Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies

  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
presentation
International Journal of Molecular Medicine

Join Editorial Board Propose a Special Issue

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

  • Selected Issue
  • Current Issue
  • Forthcoming Issue
  • Special Issues
    • Open Special Issues
    • About Special Issues
  • Trending Articles
    • Most Read
    • Most Cited (Dimensions)
      • Past Two Years
      • Total
    • Most Cited (Crossref)
      • Past Year
      • Total
    • Social Media
      • Past Month
      • Past Year
      • Total
  • Information
    • Information for Authors
    • Contact
    • Editorial Policies
    • Editorial Academy
    • Aims and Scope
    • Abstracting and Indexing
    • Bibliographic Information
  • Archive
Journal Cover
February-2018 Volume 41 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Galectin-3 as a novel biomarker for disease diagnosis and a target for therapy (Review)

Rui Dong, Min Zhang, Qunying Hu, Shan Zheng, Andrew Soh, Yijie Zheng, Hui Yuan
Pages: 599-614
Published online on: 05 December 2017

  • View Full Article Download
Review

Mitochondria-mediated damage to dopaminergic neurons in Parkinson's disease (Review)

Xiao‑Liang Liu, Ying‑Di Wang, Xiu‑Ming Yu, Da‑Wei Li, Guang‑Ren Li
Pages: 615-623
Published online on: 16 November 2017

  • View Full Article Download
Review

Necroptosis: A novel manner of cell death, associated with stroke (Review)

Chenglin Liu, Kai Zhang, Haitao Shen, Xiyang Yao, Qing Sun, Gang Chen
Pages: 624-630
Published online on: 22 November 2017

  • View Full Article Download
Review Open Access

The role and mechanism of β‑arrestins in cancer invasion and metastasis (Review)

Qing Song, Qing Ji, Qi Li
Pages: 631-639
Published online on: 27 November 2017

  • View Full Article Download
Article Open Access

A common African variant of human connexin 37 is associated with Caucasian primary ovarian insufficiency and has a deleterious effect in vitro

Anne Bachelot, Jerome Gilleron, Geri Meduri, Mihelai Guberto, Jerome Dulon, Sylviane Boucherie, Philippe Touraine, Micheline Misrahi
Pages: 640-648
Published online on: 16 November 2017

  • View Full Article Download
Article Open Access

Naringenin induces laxative effects by upregulating the expression levels of c-Kit and SCF, as well as those of aquaporin 3 in mice with loperamide-induced constipation

Jianqiao Yin, Yichao Liang, Dalu Wang, Zhaopeng Yan, Hongzhuan Yin, Di Wu, Qi Su
Pages: 649-658
Published online on: 01 December 2017

  • View Full Article Download
Article Open Access

Therapeutic effects of conditioned medium from bone marrow-derived mesenchymal stem cells on epithelial-mesenchymal transition in A549 cells

Xin Wang, Jun-Ling Gao, Man-Man Zhao, Hui-Xing Zhu, Yan-Xia Tian, Ran Li, Xiao-Hua Jiang, Lei Yu, Jing-Rui Tian, Jian-Zhong Cui
Pages: 659-668
Published online on: 24 November 2017

  • View Full Article Download
Article Open Access

In vitro cell behaviors of bone mesenchymal stem cells derived from normal and postmenopausal osteoporotic rats

Qian Liu, Xiaoxia Zhang, Yang Jiao, Xin Liu, Yirong Wang, Song-Lun Li, Wei Zhang, Fa-Ming Chen, Yin Ding, Chuan Jiang, Zuolin Jin
Pages: 669-678
Published online on: 22 November 2017

  • View Full Article Download
Article Open Access

Use of methylation profiling to identify significant differentially methylated genes in bone marrow mesenchymal stromal cells from acute myeloid leukemia Corrigendum in /10.3892/ijmm.2025.5520

Jing Huang, Zhi Liu, Yufan Sun, Qi Zhong, Li Xu, Ruimin Ou, Cheng Li, Rui Chen, Mengdong Yao, Qing Zhang, Shuang Liu
Pages: 679-686
Published online on: 17 November 2017

  • View Full Article Download
Article Open Access

Stromal-epithelial lactate shuttle induced by tumor‑derived interleukin‑1β promotes cell proliferation in oral squamous cell carcinoma

Jie Wu, Yun Hong, Tong Wu, Juan Wang, Xiaobing Chen, Zhi Wang, Bin Cheng, Juan Xia
Pages: 687-696
Published online on: 17 November 2017

  • View Full Article Download
Article Open Access

Interaction of iPSC-derived neural stem cells on poly(L-lactic acid) nanofibrous scaffolds for possible use in neural tissue engineering

Chengkai Lin, Chang Liu, Liangming Zhang, Zhi Huang, Peipei Zhao, Ruiqiang Chen, Mao Pang, Zhenxiang Chen, Liumin He, Chunxiao Luo, Limin Rong, Bin Liu
Pages: 697-708
Published online on: 30 November 2017

  • View Full Article Download
Article Open Access

Neurochemical changes in the hippocampus and prefrontal cortex associated with electroacupuncture for learning and memory impairment

