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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February-2018 Volume 41 Issue 2

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Journal Metrics

Impact Factor: 5.8

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Galectin-3 as a novel biomarker for disease diagnosis and a target for therapy (Review)

Rui Dong, Min Zhang, Qunying Hu, Shan Zheng, Andrew Soh, Yijie Zheng, Hui Yuan
Pages: 599-614
Published online on: 05 December 2017

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Review

Mitochondria-mediated damage to dopaminergic neurons in Parkinson's disease (Review)

Xiao‑Liang Liu, Ying‑Di Wang, Xiu‑Ming Yu, Da‑Wei Li, Guang‑Ren Li
Pages: 615-623
Published online on: 16 November 2017

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Review

Necroptosis: A novel manner of cell death, associated with stroke (Review)

Chenglin Liu, Kai Zhang, Haitao Shen, Xiyang Yao, Qing Sun, Gang Chen
Pages: 624-630
Published online on: 22 November 2017

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Review Open Access

The role and mechanism of β‑arrestins in cancer invasion and metastasis (Review)

Qing Song, Qing Ji, Qi Li
Pages: 631-639
Published online on: 27 November 2017

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Article Open Access

A common African variant of human connexin 37 is associated with Caucasian primary ovarian insufficiency and has a deleterious effect in vitro

Anne Bachelot, Jerome Gilleron, Geri Meduri, Mihelai Guberto, Jerome Dulon, Sylviane Boucherie, Philippe Touraine, Micheline Misrahi
Pages: 640-648
Published online on: 16 November 2017

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Article Open Access

Naringenin induces laxative effects by upregulating the expression levels of c-Kit and SCF, as well as those of aquaporin 3 in mice with loperamide-induced constipation

Jianqiao Yin, Yichao Liang, Dalu Wang, Zhaopeng Yan, Hongzhuan Yin, Di Wu, Qi Su
Pages: 649-658
Published online on: 01 December 2017

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Article Open Access

Therapeutic effects of conditioned medium from bone marrow-derived mesenchymal stem cells on epithelial-mesenchymal transition in A549 cells

Xin Wang, Jun-Ling Gao, Man-Man Zhao, Hui-Xing Zhu, Yan-Xia Tian, Ran Li, Xiao-Hua Jiang, Lei Yu, Jing-Rui Tian, Jian-Zhong Cui
Pages: 659-668
Published online on: 24 November 2017

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Article Open Access

In vitro cell behaviors of bone mesenchymal stem cells derived from normal and postmenopausal osteoporotic rats

Qian Liu, Xiaoxia Zhang, Yang Jiao, Xin Liu, Yirong Wang, Song-Lun Li, Wei Zhang, Fa-Ming Chen, Yin Ding, Chuan Jiang, Zuolin Jin
Pages: 669-678
Published online on: 22 November 2017

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Article Open Access

Use of methylation profiling to identify significant differentially methylated genes in bone marrow mesenchymal stromal cells from acute myeloid leukemia Corrigendum in /10.3892/ijmm.2025.5520

Jing Huang, Zhi Liu, Yufan Sun, Qi Zhong, Li Xu, Ruimin Ou, Cheng Li, Rui Chen, Mengdong Yao, Qing Zhang, Shuang Liu
Pages: 679-686
Published online on: 17 November 2017

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Article Open Access

Stromal-epithelial lactate shuttle induced by tumor‑derived interleukin‑1β promotes cell proliferation in oral squamous cell carcinoma

Jie Wu, Yun Hong, Tong Wu, Juan Wang, Xiaobing Chen, Zhi Wang, Bin Cheng, Juan Xia
Pages: 687-696
Published online on: 17 November 2017

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Article Open Access

Interaction of iPSC-derived neural stem cells on poly(L-lactic acid) nanofibrous scaffolds for possible use in neural tissue engineering

Chengkai Lin, Chang Liu, Liangming Zhang, Zhi Huang, Peipei Zhao, Ruiqiang Chen, Mao Pang, Zhenxiang Chen, Liumin He, Chunxiao Luo, Limin Rong, Bin Liu
Pages: 697-708
Published online on: 30 November 2017

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Article Open Access

Neurochemical changes in the hippocampus and prefrontal cortex associated with electroacupuncture for learning and memory impairment

Jian He, Congkuai Zhao, Weilin Liu, Jia Huang, Shengxiang Liang, Lidian Chen, Jing Tao
Pages: 709-716
Published online on: 24 November 2017

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Article Open Access

A type 2 diabetes-associated SNP in KCNQ1 (rs163184) modulates the binding activity of the locus for Sp3 and Lsd1/Kdm1a, potentially affecting CDKN1C expression

Masaki Hiramoto, Haruhide Udagawa, Naoko Ishibashi, Eri Takahashi, Yasushi Kaburagi, Keisuke Miyazawa, Nobuaki Funahashi, Takao Nammo, Kazuki Yasuda
Pages: 717-728
Published online on: 20 November 2017

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Article Open Access

Platelet-rich plasma inhibits RANKL-induced osteoclast differentiation through activation of Wnt pathway during bone remodeling

