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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
June-2018 Volume 41 Issue 6

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

High glucose induces the proliferation of prostatic cells via downregulating MRE11

Chunwei Ye, Yi Cai, Qian Cai, Shunhui Yuan, Fan Huang, Xiaofang Yang, Shuchen He, Zhuoheng Li, Yanwen Wang, Delin Yang, Zhipeng Li
Pages: 3105-3114
Published online on: 07 March 2018

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Article Open Access

SUMO2 modification of Aurora B and its impact on follicular development and atresia in the mouse ovary

Jing Cao, Xiao‑Ming Liu, Li‑Lin Huang, Li Wang, Xiao‑Fei Jiao, Li‑Jun Huo
Pages: 3115-3126
Published online on: 07 March 2018

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Article Open Access

Triptolide reduces ischemia/reperfusion injury in rats and H9C2 cells via inhibition of NF‑κB, ROS and the ERK1/2 pathway

Bin Yang, Ping Yan, Guang‑Zhao Yang, Hui‑Li Cao, Fei Wang, Bao Li
Pages: 3127-3136
Published online on: 06 March 2018

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Article Open Access

Inhibition effects of total flavonoids from Sculellaria barbata D. Don on human breast carcinoma bone metastasis via downregulating PTHrP pathway

Xiao Zheng, Wen Kang, Huihui Liu, Shanyu Guo
Pages: 3137-3146
Published online on: 27 February 2018

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Article Open Access

miR‑377 targets CUL4A and regulates metastatic capability in ovarian cancer

Rufen Yu, Limei Cai, Yingui Chi, Xiangcui Ding, Xueqing Wu
Pages: 3147-3156
Published online on: 07 March 2018

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Article Open Access

Deguelin exerts anticancer activity of human gastric cancer MGC-803 and MKN-45 cells in vitro

Wen Kang, Xiao Zheng, Ping Wang, Shanyu Guo
Pages: 3157-3166
Published online on: 05 March 2018

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Article Open Access

REG3A overexpression suppresses gastric cancer cell invasion, proliferation and promotes apoptosis through PI3K/Akt signaling pathway

Yan-Song Qiu, Guang-Jun Liao, Ning-Ning Jiang
Pages: 3167-3174
Published online on: 28 February 2018

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Article Open Access

Transplantation of human matrix metalloproteinase-1 gene-modified bone marrow-derived mesenchymal stem cell attenuates CCL4-induced liver fibrosis in rats

Chao Du, Mingde Jiang, Xiaolong Wei, Jianpin Qin, Hui Xu, Yunxia Wang, Yong Zhang, Dejiang Zhou, Hongli Xue, Shumei Zheng, Weizheng Zeng
Pages: 3175-3184
Published online on: 27 February 2018

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Article Open Access

Intravenous administration of DPSCs and BDNF improves neurological performance in rats with focal cerebral ischemia

Xuemei Zhang, Yinglian Zhou, Hulun Li, Rui Wang, Dan Yang, Bing Li, Jin Fu
Pages: 3185-3194
Published online on: 28 February 2018

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Article Open Access

Effect of lithocholic acid on biologically active α,β-unsaturated aldehydes induced by H2O2 in glioma mitochondria for use in glioma treatment

Dan Wang, Li Bie, Yanbin Su, Haoran Xu, Fengrong Zhang, Yanwen Su, Bo Zhang
Pages: 3195-3202
Published online on: 02 March 2018

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Article Open Access

Biphasic activation of nuclear factor-κB and expression of p65 and c-Rel following traumatic neuronal injury

Huasheng Zhang, Dingding Zhang, Hua Li, Huiying Yan, Zihuan Zhang, Chenhui Zhou, Qiang Chen, Zhennan Ye, Chunhua Hang
Pages: 3203-3210
Published online on: 14 March 2018

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Article Open Access

hTERT peptide fragment GV1001 demonstrates radioprotective and antifibrotic effects through suppression of TGF‑β signaling

Wei Chen, Ki‑Hyuk Shin, Sangjae Kim, Won‑Jun Shon, Reuben H. Kim, No‑Hee Park, Mo K. Kang
Pages: 3211-3220
Published online on: 14 March 2018

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Article Open Access

MicroRNA-30e protects the heart against ischemia and reperfusion injury through autophagy and the Notch1/Hes1/Akt signaling pathway

