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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
June-2018 Volume 41 Issue 6

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

High glucose induces the proliferation of prostatic cells via downregulating MRE11

Chunwei Ye, Yi Cai, Qian Cai, Shunhui Yuan, Fan Huang, Xiaofang Yang, Shuchen He, Zhuoheng Li, Yanwen Wang, Delin Yang, Zhipeng Li
Pages: 3105-3114
Published online on: 07 March 2018

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Article Open Access

SUMO2 modification of Aurora B and its impact on follicular development and atresia in the mouse ovary

Jing Cao, Xiao‑Ming Liu, Li‑Lin Huang, Li Wang, Xiao‑Fei Jiao, Li‑Jun Huo
Pages: 3115-3126
Published online on: 07 March 2018

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Article Open Access

Triptolide reduces ischemia/reperfusion injury in rats and H9C2 cells via inhibition of NF‑κB, ROS and the ERK1/2 pathway

Bin Yang, Ping Yan, Guang‑Zhao Yang, Hui‑Li Cao, Fei Wang, Bao Li
Pages: 3127-3136
Published online on: 06 March 2018

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Article Open Access

Inhibition effects of total flavonoids from Sculellaria barbata D. Don on human breast carcinoma bone metastasis via downregulating PTHrP pathway

Xiao Zheng, Wen Kang, Huihui Liu, Shanyu Guo
Pages: 3137-3146
Published online on: 27 February 2018

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Article Open Access

miR‑377 targets CUL4A and regulates metastatic capability in ovarian cancer

Rufen Yu, Limei Cai, Yingui Chi, Xiangcui Ding, Xueqing Wu
Pages: 3147-3156
Published online on: 07 March 2018

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Article Open Access

Deguelin exerts anticancer activity of human gastric cancer MGC-803 and MKN-45 cells in vitro

Wen Kang, Xiao Zheng, Ping Wang, Shanyu Guo
Pages: 3157-3166
Published online on: 05 March 2018

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Article Open Access

REG3A overexpression suppresses gastric cancer cell invasion, proliferation and promotes apoptosis through PI3K/Akt signaling pathway

Yan-Song Qiu, Guang-Jun Liao, Ning-Ning Jiang
Pages: 3167-3174
Published online on: 28 February 2018

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Article Open Access

Transplantation of human matrix metalloproteinase-1 gene-modified bone marrow-derived mesenchymal stem cell attenuates CCL4-induced liver fibrosis in rats

Chao Du, Mingde Jiang, Xiaolong Wei, Jianpin Qin, Hui Xu, Yunxia Wang, Yong Zhang, Dejiang Zhou, Hongli Xue, Shumei Zheng, Weizheng Zeng
Pages: 3175-3184
Published online on: 27 February 2018

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Article Open Access

Intravenous administration of DPSCs and BDNF improves neurological performance in rats with focal cerebral ischemia

Xuemei Zhang, Yinglian Zhou, Hulun Li, Rui Wang, Dan Yang, Bing Li, Jin Fu
Pages: 3185-3194
Published online on: 28 February 2018

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Article Open Access

Effect of lithocholic acid on biologically active α,β-unsaturated aldehydes induced by H2O2 in glioma mitochondria for use in glioma treatment

Dan Wang, Li Bie, Yanbin Su, Haoran Xu, Fengrong Zhang, Yanwen Su, Bo Zhang
Pages: 3195-3202
Published online on: 02 March 2018

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Article Open Access

Biphasic activation of nuclear factor-κB and expression of p65 and c-Rel following traumatic neuronal injury

Huasheng Zhang, Dingding Zhang, Hua Li, Huiying Yan, Zihuan Zhang, Chenhui Zhou, Qiang Chen, Zhennan Ye, Chunhua Hang
Pages: 3203-3210
Published online on: 14 March 2018

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Article Open Access

hTERT peptide fragment GV1001 demonstrates radioprotective and antifibrotic effects through suppression of TGF‑β signaling

Wei Chen, Ki‑Hyuk Shin, Sangjae Kim, Won‑Jun Shon, Reuben H. Kim, No‑Hee Park, Mo K. Kang
Pages: 3211-3220
Published online on: 14 March 2018

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Article Open Access

MicroRNA-30e protects the heart against ischemia and reperfusion injury through autophagy and the Notch1/Hes1/Akt signaling pathway