Dongyue Wang, Yajuan Weng, Shuyu Guo, Yuxin Zhang, Tingting Zhou, Mengnan Zhang, Lin Wang, Junqing Ma
Pages: 729-738
Published online on: 16 November 2017

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Article Open Access

Geraniin protects bone marrow‑derived mesenchymal stem cells against hydrogen peroxide‑induced cellular oxidative stress in vitro

Dan Huang, Li Yin, Xinxin Liu, Bo Lv, Zulong Xie, Xuedong Wang, Bo Yu, Yao Zhang
Pages: 739-748
Published online on: 21 November 2017

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Article Open Access

Effects of kartogenin on the attenuated nucleus pulposus cell degeneration of intervertebral discs induced by interleukin-1β and tumor necrosis factor-α

Yao Huang, Tao Jiang, Jian Chen, Guo-Yong Yin, Jin Fan
Pages: 749-756
Published online on: 24 November 2017

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Article Open Access

Der f1 induces pyroptosis in human bronchial epithelia via the NLRP3 inflammasome

Ying‑Ming Tsai, Kuo‑Hwa Chiang, Jen‑Yu Hung, Wei‑An Chang, Hui‑Ping Lin, Jiunn‑Min Shieh, Inn‑Wen Chong, Ya‑Ling Hsu
Pages: 757-764
Published online on: 05 December 2017

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Article Open Access

Chlorogenic acid attenuates hydrogen peroxide‑induced oxidative stress in lens epithelial cells

Jike Song, Dadong Guo, Hongsheng Bi
Pages: 765-772
Published online on: 01 December 2017

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Article Open Access

Clinical and next-generation sequencing findings in a Chinese family exhibiting severe familial exudative vitreoretinopathy

Ying Lin, Hongbin Gao, Chuan Chen, Yi Zhu, Tao Li, Bingqian Liu, Chenghong Ma, Hongye Jiang, Yonghao Li, Ying Huang, Qingxiu Wu, Haichun Li, Xiaoling Liang, Chenjin Jin, Jianhua Ye, Xinhua Huang, Lin Lu
Pages: 773-782
Published online on: 05 December 2017

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Article Open Access

Comparative analysis of human embryonic stem cell‑derived neural stem cells as an in vitro human model

Jung‑Hwa Oh, Cho‑Rok Jung, Mi‑Ok Lee, Janghwan Kim, Mi‑Young Son
Pages: 783-790
Published online on: 30 November 2017

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Article Open Access

Human amniotic epithelial cells regulate osteoblast differentiation through the secretion of TGFβ1 and microRNA-34a-5p

Guiling Wang, Feng Zhao, Di Yang, Jing Wang, Lihong Qiu, Xining Pang
Pages: 791-799
Published online on: 17 November 2017

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Article Open Access

Autophagy relieves the function inhibition and apoptosis‑promoting effects on osteoblast induced by glucocorticoid

Yudi Han, Lihai Zhang, Yaling Xing, Licheng Zhang, Xiaojuan Chen, Peifu Tang, Zhongbin Chen
Pages: 800-808
Published online on: 17 November 2017

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Article Open Access

TAT‑fused IP3R‑derived peptide enhances cisplatin sensitivity of ovarian cancer cells by increasing ER Ca2+ release

Qi Xie, Ye Xu, Weinan Gao, Yong Zhang, Jing Su, Yanan Liu, Yuting Guo, Minghan Dou, Kebang Hu, Liankun Sun
Pages: 809-817
Published online on: 16 November 2017

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Article Open Access

Epigallocatechin-3-gallate inhibits inflammation and epithelial‑mesenchymal transition through the PI3K/AKT pathway via upregulation of PTEN in asthma

Nan Yang, Han Zhang, Xuxu Cai, Yunxiao Shang
Pages: 818-828
Published online on: 28 November 2017

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Article Open Access

Erythropoietin induces the osteogenesis of periodontal mesenchymal stem cells from healthy and periodontitis sources via activation of the p38 MAPK pathway

Liying Wang, Fan Wu, Yang Song, Yinzhong Duan, Zoulin Jin
Pages: 829-835
Published online on: 28 November 2017

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Article Open Access

Clinical significance of interleukin‑6 and inducible nitric oxide synthase in ketamine‑induced cystitis

Chi‑Jung Huang, Fa‑Kung Lee, Shao‑Kuan Chen, Chih‑Cheng Chien, Sheng‑Tang Wu, Yen‑Chieh Wang
Pages: 836-844
Published online on: 17 November 2017

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Article Open Access

Transcription factor TBX18 promotes adult rat bone mesenchymal stem cell differentiation to biological pacemaker cells

Yanjun Li, Mei Yang, Gege Zhang, Le Li, Bingjie Ye, Congxin Huang, Yanhong Tang
Pages: 845-851
Published online on: 16 November 2017

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Article Open Access

Chronic prenatal hypoxia impairs cochlear development, a mechanism involving connexin26 expression and promoter methylation

Jingcang Lin, Huang Huang, Guorong Lv, Xiangyang Xu, Wendong Lin, Xianyan Xu, Jing Cheng, Ming Zheng
Pages: 852-858
Published online on: 01 December 2017