Jian He, Congkuai Zhao, Weilin Liu, Jia Huang, Shengxiang Liang, Lidian Chen, Jing Tao
Pages: 709-716
Published online on: 24 November 2017

  • View Full Article Download
Article Open Access

A type 2 diabetes-associated SNP in KCNQ1 (rs163184) modulates the binding activity of the locus for Sp3 and Lsd1/Kdm1a, potentially affecting CDKN1C expression

Masaki Hiramoto, Haruhide Udagawa, Naoko Ishibashi, Eri Takahashi, Yasushi Kaburagi, Keisuke Miyazawa, Nobuaki Funahashi, Takao Nammo, Kazuki Yasuda
Pages: 717-728
Published online on: 20 November 2017

  • View Full Article Download
Article Open Access

Platelet-rich plasma inhibits RANKL-induced osteoclast differentiation through activation of Wnt pathway during bone remodeling

Dongyue Wang, Yajuan Weng, Shuyu Guo, Yuxin Zhang, Tingting Zhou, Mengnan Zhang, Lin Wang, Junqing Ma
Pages: 729-738
Published online on: 16 November 2017

  • View Full Article Download
Article Open Access

Geraniin protects bone marrow‑derived mesenchymal stem cells against hydrogen peroxide‑induced cellular oxidative stress in vitro

Dan Huang, Li Yin, Xinxin Liu, Bo Lv, Zulong Xie, Xuedong Wang, Bo Yu, Yao Zhang
Pages: 739-748
Published online on: 21 November 2017

  • View Full Article Download
Article Open Access

Effects of kartogenin on the attenuated nucleus pulposus cell degeneration of intervertebral discs induced by interleukin-1β and tumor necrosis factor-α

Yao Huang, Tao Jiang, Jian Chen, Guo-Yong Yin, Jin Fan
Pages: 749-756
Published online on: 24 November 2017

  • View Full Article Download
Article Open Access

Der f1 induces pyroptosis in human bronchial epithelia via the NLRP3 inflammasome

Ying‑Ming Tsai, Kuo‑Hwa Chiang, Jen‑Yu Hung, Wei‑An Chang, Hui‑Ping Lin, Jiunn‑Min Shieh, Inn‑Wen Chong, Ya‑Ling Hsu
Pages: 757-764
Published online on: 05 December 2017

  • View Full Article Download
Article Open Access

Chlorogenic acid attenuates hydrogen peroxide‑induced oxidative stress in lens epithelial cells

Jike Song, Dadong Guo, Hongsheng Bi
Pages: 765-772
Published online on: 01 December 2017

  • View Full Article Download
Article Open Access

Clinical and next-generation sequencing findings in a Chinese family exhibiting severe familial exudative vitreoretinopathy

Ying Lin, Hongbin Gao, Chuan Chen, Yi Zhu, Tao Li, Bingqian Liu, Chenghong Ma, Hongye Jiang, Yonghao Li, Ying Huang, Qingxiu Wu, Haichun Li, Xiaoling Liang, Chenjin Jin, Jianhua Ye, Xinhua Huang, Lin Lu
Pages: 773-782
Published online on: 05 December 2017

  • View Full Article Download
Article Open Access

Comparative analysis of human embryonic stem cell‑derived neural stem cells as an in vitro human model

Jung‑Hwa Oh, Cho‑Rok Jung, Mi‑Ok Lee, Janghwan Kim, Mi‑Young Son
Pages: 783-790
Published online on: 30 November 2017

  • View Full Article Download
Article Open Access

Human amniotic epithelial cells regulate osteoblast differentiation through the secretion of TGFβ1 and microRNA-34a-5p

Guiling Wang, Feng Zhao, Di Yang, Jing Wang, Lihong Qiu, Xining Pang
Pages: 791-799
Published online on: 17 November 2017

  • View Full Article Download
Article Open Access

Autophagy relieves the function inhibition and apoptosis‑promoting effects on osteoblast induced by glucocorticoid

Yudi Han, Lihai Zhang, Yaling Xing, Licheng Zhang, Xiaojuan Chen, Peifu Tang, Zhongbin Chen
Pages: 800-808
Published online on: 17 November 2017

  • View Full Article Download
Article Open Access

TAT‑fused IP3R‑derived peptide enhances cisplatin sensitivity of ovarian cancer cells by increasing ER Ca2+ release

Qi Xie, Ye Xu, Weinan Gao, Yong Zhang, Jing Su, Yanan Liu, Yuting Guo, Minghan Dou, Kebang Hu, Liankun Sun
Pages: 809-817
Published online on: 16 November 2017

  • View Full Article Download
Article Open Access

Epigallocatechin-3-gallate inhibits inflammation and epithelial‑mesenchymal transition through the PI3K/AKT pathway via upregulation of PTEN in asthma

Nan Yang, Han Zhang, Xuxu Cai, Yunxiao Shang
Pages: 818-828
Published online on: 28 November 2017