Jianjie Zheng, Jing Li, Bo Kou, Qiuyue Yi , Tao Shi
Pages: 3221-3230
Published online on: 07 March 2018

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Article Open Access

Mangiferin induces islet regeneration in aged mice through regulating p16INK4a

Hailian Wang, Xia He, Tiantian Lei, Yilong Liu, Guoli Huai, Minghan Sun, Shaoping Deng, Hongji Yang, Rongsheng Tong, Yi Wang
Pages: 3231-3242
Published online on: 01 March 2018

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Article Open Access

PEDF improves cardiac function in rats subjected to myocardial ischemia/reperfusion injury by inhibiting ROS generation via PEDF‑R

Qixiang Zhao, Zhiwei Liu, Bing Huang, Yanliang Yuan, Xiucheng Liu, Hu Zhang, Fan Qiu, Yiqian Zhang, Yufeng Li, Haoran Miao, Hongyan Dong, Zhongming Zhang
Pages: 3243-3252
Published online on: 09 March 2018

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Article Open Access

Aspirin modulates the inflammatory response in a thrombus‑stimulated LMVEC model

Lingcong Wang, Rongbiao Ying, Huifang Jiang, Qun Jin, Jing Kuang, Zhirong Zhang, Ying Shi, Danli Cai, Ruhui Yang
Pages: 3253-3266
Published online on: 13 March 2018

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Article Open Access

Tree shrew neural stem cell transplantation promotes functional recovery of tree shrews with a hemi‑sectioned spinal cord injury by upregulating nerve growth factor expression

Liu‑Lin Xiong, Yu Zou, Yu Shi, Piao Zhang, Rong‑Ping Zhang, Xie‑Jie Dai, Bin Liu, Ting‑Hua Wang
Pages: 3267-3277
Published online on: 09 March 2018

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Article Open Access

Trifluoperazine induces apoptosis through the upregulation of Bax/Bcl‑2 and downregulated phosphorylation of AKT in mesangial cells and improves renal function in lupus nephritis mice

Baodong Wang, Yankun Luo, Xiaoshuang Zhou, Rongshan Li
Pages: 3278-3286
Published online on: 13 March 2018

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Article Open Access

RP105 alleviates myocardial ischemia reperfusion injury via inhibiting TLR4/TRIF signaling pathways

Jun Yang, Chaojun Yang, Jian Yang, Jiawang Ding, Xinxin Li, Qinqin Yu, Xin Guo, Zhixing Fan, Huibo Wang
Pages: 3287-3295
Published online on: 06 March 2018

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Article Open Access

Expression of immunoglobulin G in human podocytes, and its role in cell viability and adhesion

Ziyang Jing, Hui Deng, Junfan Ma, Yanhong Guo, Yaoxian Liang, Rui Wu, Lata A, Zihan Geng, Xiaoyan Qiu, Yue Wang
Pages: 3296-3306
Published online on: 01 March 2018

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Article Open Access

Effect of electro-acupuncture on the BDNF-TrkB pathway in the spinal cord of CCI rats

Wen-Zhan Tu, Si-Si Li, Xia Jiang, Xin-Ru Qian, Guan-Hu Yang, Peng-Peng Gu, Bin Lu, Song-He Jiang
Pages: 3307-3315
Published online on: 13 March 2018

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Article Open Access

Cyclic mechanical tension reinforces DNA damage and activates the p53-p21-Rb pathway to induce premature senescence of nucleus pulposus cells

Chencheng Feng, Minghui Yang, Yang Zhang, Minghong Lan, Bo Huang, Huan Liu, Yue Zhou
Pages: 3316-3326
Published online on: 28 February 2018

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Article Open Access

Transcriptomic and proteomic analysis of potential therapeutic target genes in the liver of metformin‑treated Sprague‑Dawley rats with type 2 diabetes mellitus

Yitao Chen, Yangsheng Wu, Yuanxiao Yang, Zhiwei Xu, Junfeng Tong, Zheming Li, Xiaojie Zhou, Changyu Li
Pages: 3327-3341
Published online on: 06 March 2018

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Article Open Access

Overexpression of adrenomedullin protects mesenchymal stem cells against hypoxia and serum deprivation‑induced apoptosis via the Akt/GSK3β and Bcl‑2 signaling pathways

