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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
February-2018 Volume 41 Issue 2

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Galectin-3 as a novel biomarker for disease diagnosis and a target for therapy (Review)

Rui Dong, Min Zhang, Qunying Hu, Shan Zheng, Andrew Soh, Yijie Zheng, Hui Yuan
Pages: 599-614
Published online on: 05 December 2017

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Review

Mitochondria-mediated damage to dopaminergic neurons in Parkinson's disease (Review)

Xiao‑Liang Liu, Ying‑Di Wang, Xiu‑Ming Yu, Da‑Wei Li, Guang‑Ren Li
Pages: 615-623
Published online on: 16 November 2017

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Review

Necroptosis: A novel manner of cell death, associated with stroke (Review)

Chenglin Liu, Kai Zhang, Haitao Shen, Xiyang Yao, Qing Sun, Gang Chen
Pages: 624-630
Published online on: 22 November 2017

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Review Open Access

The role and mechanism of β‑arrestins in cancer invasion and metastasis (Review)

Qing Song, Qing Ji, Qi Li
Pages: 631-639
Published online on: 27 November 2017

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Article Open Access

A common African variant of human connexin 37 is associated with Caucasian primary ovarian insufficiency and has a deleterious effect in vitro

Anne Bachelot, Jerome Gilleron, Geri Meduri, Mihelai Guberto, Jerome Dulon, Sylviane Boucherie, Philippe Touraine, Micheline Misrahi
Pages: 640-648
Published online on: 16 November 2017

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Article Open Access

Naringenin induces laxative effects by upregulating the expression levels of c-Kit and SCF, as well as those of aquaporin 3 in mice with loperamide-induced constipation

Jianqiao Yin, Yichao Liang, Dalu Wang, Zhaopeng Yan, Hongzhuan Yin, Di Wu, Qi Su
Pages: 649-658
Published online on: 01 December 2017

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Article Open Access

Therapeutic effects of conditioned medium from bone marrow-derived mesenchymal stem cells on epithelial-mesenchymal transition in A549 cells

Xin Wang, Jun-Ling Gao, Man-Man Zhao, Hui-Xing Zhu, Yan-Xia Tian, Ran Li, Xiao-Hua Jiang, Lei Yu, Jing-Rui Tian, Jian-Zhong Cui
Pages: 659-668
Published online on: 24 November 2017

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Article Open Access

In vitro cell behaviors of bone mesenchymal stem cells derived from normal and postmenopausal osteoporotic rats

Qian Liu, Xiaoxia Zhang, Yang Jiao, Xin Liu, Yirong Wang, Song-Lun Li, Wei Zhang, Fa-Ming Chen, Yin Ding, Chuan Jiang, Zuolin Jin
Pages: 669-678
Published online on: 22 November 2017

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Article Open Access

Use of methylation profiling to identify significant differentially methylated genes in bone marrow mesenchymal stromal cells from acute myeloid leukemia Corrigendum in /10.3892/ijmm.2025.5520

Jing Huang, Zhi Liu, Yufan Sun, Qi Zhong, Li Xu, Ruimin Ou, Cheng Li, Rui Chen, Mengdong Yao, Qing Zhang, Shuang Liu
Pages: 679-686
Published online on: 17 November 2017

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Article Open Access

Stromal-epithelial lactate shuttle induced by tumor‑derived interleukin‑1β promotes cell proliferation in oral squamous cell carcinoma

Jie Wu, Yun Hong, Tong Wu, Juan Wang, Xiaobing Chen, Zhi Wang, Bin Cheng, Juan Xia
Pages: 687-696
Published online on: 17 November 2017

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Article Open Access

Interaction of iPSC-derived neural stem cells on poly(L-lactic acid) nanofibrous scaffolds for possible use in neural tissue engineering

Chengkai Lin, Chang Liu, Liangming Zhang, Zhi Huang, Peipei Zhao, Ruiqiang Chen, Mao Pang, Zhenxiang Chen, Liumin He, Chunxiao Luo, Limin Rong, Bin Liu
Pages: 697-708
Published online on: 30 November 2017

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Article Open Access

Neurochemical changes in the hippocampus and prefrontal cortex associated with electroacupuncture for learning and memory impairment

