiaotong Ma, Mingyu Wu, Ke Li, Haoyang Gao, Wenhong Wang, Weihua Xiao
Article Number: 212
Published online on: 05 June 2026

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Functional hydrogels in cardiovascular therapy: Design, applications and clinical challenges (Review)

Zheming Yang, Jiayin Li, Lingxiao Zhao, Dali Zhang, Chenghui Yan, Dan Liu, Yaling Han
Article Number: 211
Published online on: 04 June 2026

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Experimental rodent models of cardiorenal syndrome types 3 and 4: Insights and clinical relevance (Review)

Stefanny M. Figueroa, Siyi Huang, Javier Reyes‑Osorio, Jean-Jacques Boffa, Cristián A. Amador, Christos E. Chadjichristos, Louis Boutin
Article Number: 210
Published online on: 04 June 2026

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Expression of Concern Open Access

[Expression of Concern] Novel insights into the role of HSP90 in cytoprotection of H2S against chemical hypoxia‑induced injury in H9c2  cardiac myocytes

Zhanli Yang, Chuntao Yang, Liangcan Xiao, Xinxue Liao, Aiping Lan, Xiuyu Wang, Ruixian Guo, Peixi Chen, Chengheng Hu, Jianqiang Feng
Article Number: 209
Published online on: 03 June 2026

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Microbiota‑derived indole‑3‑propionic acid reprograms bone marrow stem cell fate via PPARγ suppression to rescue osteoporosis

Jinwu Bai, Ruideng Wang, Jixing Fan, Shilong Su, Gao Si, Qinyong You, Ao Sun, Daole Hu, Shan Gao, Yang Lv, Fang Zhou
Article Number: 208
Published online on: 03 June 2026

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Article Open Access

Lactate regulates osteoclastogenesis via H3k18la in osteoarthritis

Zhibo Fan, Qiyue Fu, Tao Sun, Yutong Zhong, Yuefan Ma, Jingwei Jian, Shuosheng Yuan, Shenghong Li, Xiaomei Xu
Article Number: 207
Published online on: 02 June 2026

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Retraction Open Access

[Retracted] miR‑215 promotes epithelial to mesenchymal transition and proliferation by regulating LEFTY2 in endometrial cancert

Xiaoxu Gao, Yan Cai, Ruifang An
Article Number: 206
Published online on: 02 June 2026

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Review

Multi‑scale experimental models for the study of angiogenesis (Review)

Qin Yu, Jiarui Hu, Shuangshuang Yuan, Jiexia Gan, Mao Luo, Jianbo Wu, Liqun Wang
Article Number: 205
Published online on: 28 May 2026

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Targeting lactylation in hepatocellular carcinoma: Mechanistic insights and therapeutic opportunities (Review)

Lianting Chen, Feiqiong Gao, Qianru Mei, Yujie Li, Qun Cai, Xudong Feng
Article Number: 204
Published online on: 28 May 2026

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Article Open Access

Oxygen‑sensing histone demethylase KDM6A modulates chondrocyte‑to‑osteoblast transdifferentiation by activating the Wnt/β‑catenin pathway

Yi Rong, Hao Yu, Heng Yin, Shaoshuo Li, Jianwei Wang, Zhongyuan Shen, Xinxin Ding, Fanchen Bu, Tianyi Dai, Gean Wu, Zhen Hua
Article Number: 203
Published online on: 28 May 2026

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Journal Cover
September-2026 Volume 58 Issue 3

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Gut‑bone metabolites: SCFAs, polyamines and microbial metabolomics in osteoporosis risk and therapy (Review)

Fuchao Chen, Jingyue Sun, Xiao Wang
Article Number: 263
Published online on: 21 July 2026

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Expression of Concern Open Access

[Expression of Concern] Exposure to acoustic stimuli promotes the development and differentiation of neural stem cells from the cochlear nuclei through the clusterin pathway

Tao Xue, Li Wei, Ding-Jun Zha, Li Qiao, Lian-Jun Lu, Fu-Quan Chen, Jian-Hua Qiu
Article Number: 262
Published online on: 20 July 2026

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Cepharanthine inhibits tick‑borne encephalitis virus infection through modulation of the stress and inflammation response

Wan-Da Tang, Lan-Juan Zhao
Article Number: 261
Published online on: 16 July 2026

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Article Open Access

circCACNA1D drives pulmonary fibrosis by regulating pyruvate kinase M2 dimer‑tetramer switching

Yujie Wang, Xiaoting Li, Meirong Wang, Nailiang Zhai, Mengqi Jiang, Bo Liu, Changjun Lv, Songzi Zhang, Xiaodong Song, Jinjin Zhang
Article Number: 260
Published online on: 15 July 2026