Hongjin Si, Yao Zhang, Yuqing Song, Lili Li
Pages: 3342-3352
Published online on: 05 March 2018

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Article Open Access

Juglanin suppresses fibrosis and inflammation response caused by LPS in acute lung injury

Ze-Wu Dong, Yu-Fang Yuan
Pages: 3353-3365
Published online on: 09 March 2018

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Article Open Access

c-Myc regulates the CDK1/cyclin B1 dependent‑G2/M cell cycle progression by histone H4 acetylation in Raji cells Corrigendum in /10.3892/ijmm.2019.4318

Yan Yang, Kai Xue, Zhi Li, Wei Zheng, Weijie Dong, Jiazhe Song, Shijie Sun, Tonghui Ma, Wenzhe Li
Pages: 3366-3378
Published online on: 28 February 2018

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Article Open Access

MicroRNA-155 inhibits the osteogenic differentiation of mesenchymal stem cells induced by BMP9 via downregulation of BMP signaling pathway

Hongxia Liu, Liang Zhong, Taixian Yuan, Sicheng Chen, Yiqing Zhou, Liqin An, Yangliu Guo, Mengtian Fan, Ya Li, Yanting Sun, Wang Li, Qiong Shi, Yaguang Weng
Pages: 3379-3393
Published online on: 01 March 2018

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Article Open Access

PEDF protects cardiomyocytes by promoting FUNDC1‑mediated mitophagy via PEDF-R under hypoxic condition

Yufeng Li, Zhiwei Liu, Yiqian Zhang, Qixiang Zhao, Xiaoyu Wang, Peng Lu, Hao Zhang, Zhu Wang, Hongyan Dong, Zhongming Zhang
Pages: 3394-3404
Published online on: 06 March 2018

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Article Open Access

Accelerated inflammation and oxidative stress induced by LPS in acute lung injury: Ιnhibition by ST1926

Zewu Dong, Yufang Yuan
Pages: 3405-3421
Published online on: 19 March 2018

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Article Open Access

Transcriptome and alternative splicing analysis of nucleus pulposus cells in response to high oxygen tension: Involvement of high oxygen tension in the pathogenesis of intervertebral disc degeneration

Chencheng Feng, Yang Zhang, Minghui Yang, Minghong Lan, Bo Huang, Huan Liu, Yue Zhou
Pages: 3422-3432
Published online on: 28 February 2018

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Article Open Access

Valproic acid prevents glucocorticoid‑induced osteonecrosis of the femoral head of rats

Ding Zhou, Yi‑Xuan Chen, Jun‑Hui Yin, Shi‑Cong Tao, Shang‑Chun Guo, Zhan‑Ying Wei, Yong Feng, Chang‑Qing Zhang
Pages: 3433-3447
Published online on: 06 March 2018

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Article Open Access

MCMV triggers ROS/NLRP3-associated inflammasome activation in the inner ear of mice and cultured spiral ganglion neurons, contributing to sensorineural hearing loss Corrigendum in /10.3892/ijmm.2025.5514

Wei Zhuang, Caiji Wang, Xi Shi, Shiwei Qiu, Shili Zhang, Bing Xu, Min Chen, Wen Jiang, Hongyan Dong, Yuehua Qiao
Pages: 3448-3456
Published online on: 06 March 2018

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Article Open Access

Ephrin‑b3 modulates hippocampal neurogenesis and the reelin signaling pathway in a pilocarpine‑induced model of epilepsy

Tian‑Tian Liu, Yi Li, Yi Shu, Bo Xiao, Li Feng
Pages: 3457-3467
Published online on: 07 March 2018

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Article

miR-124/MCP-1 signaling pathway modulates the protective effect of itraconazole on acute kidney injury in a mouse model of disseminated candidiasis

Xiao‑Yue Li, Yu‑Qi Zhang, Gang Xu, Shao‑Hong Li, Heng Li
Pages: 3468-3476
Published online on: 13 March 2018

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Article

Microarray analysis of the expression profile of lncRNAs reveals the key role of lncRNA BC088327 as an agonist to heregulin‑1β‑induced cell proliferation in peripheral nerve injury