Jian He, Congkuai Zhao, Weilin Liu, Jia Huang, Shengxiang Liang, Lidian Chen, Jing Tao
Pages: 709-716
Published online on: 24 November 2017

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Article Open Access

A type 2 diabetes-associated SNP in KCNQ1 (rs163184) modulates the binding activity of the locus for Sp3 and Lsd1/Kdm1a, potentially affecting CDKN1C expression

Masaki Hiramoto, Haruhide Udagawa, Naoko Ishibashi, Eri Takahashi, Yasushi Kaburagi, Keisuke Miyazawa, Nobuaki Funahashi, Takao Nammo, Kazuki Yasuda
Pages: 717-728
Published online on: 20 November 2017

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Article Open Access

Platelet-rich plasma inhibits RANKL-induced osteoclast differentiation through activation of Wnt pathway during bone remodeling

Dongyue Wang, Yajuan Weng, Shuyu Guo, Yuxin Zhang, Tingting Zhou, Mengnan Zhang, Lin Wang, Junqing Ma
Pages: 729-738
Published online on: 16 November 2017

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Article Open Access

Geraniin protects bone marrow‑derived mesenchymal stem cells against hydrogen peroxide‑induced cellular oxidative stress in vitro

Dan Huang, Li Yin, Xinxin Liu, Bo Lv, Zulong Xie, Xuedong Wang, Bo Yu, Yao Zhang
Pages: 739-748
Published online on: 21 November 2017

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Article Open Access

Effects of kartogenin on the attenuated nucleus pulposus cell degeneration of intervertebral discs induced by interleukin-1β and tumor necrosis factor-α

Yao Huang, Tao Jiang, Jian Chen, Guo-Yong Yin, Jin Fan
Pages: 749-756
Published online on: 24 November 2017

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Article Open Access

Der f1 induces pyroptosis in human bronchial epithelia via the NLRP3 inflammasome

Ying‑Ming Tsai, Kuo‑Hwa Chiang, Jen‑Yu Hung, Wei‑An Chang, Hui‑Ping Lin, Jiunn‑Min Shieh, Inn‑Wen Chong, Ya‑Ling Hsu
Pages: 757-764
Published online on: 05 December 2017

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Article Open Access

Chlorogenic acid attenuates hydrogen peroxide‑induced oxidative stress in lens epithelial cells

Jike Song, Dadong Guo, Hongsheng Bi
Pages: 765-772
Published online on: 01 December 2017

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Article Open Access

Clinical and next-generation sequencing findings in a Chinese family exhibiting severe familial exudative vitreoretinopathy

Ying Lin, Hongbin Gao, Chuan Chen, Yi Zhu, Tao Li, Bingqian Liu, Chenghong Ma, Hongye Jiang, Yonghao Li, Ying Huang, Qingxiu Wu, Haichun Li, Xiaoling Liang, Chenjin Jin, Jianhua Ye, Xinhua Huang, Lin Lu
Pages: 773-782
Published online on: 05 December 2017

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Article Open Access

Comparative analysis of human embryonic stem cell‑derived neural stem cells as an in vitro human model

Jung‑Hwa Oh, Cho‑Rok Jung, Mi‑Ok Lee, Janghwan Kim, Mi‑Young Son
Pages: 783-790
Published online on: 30 November 2017

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Article Open Access

Human amniotic epithelial cells regulate osteoblast differentiation through the secretion of TGFβ1 and microRNA-34a-5p

Guiling Wang, Feng Zhao, Di Yang, Jing Wang, Lihong Qiu, Xining Pang
Pages: 791-799
Published online on: 17 November 2017

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Article Open Access

Autophagy relieves the function inhibition and apoptosis‑promoting effects on osteoblast induced by glucocorticoid

Yudi Han, Lihai Zhang, Yaling Xing, Licheng Zhang, Xiaojuan Chen, Peifu Tang, Zhongbin Chen
Pages: 800-808
Published online on: 17 November 2017

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Article Open Access

TAT‑fused IP3R‑derived peptide enhances cisplatin sensitivity of ovarian cancer cells by increasing ER Ca2+ release