  • View Full Article Download
Article Open Access

Erythropoietin induces the osteogenesis of periodontal mesenchymal stem cells from healthy and periodontitis sources via activation of the p38 MAPK pathway

Liying Wang, Fan Wu, Yang Song, Yinzhong Duan, Zoulin Jin
Pages: 829-835
Published online on: 28 November 2017

  • View Full Article Download
Article Open Access

Clinical significance of interleukin‑6 and inducible nitric oxide synthase in ketamine‑induced cystitis

Chi‑Jung Huang, Fa‑Kung Lee, Shao‑Kuan Chen, Chih‑Cheng Chien, Sheng‑Tang Wu, Yen‑Chieh Wang
Pages: 836-844
Published online on: 17 November 2017

  • View Full Article Download
Article Open Access

Transcription factor TBX18 promotes adult rat bone mesenchymal stem cell differentiation to biological pacemaker cells

Yanjun Li, Mei Yang, Gege Zhang, Le Li, Bingjie Ye, Congxin Huang, Yanhong Tang
Pages: 845-851
Published online on: 16 November 2017

  • View Full Article Download
Article Open Access

Chronic prenatal hypoxia impairs cochlear development, a mechanism involving connexin26 expression and promoter methylation

Jingcang Lin, Huang Huang, Guorong Lv, Xiangyang Xu, Wendong Lin, Xianyan Xu, Jing Cheng, Ming Zheng
Pages: 852-858
Published online on: 01 December 2017

  • View Full Article Download
Article Open Access

The potential inhibitory effects of miR‑19b on vulnerable plaque formation via the suppression of STAT3 transcriptional activity

Sufang Li, Qiang Geng, Hong Chen, Jing Zhang, Chengfu Cao, Feng Zhang, Junxian Song, Chuanfen Liu, Wenqing Liang
Pages: 859-867
Published online on: 17 November 2017

  • View Full Article Download
Article Open Access

Aryl hydrocarbon receptor inhibits inflammation in DSS‑induced colitis via the MK2/p‑MK2/TTP pathway

Qimeng Wang, Kunqiu Yang, Bin Han, Baifa Sheng, Jiuheng Yin, Aimin Pu, Liangzi Li, Lihua Sun, Min Yu, Yuan Qiu, Weidong Xiao, Hua Yang
Pages: 868-876
Published online on: 17 November 2017

  • View Full Article Download
Article Open Access

Coordinated microRNA/mRNA expression profiles reveal a putative mechanism of corneal epithelial cell transdifferentiation from skin epidermal stem cells

Yanjie Guo, Xiya Ma, Weini Wu, Mingyan Shi, Junlong Ma, Yaping Zhang, Erkang Zhao, Xueyi Yang
Pages: 877-887
Published online on: 01 December 2017

  • View Full Article Download
Article Open Access

Anti‑inflammatory effect of quercetin and galangin in LPS‑stimulated RAW264.7 macrophages and DNCB‑induced atopic dermatitis animal models

Hae Nim Lee, Seong Ah Shin, Gang Sik Choo, Hyeong Jin Kim, Young Seok Park, Byeong Soo Kim, Sang Ki Kim, Sung Dae Cho, Jeong Seok Nam, Chang Sun Choi, Jeong Hwan Che, Byung Kwon Park, Ji Youn Jung
Pages: 888-898
Published online on: 29 November 2017

  • View Full Article Download
Article Open Access

Ginsenoside Rg1 inhibits inflammatory responses via modulation of the nuclear factor‑κB pathway and inhibition of inflammasome activation in alcoholic hepatitis Corrigendum in /10.3892/ijmm.2024.5407

Jiajun Li, Cheng Yang, Shu Zhang, Shu Liu, Luole Zhao, Huan Luo, Yatang Chen, Wenxiang Huang
Pages: 899-907
Published online on: 29 November 2017

  • View Full Article Download
Article Open Access

Pentosan polysulfate ameliorates apoptosis and inflammation by suppressing activation of the p38 MAPK pathway in high glucose‑treated HK‑2 cells

Ping Chen, Yang Yuan, Tianying Zhang, Bo Xu, Qing Gao, Tianjun Guan
Pages: 908-914
Published online on: 27 November 2017

  • View Full Article Download
Article Open Access

Molecular expression of multiple Nav1.5 splice variants in the frontal lobe of the human brain

Jun Wang, Shao‑Wu Ou, Zhi‑Yong Zhang, Bo Qiu, Yun‑Jie Wang
Pages: 915-923
Published online on: 24 November 2017

  • View Full Article Download
Article Open Access

Anti-obesity effects of pectinase and cellulase enzyme‑treated Ecklonia cava extract in high‑fat diet‑fed C57BL/6N mice

In‑Hye Kim, Jung‑Wook Choi, Min‑Kyeong Lee, Chang‑Ju Kwon, Taek‑Jeong Nam
Pages: 924-934
Published online on: 28 November 2017

  • View Full Article Download
Article Open Access

Hepatic recruitment of CD11b+Ly6C+ inflammatory monocytes promotes hepatic ischemia/reperfusion injury