Houlei Wang, Jingping Wu, Xinchao Zhang, Lei Ding, Qingmin Zeng
Pages: 3477-3484
Published online on: 15 March 2018

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Article

Daidzein exerts anticancer activity towards SKOV3 human ovarian cancer cells by inducing apoptosis and cell cycle arrest, and inhibiting the Raf/MEK/ERK cascade Retraction in /10.3892/ijmm.2021.4929

Fu Hua, Chang‑Hua Li, Xiao‑Gang Chen, Xiao‑Ping Liu
Pages: 3485-3492
Published online on: 05 March 2018

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Article

3,5,4'-Tri-O-acetylresveratrol attenuates seawater inhalation-induced acute respiratory distress syndrome via thioredoxin 1 pathway

Yilin Zhao, Lijie Ma, Ruixuan Wang, Tingting Chen, Xueying Liu, Faguang Jin
Pages: 3493-3500
Published online on: 01 March 2018

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Article

CFTR ameliorates high glucose-induced oxidative stress and inflammation by mediating the NF-κB and MAPK signaling pathways in endothelial cells

Yang Fei, Liqin Sun, Chungang Yuan, Min Jiang, Qinhua Lou, Yan Xu
Pages: 3501-3508
Published online on: 07 March 2018

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Article

Cardioprotective effect of rosuvastatin against isoproterenol-induced myocardial infarction injury in rats

Ying Yu, Lin Jin, Yamin Zhuang, Yan Hu, Jing Cang, Kefang Guo
Pages: 3509-3516
Published online on: 15 March 2018

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Article

SIRT3 deficiency exacerbates p53/Parkin‑mediated mitophagy inhibition and promotes mitochondrial dysfunction: Implication for aged hearts

Yan Li, Ying Ma, Liqiang Song, Lu Yu, Le Zhang, Yingmei Zhang, Yuan Xing, Yue Yin, Heng Ma
Pages: 3517-3526
Published online on: 09 March 2018

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Article

Selection of reference genes for expression analysis in mouse models of acute alcoholic liver injury

Sheng  Wang, Jianqing  Wang, Xiongwen  Lv
Pages: 3527-3536
Published online on: 01 March 2018

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Article Open Access

Identification of aberrantly expressed long non-coding RNAs in postmenopausal osteoporosis

Qi Fei, Xiaodong Bai, Jisheng Lin, Hai Meng, Yong Yang , Ai Guo
Pages: 3537-3550
Published online on: 19 March 2018

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Article

Angiopoietin-2 promotes extracellular matrix degradation in human degenerative nucleus pulposus cells

Kun Wang, Liang Kang, Wei Liu, Yu Song, Xinghuo Wu, Yukun Zhang, Wenbin Hua, Kangcheng Zhao, Shuai Li, Ji Tu, Rongjin Luo, Cao Yang
Pages: 3551-3558
Published online on: 19 March 2018

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Article

An adenosine A1R-A2aR imbalance regulates low glucose/hypoxia-induced microglial activation, thereby contributing to oligodendrocyte damage through NF-κB and CREB phosphorylation

Wen Huang, Shunjie Bai, Xuzheng Zuo, Weiju Tang, Pengfei Chen, Xiuying Chen, Gong Wang, Haoxiang Wang, Peng Xie
Pages: 3559-3569
Published online on: 07 March 2018

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Article

Secoisolariciresinol diglucoside prevents the oxidative stress-induced apoptosis of myocardial cells through activation of the JAK2/STAT3 signaling pathway

Guiqiong Huang, Xiaofang Huang, Min Liu, Yue Hua, Bo Deng, Wen Jin, Wen Yan, Zhangbin Tan, Yifen Wu, Bin Liu, Yingchun Zhou
Pages: 3570-3576
Published online on: 13 March 2018

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Article Open Access

The deficiency of CX3CL1/CX3CR1 system ameliorates high fructose diet-induced kidney injury by regulating NF-κB pathways in CX3CR1-knock out mice

Yong-Wu Yu, Ming-Xu Li, Zhi-Yong Zhang, Hai Yu
Pages: 3577-3585
Published online on: 16 March 2018

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Article

Enhanced rapamycin delivery to hemangiomas by lipid polymer nanoparticles coupled with anti-VEGFR antibody

