Necroptosis: A novel manner of cell death, associated with stroke (Review)

  • Authors:
    • Chenglin Liu
    • Kai Zhang
    • Haitao Shen
    • Xiyang Yao
    • Qing Sun
    • Gang Chen
  • View Affiliations

  • Published online on: November 22, 2017     https://doi.org/10.3892/ijmm.2017.3279
  • Pages: 624-630
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Abstract

Cell death is indispensable in the physiology, pathology, growth, development, senility and death of an organism. In recent years, the identification of a highly regulated form of necrosis, known as necroptosis, has challenged the traditional concept of necrosis and apoptosis, which are two major modes of cell death. This novel manner of cell death is similar in form to necrosis in terms of morphological features, and it can also be regulated in a caspase‑independent manner. Therefore, necroptosis can be understood initially as a combination of necrosis and apoptosis. The mechanism of its regulation, induction and inhibition is complicated, and involves a range of molecular expression and regulation. According to the recent literature, necroptosis takes place in the physiological regulatory processes of an organism and is involved in the occurrence, development and prognosis of a variety of diseases that have a necrosis phenotype, including neurodegenerative diseases, ischemic disease, hemorrhagic disease, inflammation and viral infectious diseases. In the present review, the features, molecular mechanism and identification of necroptosis under pathological conditions are discussed, with particular emphasis on its association with stroke.

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February 2018
Volume 41 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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APA
Liu, C., Zhang, K., Shen, H., Yao, X., Sun, Q., & Chen, G. (2018). Necroptosis: A novel manner of cell death, associated with stroke (Review). International Journal of Molecular Medicine, 41, 624-630. https://doi.org/10.3892/ijmm.2017.3279
MLA
Liu, C., Zhang, K., Shen, H., Yao, X., Sun, Q., Chen, G."Necroptosis: A novel manner of cell death, associated with stroke (Review)". International Journal of Molecular Medicine 41.2 (2018): 624-630.
Chicago
Liu, C., Zhang, K., Shen, H., Yao, X., Sun, Q., Chen, G."Necroptosis: A novel manner of cell death, associated with stroke (Review)". International Journal of Molecular Medicine 41, no. 2 (2018): 624-630. https://doi.org/10.3892/ijmm.2017.3279