Peng Song, Junbin Zhang, Yunwei Zhang, Zhiping Shu, Peng Xu, Long He, Chao Yang, Jinxiang Zhang, Hui Wang, Yiqing Li, Qin Li
Pages: 935-945
Published online on: 08 December 2017

  • View Full Article Download
Article Open Access

CD90 promotes cell migration, viability and sphere‑forming ability of hepatocellular carcinoma cells

Ketao Zhang, Siyao Che, Zheng Su, Shangyou Zheng, Huayao Zhang, Shanglin Yang, Wenda Li, Jianping Liu
Pages: 946-954
Published online on: 08 December 2017

  • View Full Article Download
Article

Melatonin exerts an inhibitory effect on insulin gene transcription via MTNR1B and the downstream Raf‑1/ERK signaling pathway

Yanliang Li, Huihui Wu, Naijia Liu, Xinyi Cao, Zhen Yang, Bin Lu, Renming Hu, Xuanchun Wang, Jie Wen
Pages: 955-961
Published online on: 01 December 2017

  • View Full Article Download
Article

Effective component of Salvia miltiorrhiza in promoting cardiomyogenic differentiation of human placenta‑derived mesenchymal stem cells

Kun Li, Jieqiong Song, Qian Zhao, Bo Wang, Yunli Zhang, Xuezhe Wang, Tiantian Tang, Shizheng Li
Pages: 962-968
Published online on: 28 November 2017

  • View Full Article Download
Article

Stromal cell‑derived factor‑1 induces matrix metalloproteinase expression in human endplate chondrocytes, cartilage endplate degradation in explant culture, and the amelioration of nucleus pulposus degeneration in vivo

Hua Zhang, Ting Zhu, Li Zhang, Qionghua Wu
Pages: 969-976
Published online on: 22 November 2017

  • View Full Article Download
Article

Different roles of Akt and mechanistic target of rapamycin in serum‑dependent chondroprotection of human osteoarthritic chondrocytes

Tongen Zhang, Jijie Liu, Xinpeng Zheng, Bing Zhang, Chun Xia
Pages: 977-984
Published online on: 24 November 2017

  • View Full Article Download
Article

Mechanism of endogenous digitalis-like factor‑induced vascular endothelial cell damage in patients with severe preeclampsia

Mei Peng, Mengyuan Yang, Yiling Ding, Ling Yu, Yali Deng, Weisi Lai, Yun Hu
Pages: 985-994
Published online on: 11 December 2017

  • View Full Article Download
Article

Sevoflurane inhibits the malignant potential of head and neck squamous cell carcinoma via activating the hypoxia‑inducible factor-1α signaling pathway in vitro

Yaqiong Yang, Rong Hu, Jia Yan, Zhifeng Chen, Yi Lu, Jue Jiang, Hong Jiang
Pages: 995-1002
Published online on: 04 December 2017

  • View Full Article Download
Article

Periostin has a protective role in melatonin‑induced cell apoptosis by inhibiting the eIF2α‑ATF4 pathway in human osteoblasts

Xiaotong Meng, Yue Zhu, Lin Tao, Sichao Zhao, Shui Qiu
Pages: 1003-1012
Published online on: 30 November 2017

  • View Full Article Download
Article

Co-expression network analysis of lncRNAs and mRNAs in OPTN-silenced cells

Lin Jin, Yuanyuan Li, Xinrong Zhou, Huiping Yuan
Pages: 1013-1020
Published online on: 06 December 2017

  • View Full Article Download
Article

MicroRNA‑30a‑5p suppresses tumor cell proliferation of human renal cancer via the MTDH/PTEN/AKT pathway

Jianmin Li, Changying Li, Hongjie Li, Ting Zhang, Xiaodong Hao, Jiwu Chang, Yong Xu
Pages: 1021-1029
Published online on: 17 November 2017

  • View Full Article Download
Article

MicroRNA-21 promotes the progression of peritoneal fibrosis through the activation of the TGF-?/Smad signaling pathway: An in vitro and in vivo study Retraction in /10.3892/ijmm.2020.4510

Ya-Li Ma, Fang Chen, Su-Xia Yang, Bao-Ping Chen, Jun Shi
Pages: 1030-1038
Published online on: 17 November 2017

  • View Full Article Download
Article

Icariin possesses chondroprotective efficacy in a rat model of dexamethasone-induced cartilage injury through the activation of miR-206 targeting of cathepsin K

Ning Liu, Tao Zhang, Bo-Ran Cao, Fei-Yu Luan, Rui-Xuan Liu, Hao-Rong Yin, Wen-Bo Wang
Pages: 1039-1047
Published online on: 27 November 2017

  • View Full Article Download
Article

Investigation of the pro-apoptotic effects of arbutin and its acetylated derivative on murine melanoma cells

Liyan Jiang, Di Wang, Yongfeng Zhang, Junyang Li, Zhiping Wu, Zhi Wang
Pages: 1048-1054
Published online on: 16 November 2017

  • View Full Article Download
Article

Role of inhibitor of growth 4 in the suppression of human melanoma cells through the Fas/FasL-mediated apoptosis pathway