Haitao Li, Yunfei Teng, Xia Xu, Jianyong Liu
Pages: 3586-3596
Published online on: 28 February 2018

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Article

Screening pathogenic genes in oral squamous cell carcinoma based on the mRNA expression microarray data

Yang Ding, Pengfei Liu, Shengsheng Zhang, Lin Tao, Jianmin Han
Pages: 3597-3603
Published online on: 27 February 2018

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Article

Interfering RNA with multi-targets for efficient gene suppression in HCC cells

Tiejun Li, York Yuanyuan Zhu, Yi Ji, Songfeng Zhou
Pages: 3604-3610
Published online on: 09 March 2018

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Article

Isolation, culture and biological characteristics of multipotent porcine tendon-derived stem cells

Jinjuan Yang, Qianjun Zhao, Kunfu Wang, Caiyun Ma, Hao Liu, Yingjie Liu, Weijun Guan
Pages: 3611-3619
Published online on: 07 March 2018

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Article

In vivo effects of the NLRP1/NLRP3 inflammasome pathway on latent respiratory virus infection

Yong‑Huai Li, Xiang Wei, Shuang Ji, Shu‑Yu Gui, Su‑Mei Zhang
Pages: 3620-3628
Published online on: 28 February 2018

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Article

Low expression of PTEN is essential for maintenance of a malignant state in human gastric adenocarcinoma via upregulation of p‑AURKA mediated by activation of AURKA

Liwei Li, Yue Song, Qing Liu, Xi Liu, Rui Wang, Chunsheng Kang, Qingyu Zhang
Pages: 3629-3641
Published online on: 07 March 2018

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Article

Rhododendron album Blume extract inhibits TNF-α/IFN-γ-induced chemokine production via blockade of NF-κB and JAK/STAT activation in human epidermal keratinocytes

Ji‑Won Park, Han‑Sol Lee, Yourim Lim, Jin‑Hyub Paik, Ok‑Kyoung Kwon, Jung‑Hee Kim, Imam Paryanto, Prasetyawan Yunianto, Sangho Choi, Sei‑Ryang Oh, Kyung‑Seop Ahn
Pages: 3642-3652
Published online on: 09 March 2018

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Article

Hydrogen ameliorates oxidative stress via PI3K-Akt signaling pathway in UVB-induced HaCaT cells

Bingxin Zhang, Zishen Zhao, Xiaoyin Meng, Hongguang Chen, Guojun Fu, Keliang Xie
Pages: 3653-3661
Published online on: 07 March 2018

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Article

Novel mutations of the SERPINF1 and FKBP10 genes in Chinese families with autosomal recessive osteogenesis imperfecta

Hao Zhang, Yang Xu, Hua Yue, Chun Wang, Jiemei Gu, Jinwei He, Wenzhen Fu, Weiwei Hu, Zhenlin Zhang
Pages: 3662-3670
Published online on: 07 March 2018

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Article

Incorporation of CD40 ligand enhances the immunogenicity of tumor‑associated calcium signal transducer 2 virus‑like particles against lung cancer

Wang Xi, Dong Ke, Long Min, Wang Lin, Zuo Jiahui, Lin Fang, Gao Zhaowei, Zhang Zhe, Chen Xi, Zhang Huizhong
Pages: 3671-3679
Published online on: 15 March 2018

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Article

Islet-1 promotes the proliferation and invasion, and inhibits the apoptosis of A375 human melanoma cells

Xiaoling Zhu, Yuzhen Li, Qinggang Meng
Pages: 3680-3690
Published online on: 14 March 2018

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Article

Simvastatin induces apoptosis in PTEN‑haploinsufficient lipoma cells

Franziska Kässner, Tina Sauer, Melanie Penke, Sandy Richter, Kathrin Landgraf, Antje Körner, Wieland Kiess, Norman Händel, Antje Garten
Pages: 3691-3698
Published online on: 14 March 2018

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Article

MicroRNA-130a regulates chondrocyte proliferation and alleviates osteoarthritis through PTEN/PI3K/Akt signaling pathway

Yun Zhang, Shaochen Xu, Eric Huang, Haichao Zhou, Bing Li, Chenni Shao, Yunfeng Yang
Pages: 3699-3708
Published online on: 09 March 2018