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Article Open Access

The potential inhibitory effects of miR‑19b on vulnerable plaque formation via the suppression of STAT3 transcriptional activity

Sufang Li, Qiang Geng, Hong Chen, Jing Zhang, Chengfu Cao, Feng Zhang, Junxian Song, Chuanfen Liu, Wenqing Liang
Pages: 859-867
Published online on: 17 November 2017

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Article Open Access

Aryl hydrocarbon receptor inhibits inflammation in DSS‑induced colitis via the MK2/p‑MK2/TTP pathway

Qimeng Wang, Kunqiu Yang, Bin Han, Baifa Sheng, Jiuheng Yin, Aimin Pu, Liangzi Li, Lihua Sun, Min Yu, Yuan Qiu, Weidong Xiao, Hua Yang
Pages: 868-876
Published online on: 17 November 2017

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Article Open Access

Coordinated microRNA/mRNA expression profiles reveal a putative mechanism of corneal epithelial cell transdifferentiation from skin epidermal stem cells

Yanjie Guo, Xiya Ma, Weini Wu, Mingyan Shi, Junlong Ma, Yaping Zhang, Erkang Zhao, Xueyi Yang
Pages: 877-887
Published online on: 01 December 2017

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Article Open Access

Anti‑inflammatory effect of quercetin and galangin in LPS‑stimulated RAW264.7 macrophages and DNCB‑induced atopic dermatitis animal models

Hae Nim Lee, Seong Ah Shin, Gang Sik Choo, Hyeong Jin Kim, Young Seok Park, Byeong Soo Kim, Sang Ki Kim, Sung Dae Cho, Jeong Seok Nam, Chang Sun Choi, Jeong Hwan Che, Byung Kwon Park, Ji Youn Jung
Pages: 888-898
Published online on: 29 November 2017

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Article Open Access

Ginsenoside Rg1 inhibits inflammatory responses via modulation of the nuclear factor‑κB pathway and inhibition of inflammasome activation in alcoholic hepatitis Corrigendum in /10.3892/ijmm.2024.5407

Jiajun Li, Cheng Yang, Shu Zhang, Shu Liu, Luole Zhao, Huan Luo, Yatang Chen, Wenxiang Huang
Pages: 899-907
Published online on: 29 November 2017

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Article Open Access

Pentosan polysulfate ameliorates apoptosis and inflammation by suppressing activation of the p38 MAPK pathway in high glucose‑treated HK‑2 cells

Ping Chen, Yang Yuan, Tianying Zhang, Bo Xu, Qing Gao, Tianjun Guan
Pages: 908-914
Published online on: 27 November 2017

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Article Open Access

Molecular expression of multiple Nav1.5 splice variants in the frontal lobe of the human brain

Jun Wang, Shao‑Wu Ou, Zhi‑Yong Zhang, Bo Qiu, Yun‑Jie Wang
Pages: 915-923
Published online on: 24 November 2017

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Article Open Access

Anti-obesity effects of pectinase and cellulase enzyme‑treated Ecklonia cava extract in high‑fat diet‑fed C57BL/6N mice

In‑Hye Kim, Jung‑Wook Choi, Min‑Kyeong Lee, Chang‑Ju Kwon, Taek‑Jeong Nam
Pages: 924-934
Published online on: 28 November 2017

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Article Open Access

Hepatic recruitment of CD11b+Ly6C+ inflammatory monocytes promotes hepatic ischemia/reperfusion injury

Peng Song, Junbin Zhang, Yunwei Zhang, Zhiping Shu, Peng Xu, Long He, Chao Yang, Jinxiang Zhang, Hui Wang, Yiqing Li, Qin Li
Pages: 935-945
Published online on: 08 December 2017

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Article Open Access

CD90 promotes cell migration, viability and sphere‑forming ability of hepatocellular carcinoma cells

Ketao Zhang, Siyao Che, Zheng Su, Shangyou Zheng, Huayao Zhang, Shanglin Yang, Wenda Li, Jianping Liu
Pages: 946-954
Published online on: 08 December 2017

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Article

Melatonin exerts an inhibitory effect on insulin gene transcription via MTNR1B and the downstream Raf‑1/ERK signaling pathway

Yanliang Li, Huihui Wu, Naijia Liu, Xinyi Cao, Zhen Yang, Bin Lu, Renming Hu, Xuanchun Wang, Jie Wen
Pages: 955-961
Published online on: 01 December 2017

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Article

Effective component of Salvia miltiorrhiza in promoting cardiomyogenic differentiation of human placenta‑derived mesenchymal stem cells

Kun Li, Jieqiong Song, Qian Zhao, Bo Wang, Yunli Zhang, Xuezhe Wang, Tiantian Tang, Shizheng Li
Pages: 962-968
Published online on: 28 November 2017

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Article

Stromal cell‑derived factor‑1 induces matrix metalloproteinase expression in human endplate chondrocytes, cartilage endplate degradation in explant culture, and the amelioration of nucleus pulposus degeneration in vivo