Jianjie Zheng, Jing Li, Bo Kou, Qiuyue Yi , Tao Shi
Pages: 3221-3230
Published online on: 07 March 2018

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Article Open Access

Mangiferin induces islet regeneration in aged mice through regulating p16INK4a

Hailian Wang, Xia He, Tiantian Lei, Yilong Liu, Guoli Huai, Minghan Sun, Shaoping Deng, Hongji Yang, Rongsheng Tong, Yi Wang
Pages: 3231-3242
Published online on: 01 March 2018

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Article Open Access

PEDF improves cardiac function in rats subjected to myocardial ischemia/reperfusion injury by inhibiting ROS generation via PEDF‑R

Qixiang Zhao, Zhiwei Liu, Bing Huang, Yanliang Yuan, Xiucheng Liu, Hu Zhang, Fan Qiu, Yiqian Zhang, Yufeng Li, Haoran Miao, Hongyan Dong, Zhongming Zhang
Pages: 3243-3252
Published online on: 09 March 2018

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Article Open Access

Aspirin modulates the inflammatory response in a thrombus‑stimulated LMVEC model

Lingcong Wang, Rongbiao Ying, Huifang Jiang, Qun Jin, Jing Kuang, Zhirong Zhang, Ying Shi, Danli Cai, Ruhui Yang
Pages: 3253-3266
Published online on: 13 March 2018

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Article Open Access

Tree shrew neural stem cell transplantation promotes functional recovery of tree shrews with a hemi‑sectioned spinal cord injury by upregulating nerve growth factor expression

Liu‑Lin Xiong, Yu Zou, Yu Shi, Piao Zhang, Rong‑Ping Zhang, Xie‑Jie Dai, Bin Liu, Ting‑Hua Wang
Pages: 3267-3277
Published online on: 09 March 2018

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Article Open Access

Trifluoperazine induces apoptosis through the upregulation of Bax/Bcl‑2 and downregulated phosphorylation of AKT in mesangial cells and improves renal function in lupus nephritis mice

Baodong Wang, Yankun Luo, Xiaoshuang Zhou, Rongshan Li
Pages: 3278-3286
Published online on: 13 March 2018

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Article Open Access

RP105 alleviates myocardial ischemia reperfusion injury via inhibiting TLR4/TRIF signaling pathways

Jun Yang, Chaojun Yang, Jian Yang, Jiawang Ding, Xinxin Li, Qinqin Yu, Xin Guo, Zhixing Fan, Huibo Wang
Pages: 3287-3295
Published online on: 06 March 2018

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Article Open Access

Expression of immunoglobulin G in human podocytes, and its role in cell viability and adhesion

Ziyang Jing, Hui Deng, Junfan Ma, Yanhong Guo, Yaoxian Liang, Rui Wu, Lata A, Zihan Geng, Xiaoyan Qiu, Yue Wang
Pages: 3296-3306
Published online on: 01 March 2018

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Article Open Access

Effect of electro-acupuncture on the BDNF-TrkB pathway in the spinal cord of CCI rats

Wen-Zhan Tu, Si-Si Li, Xia Jiang, Xin-Ru Qian, Guan-Hu Yang, Peng-Peng Gu, Bin Lu, Song-He Jiang
Pages: 3307-3315
Published online on: 13 March 2018

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Article Open Access

Cyclic mechanical tension reinforces DNA damage and activates the p53-p21-Rb pathway to induce premature senescence of nucleus pulposus cells

Chencheng Feng, Minghui Yang, Yang Zhang, Minghong Lan, Bo Huang, Huan Liu, Yue Zhou
Pages: 3316-3326
Published online on: 28 February 2018

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Article Open Access

Transcriptomic and proteomic analysis of potential therapeutic target genes in the liver of metformin‑treated Sprague‑Dawley rats with type 2 diabetes mellitus

Yitao Chen, Yangsheng Wu, Yuanxiao Yang, Zhiwei Xu, Junfeng Tong, Zheming Li, Xiaojie Zhou, Changyu Li
Pages: 3327-3341
Published online on: 06 March 2018

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Article Open Access

Overexpression of adrenomedullin protects mesenchymal stem cells against hypoxia and serum deprivation‑induced apoptosis via the Akt/GSK3β and Bcl‑2 signaling pathways