Limin Cai, Haiyan Li, Cui Chen, Xue Cheng, Yu Wang, Jing Liu, Yongchen Wang, Lijun Hao
Pages: 1055-1061
Published online on: 20 November 2017

  • View Full Article Download
Article

Macrophage migration inhibitory factor promotes Warburg effect via activation of the NF‑κB/HIF‑1α pathway in lung cancer

Jun Li, Junhua Zhang, Fengjiao Xie, Jiangzhou Peng, Xu Wu
Pages: 1062-1068
Published online on: 22 November 2017

  • View Full Article Download
Article

High-resolution metabolomics determines the mode of onset of type 2 diabetes in a 3-year prospective cohort study

Yeseung Lee, Aryo Dimas Pamungkas, Carl Angelo D. Medriano, Jinsung Park, Seri Hong, Sun Ha Jee, Youngja H. Park
Pages: 1069-1077
Published online on: 21 November 2017

  • View Full Article Download
Article

Astragaloside IV prevents kidney injury caused by iatrogenic hyperinsulinemia in a streptozotocin‑induced diabetic rat model

Ke‑Qiang He, Wei‑Zu Li, Xiao‑Qing Chai, Yan‑Yan Yin, Yan Jiang, Wei‑Ping Li
Pages: 1078-1088
Published online on: 17 November 2017

  • View Full Article Download
Article

Diosgenin prevents high-fat diet-induced rat non-alcoholic fatty liver disease through the AMPK and LXR signaling pathways

Silu Cheng, Shufang Liang, Qun Liu, Zhengting Deng, Yuanhui Zhang, Juan Du, Ya'ni Zhang, Shu Li, Binbin Cheng, Changquan Ling
Pages: 1089-1095
Published online on: 28 November 2017

  • View Full Article Download
Article

Role of the cofilin 2 gene in regulating the myosin heavy chain genes in mouse myoblast C2C12 cells

Hongyan Zhu, Huixin Yang, Song Zhao, Junfeng Zhang, Dan Liu, Yumin Tian, Zhiyi Shen, Yuhong Su
Pages: 1096-1102
Published online on: 17 November 2017

  • View Full Article Download
Article

Anti-inflammatory effect of lovastatin is mediated via the modulation of NF-κB and inhibition of HDAC1 and the PI3K/Akt/mTOR pathway in RAW264.7 macrophages

Hyung-Wook Choi, Pyung-Gyun Shin, Ji-Hyun Lee, Woo-Suk Choi, Min-Jae Kang, Won-Sik Kong, Min-Ji Oh, Yong-Bae Seo, Gun-Do Kim
Pages: 1103-1109
Published online on: 05 December 2017

  • View Full Article Download
Article

Periodontal ligament‑associated protein‑1 delays rat periodontal bone defect repair by regulating osteogenic differentiation of bone marrow stromal cells and osteoclast activation

Xijiao Yu, Shuang Liu, Wei Wang, Shu Li
Pages: 1110-1118
Published online on: 06 December 2017

  • View Full Article Download
Article

Role of the c-Jun N-terminal kinase signaling pathway in the activation of trypsinogen in rat pancreatic acinar cells

Zhengpeng Yang, Weiguang Yang, Ming Lu, Zhituo Li, Xin Qiao, Bei Sun, Weihui Zhang, Dongbo Xue
Pages: 1119-1126
Published online on: 17 November 2017

  • View Full Article Download
Article

Macrophage migration inhibitory factor rescues mesenchymal stem cells from doxorubicin-induced senescence though the PI3K-Akt signaling pathway

Wenzheng Xia, Meng Hou
Pages: 1127-1137
Published online on: 23 November 2017

  • View Full Article Download
Article

Quercetin inhibits okadaic acid-induced tau protein hyperphosphorylation through the Ca2+‑calpain‑p25‑CDK5 pathway in HT22 cells

Xiu‑Yin Shen, Tao Luo, Sheng Li, Ou‑Yang Ting, Feng He, Jie Xu, Hua‑Qiao Wang
Pages: 1138-1146
Published online on: 22 November 2017

  • View Full Article Download
Article

Prohibitin-2 negatively regulates AKT2 expression to promote prostate cancer cell migration

Yongmei Shen, Yu Gao, Hui Yuan, Jiasong Cao, Bona Jia, Mingming Li, Yanfei Peng, Xiaoling Du, Ju Zhang, Jiandang Shi
Pages: 1147-1155
Published online on: 04 December 2017

  • View Full Article Download
Journal Cover
September-2026 Volume 58 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Mechanisms and therapeutic strategies of pyroptosis in sepsis‑induced acute lung injury (Review)

Wenyu Wu, Nuoran Li, Guoshu Deng, Suyi Yang, Ruifeng Zeng, Rui Chen, Jun Li
Article Number: 264
Published online on: 22 July 2026

  • View Full Article Download
Review Open Access

Gut‑bone metabolites: SCFAs, polyamines and microbial metabolomics in osteoporosis risk and therapy (Review)