Hua Zhang, Ting Zhu, Li Zhang, Qionghua Wu
Pages: 969-976
Published online on: 22 November 2017

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Article

Different roles of Akt and mechanistic target of rapamycin in serum‑dependent chondroprotection of human osteoarthritic chondrocytes

Tongen Zhang, Jijie Liu, Xinpeng Zheng, Bing Zhang, Chun Xia
Pages: 977-984
Published online on: 24 November 2017

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Article

Mechanism of endogenous digitalis-like factor‑induced vascular endothelial cell damage in patients with severe preeclampsia

Mei Peng, Mengyuan Yang, Yiling Ding, Ling Yu, Yali Deng, Weisi Lai, Yun Hu
Pages: 985-994
Published online on: 11 December 2017

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Article

Sevoflurane inhibits the malignant potential of head and neck squamous cell carcinoma via activating the hypoxia‑inducible factor-1α signaling pathway in vitro

Yaqiong Yang, Rong Hu, Jia Yan, Zhifeng Chen, Yi Lu, Jue Jiang, Hong Jiang
Pages: 995-1002
Published online on: 04 December 2017

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Article

Periostin has a protective role in melatonin‑induced cell apoptosis by inhibiting the eIF2α‑ATF4 pathway in human osteoblasts

Xiaotong Meng, Yue Zhu, Lin Tao, Sichao Zhao, Shui Qiu
Pages: 1003-1012
Published online on: 30 November 2017

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Article

Co-expression network analysis of lncRNAs and mRNAs in OPTN-silenced cells

Lin Jin, Yuanyuan Li, Xinrong Zhou, Huiping Yuan
Pages: 1013-1020
Published online on: 06 December 2017

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Article

MicroRNA‑30a‑5p suppresses tumor cell proliferation of human renal cancer via the MTDH/PTEN/AKT pathway

Jianmin Li, Changying Li, Hongjie Li, Ting Zhang, Xiaodong Hao, Jiwu Chang, Yong Xu
Pages: 1021-1029
Published online on: 17 November 2017

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Article

MicroRNA-21 promotes the progression of peritoneal fibrosis through the activation of the TGF-?/Smad signaling pathway: An in vitro and in vivo study Retraction in /10.3892/ijmm.2020.4510

Ya-Li Ma, Fang Chen, Su-Xia Yang, Bao-Ping Chen, Jun Shi
Pages: 1030-1038
Published online on: 17 November 2017

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Article

Icariin possesses chondroprotective efficacy in a rat model of dexamethasone-induced cartilage injury through the activation of miR-206 targeting of cathepsin K

Ning Liu, Tao Zhang, Bo-Ran Cao, Fei-Yu Luan, Rui-Xuan Liu, Hao-Rong Yin, Wen-Bo Wang
Pages: 1039-1047
Published online on: 27 November 2017

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Article

Investigation of the pro-apoptotic effects of arbutin and its acetylated derivative on murine melanoma cells

Liyan Jiang, Di Wang, Yongfeng Zhang, Junyang Li, Zhiping Wu, Zhi Wang
Pages: 1048-1054
Published online on: 16 November 2017

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Article

Role of inhibitor of growth 4 in the suppression of human melanoma cells through the Fas/FasL-mediated apoptosis pathway

Limin Cai, Haiyan Li, Cui Chen, Xue Cheng, Yu Wang, Jing Liu, Yongchen Wang, Lijun Hao
Pages: 1055-1061
Published online on: 20 November 2017

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Article

Macrophage migration inhibitory factor promotes Warburg effect via activation of the NF‑κB/HIF‑1α pathway in lung cancer

Jun Li, Junhua Zhang, Fengjiao Xie, Jiangzhou Peng, Xu Wu
Pages: 1062-1068
Published online on: 22 November 2017

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Article

High-resolution metabolomics determines the mode of onset of type 2 diabetes in a 3-year prospective cohort study

Yeseung Lee, Aryo Dimas Pamungkas, Carl Angelo D. Medriano, Jinsung Park, Seri Hong, Sun Ha Jee, Youngja H. Park
Pages: 1069-1077
Published online on: 21 November 2017

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Article

Astragaloside IV prevents kidney injury caused by iatrogenic hyperinsulinemia in a streptozotocin‑induced diabetic rat model

Ke‑Qiang He, Wei‑Zu Li, Xiao‑Qing Chai, Yan‑Yan Yin, Yan Jiang, Wei‑Ping Li
Pages: 1078-1088
Published online on: 17 November 2017

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Article

Diosgenin prevents high-fat diet-induced rat non-alcoholic fatty liver disease through the AMPK and LXR signaling pathways

Silu Cheng, Shufang Liang, Qun Liu, Zhengting Deng, Yuanhui Zhang, Juan Du, Ya'ni Zhang, Shu Li, Binbin Cheng, Changquan Ling
Pages: 1089-1095
Published online on: 28 November 2017

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Article

Role of the cofilin 2 gene in regulating the myosin heavy chain genes in mouse myoblast C2C12 cells