Qi Xie, Ye Xu, Weinan Gao, Yong Zhang, Jing Su, Yanan Liu, Yuting Guo, Minghan Dou, Kebang Hu, Liankun Sun
Pages: 809-817
Published online on: 16 November 2017

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Article Open Access

Epigallocatechin-3-gallate inhibits inflammation and epithelial‑mesenchymal transition through the PI3K/AKT pathway via upregulation of PTEN in asthma

Nan Yang, Han Zhang, Xuxu Cai, Yunxiao Shang
Pages: 818-828
Published online on: 28 November 2017

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Article Open Access

Erythropoietin induces the osteogenesis of periodontal mesenchymal stem cells from healthy and periodontitis sources via activation of the p38 MAPK pathway

Liying Wang, Fan Wu, Yang Song, Yinzhong Duan, Zoulin Jin
Pages: 829-835
Published online on: 28 November 2017

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Article Open Access

Clinical significance of interleukin‑6 and inducible nitric oxide synthase in ketamine‑induced cystitis

Chi‑Jung Huang, Fa‑Kung Lee, Shao‑Kuan Chen, Chih‑Cheng Chien, Sheng‑Tang Wu, Yen‑Chieh Wang
Pages: 836-844
Published online on: 17 November 2017

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Article Open Access

Transcription factor TBX18 promotes adult rat bone mesenchymal stem cell differentiation to biological pacemaker cells

Yanjun Li, Mei Yang, Gege Zhang, Le Li, Bingjie Ye, Congxin Huang, Yanhong Tang
Pages: 845-851
Published online on: 16 November 2017

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Article Open Access

Chronic prenatal hypoxia impairs cochlear development, a mechanism involving connexin26 expression and promoter methylation

Jingcang Lin, Huang Huang, Guorong Lv, Xiangyang Xu, Wendong Lin, Xianyan Xu, Jing Cheng, Ming Zheng
Pages: 852-858
Published online on: 01 December 2017

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Article Open Access

The potential inhibitory effects of miR‑19b on vulnerable plaque formation via the suppression of STAT3 transcriptional activity

Sufang Li, Qiang Geng, Hong Chen, Jing Zhang, Chengfu Cao, Feng Zhang, Junxian Song, Chuanfen Liu, Wenqing Liang
Pages: 859-867
Published online on: 17 November 2017

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Article Open Access

Aryl hydrocarbon receptor inhibits inflammation in DSS‑induced colitis via the MK2/p‑MK2/TTP pathway

Qimeng Wang, Kunqiu Yang, Bin Han, Baifa Sheng, Jiuheng Yin, Aimin Pu, Liangzi Li, Lihua Sun, Min Yu, Yuan Qiu, Weidong Xiao, Hua Yang
Pages: 868-876
Published online on: 17 November 2017

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Article Open Access

Coordinated microRNA/mRNA expression profiles reveal a putative mechanism of corneal epithelial cell transdifferentiation from skin epidermal stem cells

Yanjie Guo, Xiya Ma, Weini Wu, Mingyan Shi, Junlong Ma, Yaping Zhang, Erkang Zhao, Xueyi Yang
Pages: 877-887
Published online on: 01 December 2017

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Article Open Access

Anti‑inflammatory effect of quercetin and galangin in LPS‑stimulated RAW264.7 macrophages and DNCB‑induced atopic dermatitis animal models

Hae Nim Lee, Seong Ah Shin, Gang Sik Choo, Hyeong Jin Kim, Young Seok Park, Byeong Soo Kim, Sang Ki Kim, Sung Dae Cho, Jeong Seok Nam, Chang Sun Choi, Jeong Hwan Che, Byung Kwon Park, Ji Youn Jung
Pages: 888-898
Published online on: 29 November 2017

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Article Open Access

Ginsenoside Rg1 inhibits inflammatory responses via modulation of the nuclear factor‑κB pathway and inhibition of inflammasome activation in alcoholic hepatitis Corrigendum in /10.3892/ijmm.2024.5407

Jiajun Li, Cheng Yang, Shu Zhang, Shu Liu, Luole Zhao, Huan Luo, Yatang Chen, Wenxiang Huang
Pages: 899-907
Published online on: 29 November 2017