Hongjin Si, Yao Zhang, Yuqing Song, Lili Li
Pages: 3342-3352
Published online on: 05 March 2018

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Article Open Access

Juglanin suppresses fibrosis and inflammation response caused by LPS in acute lung injury

Ze-Wu Dong, Yu-Fang Yuan
Pages: 3353-3365
Published online on: 09 March 2018

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Article Open Access

c-Myc regulates the CDK1/cyclin B1 dependent‑G2/M cell cycle progression by histone H4 acetylation in Raji cells Corrigendum in /10.3892/ijmm.2019.4318

Yan Yang, Kai Xue, Zhi Li, Wei Zheng, Weijie Dong, Jiazhe Song, Shijie Sun, Tonghui Ma, Wenzhe Li
Pages: 3366-3378
Published online on: 28 February 2018

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Article Open Access

MicroRNA-155 inhibits the osteogenic differentiation of mesenchymal stem cells induced by BMP9 via downregulation of BMP signaling pathway

Hongxia Liu, Liang Zhong, Taixian Yuan, Sicheng Chen, Yiqing Zhou, Liqin An, Yangliu Guo, Mengtian Fan, Ya Li, Yanting Sun, Wang Li, Qiong Shi, Yaguang Weng
Pages: 3379-3393
Published online on: 01 March 2018

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Article Open Access

PEDF protects cardiomyocytes by promoting FUNDC1‑mediated mitophagy via PEDF-R under hypoxic condition

Yufeng Li, Zhiwei Liu, Yiqian Zhang, Qixiang Zhao, Xiaoyu Wang, Peng Lu, Hao Zhang, Zhu Wang, Hongyan Dong, Zhongming Zhang
Pages: 3394-3404
Published online on: 06 March 2018

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Article Open Access

Accelerated inflammation and oxidative stress induced by LPS in acute lung injury: Ιnhibition by ST1926

Zewu Dong, Yufang Yuan
Pages: 3405-3421
Published online on: 19 March 2018

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Article Open Access

Transcriptome and alternative splicing analysis of nucleus pulposus cells in response to high oxygen tension: Involvement of high oxygen tension in the pathogenesis of intervertebral disc degeneration

Chencheng Feng, Yang Zhang, Minghui Yang, Minghong Lan, Bo Huang, Huan Liu, Yue Zhou
Pages: 3422-3432
Published online on: 28 February 2018

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Article Open Access

Valproic acid prevents glucocorticoid‑induced osteonecrosis of the femoral head of rats

Ding Zhou, Yi‑Xuan Chen, Jun‑Hui Yin, Shi‑Cong Tao, Shang‑Chun Guo, Zhan‑Ying Wei, Yong Feng, Chang‑Qing Zhang
Pages: 3433-3447
Published online on: 06 March 2018

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Article Open Access

MCMV triggers ROS/NLRP3-associated inflammasome activation in the inner ear of mice and cultured spiral ganglion neurons, contributing to sensorineural hearing loss Corrigendum in /10.3892/ijmm.2025.5514

Wei Zhuang, Caiji Wang, Xi Shi, Shiwei Qiu, Shili Zhang, Bing Xu, Min Chen, Wen Jiang, Hongyan Dong, Yuehua Qiao
Pages: 3448-3456
Published online on: 06 March 2018

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Article Open Access

Ephrin‑b3 modulates hippocampal neurogenesis and the reelin signaling pathway in a pilocarpine‑induced model of epilepsy

Tian‑Tian Liu, Yi Li, Yi Shu, Bo Xiao, Li Feng
Pages: 3457-3467
Published online on: 07 March 2018

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Article

miR-124/MCP-1 signaling pathway modulates the protective effect of itraconazole on acute kidney injury in a mouse model of disseminated candidiasis

Xiao‑Yue Li, Yu‑Qi Zhang, Gang Xu, Shao‑Hong Li, Heng Li
Pages: 3468-3476
Published online on: 13 March 2018

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Article

Microarray analysis of the expression profile of lncRNAs reveals the key role of lncRNA BC088327 as an agonist to heregulin‑1β‑induced cell proliferation in peripheral nerve injury

Houlei Wang, Jingping Wu, Xinchao Zhang, Lei Ding, Qingmin Zeng
Pages: 3477-3484
Published online on: 15 March 2018