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Recent progress and therapeutic strategies in the treatment of cervical neuroendocrine neoplasms (Review)

Yanpeng Tian, Yu Zhang, Liling Wang, Zhongkang Li, Xiaotong Xu, Shouze Liu, Shenyu Yang, Xiangyang Ren, Menghan Xu, Xingzi Chang, Xianghua Huang, Qian Zhao, Ruixia Guo
Article Number: 259
Published online on: 15 July 2026

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Neurofibromin in bone disease: Mechanisms and therapeutic implications (Review)

Shuhong Zhang, Ge Yang
Article Number: 258
Published online on: 14 July 2026

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Exercise‑induced exosomal noncoding RNAs: Molecular signaling cascades in bone remodeling and translational applications in sports‑related bone injuries (Review)

Bin Tian, Xuesong Chen, Jiang Zheng, Xin Kang
Article Number: 257
Published online on: 14 July 2026

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Review Open Access

Targeting alveolar type II cell dysfunction in idiopathic pulmonary fibrosis: Molecular mechanisms and emerging therapeutic strategies (Review)

Tianhao Xie, Kang Hu, Shu Pan, Xin Tong, Haitong Huang, Hao Ding, Jun Zhao
Article Number: 256
Published online on: 13 July 2026

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Article Open Access

Tubular PFKFB3 drives diabetic kidney fibrosis via lactate‑dependent H4K12 lactylation and HIPK2 transactivation

Mingkun Xu, Linhang Fu, Yulong Zhang, Xiuli Guo, Han Wu, Sijing Gao, Fei Xiao, Li Xu
Article Number: 255
Published online on: 13 July 2026

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Retraction Open Access

[Retracted] p73 participates in WWOX-mediated apoptosis in leukemia cells

Donghong Lin, Zhaolei Cui, Lingying Kong, Feng Cheng, Jianping Xu, Fenghua Lan
Article Number: 254
Published online on: 13 July 2026

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Article Open Access

Role of hyperthermia in overcoming HPV‑mediated MHC‑Ⅰ downregulation and promoting immune surveillance

Hanyu Wang, Hongxin Lang, Yaoxing Guo, Te Sun, Yuansong Bai, Tao Zhang, Rui-Qun Qi
Article Number: 253
Published online on: 10 July 2026

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Review Open Access

Endocrine‑metabolic imbalance drives osteoarthritis: From whole‑joint pathobiology to precision therapy (Review)

Ruhui Yang, Haimin Zeng, Qi Xiao, Yining Xie, Yi Long, Xiang Chen
Article Number: 252
Published online on: 09 July 2026

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Expression of Concern Open Access

[Expression of Concern] Roles and mechanisms of action of HNF‑4α in the hepatic differentiation of WB‑F344 cells

Yumeng Shi, Dehua Zhou, Bingyi Wang, Deren Zhou, Baomin Shi
Article Number: 251
Published online on: 08 July 2026

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Phenylalanine exacerbates psoriasiform inflammation through NF‑κB‑mediated dendritic cell activation and Th17 polarization

Yaohan Xu, Jing Pan, Jie Chen, Yutao Zhu, Miaolian Cai, Zeyu Ma, Siji Chen, Tianze Yu, Yushu Wei, Jingying Pan, Kunliang Luo, Yinjing Song, Stijn Van Der Veen, Hao Cheng
Article Number: 250
Published online on: 08 July 2026

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Review Open Access

Protective effects of Astragaloside IV on various liver diseases: From chemistry to herbal medicines (Review)

Jialu Shi, Xiaoyu Zhou, Jiabin Wu, Liru Zeng, Xia Wang, Wei Li, Xiao Huang, Xiaoyu Deng, Wenhong Wang
Article Number: 249
Published online on: 07 July 2026

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Review Open Access

GRP78 dysregulation: A proposed molecular mechanism linking the tumor microenvironment to sepsis susceptibility in patients with cancer (Review)

Hang Ruan, Meipeng Zhu, Shi-Yan Liu, Li-Juan Zou, Shu-Sheng Li
Article Number: 248
Published online on: 07 July 2026

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Review Open Access

FGFR1 signaling in rheumatoid arthritis: Mechanisms of bone destruction and therapeutic targeting (Review)

Changzhong Qian, Zhenyu Zhang, Xian Wu, Huibo Ti, Junjie Wu, Zhengdong Yuan, Xia Li, Feng-Lai Yuan
Article Number: 247
Published online on: 06 July 2026

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Retraction Open Access

[Retracted] β‑catenin signaling induces the osteoblastogenic differentiation of human pre‑osteoblastic and bone marrow stromal cells mainly through the upregulation of osterix expression

Bo Liu, Song Wu, Lihua Han, Chaoyue Zhang
Article Number: 246
Published online on: 06 July 2026