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Article Open Access

Pentosan polysulfate ameliorates apoptosis and inflammation by suppressing activation of the p38 MAPK pathway in high glucose‑treated HK‑2 cells

Ping Chen, Yang Yuan, Tianying Zhang, Bo Xu, Qing Gao, Tianjun Guan
Pages: 908-914
Published online on: 27 November 2017

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Article Open Access

Molecular expression of multiple Nav1.5 splice variants in the frontal lobe of the human brain

Jun Wang, Shao‑Wu Ou, Zhi‑Yong Zhang, Bo Qiu, Yun‑Jie Wang
Pages: 915-923
Published online on: 24 November 2017

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Article Open Access

Anti-obesity effects of pectinase and cellulase enzyme‑treated Ecklonia cava extract in high‑fat diet‑fed C57BL/6N mice

In‑Hye Kim, Jung‑Wook Choi, Min‑Kyeong Lee, Chang‑Ju Kwon, Taek‑Jeong Nam
Pages: 924-934
Published online on: 28 November 2017

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Article Open Access

Hepatic recruitment of CD11b+Ly6C+ inflammatory monocytes promotes hepatic ischemia/reperfusion injury

Peng Song, Junbin Zhang, Yunwei Zhang, Zhiping Shu, Peng Xu, Long He, Chao Yang, Jinxiang Zhang, Hui Wang, Yiqing Li, Qin Li
Pages: 935-945
Published online on: 08 December 2017

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Article Open Access

CD90 promotes cell migration, viability and sphere‑forming ability of hepatocellular carcinoma cells

Ketao Zhang, Siyao Che, Zheng Su, Shangyou Zheng, Huayao Zhang, Shanglin Yang, Wenda Li, Jianping Liu
Pages: 946-954
Published online on: 08 December 2017

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Article

Melatonin exerts an inhibitory effect on insulin gene transcription via MTNR1B and the downstream Raf‑1/ERK signaling pathway

Yanliang Li, Huihui Wu, Naijia Liu, Xinyi Cao, Zhen Yang, Bin Lu, Renming Hu, Xuanchun Wang, Jie Wen
Pages: 955-961
Published online on: 01 December 2017

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Article

Effective component of Salvia miltiorrhiza in promoting cardiomyogenic differentiation of human placenta‑derived mesenchymal stem cells

Kun Li, Jieqiong Song, Qian Zhao, Bo Wang, Yunli Zhang, Xuezhe Wang, Tiantian Tang, Shizheng Li
Pages: 962-968
Published online on: 28 November 2017

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Article

Stromal cell‑derived factor‑1 induces matrix metalloproteinase expression in human endplate chondrocytes, cartilage endplate degradation in explant culture, and the amelioration of nucleus pulposus degeneration in vivo

Hua Zhang, Ting Zhu, Li Zhang, Qionghua Wu
Pages: 969-976
Published online on: 22 November 2017

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Article

Different roles of Akt and mechanistic target of rapamycin in serum‑dependent chondroprotection of human osteoarthritic chondrocytes

Tongen Zhang, Jijie Liu, Xinpeng Zheng, Bing Zhang, Chun Xia
Pages: 977-984
Published online on: 24 November 2017

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Article

Mechanism of endogenous digitalis-like factor‑induced vascular endothelial cell damage in patients with severe preeclampsia

Mei Peng, Mengyuan Yang, Yiling Ding, Ling Yu, Yali Deng, Weisi Lai, Yun Hu
Pages: 985-994
Published online on: 11 December 2017

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Article

Sevoflurane inhibits the malignant potential of head and neck squamous cell carcinoma via activating the hypoxia‑inducible factor-1α signaling pathway in vitro

Yaqiong Yang, Rong Hu, Jia Yan, Zhifeng Chen, Yi Lu, Jue Jiang, Hong Jiang
Pages: 995-1002
Published online on: 04 December 2017

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Article

Periostin has a protective role in melatonin‑induced cell apoptosis by inhibiting the eIF2α‑ATF4 pathway in human osteoblasts