Fuchao Chen, Jingyue Sun, Xiao Wang
Article Number: 263
Published online on: 21 July 2026

  • View Full Article Download
Expression of Concern Open Access

[Expression of Concern] Exposure to acoustic stimuli promotes the development and differentiation of neural stem cells from the cochlear nuclei through the clusterin pathway

Tao Xue, Li Wei, Ding-Jun Zha, Li Qiao, Lian-Jun Lu, Fu-Quan Chen, Jian-Hua Qiu
Article Number: 262
Published online on: 20 July 2026

  • View Full Article Download
Article Open Access

Cepharanthine inhibits tick‑borne encephalitis virus infection through modulation of the stress and inflammation response

Wan-Da Tang, Lan-Juan Zhao
Article Number: 261
Published online on: 16 July 2026

  • View Full Article Download
Article Open Access

circCACNA1D drives pulmonary fibrosis by regulating pyruvate kinase M2 dimer‑tetramer switching

Yujie Wang, Xiaoting Li, Meirong Wang, Nailiang Zhai, Mengqi Jiang, Bo Liu, Changjun Lv, Songzi Zhang, Xiaodong Song, Jinjin Zhang
Article Number: 260
Published online on: 15 July 2026

  • View Full Article Download
Review Open Access

Recent progress and therapeutic strategies in the treatment of cervical neuroendocrine neoplasms (Review)

Yanpeng Tian, Yu Zhang, Liling Wang, Zhongkang Li, Xiaotong Xu, Shouze Liu, Shenyu Yang, Xiangyang Ren, Menghan Xu, Xingzi Chang, Xianghua Huang, Qian Zhao, Ruixia Guo
Article Number: 259
Published online on: 15 July 2026

  • View Full Article Download
Review Open Access

Neurofibromin in bone disease: Mechanisms and therapeutic implications (Review)

Shuhong Zhang, Ge Yang
Article Number: 258
Published online on: 14 July 2026

  • View Full Article Download
Review Open Access

Exercise‑induced exosomal noncoding RNAs: Molecular signaling cascades in bone remodeling and translational applications in sports‑related bone injuries (Review)

Bin Tian, Xuesong Chen, Jiang Zheng, Xin Kang
Article Number: 257
Published online on: 14 July 2026

  • View Full Article Download
Review Open Access

Targeting alveolar type II cell dysfunction in idiopathic pulmonary fibrosis: Molecular mechanisms and emerging therapeutic strategies (Review)

Tianhao Xie, Kang Hu, Shu Pan, Xin Tong, Haitong Huang, Hao Ding, Jun Zhao
Article Number: 256
Published online on: 13 July 2026

  • View Full Article Download
Article Open Access

Tubular PFKFB3 drives diabetic kidney fibrosis via lactate‑dependent H4K12 lactylation and HIPK2 transactivation

Mingkun Xu, Linhang Fu, Yulong Zhang, Xiuli Guo, Han Wu, Sijing Gao, Fei Xiao, Li Xu
Article Number: 255
Published online on: 13 July 2026

  • View Full Article Download
Retraction Open Access

[Retracted] p73 participates in WWOX-mediated apoptosis in leukemia cells

Donghong Lin, Zhaolei Cui, Lingying Kong, Feng Cheng, Jianping Xu, Fenghua Lan
Article Number: 254
Published online on: 13 July 2026

  • View Full Article Download
Article Open Access

Role of hyperthermia in overcoming HPV‑mediated MHC‑Ⅰ downregulation and promoting immune surveillance

Hanyu Wang, Hongxin Lang, Yaoxing Guo, Te Sun, Yuansong Bai, Tao Zhang, Rui-Qun Qi
Article Number: 253
Published online on: 10 July 2026

  • View Full Article Download
Review Open Access

Endocrine‑metabolic imbalance drives osteoarthritis: From whole‑joint pathobiology to precision therapy (Review)

Ruhui Yang, Haimin Zeng, Qi Xiao, Yining Xie, Yi Long, Xiang Chen
Article Number: 252
Published online on: 09 July 2026

  • View Full Article Download
Expression of Concern Open Access

[Expression of Concern] Roles and mechanisms of action of HNF‑4α in the hepatic differentiation of WB‑F344 cells

Yumeng Shi, Dehua Zhou, Bingyi Wang, Deren Zhou, Baomin Shi
Article Number: 251
Published online on: 08 July 2026

  • View Full Article Download
Article Open Access

Phenylalanine exacerbates psoriasiform inflammation through NF‑κB‑mediated dendritic cell activation and Th17 polarization

Yaohan Xu, Jing Pan, Jie Chen, Yutao Zhu, Miaolian Cai, Zeyu Ma, Siji Chen, Tianze Yu, Yushu Wei, Jingying Pan, Kunliang Luo, Yinjing Song, Stijn Van Der Veen, Hao Cheng
Article Number: 250
Published online on: 08 July 2026

  • View Full Article Download
Review Open Access

Protective effects of Astragaloside IV on various liver diseases: From chemistry to herbal medicines (Review)