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Article

Daidzein exerts anticancer activity towards SKOV3 human ovarian cancer cells by inducing apoptosis and cell cycle arrest, and inhibiting the Raf/MEK/ERK cascade Retraction in /10.3892/ijmm.2021.4929

Fu Hua, Chang‑Hua Li, Xiao‑Gang Chen, Xiao‑Ping Liu
Pages: 3485-3492
Published online on: 05 March 2018

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Article

3,5,4'-Tri-O-acetylresveratrol attenuates seawater inhalation-induced acute respiratory distress syndrome via thioredoxin 1 pathway

Yilin Zhao, Lijie Ma, Ruixuan Wang, Tingting Chen, Xueying Liu, Faguang Jin
Pages: 3493-3500
Published online on: 01 March 2018

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Article

CFTR ameliorates high glucose-induced oxidative stress and inflammation by mediating the NF-κB and MAPK signaling pathways in endothelial cells

Yang Fei, Liqin Sun, Chungang Yuan, Min Jiang, Qinhua Lou, Yan Xu
Pages: 3501-3508
Published online on: 07 March 2018

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Article

Cardioprotective effect of rosuvastatin against isoproterenol-induced myocardial infarction injury in rats

Ying Yu, Lin Jin, Yamin Zhuang, Yan Hu, Jing Cang, Kefang Guo
Pages: 3509-3516
Published online on: 15 March 2018

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Article

SIRT3 deficiency exacerbates p53/Parkin‑mediated mitophagy inhibition and promotes mitochondrial dysfunction: Implication for aged hearts

Yan Li, Ying Ma, Liqiang Song, Lu Yu, Le Zhang, Yingmei Zhang, Yuan Xing, Yue Yin, Heng Ma
Pages: 3517-3526
Published online on: 09 March 2018

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Article

Selection of reference genes for expression analysis in mouse models of acute alcoholic liver injury

Sheng  Wang, Jianqing  Wang, Xiongwen  Lv
Pages: 3527-3536
Published online on: 01 March 2018

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Article Open Access

Identification of aberrantly expressed long non-coding RNAs in postmenopausal osteoporosis

Qi Fei, Xiaodong Bai, Jisheng Lin, Hai Meng, Yong Yang , Ai Guo
Pages: 3537-3550
Published online on: 19 March 2018

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Article

Angiopoietin-2 promotes extracellular matrix degradation in human degenerative nucleus pulposus cells

Kun Wang, Liang Kang, Wei Liu, Yu Song, Xinghuo Wu, Yukun Zhang, Wenbin Hua, Kangcheng Zhao, Shuai Li, Ji Tu, Rongjin Luo, Cao Yang
Pages: 3551-3558
Published online on: 19 March 2018

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Article

An adenosine A1R-A2aR imbalance regulates low glucose/hypoxia-induced microglial activation, thereby contributing to oligodendrocyte damage through NF-κB and CREB phosphorylation

Wen Huang, Shunjie Bai, Xuzheng Zuo, Weiju Tang, Pengfei Chen, Xiuying Chen, Gong Wang, Haoxiang Wang, Peng Xie
Pages: 3559-3569
Published online on: 07 March 2018

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Article

Secoisolariciresinol diglucoside prevents the oxidative stress-induced apoptosis of myocardial cells through activation of the JAK2/STAT3 signaling pathway

Guiqiong Huang, Xiaofang Huang, Min Liu, Yue Hua, Bo Deng, Wen Jin, Wen Yan, Zhangbin Tan, Yifen Wu, Bin Liu, Yingchun Zhou
Pages: 3570-3576
Published online on: 13 March 2018

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Article Open Access

The deficiency of CX3CL1/CX3CR1 system ameliorates high fructose diet-induced kidney injury by regulating NF-κB pathways in CX3CR1-knock out mice

Yong-Wu Yu, Ming-Xu Li, Zhi-Yong Zhang, Hai Yu
Pages: 3577-3585
Published online on: 16 March 2018

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Article

Enhanced rapamycin delivery to hemangiomas by lipid polymer nanoparticles coupled with anti-VEGFR antibody

Haitao Li, Yunfei Teng, Xia Xu, Jianyong Liu
Pages: 3586-3596
Published online on: 28 February 2018

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Article

Screening pathogenic genes in oral squamous cell carcinoma based on the mRNA expression microarray data