Hongyan Zhu, Huixin Yang, Song Zhao, Junfeng Zhang, Dan Liu, Yumin Tian, Zhiyi Shen, Yuhong Su
Pages: 1096-1102
Published online on: 17 November 2017

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Article

Anti-inflammatory effect of lovastatin is mediated via the modulation of NF-κB and inhibition of HDAC1 and the PI3K/Akt/mTOR pathway in RAW264.7 macrophages

Hyung-Wook Choi, Pyung-Gyun Shin, Ji-Hyun Lee, Woo-Suk Choi, Min-Jae Kang, Won-Sik Kong, Min-Ji Oh, Yong-Bae Seo, Gun-Do Kim
Pages: 1103-1109
Published online on: 05 December 2017

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Article

Periodontal ligament‑associated protein‑1 delays rat periodontal bone defect repair by regulating osteogenic differentiation of bone marrow stromal cells and osteoclast activation

Xijiao Yu, Shuang Liu, Wei Wang, Shu Li
Pages: 1110-1118
Published online on: 06 December 2017

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Role of the c-Jun N-terminal kinase signaling pathway in the activation of trypsinogen in rat pancreatic acinar cells

Zhengpeng Yang, Weiguang Yang, Ming Lu, Zhituo Li, Xin Qiao, Bei Sun, Weihui Zhang, Dongbo Xue
Pages: 1119-1126
Published online on: 17 November 2017

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Macrophage migration inhibitory factor rescues mesenchymal stem cells from doxorubicin-induced senescence though the PI3K-Akt signaling pathway

Wenzheng Xia, Meng Hou
Pages: 1127-1137
Published online on: 23 November 2017

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Quercetin inhibits okadaic acid-induced tau protein hyperphosphorylation through the Ca2+‑calpain‑p25‑CDK5 pathway in HT22 cells

Xiu‑Yin Shen, Tao Luo, Sheng Li, Ou‑Yang Ting, Feng He, Jie Xu, Hua‑Qiao Wang
Pages: 1138-1146
Published online on: 22 November 2017

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Prohibitin-2 negatively regulates AKT2 expression to promote prostate cancer cell migration

Yongmei Shen, Yu Gao, Hui Yuan, Jiasong Cao, Bona Jia, Mingming Li, Yanfei Peng, Xiaoling Du, Ju Zhang, Jiandang Shi
Pages: 1147-1155
Published online on: 04 December 2017

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July-2026 Volume 58 Issue 1

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Impact Factor: 5.8

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Sex differences in cardiovascular‑kidney‑metabolic syndrome: From pathogenesis to treatment response (Review)

Yanqin Fan, Hongtu Hu, Jing Cheng
Article Number: 202
Published online on: 27 May 2026

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[Retracted] BAMBI inhibits inflammation through the activation of autophagy in experimental spinal cord injury

Yin Yang, Chunyang Guo, Bo Liao, Junjun Cao, Chen Liang, Xijing He
Article Number: 201
Published online on: 25 May 2026

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Integrative transcriptomic analysis unveils FXR as a key regulator of intestinal stemness and inflammation in ulcerative colitis

Hao Lin, Xinran Cheng, Yangyang Ren, Yongmei Zhang, Weixu Chen, Qingyan Lu, Yiqing Tian
Article Number: 200
Published online on: 22 May 2026

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Ginsenoside Rg3 potentiates cisplatin antitumor activity while mitigating nephrotoxicity through SIRT1‑mediated suppression of the NLRP3 inflammasome

Jinghui Zhai, Yueming Zhang, Jiawei Gong, Li Fu, Sixi Zhang
Article Number: 199
Published online on: 22 May 2026

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Identification of diagnostic markers for diabetic kidney disease by weighted gene co‑expression network analysis and machine learning

Qiming Xu, Chunjing Xu, Ziyang Liu, Jianrao Lu, Jing Hu, Lin Liao
Article Number: 198
Published online on: 21 May 2026

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CTRP3 alleviates neuropathic pain by improving mitochondrial biogenesis and mitochondrial unfolded protein response via spinal SIRT1 in rats

Tianzhu Liu, Longqing Zhang, Wei Mei
Article Number: 197
Published online on: 21 May 2026

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Correction Open Access

[Corrigendum] Activated Wnt signaling induces myofibroblast differentiation of mesenchymal stem cells, contributing to pulmonary fibrosis

Zhaorui Sun, Cong Wang, Chaowen Shi, Fangfang Sun, Xiaomeng Xu, Weiping Qian, Shinan Nie, Xiaodong Han
Article Number: 196
Published online on: 20 May 2026

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Ganoderma lucidum polysaccharides improve liver metabolic disorders by modulating gut microbiota of ovariectomized mice

Xin Jin, Xuan Liu, Yun-Juan Wang, Zi-Li Lei, Yan-Hong Yang
Article Number: 195
Published online on: 20 May 2026

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Endothelial NOX4‑driven oxidative stress inhibition reverses HtrA1 deficiency‑induced blood‑brain barrier disruption and cognitive impairment

Shi-Na Song, Jun-Ying Wu, Mao-Mei Song, Xiao-Feng Li, Jian-Ming Wang, Wen-Hui Jia, Chang-Xin Li, Sui-Yi Xu
Article Number: 194
Published online on: 19 May 2026