Jialu Shi, Xiaoyu Zhou, Jiabin Wu, Liru Zeng, Xia Wang, Wei Li, Xiao Huang, Xiaoyu Deng, Wenhong Wang
Article Number: 249
Published online on: 07 July 2026

  • View Full Article Download
Review Open Access

GRP78 dysregulation: A proposed molecular mechanism linking the tumor microenvironment to sepsis susceptibility in patients with cancer (Review)

Hang Ruan, Meipeng Zhu, Shi-Yan Liu, Li-Juan Zou, Shu-Sheng Li
Article Number: 248
Published online on: 07 July 2026

  • View Full Article Download
Review Open Access

FGFR1 signaling in rheumatoid arthritis: Mechanisms of bone destruction and therapeutic targeting (Review)

Changzhong Qian, Zhenyu Zhang, Xian Wu, Huibo Ti, Junjie Wu, Zhengdong Yuan, Xia Li, Feng-Lai Yuan
Article Number: 247
Published online on: 06 July 2026

  • View Full Article Download
Retraction Open Access

[Retracted] β‑catenin signaling induces the osteoblastogenic differentiation of human pre‑osteoblastic and bone marrow stromal cells mainly through the upregulation of osterix expression

Bo Liu, Song Wu, Lihua Han, Chaoyue Zhang
Article Number: 246
Published online on: 06 July 2026

  • View Full Article Download
Article Open Access

Single‑cell atlas reveals a Wilms' tumor 1‑mediated axis driving granulosa cell senescence in human ovarian aging

Yanfang Du, Congyu Zhou, Yanpeng Tian, Zhongkang Li, Xianghua Huang
Article Number: 245
Published online on: 03 July 2026

  • View Full Article Download
Review Open Access

TRPV1‑mediated central sensitisation: Core mechanisms of migraine chronification and novel targeted therapeutic strategies (Review)

Mingxia Zhang, Yuting Pu, Yujie Zhang, Jia Hu, Shuangyang Li, Hongmei Tang, Bangjiang Fang, Xue Bai
Article Number: 244
Published online on: 02 July 2026

  • View Full Article Download
Correction Open Access

[Corrigendum] Arginine ADP‑ribosyltransferase 1 promotes angiogenesis in colorectal cancer via the PI3K/Akt pathway

Lian Yang, Ming Xiao, Xian Li, Yi Tang, Ya-Lan Wang
Article Number: 243
Published online on: 02 July 2026

  • View Full Article Download
Review Open Access

Research progress on the chemical and pharmacological effects of Semen Strychni (Review)

Jingxin Mao, Xin Du, Dan Zeng, Xin Luo, Yan Li
Article Number: 242
Published online on: 02 July 2026

  • View Full Article Download
Article Open Access

FLI1 enhances the malignant phenotype of glioma cells and exerts immunomodulatory effects through feedback crosstalk with exonic circRNA FECR1 and interferon‑induced ISG15

Xue Wen, Xiaoyi Gu, Xu Yan, Naifei Chen, Lei Zhou, Hui Li, Andrew R. Hoffman, Wei Li, Ji-Fan Hu, Jiuwei Cui
Article Number: 241
Published online on: 01 July 2026

  • View Full Article Download
Review Open Access

Role of ZEB1 in angiogenesis and therapeutic potential (Review)

Ruoxin Ren, Chunxiao Yan, Yao Xiang, Lin Jin, Fang Cheng, Lijun Zhang
Article Number: 240
Published online on: 01 July 2026

  • View Full Article Download
Review Open Access

Endothelial dysfunction: A central mechanism linking autosomal dominant polycystic kidney disease and intracranial aneurysms (Review)

Xiaohong Xu, Ruyi Xu, Liexiang Zhang
Article Number: 239
Published online on: 01 July 2026

  • View Full Article Download
Correction Open Access

[Corrigendum] Effect of SDF‑1/CXCR4 axis on the migration of transplanted bone mesenchymal stem cells mobilized by erythropoietin toward lesion sites following spinal cord injury

Jun Li, Weichun Guo, Min Xiong, Heng Han, Jie Chen, Dan Mao, Bing Tang, Hualong Yu, Yun Zeng
Article Number: 238
Published online on: 01 July 2026

  • View Full Article Download
Review Open Access

Exercise and fluoxetine in Alzheimer's disease: Molecular mechanisms of synergistic and antagonistic effects (Review)

Mei Wu, Yan Li
Article Number: 237
Published online on: 30 June 2026

  • View Full Article Download
Review Open Access

Oral‑gut axis in systemic disease: A barrier‑metabolism‑immunity three‑dimensional regulatory model (Review)

Qing Li, Mingrong Cheng, Weiwei Li, Xiaoyue Wang, Xiaoqing Liu, Yujie Yan
Article Number: 236
Published online on: 30 June 2026

  • View Full Article Download
Review Open Access

ABCG2 transporter: Structural and functional associations with gout (Review)

Muhammad Arslan Asif, Zeshan Zulfiqar, Bahar E. Mustafa, Usman Nazir, Jiamen Sun, Zhichang Wang, Yalei Cui, Sun Hao, Liu Boshuai, Yinghua Shi
Article Number: 235
Published online on: 30 June 2026