Xiaotong Meng, Yue Zhu, Lin Tao, Sichao Zhao, Shui Qiu
Pages: 1003-1012
Published online on: 30 November 2017

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Article

Co-expression network analysis of lncRNAs and mRNAs in OPTN-silenced cells

Lin Jin, Yuanyuan Li, Xinrong Zhou, Huiping Yuan
Pages: 1013-1020
Published online on: 06 December 2017

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Article

MicroRNA‑30a‑5p suppresses tumor cell proliferation of human renal cancer via the MTDH/PTEN/AKT pathway

Jianmin Li, Changying Li, Hongjie Li, Ting Zhang, Xiaodong Hao, Jiwu Chang, Yong Xu
Pages: 1021-1029
Published online on: 17 November 2017

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Article

MicroRNA-21 promotes the progression of peritoneal fibrosis through the activation of the TGF-?/Smad signaling pathway: An in vitro and in vivo study Retraction in /10.3892/ijmm.2020.4510

Ya-Li Ma, Fang Chen, Su-Xia Yang, Bao-Ping Chen, Jun Shi
Pages: 1030-1038
Published online on: 17 November 2017

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Article

Icariin possesses chondroprotective efficacy in a rat model of dexamethasone-induced cartilage injury through the activation of miR-206 targeting of cathepsin K

Ning Liu, Tao Zhang, Bo-Ran Cao, Fei-Yu Luan, Rui-Xuan Liu, Hao-Rong Yin, Wen-Bo Wang
Pages: 1039-1047
Published online on: 27 November 2017

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Article

Investigation of the pro-apoptotic effects of arbutin and its acetylated derivative on murine melanoma cells

Liyan Jiang, Di Wang, Yongfeng Zhang, Junyang Li, Zhiping Wu, Zhi Wang
Pages: 1048-1054
Published online on: 16 November 2017

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Article

Role of inhibitor of growth 4 in the suppression of human melanoma cells through the Fas/FasL-mediated apoptosis pathway

Limin Cai, Haiyan Li, Cui Chen, Xue Cheng, Yu Wang, Jing Liu, Yongchen Wang, Lijun Hao
Pages: 1055-1061
Published online on: 20 November 2017

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Article

Macrophage migration inhibitory factor promotes Warburg effect via activation of the NF‑κB/HIF‑1α pathway in lung cancer

Jun Li, Junhua Zhang, Fengjiao Xie, Jiangzhou Peng, Xu Wu
Pages: 1062-1068
Published online on: 22 November 2017

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Article

High-resolution metabolomics determines the mode of onset of type 2 diabetes in a 3-year prospective cohort study

Yeseung Lee, Aryo Dimas Pamungkas, Carl Angelo D. Medriano, Jinsung Park, Seri Hong, Sun Ha Jee, Youngja H. Park
Pages: 1069-1077
Published online on: 21 November 2017

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Article

Astragaloside IV prevents kidney injury caused by iatrogenic hyperinsulinemia in a streptozotocin‑induced diabetic rat model

Ke‑Qiang He, Wei‑Zu Li, Xiao‑Qing Chai, Yan‑Yan Yin, Yan Jiang, Wei‑Ping Li
Pages: 1078-1088
Published online on: 17 November 2017

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Article

Diosgenin prevents high-fat diet-induced rat non-alcoholic fatty liver disease through the AMPK and LXR signaling pathways

Silu Cheng, Shufang Liang, Qun Liu, Zhengting Deng, Yuanhui Zhang, Juan Du, Ya'ni Zhang, Shu Li, Binbin Cheng, Changquan Ling
Pages: 1089-1095
Published online on: 28 November 2017

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Article

Role of the cofilin 2 gene in regulating the myosin heavy chain genes in mouse myoblast C2C12 cells

Hongyan Zhu, Huixin Yang, Song Zhao, Junfeng Zhang, Dan Liu, Yumin Tian, Zhiyi Shen, Yuhong Su
Pages: 1096-1102
Published online on: 17 November 2017

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Article

Anti-inflammatory effect of lovastatin is mediated via the modulation of NF-κB and inhibition of HDAC1 and the PI3K/Akt/mTOR pathway in RAW264.7 macrophages