Yang Ding, Pengfei Liu, Shengsheng Zhang, Lin Tao, Jianmin Han
Pages: 3597-3603
Published online on: 27 February 2018

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Article

Interfering RNA with multi-targets for efficient gene suppression in HCC cells

Tiejun Li, York Yuanyuan Zhu, Yi Ji, Songfeng Zhou
Pages: 3604-3610
Published online on: 09 March 2018

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Article

Isolation, culture and biological characteristics of multipotent porcine tendon-derived stem cells

Jinjuan Yang, Qianjun Zhao, Kunfu Wang, Caiyun Ma, Hao Liu, Yingjie Liu, Weijun Guan
Pages: 3611-3619
Published online on: 07 March 2018

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Article

In vivo effects of the NLRP1/NLRP3 inflammasome pathway on latent respiratory virus infection

Yong‑Huai Li, Xiang Wei, Shuang Ji, Shu‑Yu Gui, Su‑Mei Zhang
Pages: 3620-3628
Published online on: 28 February 2018

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Article

Low expression of PTEN is essential for maintenance of a malignant state in human gastric adenocarcinoma via upregulation of p‑AURKA mediated by activation of AURKA

Liwei Li, Yue Song, Qing Liu, Xi Liu, Rui Wang, Chunsheng Kang, Qingyu Zhang
Pages: 3629-3641
Published online on: 07 March 2018

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Article

Rhododendron album Blume extract inhibits TNF-α/IFN-γ-induced chemokine production via blockade of NF-κB and JAK/STAT activation in human epidermal keratinocytes

Ji‑Won Park, Han‑Sol Lee, Yourim Lim, Jin‑Hyub Paik, Ok‑Kyoung Kwon, Jung‑Hee Kim, Imam Paryanto, Prasetyawan Yunianto, Sangho Choi, Sei‑Ryang Oh, Kyung‑Seop Ahn
Pages: 3642-3652
Published online on: 09 March 2018

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Article

Hydrogen ameliorates oxidative stress via PI3K-Akt signaling pathway in UVB-induced HaCaT cells

Bingxin Zhang, Zishen Zhao, Xiaoyin Meng, Hongguang Chen, Guojun Fu, Keliang Xie
Pages: 3653-3661
Published online on: 07 March 2018

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Article

Novel mutations of the SERPINF1 and FKBP10 genes in Chinese families with autosomal recessive osteogenesis imperfecta

Hao Zhang, Yang Xu, Hua Yue, Chun Wang, Jiemei Gu, Jinwei He, Wenzhen Fu, Weiwei Hu, Zhenlin Zhang
Pages: 3662-3670
Published online on: 07 March 2018

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Article

Incorporation of CD40 ligand enhances the immunogenicity of tumor‑associated calcium signal transducer 2 virus‑like particles against lung cancer

Wang Xi, Dong Ke, Long Min, Wang Lin, Zuo Jiahui, Lin Fang, Gao Zhaowei, Zhang Zhe, Chen Xi, Zhang Huizhong
Pages: 3671-3679
Published online on: 15 March 2018

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Article

Islet-1 promotes the proliferation and invasion, and inhibits the apoptosis of A375 human melanoma cells

Xiaoling Zhu, Yuzhen Li, Qinggang Meng
Pages: 3680-3690
Published online on: 14 March 2018

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Article

Simvastatin induces apoptosis in PTEN‑haploinsufficient lipoma cells

Franziska Kässner, Tina Sauer, Melanie Penke, Sandy Richter, Kathrin Landgraf, Antje Körner, Wieland Kiess, Norman Händel, Antje Garten
Pages: 3691-3698
Published online on: 14 March 2018

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Article

MicroRNA-130a regulates chondrocyte proliferation and alleviates osteoarthritis through PTEN/PI3K/Akt signaling pathway

Yun Zhang, Shaochen Xu, Eric Huang, Haichao Zhou, Bing Li, Chenni Shao, Yunfeng Yang
Pages: 3699-3708
Published online on: 09 March 2018

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Anti-inflammatory effects of Passiflora foetida L. in LPS-stimulated RAW264.7 macrophages

