Downregulation of microRNA‑124‑3p suppresses the mTOR signaling pathway by targeting DDIT4 in males with major depressive disorder

  • Authors:
    • Qiuling Wang
    • Gaofeng Zhao
    • Zhenzhen Yang
    • Xia Liu
    • Ping Xie
  • View Affiliations

  • Published online on: November 6, 2017     https://doi.org/10.3892/ijmm.2017.3235
  • Pages:493-500
Metrics: HTML 0 views | PDF 0 views
0

Abstract

Recent investigations have suggested that microRNAs (miRNAs or miRs) are involved in several pathways that may contribute to the pathomechanism of major depressive disorder (MDD). Sex may not only act as a demographic factor in clinical practive, but may also play a vital role in the molecular heterogeneity of MDD. Although many molecular changes correlated with MDD are found in males, the molecular mechanisms of MDD remain poorly understood. The present study performed bioinformatics analysis to investigate the pathomechanism of MDD in males. The present study identified miR‑124‑3p as one of the most dysregulated miRNAs in MDD, with decreased expression in the post‑mortem BA44 brain area of male patients with MDD. In addition, miR‑124‑3p targets DNA damage‑inducible transcript 4 (DDIT4) and specificity protein 1 (SP1), a DDIT4 transcription factor, in the validated target module of the miRWalk 2.0 database. This is concurrent with an increase in the expression level of DDIT4, which is an inhibitor of the mammalian target of rapamycin (mTOR) signaling pathway. It was also demonstrated that miR‑124‑3p expression was positively associated with mTOR signaling and this relationship was dependent on the tuberous sclerosis proteins 1/2 complex. Taken together, these results provided a novel insight on miR‑124‑3p involvement in the biological alterations of male patients with MDD and suggested that this miRNA may also serve as a male‑specific target for antidepressant treatment.

Related Articles

Journal Cover

January 2018
Volume 41 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

2016 Impact Factor: 2.341
Ranked #21/128 Medicine Research and Experimental
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Wang, Q., Zhao, G., Yang, Z., Liu, X., & Xie, P. (2018). Downregulation of microRNA‑124‑3p suppresses the mTOR signaling pathway by targeting DDIT4 in males with major depressive disorder. International Journal of Molecular Medicine, 41, 493-500. https://doi.org/10.3892/ijmm.2017.3235
MLA
Wang, Q., Zhao, G., Yang, Z., Liu, X., Xie, P."Downregulation of microRNA‑124‑3p suppresses the mTOR signaling pathway by targeting DDIT4 in males with major depressive disorder". International Journal of Molecular Medicine 41.1 (2018): 493-500.
Chicago
Wang, Q., Zhao, G., Yang, Z., Liu, X., Xie, P."Downregulation of microRNA‑124‑3p suppresses the mTOR signaling pathway by targeting DDIT4 in males with major depressive disorder". International Journal of Molecular Medicine 41, no. 1 (2018): 493-500. https://doi.org/10.3892/ijmm.2017.3235