Open Access

Juglanin suppresses fibrosis and inflammation response caused by LPS in acute lung injury

  • Authors:
    • Ze-Wu Dong
    • Yu-Fang Yuan
  • View Affiliations

  • Published online on: March 9, 2018     https://doi.org/10.3892/ijmm.2018.3554
  • Pages: 3353-3365
  • Copyright: © Dong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Acute lung injury in children is a complication showing devastating disorders linked to fibrosis progression and inflammation response. Fibrosis and inflammation response are two markers for acute lung injury. Juglanin is a natural product mainly isolated from green walnut husks of Juglans mandshurica, which isconsidered as the functional composition among a series of compounds. It exhibited effective role in various diseases by inhibiting inflammation response. In our study, the protective effects and anti-inflammatory activity of juglanin were investigated in mice and lung cells treated by lipopolysaccharide (LPS) to reveal the possible mechanism by which juglanin attenuates acute lung injury. The mice were separated into four groups. The mouse model was established with 15 mg/kg LPS injection. Juglanin dramatically reduced the inflammation of cell infiltration. Compared to mice only treated with LPS, LPS-treated mice in the presence of juglanin developed less lung fibrosis with lower levels of α-smooth muscle-actin (α-SMA), collagen type I, collagen type III, and transforming growth factor-β1 (TGF-β1). Additionally, juglanin markedly downregulated inflammatory cytokine secretion and phosphorylated nuclear factor-κB (NF-κB) expression via inhibiting IKKα/IκBα signaling pathway. Our results indicate that juglanin has a protective role in LPS-triggered acute lung injury via suppression of fibrosis and inflammation response by NF-κB signaling pathways inactivation. Thus, juglanin may be a potential candidate as dietary supplement for acute lung injury for children in future.
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June-2018
Volume 41 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Dong Z and Dong Z: Juglanin suppresses fibrosis and inflammation response caused by LPS in acute lung injury. Int J Mol Med 41: 3353-3365, 2018
APA
Dong, Z., & Dong, Z. (2018). Juglanin suppresses fibrosis and inflammation response caused by LPS in acute lung injury. International Journal of Molecular Medicine, 41, 3353-3365. https://doi.org/10.3892/ijmm.2018.3554
MLA
Dong, Z., Yuan, Y."Juglanin suppresses fibrosis and inflammation response caused by LPS in acute lung injury". International Journal of Molecular Medicine 41.6 (2018): 3353-3365.
Chicago
Dong, Z., Yuan, Y."Juglanin suppresses fibrosis and inflammation response caused by LPS in acute lung injury". International Journal of Molecular Medicine 41, no. 6 (2018): 3353-3365. https://doi.org/10.3892/ijmm.2018.3554