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Anti-inflammatory effects of Passiflora foetida L. in LPS-stimulated RAW264.7 macrophages

Ji-Won Park, Ok-Kyoung Kwon, Hyung Won Ryu, Jin-Hyub Paik, Imam Paryanto, Prasetyawan Yuniato, Sangho Choi, Sei-Ryang Oh, Kyung-Seop Ahn
Pages: 3709-3716
Published online on: 12 March 2018

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Inhibitory effects of bee venom on mast cell-mediated allergic inflammatory responses

Yun‑Mi Kang, Kyung‑Sook Chung, In‑Hoon Kook, Yoon‑Bum Kook, Hyunsu Bae, Minho Lee, Hyo‑Jin An
Pages: 3717-3726
Published online on: 12 March 2018

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A novel psoralen derivative-MPFC enhances melanogenesis via activation of p38 MAPK and PKA signaling pathways in B16 cells

Li Yin, Guangxian Pang, Chao Niu, Maidina Habasi, Jun Dou, Haji Akber Aisa
Pages: 3727-3735
Published online on: 02 March 2018

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Retraction Open Access

[Retracted] Rivaroxaban attenuates thrombosis by targeting the NF-κB signaling pathway in a rat model of deep venous thrombus

Junhao Ma, Xinxi Li, Yang Wang, Zhenwei Yang, Jun Luo
Pages: 3736-3736
Published online on: 14 March 2018

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Journal Cover
May-2026 Volume 57 Issue 5

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Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Macrophage SH3 domain‑containing GRB2‑like protein B1 is required for Rab7‑mediated mitophagy in inflammation during sea water drowning acute lung injury

Hongjuan Ning, Jingyu Deng, Yongheng Gao, Wei Zhang, Jian Chen, Xian Guo, Faguang Jin
Article Number: 138
Published online on: 24 March 2026

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Deferoxamine mitigates neuronal loss following spinal cord injury via ferroptosis inhibition and Nrf2/HO‑1 pathway activation

Ziqian Ma, Xinwei Zhang, Tao Liu, Yan Zhang, Guanghao Li, Xin Yuan, Benqiang Tang, Hangyi Zhao, Liang Liu, Xueming Chen
Article Number: 137
Published online on: 23 March 2026

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USP10 deubiquitinase: Physiological function, diseases and therapeutic target (Review)

Linlin Zhang, Huajing Sun, Zifan Wang, Zhimei Wang, Qiang Mu, Yukun Liu
Article Number: 136
Published online on: 23 March 2026

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Siglec‑15 dysregulation and its therapeutic implications in new‑onset type 1 diabetes 

Heming Guo, Yunwen Tao, Sicheng Li, Ying Gu, Yiting Huang, Chen Fang, Ji Hu
Article Number: 135
Published online on: 20 March 2026

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ZEB1 maintains mitochondrial fission and macrophage efferocytosis by restraining MFN2, thereby limiting inflammation and improving tendon‑bone healing

Yan Zhao, Yuankai Zhang, Tian Lei, Shangqing Zhang, Kai Nan, Xin Zhang, Li-Hong Fan
Article Number: 134
Published online on: 19 March 2026

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Targeting pyroptosis in renal fibrosis: From molecular mechanisms to therapeutic horizons (Review)

Yihuai Tian, Quwu Mushuo, Hui Fan, Hongwei Su, Jianchun Li, Qiong Zhang
Article Number: 133
Published online on: 19 March 2026

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Expression of Concern Open Access

[Expression of Concern] Fasudil, a Rho‑associated protein kinase inhibitor, attenuates retinal ischemia and reperfusion injury in rats

Haishan Song, Dianwen Gao
Article Number: 132
Published online on: 18 March 2026

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Epigenetic regulation in a high-sugar environment (Review)

Huili Zhou, Xinhe Lv, Yu Liang, Dehai Yu, Wanning Wang
Article Number: 131
Published online on: 17 March 2026

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The roles and heterogeneity of CD8+ T cells in inflammatory bowel disease: A narrative review of insights from single‑cell transcriptomics (Review)

Rui Zhong, Jing Guo, Wujie Ye, Zhihui Deng, Huangan Wu, Qin Qi, Guona Li, Lu Zhu, Yan Huang, Luyi Wu
Article Number: 130
Published online on: 17 March 2026