Hyung-Wook Choi, Pyung-Gyun Shin, Ji-Hyun Lee, Woo-Suk Choi, Min-Jae Kang, Won-Sik Kong, Min-Ji Oh, Yong-Bae Seo, Gun-Do Kim
Pages: 1103-1109
Published online on: 05 December 2017

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Article

Periodontal ligament‑associated protein‑1 delays rat periodontal bone defect repair by regulating osteogenic differentiation of bone marrow stromal cells and osteoclast activation

Xijiao Yu, Shuang Liu, Wei Wang, Shu Li
Pages: 1110-1118
Published online on: 06 December 2017

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Role of the c-Jun N-terminal kinase signaling pathway in the activation of trypsinogen in rat pancreatic acinar cells

Zhengpeng Yang, Weiguang Yang, Ming Lu, Zhituo Li, Xin Qiao, Bei Sun, Weihui Zhang, Dongbo Xue
Pages: 1119-1126
Published online on: 17 November 2017

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Macrophage migration inhibitory factor rescues mesenchymal stem cells from doxorubicin-induced senescence though the PI3K-Akt signaling pathway

Wenzheng Xia, Meng Hou
Pages: 1127-1137
Published online on: 23 November 2017

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Quercetin inhibits okadaic acid-induced tau protein hyperphosphorylation through the Ca2+‑calpain‑p25‑CDK5 pathway in HT22 cells

Xiu‑Yin Shen, Tao Luo, Sheng Li, Ou‑Yang Ting, Feng He, Jie Xu, Hua‑Qiao Wang
Pages: 1138-1146
Published online on: 22 November 2017

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Prohibitin-2 negatively regulates AKT2 expression to promote prostate cancer cell migration

Yongmei Shen, Yu Gao, Hui Yuan, Jiasong Cao, Bona Jia, Mingming Li, Yanfei Peng, Xiaoling Du, Ju Zhang, Jiandang Shi
Pages: 1147-1155
Published online on: 04 December 2017

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Journal Cover
March-2026 Volume 57 Issue 3

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Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

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Ginkgolide C alleviates atherosclerosis via activating Nrf2 to inhibit ROS‑dependent NLRP3 inflammasome activation

Rui Zhang
Article Number: 75
Published online on: 27 January 2026

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MicroRNA‑microbiome cross‑kingdom networks drive inflammatory bowel disease through dynamic regulatory ecosystems (Review)

Liping Liang, Xiaoyan Liu, Bang Li, Huyi Lei, Zibo Tang, Shijie Mai, Chenghai Yang, Yongjian Zhou, Shaoheng Zhang, Le Liu
Article Number: 74
Published online on: 27 January 2026

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Mechanistic insights into pancreatic cancer progression from circadian rhythm disruption and gut microbiota dysbiosis (Review)

Yang Liu, Yongfeng Li, Heng Ma, Shichang Deng, Chao Cheng
Article Number: 73
Published online on: 26 January 2026

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Retraction Open Access

[Retracted] miR‑124‑3p inhibits the viability and motility of glioblastoma multiforme by targeting RhoG  

Shan Cai, Chao-Jia Shi, Jian-Xiang Lu, Yan-Pei Wang, Tian Yuan, Xiang-Peng Wang
Article Number: 72
Published online on: 26 January 2026

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Natural products as multi‑target therapies for sepsis‑induced myocardial dysfunction (Review)

Fei Tang, Dong Liu, Shi-Chao Zhu, Hui-Min Zhou, Xue-Wen Qiu
Article Number: 71
Published online on: 22 January 2026

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MTHFR‑folate axis as a modulator of the epigenetic landscape in autoimmune diseases (Review)

Pablo Michael Navarro‑Rodríguez, Ramón Francisco Bajeca‑Serrano, Francisco Javier Turrubiates‑Hernández, Hazael Ramiro Ceja‑Gálvez, Jorge Hernández‑Bello, Cristian Oswaldo Hernández‑Ramírez, Saúl Ramírez‑de Los Santos, José Francisco Muñoz‑Valle
Article Number: 70
Published online on: 22 January 2026

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Natural compound 5,7,8‑trimethoxyflavone mitigates radiation‑induced lung injury by suppressing EMT and PI3K/Akt pathway