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Bone‑origin repair in diabetic foot ulcers: Mechanisms of callus formation and endocrine effects in healing (Review)

Sen Chen, Xiaofei Cui
Article Number: 193
Published online on: 19 May 2026

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Unraveling the molecular landscape of chronic radiation injury: From oxidative stress signaling to translational modeling (Review)

Zhenjun Xi, Xiaodong Li, Chunhui Yang, Li Wang, Jingxin Mao, Qianqian Liu, Chang Liu, Qian Li, Yuanfang Hou, Jie Wan, Chengzhuo Yang, Feiji Sun, Chao Yu, Miao Wang, Baocheng Yuan, Yongsheng Liu, Qing Hu, Li Zhang, Xuemei Li, Xiaobing Li
Article Number: 192
Published online on: 19 May 2026

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[Retracted] Cocktail therapy with a combination of interferon, ribavirin and angiotensin‑II type 1 receptor blocker attenuates murine liver fibrosis development

Hitoshi Yoshiji, Ryuichi Noguchi, Yasuhide Ikenaka, Kosuke Kaji, Yosuke Aihara, Yusaku Shirai, Junichi Yoshii, Koji Yanase, Hiroshi Fukui
Article Number: 191
Published online on: 18 May 2026

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Autophagy and metabolic homeostasis: Exploration in obesity‑related metabolic diseases (Review)

Chenglin Lu, Xiangyu Qi, Yuting Tong, Peng Lu, Dandan Luo, Qingbo Guan, Chunxiao Yu
Article Number: 190
Published online on: 14 May 2026

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Primary cilia dysfunction: A critical driver of metabolic diseases (Review)

Xiaojing Wang, Yi Jin, Kejia Xie, Pengfei Yao, Liguo Song, Hongdan Liu, Yanjie Tan
Article Number: 189
Published online on: 14 May 2026

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Gut‑brain axis in anesthesia and critical illness: Molecular crosstalk and its impact on delirium and outcome (Review)

Xigang Ma, Yongsen Zhao
Article Number: 188
Published online on: 14 May 2026

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Betulinic acid alleviates the inflammatory injury of osteoblasts in osteoporosis by augmenting autophagy via the AMPK-mTOR signaling pathway

Yiwei Zhao, Zechao Qu, Lin Liu, Yong Zhang, Xiaohao Wang, Bo Zhang, Yining Gong, Liang Yan
Article Number: 187
Published online on: 13 May 2026

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Correction Open Access

[Corrigendum] Induction of cardiomyocyte‑like cells from hair follicle cells in mice

Yong-Hee Kim, Bang-Jin Kim, Seok-Man Kim, Sun-Uk Kim, Buom-Yong Ryu
Article Number: 186
Published online on: 13 May 2026

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Spatial hepatology: Decoding liver zonation for metabolic and regenerative therapeutics (Review)

Guiqing Chen, Hongyan Jia, Kai Zhao, Chang Gao, Yue Liu, Hong Zhu, Dakai Yang, Yun Cai
Article Number: 185
Published online on: 13 May 2026

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Hepatic p38γ exacerbates acetaminophen‑induced acute liver injury via PI3K/Akt‑dependent mechanisms

Hui Fang, Min Shu, Jiaju Wang, Heng Tian, Jianguo Zhang, Ying Hu, He Li, Huan Zhou, Kangsheng Gu, Zhenhua Ren
Article Number: 184
Published online on: 12 May 2026

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Pharmacological activity, molecular mechanisms and therapeutic potential of erianin (Review)

Chengyi Ming, Ni Zhu, You Yu, Hong Zhou, Meichun Hu
Article Number: 183
Published online on: 12 May 2026

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Rab27: Molecular switch of tumor exosome secretion (Review)

Mengtian Tang, Zhongjian Zhu, Huaxin Duan, Shiming Tan, Mengzhou Shen, Xianjie Jiang, Qiu Peng, Linda Oyang, Zongyao Ren, Yujuan Zhou, Qianjin Liao
Article Number: 182
Published online on: 12 May 2026

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IL‑17A+ γδT cell activation via the HMGB1‑TLR2/4‑NF‑κB signaling pathways in biliary atresia

Meng-Xin Zhang, Jing-Feng Tang, Mei Hong, Ying Yang, Yun Zhou, Shui-Qing Chi, Li-Ying Rong, Guo-Qing Cao, Xi Zhang, Jin-Xiang Zhang, Shao-Tao Tang
Article Number: 181
Published online on: 11 May 2026

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CircRAD18 promotes glioblastoma proliferation, migration and invasion via the miR‑1231/LUC7L2 axis

Lumeng Song, Ping Xiong, Amu Jike, Xiaochao Xia, Lifang Mao, Zihao Wang, Yinchuan Cheng, Shumin Wang, Shizheng Tan, Dongnan Yu, Zheng Li, Xiaoping Tang, Shun Li
Article Number: 180
Published online on: 11 May 2026

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[Corrigendum] Expression of FKBP52 in the ovaries of PCOS rats