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Mechanism of action and clinical application of autophagy in multiple sclerosis (Review)

Dongmei Wang, Qizhi Fu, Ying Zhao, Guangda Li, Yongjie Bai, Yang Yang, Hongna Song, Mingwei Wang, Hua Fan
Article Number: 129
Published online on: 17 March 2026

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[Expression of Concern] Insulin‑dependent diabetes mellitus decreases osteoblastogenesis associated with the inhibition of Wnt signaling through increased expression of Sost and Dkk1 and inhibition of Akt activation

Mamiko Hie, Natsumi Iitsuka, Tomoyo Otsuka, Ikuyo Tsukamoto
Article Number: 128
Published online on: 16 March 2026

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Mechanotransduction and its impact on regenerative medicine in orthopedic rehabilitation (Review)

Baohui Wang, Xueqin Zeng, Huajian Liu, Liang Li, Tao Lei, Yafeng Li, Qing Fang, Yi Cao, Bo Dong
Article Number: 127
Published online on: 13 March 2026

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4‑Acetylantrocamol LT3 suppresses colorectal cancer growth and metastasis via PI3K/AKT and MAPK pathway modulation

Kuen-Tze Lin, Yu-Chieh Hsieh, Pi-Kai Chang, Chih-Wei Lai, Shih-Yu Lee, I-Chuan Yen
Article Number: 126
Published online on: 13 March 2026

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Roles of ubiquitin‑specific peptidase 22 in cellular fate: From embryonic survival to tissue repair, inflammation and metabolism (Review)

Jia-Nan Xiang, Chen-Yang Zhou, Yu-Di Zhao, Xiao Xu, Sun-Bin Ling
Article Number: 125
Published online on: 12 March 2026

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m6A in adipose tissue inflammation: A novel regulator of obesity and metabolic diseases (Review)

Xiaoting Yang, Xiaodan Wang, Haojun Tang, Shuangxi Tu, Kai Yin, Xiao Zhu
Article Number: 124
Published online on: 12 March 2026

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Expression of Concern Open Access

[Expression of Concern] Visfatin/PBEF/Nampt induces EMMPRIN and MMP‑9 production in macrophages via the NAMPT‑MAPK (p38, ERK1/2)‑NF‑κB signaling pathway

Yuqi Fan, Shu Meng, Yue Wang, Jiatian Cao, Changqian Wang
Article Number: 123
Published online on: 12 March 2026

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IL‑37/IL‑1R8 blocks keratinocyte acantholysis via suppressing ADAM17/EGFR

Fengxia Hu, Wenjing Chen, Qian Wang, Xiaoyu Zhang, Fuyang Xiao, Jinying Zhang, Junqin Liang
Article Number: 122
Published online on: 12 March 2026

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Reactive oxygen species in fetal growth restriction mechanisms and therapeutic directions (Review)

Di Cheng, Songbin Yang, Cuilan Wang, Kefeng Fan, Fengchun Gao, Qian Sun
Article Number: 121
Published online on: 12 March 2026

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Research progress on the molecular mechanisms of tanshinone IIA in the treatment of cardiovascular and cerebrovascular diseases (Review)

Wen Pei, Ping Lu, Chenhuan Ding, Ying Li, Yong Li
Article Number: 120
Published online on: 12 March 2026

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Ferritin in ferroptosis: Implications for neurodegenerative diseases (Review)

Wenjing Chen, Heng Tian, Ran Wei, Xiaomei Chen, Yiwen Jia
Article Number: 119
Published online on: 12 March 2026

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Correction Open Access

[Corrigendum] Ursolic acid protects against cisplatin‑induced ototoxicity by inhibiting oxidative stress and TRPV1‑mediated Ca2+‑signaling  

Yang Di, Tao Xu, Yuan Tian, Tingting Ma, Donghao Qu, Yan Wang, Yuhan Lin, Dongyan Bao, Li Yu, Shuangyue Liu, Aimei Wang
Article Number: 118
Published online on: 09 March 2026

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HELLS inhibits autophagy‑dependent ferroptosis in nasopharyngeal carcinoma by modulating the Nrf2/HO‑1/GPX4 pathway