  • View Full Article Download
Review Open Access

Neuropilin‑1: Emerging roles in nerve‑vessel‑bone coupling during fracture repair (Review)

Keyue Zhang, Tong Li, Huan Liu, Huibo Ti, Zhenyu Zhang, Zhengdong Yuan, Junjie Wu, Xielin Yan, Zixin Luo, Haiting Hu, Xingchen Yao, Shuwen Shi, Xian Wu, Feng-Lai Yuan, Xiao Chen
Article Number: 234
Published online on: 30 June 2026

  • View Full Article Download
Correction Open Access

[Corrigendum] Crocin exerts anti‑inflammatory and anti‑catabolic effects on rat intervertebral discs by suppressing the activation of JNK

Kang Li, Yan Li, Zhenjiang Ma, Jie Zhao
Article Number: 233
Published online on: 29 June 2026

  • View Full Article Download
Review Open Access

Skeletal muscle‑derived extracellular vesicles in multi‑organ degenerative disease: Mechanisms and therapeutic delivery perspectives (Review)

Xianji Wei, Chengyan Guo, Wei Zhang, Guanyi Wang, Wenjing Li, Binghong Gao, Bo Gao, Lingli Zhang
Article Number: 232
Published online on: 26 June 2026

  • View Full Article Download
Journal Cover
October-2026 Volume 58 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Energy stress activates AMPK to suppress ferroptosis in neurodegenerative proteinopathies

Yuanyuan Yong, Yuxin Hu, Qian Feng, Xiaogang Zhou, Lu Yu, Dalian Qin, Jianing Mi, Jianming Wu, Jianxin Liu, Anguo Wu
Article Number: 274
Published online on: 31 July 2026

  • Download
Article Open Access

Brazilin attenuates methylglyoxal‑induced endothelial injury by enhancing eIF5A hypusination and inhibiting the AMPK/mTOR‑mediated autophagy/apoptosis axis in vitro and in vivo

Yu Liang, Jinxiang Chen, Haiyang Li, Junjing Xiong, Jingcan You, Liqun Wang, Jianbo Wu, Youkun Zheng, Mao Luo
Article Number: 273
Published online on: 30 July 2026

  • Download
Review Open Access

Post‑translational modifications in atherosclerosis: Roles, mechanisms and therapeutic potential (Review)

Xiaoxiang Xu, Fei Ma, Wei Yu
Article Number: 272
Published online on: 30 July 2026

  • Download
Review Open Access

Role of extracellular matrix in liver fibrosis regression and regeneration (Review)

Yuanzhi Zhou, Zeyuan Qiang, Yang Duan, Jiwei Huang, Haichuan Wang
Article Number: 271
Published online on: 29 July 2026

  • Download
Correction Open Access

[Corrigendum] Circulating microRNA profiles and the identification of miR‑593 and miR‑511 which directly target the PROP1 gene in children with combined pituitary hormone deficiency

Yanyan Hu, Qian Wang, Zengmin Wang, Fengxue Wang, Xiaobo Guo, Guimei Li
Article Number: 270
Published online on: 29 July 2026

  • Download
Review Open Access

Unveiling the role of spatial transcriptomics in the analysis of the tumor immune microenvironment (Review)

Jialin Jiang, Xinyu Tu, Yi Cao, Qun Yan, Buqing Sai, Jian Ma
Article Number: 269
Published online on: 28 July 2026

  • Download
Expression of Concern Open Access

[Expression of Concern] Luteolin protects mice from severe acute pancreatitis by exerting HO‑1‑mediated anti‑inflammatory and antioxidant effects

Jie Xiong, Kezhou Wang, Chunxiao Yuan, Rong Xing, Jianbo Ni, Guoyong Hu, Fengling Chen, Xingpeng Wang
Article Number: 268
Published online on: 27 July 2026

  • Download
Article Open Access

circRNA_013145‑miR‑185‑5p‑RhoA axis: A novel mechanism in the pathophysiology of diabetes‑induced erectile dysfunction

Wenhan Huang, Xin Lv, Jiahua Qian, Yihao Chen, Yuhe Si, Jingwei Wang, Jianxiong Ma
Article Number: 267
Published online on: 24 July 2026

  • Download
Review Open Access

Gut‑liver‑kidney axis: A systems biology framework for understanding and treating chronic kidney disease (Review)

Jinyi Hou, Yaotan Li, Shijia Lin, Qingqing Liu, Huijuan Zheng, Weijing Liu, Yaoxian Wang, Liang Peng, Zhen Wang
Article Number: 266
Published online on: 23 July 2026

  • View Full Article Download
Review Open Access

Effects of cuproptosis and its application in inflammatory bowel disease (Review)

Li Chen, Francis Atim Akanyibah, Jing Guan, Bing Pei, Bo Wang, Fei Mao
Article Number: 265
Published online on: 23 July 2026

  • View Full Article Download
Select a topic from the Information tab...
Special issues coming soon...
No data
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team