Shiyan Song, Yong Tan
Article Number: 179
Published online on: 11 May 2026

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miR‑223‑3p promotes microglial lactylation and M1 polarization via the FBXW7/Notch1/Hes1/SIRT1 axis

Xiaoyu Wang, Lin Song, Jiafeng Wang, Qianqian Xie, Yan Wang, Chunyan Li, Tianqi Wang, Yifeng Du
Article Number: 178
Published online on: 08 May 2026

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Radiotherapy and cytokines: A systems view of immunotherapy and toxicity (Review)

Siyuan Zhou, Yurong Jiang, Jixu Fan, Minjie Guo, Yi Wen, Chunhua Dai
Article Number: 177
Published online on: 08 May 2026

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Advances in understanding the NLRP3 inflammasome‑mediated mechanisms and therapeutic targets in diabetic nephropathy (Review)

Xiwei Wang, Shuang Li, Xiaotian Ge, Tao Xie, Sainan Li, Ruiqi Yuan, Tianxi Li, Hui Yuan
Article Number: 176
Published online on: 06 May 2026

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Expression of Concern Open Access

[Expression of Concern] ISL1 promotes cancer progression and inhibits cisplatin sensitivity in triple‑negative breast cancer cells

Yang Zhang, Lu Wang, Peng Gao, Zhiguo Sun, Ning Li, Yanqin Lu, Jianglun Shen, Jian Sun, Yiming Yang, Hao Dai, Haifeng Cai
Article Number: 175
Published online on: 06 May 2026

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Phosphorylation beyond the plasma membrane: How secretory pathway kinases sculpt the cellular dialogue in cancer (Review)

Ziang Geng, Shu Guan, Shaoqi Du, Shuo Zhang, Jiaxin Hao, Siyuan Tian, Chen Zhu, Shaonan Du
Article Number: 174
Published online on: 06 May 2026

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Ferroptosis in musculoskeletal disorders: Emerging mechanisms and therapeutic opportunities (Review)

Wenhui Gu, Haifeng Zhang, Lisha Ye, Fangming Liu, Ting Xu, Yinxian Yu, Guohua Wang
Article Number: 173
Published online on: 05 May 2026

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Retraction Open Access

[Retracted] Regulation of p38 MAPK phosphorylation inhibits chondrocyte apoptosis in response to heat stress or mechanical stress

Ken Takebe, Takayuki Nishiyama, Shinya Hayashi, Shingo Hashimoto, Takaaki Fujishiro, Noriyuki Kanzaki, Kohei Kawakita, Kenjiro Iwasa, Ryosuke Kuroda, Masahiro Kurosaka
Article Number: 172
Published online on: 04 May 2026

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Dapagliflozin attenuates ferroptosis in diabetic nephropathy through activation of the Nrf2/HO‑1 signaling pathway

Hanshuang Liu, Xiaoxiao Zhang, Yubing Cui, Shengxi Xiong, Linjuan Huang, Min Li, Chen Shao, Xiaolei Hu
Article Number: 171
Published online on: 30 April 2026

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Ligustroflavone protects against acute kidney injury by inhibiting ferroptosis via acting on GSK3β/NRF2 signaling

Jiayu Song, Long Wang, Yaru Wang, Jie Meng, Jingyi Sheng, Yongfeng Zhao, San Yan Xu, Juan Lei, Fangfang Cai, Yunwen Yang
Article Number: 170
Published online on: 30 April 2026

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Correction Open Access

[Corrigendum] Differential regulation of the biosynthesis of glucose transporters by the PI3‑K and MAPK pathways of insulin signaling by treatment with novel compounds from Liriope platyphylla

Yoen Kyung Lee, Ji Eun Kim, So Hee Nam, Jun Seo Goo, Sun Il Cho, Young Hwan Choi, Chang Jun Bae, Ong Min Woo, Jung Sik Cho, Dae Youn Hwang
Article Number: 169
Published online on: 28 April 2026

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Journal Cover
August-2026 Volume 58 Issue 2

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Journal Metrics

Impact Factor: 5.8

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Effects of exercise‑derived extracellular vesicles: Epigenetic regulatory mechanisms and protective roles (Review)

Xinxin Zhang, Biao Zhang
Article Number: 220
Published online on: 15 June 2026

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Moderate downregulation of NDUFA13 promotes cardiomyocytes proliferation and heart regeneration through the glycolysis/c‑Myc/Ccnd1 axis

Ying Gao, Ningjing Qian, Junyan Jin, Jiayi Liu, Bingqi Wang, Yaping Wang
Article Number: 219
Published online on: 12 June 2026

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[Corrigendum] (‑)‑Epigallocatechin‑3‑gallate attenuates myocardial injury induced by ischemia/reperfusion in diabetic rats and in H9c2 cells under hyperglycemic conditions

Yang Wu, Zhong-Yuan Xia, Bo Zhao, Yan Leng, Juan Dou, Qing-Tao Meng, Shao-Qing Lei, Zhi-Ze Chen, Jie Zhu
Article Number: 218
Published online on: 10 June 2026