Chengxun Jin, Jinqiu Li, Siqi Han, Chaoluomeng Bai, Jingpu Yang, Zonggui Wang
Article Number: 117
Published online on: 09 March 2026

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Expression of Concern Open Access

[Expression of Concern] Inhibitory effect of curcumin on angiogenesis in ectopic endometrium of rats with experimental endometriosis

Ying Zhang, Hong Cao, Yue-Yue Hu, Hua Wang, Chang-Jun Zhang
Article Number: 116
Published online on: 09 March 2026

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Propofol upregulates MFG‑E8 in BV2 cells to inhibit pyroptosis mediated by the NF‑κB/NLRP3 pathway, thereby ameliorating ischemic‑reperfusion neuronal injury

Shewei Guo, Yingwei Zhen, Guosheng Zhou, Zhihua Zhao
Article Number: 115
Published online on: 05 March 2026

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Exosomal circ0000549 promotes MNNG‑induced gastric cancer through miR‑15b‑5p/KIF1B

Zhaofeng Liang, Zihan Gao, Yue Zhang, Jiajia Song, Hui Qian, Xuezhong Xu
Article Number: 114
Published online on: 04 March 2026

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Expression of Concern Open Access

[Expression of Concern] Syringin prevents cardiac hypertrophy induced by pressure overload through the attenuation of autophagy  

Fangfang Li, Ning Zhang, Qingqing Wu, Yuan Yuan, Zheng Yang, Mengqiao Zhou, Jinxiu Zhu, Qizhu Tang
Article Number: 113
Published online on: 04 March 2026

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Review Open Access

Treatment of pulmonary fibrosis: From disease mechanisms to future novel therapies (Review)

Sen Lu, Yunfei Liu, Xiaohua Li, Qipeng Yao
Article Number: 112
Published online on: 03 March 2026

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Review Open Access

Research progress in single‑cell omics technologies for kidney disease (Review)

Jia Xu, Ziwei Chen, Shengyao Li, Xiaoya Wang, Ming Chen
Article Number: 111
Published online on: 03 March 2026

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Review Open Access

CLDN7: Epithelial gatekeeper from physiology to pathology‑roles in cancer and epithelial‑related diseases (Review)

Xiuping Lai, Yan Yan, Lu Sun, Zili Lei, Yanhong Yang
Article Number: 110
Published online on: 03 March 2026

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Dynamic regulation and targeted intervention of neutrophils in hepatic ischemia‑reperfusion injury (Review)

Sen Lu, Jiale Tong, Jing Jiang, Qin Zhang, Youjin Huang
Article Number: 109
Published online on: 03 March 2026

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The dual role of the crosstalk between autophagy and ferroptosis in lung cancer treatment: Advances in mechanisms and therapeutic strategies (Review)

Yingying Zhang, Ruxin Shen
Article Number: 108
Published online on: 02 March 2026

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Review Open Access

Mechanistic insights into inflammatory cytokines in adenomyosis‑induced infertility (Review)

Bojiao Yang, Feng Li, Guimao Cao, Mingtu Nuo, Yaxin Shi, Zilu Wang, Jing Jia, Wei Shi, Zhiyong Liu
Article Number: 107
Published online on: 02 March 2026

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Correction Open Access

[Corrigendum] Astragaloside IV promotes the proliferation and migration of osteoblast‑like cells through the hedgehog signaling pathway

Li-Hua Guo, Yu Cao, Run-Tao Zhuang, Yan Han, Jun Li
Article Number: 106
Published online on: 02 March 2026

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Journal Cover
June-2026 Volume 57 Issue 6

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Expression of Concern Open Access

[Expression of Concern] Involvement of Cyr61 in the growth, invasiveness and adhesion of esophageal squamous cell carcinoma cells

Jian-Jun Xie, Li-Yan Xu, Yang-Min Xie, Ze-Peng Du, Cai-Hua Feng, Hui Dong, En-Min Li
Article Number: 140
Published online on: 24 March 2026

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Novel Hsp90 inhibitor JD‑02 inhibits HSV‑1 infection via the Raf/MEK/ERK signaling pathway

Yexuan Zhu, Xiaohui Wang, Jiaying Lin, Xiao Wang, Kai Zheng, Zhe Ren, Ji Xiao, Yifei Wang
Article Number: 139
Published online on: 24 March 2026

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