Cui-Cui Gong, Hua-Kang Li, Yuan-Zhen Mi, Jun-Yang Chen, Zeng-Yi Fang, Shun-Lian Fu, Li Quan, Bing Lin, Jin-Yi Lang, Qiu Chen, Ke Xu, Mei-Hua Chen
Article Number: 69
Published online on: 21 January 2026

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Epigenetic dysregulation of B‑cells in autoimmune diseases and lymphomas (Review)

Yuxing Li, Yujiao Gong, Jiaxing Zhao, Rensen Ran
Article Number: 68
Published online on: 21 January 2026

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Research progress on the effects of macrophage‑derived exosomes on muscle factors IGF‑1 and FGF‑2 mediating musculoskeletal crosstalk molecular signaling pathway on bone metabolism (Review)

Ruo-Mei Cui, Mai Zheng, Jian-Bin Hong, Zheng-Xiang Wang, Yu-Fang Cun, Shu-Ji Gao, Yan-Lin Zhu, Zi-Bin Yang, Ming-Wei Liu
Article Number: 67
Published online on: 21 January 2026

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[Expression of Concern] Long non‑coding RNA SNHG20 promotes bladder cancer via activating the Wnt/β‑catenin signalling pathway

Qingsong Zhao, Saiyue Gao, Qingyan Du, Ye Liu
Article Number: 66
Published online on: 21 January 2026

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Mangiferin in human disease: Multifaceted mechanisms and applications (Review)

Yaling Dai, Qiuling Huang, Mengquan Tan, Zhifu Wang, Cai Jiang, Zheng Liu, Shenghang Zhang, Siyuan Song
Article Number: 65
Published online on: 21 January 2026

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Deciphering the CAF‑LCN2 axis: Key to overcoming anti‑PD‑L1 immunotherapy resistance in lung cancer

Dan Xiao, Jing Yang, Jianying Zhou, Zhenzhen Hu, Ting Zhang
Article Number: 64
Published online on: 19 January 2026

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Retraction Open Access

[Retracted] DDAH2 alleviates myocardial fibrosis in diabetic cardiomyopathy through activation of the DDAH/ADMA/NOS/NO pathway in rats

Zhen-Dong Zhu, Ji-Ming Ye, Xue-Mei Fu, Xue-Chang Wang, Ji-Yun Ye, Xin-Ran Wu, Peng Hua, Yu-Qiong Liao, Wei Xuan, Jin-Lan Duan, Wei-Yuan Li, Hui Fu, Zhong-Hua Xia, Xuan Zhang
Article Number: 63
Published online on: 19 January 2026

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Beyond hepatic stellate cell heterogeneity: Resolving fibrosis, restoring regeneration (Review)

Chang Gao, Guiqing Chen, Hongyan Jia, Hong Zhu, Yun Cai, Dakai Yang, Kai Zhao
Article Number: 62
Published online on: 14 January 2026

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Correction Open Access

[Corrigendum] CDKN2A (p16INK4A) affects the anti‑tumor effect of CDK inhibitor in somatotroph adenomas

Yiyuan Chen, Zhenye Li, Qiuyue Fang, Hongyun Wang, Chuzhong Li, Hua Gao, Yazhuo Zhang
Article Number: 61
Published online on: 14 January 2026

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Harnessing MSC‑derived exosomes to modulate the pathophysiology of ASD: Recent advances and therapeutic implications (Review)

Zhaojian Sun, Nouman Amjad, Majid Muhammad, Zhiyuan Li
Article Number: 60
Published online on: 13 January 2026

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Retraction Open Access

[Retracted] Mechanism of cell death induced by silica nanoparticles in hepatocyte cells is by apoptosis

Ye Yang, Xinjing Du, Qiang Wang, Jianwei Liu, Enguo Zhang, Linlin Sai, Cheng Peng, Martin F. Lavin, Abrey Jie Yeo, Xu Yang, Hua Shao, Zhongjun Du
Article Number: 59
Published online on: 12 January 2026

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ZG16B: A key regulator of tumor progression and immune microenvironment modulation in cancer (Review)