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Melatonin ameliorates circadian rhythm disruption induced erectile dysfunction by inhibiting oxidative stress mediated pyroptosis via Nrf2/HO‑1 axis

Qingtao Yang, Wei Li, Qi Yu, Jiang Shi, Lu Yang, Jun Qiao, Xi Wei, Changshi Gu, Fa Sun, Tao Li
Article Number: 217
Published online on: 09 June 2026

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Spatial architecture of immunometabolism: Mitochondrial‑organelle interfaces in immune signaling (Review)

Yaping Wu, Hao Yu, Ling Xia, Li Yang, Yu Zhou, Qian Yu
Article Number: 216
Published online on: 08 June 2026

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Urea cycle dysregulation and arginine pathways in the pathogenesis of NAFLD and NASH (Review)

Boying Zhu, Chaoyang Wang, Peng Liu, Zhifeng Qu, Ran Qi, Shengjiang Chen, Huanzhang Niu
Article Number: 215
Published online on: 08 June 2026

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Withaferin A, a candidate drug for lupus nephritis, confers renal protection via Pon1‑mediated attenuation of oxidative stress

Miao Xue, Junshuai Feng, Xiaorong Mao
Article Number: 214
Published online on: 08 June 2026

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Retraction Open Access

[Retracted] Classical dendritic cells regulate acute lung inflammation and injury in mice with lipopolysaccharide‑induced acute respiratory distress syndrome

Lang Li, Liang Dong, Dan Zhao, Fei Gao, Jie Yan
Article Number: 213
Published online on: 08 June 2026

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Plant‑derived natural products alleviate dexamethasone‑induced skeletal muscle atrophy by modulating FoxO (Review)

Wei Dai, Jiabin Wu, Xiaotong Ma, Mingyu Wu, Ke Li, Haoyang Gao, Wenhong Wang, Weihua Xiao
Article Number: 212
Published online on: 05 June 2026

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Functional hydrogels in cardiovascular therapy: Design, applications and clinical challenges (Review)

Zheming Yang, Jiayin Li, Lingxiao Zhao, Dali Zhang, Chenghui Yan, Dan Liu, Yaling Han
Article Number: 211
Published online on: 04 June 2026

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Experimental rodent models of cardiorenal syndrome types 3 and 4: Insights and clinical relevance (Review)

Stefanny M. Figueroa, Siyi Huang, Javier Reyes‑Osorio, Jean-Jacques Boffa, Cristián A. Amador, Christos E. Chadjichristos, Louis Boutin
Article Number: 210
Published online on: 04 June 2026

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Expression of Concern Open Access

[Expression of Concern] Novel insights into the role of HSP90 in cytoprotection of H2S against chemical hypoxia‑induced injury in H9c2  cardiac myocytes

Zhanli Yang, Chuntao Yang, Liangcan Xiao, Xinxue Liao, Aiping Lan, Xiuyu Wang, Ruixian Guo, Peixi Chen, Chengheng Hu, Jianqiang Feng
Article Number: 209
Published online on: 03 June 2026

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Article Open Access

Microbiota‑derived indole‑3‑propionic acid reprograms bone marrow stem cell fate via PPARγ suppression to rescue osteoporosis

Jinwu Bai, Ruideng Wang, Jixing Fan, Shilong Su, Gao Si, Qinyong You, Ao Sun, Daole Hu, Shan Gao, Yang Lv, Fang Zhou
Article Number: 208
Published online on: 03 June 2026

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Article Open Access

Lactate regulates osteoclastogenesis via H3k18la in osteoarthritis

Zhibo Fan, Qiyue Fu, Tao Sun, Yutong Zhong, Yuefan Ma, Jingwei Jian, Shuosheng Yuan, Shenghong Li, Xiaomei Xu
Article Number: 207
Published online on: 02 June 2026

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Retraction Open Access

[Retracted] miR‑215 promotes epithelial to mesenchymal transition and proliferation by regulating LEFTY2 in endometrial cancert

Xiaoxu Gao, Yan Cai, Ruifang An
Article Number: 206
Published online on: 02 June 2026

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Review

Multi‑scale experimental models for the study of angiogenesis (Review)

Qin Yu, Jiarui Hu, Shuangshuang Yuan, Jiexia Gan, Mao Luo, Jianbo Wu, Liqun Wang
Article Number: 205
Published online on: 28 May 2026

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Review Open Access

Targeting lactylation in hepatocellular carcinoma: Mechanistic insights and therapeutic opportunities (Review)

Lianting Chen, Feiqiong Gao, Qianru Mei, Yujie Li, Qun Cai, Xudong Feng
Article Number: 204
Published online on: 28 May 2026

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Oxygen‑sensing histone demethylase KDM6A modulates chondrocyte‑to‑osteoblast transdifferentiation by activating the Wnt/β‑catenin pathway

Yi Rong, Hao Yu, Heng Yin, Shaoshuo Li, Jianwei Wang, Zhongyuan Shen, Xinxin Ding, Fanchen Bu, Tianyi Dai, Gean Wu, Zhen Hua
Article Number: 203
Published online on: 28 May 2026

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