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Single‑cell atlas reveals a Wilms' tumor 1‑mediated axis driving granulosa cell senescence in human ovarian aging

Yanfang Du, Congyu Zhou, Yanpeng Tian, Zhongkang Li, Xianghua Huang
Article Number: 245
Published online on: 03 July 2026

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Review Open Access

TRPV1‑mediated central sensitisation: Core mechanisms of migraine chronification and novel targeted therapeutic strategies (Review)

Mingxia Zhang, Yuting Pu, Yujie Zhang, Jia Hu, Shuangyang Li, Hongmei Tang, Bangjiang Fang, Xue Bai
Article Number: 244
Published online on: 02 July 2026

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Correction Open Access

[Corrigendum] Arginine ADP‑ribosyltransferase 1 promotes angiogenesis in colorectal cancer via the PI3K/Akt pathway

Lian Yang, Ming Xiao, Xian Li, Yi Tang, Ya-Lan Wang
Article Number: 243
Published online on: 02 July 2026

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Research progress on the chemical and pharmacological effects of Semen Strychni (Review)

Jingxin Mao, Xin Du, Dan Zeng, Xin Luo, Yan Li
Article Number: 242
Published online on: 02 July 2026

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Article Open Access

FLI1 enhances the malignant phenotype of glioma cells and exerts immunomodulatory effects through feedback crosstalk with exonic circRNA FECR1 and interferon‑induced ISG15

Xue Wen, Xiaoyi Gu, Xu Yan, Naifei Chen, Lei Zhou, Hui Li, Andrew R. Hoffman, Wei Li, Ji-Fan Hu, Jiuwei Cui
Article Number: 241
Published online on: 01 July 2026

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Review Open Access

Role of ZEB1 in angiogenesis and therapeutic potential (Review)

Ruoxin Ren, Chunxiao Yan, Yao Xiang, Lin Jin, Fang Cheng, Lijun Zhang
Article Number: 240
Published online on: 01 July 2026

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Endothelial dysfunction: A central mechanism linking autosomal dominant polycystic kidney disease and intracranial aneurysms (Review)

Xiaohong Xu, Ruyi Xu, Liexiang Zhang
Article Number: 239
Published online on: 01 July 2026

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Correction Open Access

[Corrigendum] Effect of SDF‑1/CXCR4 axis on the migration of transplanted bone mesenchymal stem cells mobilized by erythropoietin toward lesion sites following spinal cord injury

Jun Li, Weichun Guo, Min Xiong, Heng Han, Jie Chen, Dan Mao, Bing Tang, Hualong Yu, Yun Zeng
Article Number: 238
Published online on: 01 July 2026

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Review Open Access

Exercise and fluoxetine in Alzheimer's disease: Molecular mechanisms of synergistic and antagonistic effects (Review)

Mei Wu, Yan Li
Article Number: 237
Published online on: 30 June 2026

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Review Open Access

Oral‑gut axis in systemic disease: A barrier‑metabolism‑immunity three‑dimensional regulatory model (Review)

Qing Li, Mingrong Cheng, Weiwei Li, Xiaoyue Wang, Xiaoqing Liu, Yujie Yan
Article Number: 236
Published online on: 30 June 2026

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Review Open Access

ABCG2 transporter: Structural and functional associations with gout (Review)

Muhammad Arslan Asif, Zeshan Zulfiqar, Bahar E. Mustafa, Usman Nazir, Jiamen Sun, Zhichang Wang, Yalei Cui, Sun Hao, Liu Boshuai, Yinghua Shi
Article Number: 235
Published online on: 30 June 2026

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Neuropilin‑1: Emerging roles in nerve‑vessel‑bone coupling during fracture repair (Review)

Keyue Zhang, Tong Li, Huan Liu, Huibo Ti, Zhenyu Zhang, Zhengdong Yuan, Junjie Wu, Xielin Yan, Zixin Luo, Haiting Hu, Xingchen Yao, Shuwen Shi, Xian Wu, Feng-Lai Yuan, Xiao Chen
Article Number: 234
Published online on: 30 June 2026

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Correction Open Access

[Corrigendum] Crocin exerts anti‑inflammatory and anti‑catabolic effects on rat intervertebral discs by suppressing the activation of JNK

Kang Li, Yan Li, Zhenjiang Ma, Jie Zhao
Article Number: 233
Published online on: 29 June 2026

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Skeletal muscle‑derived extracellular vesicles in multi‑organ degenerative disease: Mechanisms and therapeutic delivery perspectives (Review)

Xianji Wei, Chengyan Guo, Wei Zhang, Guanyi Wang, Wenjing Li, Binghong Gao, Bo Gao, Lingli Zhang
Article Number: 232
Published online on: 26 June 2026

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