Xing-Ming Chen, Yu-Bo Liang, Jin-Xiang Zuo, Zi-Sheng Yang, Le-Yu Zhang, Xin-Yu Zhang, Ping Wan, Yang Ke
Article Number: 58
Published online on: 09 January 2026

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[Retracted] Silica nanoparticles induce cardiomyocyte apoptosis via the mitochondrial pathway in rats following intratracheal instillation

Zhongjun Du, Shangya Chen, Guanqun Cui, Ye Yang, Enguo Zhang, Qiang Wang, Martin F. Lavin, Abrey J. Yeo, Cunxiang Bo, Yu Zhang, Chao Li, Xiaoshan Liu, Xu Yang, Cheng Peng, Hua Shao
Article Number: 57
Published online on: 05 January 2026

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Role of cuproptosis in digestive system tumors (Review)

Li Zhang, Yongpeng Cheng, Lulu Tang, Jiaxing Zhu, Biguang Tuo
Article Number: 56
Published online on: 02 January 2026

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Environmental exposure to air pollution and climate: Intersecting the impact on ear and nose health and chemosensory function (Review)

Yu-Chen Zhang, Lei Zhang, Ping-Ting Zhou, Zi-Hui Xie, Wen-Jie Zhang, Min Fan, Yan-Xun Han, Ye-Hai Liu, Yu-Chen Liu
Article Number: 55
Published online on: 31 December 2025

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Role and mechanisms of ferroptosis in cognitive impairment: From molecular pathways to therapeutic targets (Review)

Shenghui Ge, Deyue Kong, Shuyue Fan, Yi Luo, Xiao Yin, Zehua Jin, Wenqing Xia, Jianhua Ma
Article Number: 54
Published online on: 30 December 2025

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The GPR124‑Wnt‑PPARγ regulatory axis: Molecular mechanisms and therapeutic implications in chronic inflammatory diseases (Review)

Ming-Wang Cui, Si-Yu Tao, Tao Wen, Zhu-Ling Guo
Article Number: 53
Published online on: 30 December 2025

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Advances in RPGR gene therapy for X‑linked retinitis pigmentosa: From preclinical insights to clinical application (Review)

Yushan Long, Jia Qi, Wenliang Zhang, Huan Qin, Kai Yao
Article Number: 52
Published online on: 30 December 2025

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Journal Cover
April-2026 Volume 57 Issue 4

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Ebastine targets HER2/HER3 signaling and cancer stem cell traits to overcome trastuzumab resistance in HER2‑positive breast cancer

Eunsun Jung, Ji Young Kim, Dongmi Ko, Juyeon Seo, Sang Yoon Lee, Daeun Lee, Subeen Kim, Minsu Park, Seongjae Kim, Soeun Park, Kyoungmin Lee, Yong Koo Kang, Kee Dal Nam, Yoon-Jae Kim, Jae Hong Seo
Article Number: 80
Published online on: 02 February 2026

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[Corrigendum] Inhibition of acid‑sensing ion channel 1a attenuates acid‑induced activation of autophagy via a calcium signaling pathway in articular chondrocytes

Wen-Fan Gao, Ya-Yun Xu, Jin-Fang Ge, Fei-Hu Chen
Article Number: 79
Published online on: 02 February 2026

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Immunological mechanisms and novel therapeutic strategies for sepsis‑associated acute kidney injury (Review)

Lu Xu, Wei Jiang, Lin Song, Jing Wang, Jiangquan Yu, Ruiqiang Zheng
Article Number: 78
Published online on: 30 January 2026

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[Corrigendum] Role of Smad3 signaling in the epithelial‑mesenchymal transition of the lens epithelium following injury

Fanlan Meng, Jun Li, Xiao Yang, Xiaoyong Yuan, Xin Tang
Article Number: 77
Published online on: 29 January 2026

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Spatial metabolomics: A new tool for unravelling the metabolic disorders and heterogeneity in diabetic kidney disease (Review)

Hanfei Li, Yuxi Li, Bo Zhang, Wenhao Cheng, Guowei Ma, Jin Rong, Shiru Duan, Di Feng, Tingting Zhao
Article Number: 76
Published online on: 29 January 2026

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