Ji-Won Park, Ok-Kyoung Kwon, Hyung Won Ryu, Jin-Hyub Paik, Imam Paryanto, Prasetyawan Yuniato, Sangho Choi, Sei-Ryang Oh, Kyung-Seop Ahn
Pages: 3709-3716
Published online on: 12 March 2018

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Inhibitory effects of bee venom on mast cell-mediated allergic inflammatory responses

Yun‑Mi Kang, Kyung‑Sook Chung, In‑Hoon Kook, Yoon‑Bum Kook, Hyunsu Bae, Minho Lee, Hyo‑Jin An
Pages: 3717-3726
Published online on: 12 March 2018

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Article

A novel psoralen derivative-MPFC enhances melanogenesis via activation of p38 MAPK and PKA signaling pathways in B16 cells

Li Yin, Guangxian Pang, Chao Niu, Maidina Habasi, Jun Dou, Haji Akber Aisa
Pages: 3727-3735
Published online on: 02 March 2018

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Retraction Open Access

[Retracted] Rivaroxaban attenuates thrombosis by targeting the NF-κB signaling pathway in a rat model of deep venous thrombus

Junhao Ma, Xinxi Li, Yang Wang, Zhenwei Yang, Jun Luo
Pages: 3736-3736
Published online on: 14 March 2018

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Journal Cover
November-2026 Volume 58 Issue 5

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Spatial multi‑omics identifies an SPP1+ macrophage‑driven anti‑apoptotic niche in osteoarthritis synovium via the SPP1‑CD44 axis

Han Gong, Hao Shen, Feng Zhang, Wei Wang, Sheng Zhou, Lei Wang, Yu Sun
Article Number: 334
Published online on: 29 September 2026

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Review Open Access

Novel insights into the role of the renal interstitial microenvironment in Randall's plaque formation (Review)

Jialiang Wang, Zhangcheng Liao, Minghui Liu, Yizhou Wang, Yu Cui, Hequn Chen, Feng Zeng, Zewu Zhu
Article Number: 333
Published online on: 29 September 2026

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Correction Open Access

[Corrigendum] Alteration of the Wnt/GSK3β/β‑catenin signalling pathway by rapamycin ameliorates pathology in an Alzheimer's disease model

Jingfei Chen, Zhimin Long, Yanzhen Li, Min  Luo, Shifang  Luo, Guiqiong He
Article Number: 332
Published online on: 28 September 2026

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miR‑222‑3p inhibits diabetic skin wound healing by targeting APLN

Ruyan Jie, Ying Tang, Tingting Wu, Chenfan Zhang, Man Song, Xiaotong Zhao, Mingwei Chen
Article Number: 331
Published online on: 25 September 2026

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Correction Open Access

[Corrigendum] Adjudin delays cellular senescence through Sirt3‑mediated attenuation of ROS production

Keyi Geng, Ningzhen Fu, Xiao Yang, Weiliang Xia
Article Number: 330
Published online on: 23 September 2026

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Salidroside attenuates myocardial ischemia‑reperfusion‑induced oxidative stress and ferroptosis by promoting USP11‑mediated  deubiquitination of PRDX2

Zhi-Cong Qiu, Jian-Nan Li, Yi-Zhou Li, Zi-Ming Wu, Xu-Dong Luo, Rui-Yuan Zeng, Song-Qing Lai, Shi-Tao Zhao, Li Wan
Article Number: 329
Published online on: 23 September 2026

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Reprogramming of cell death in gastric cancer: From molecular mechanisms to therapeutic potential (Review)

Mengru Liu, Zhujun Wu, Qiao Chen, Weiguo Ni, Ying Chen, Yixin Zhu, Yu Chen, Haifeng Ma, Yan Lin
Article Number: 328
Published online on: 23 September 2026

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Remimazolam attenuates myocardial ischemia/reperfusion injury by inhibiting ferroptosis involving the AKT/SLC7A11/GPX4 axis

Xiyuan Chen, Jianghong Zhao, Xingtong He, Yuqi Zhang, Jiao Wu, Chao Jiang, Yi Yang, Ji Xiao
Article Number: 327
Published online on: 22 September 2026

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Tumor‑immune spatiotemporal co‑evolution: A new paradigm for understanding and overcoming therapy resistance in metastatic castration‑resistant prostate cancer (Review)

Li Yan, Xiaoke Sun, Pengxiao Su
Article Number: 326
Published online on: 21 September 2026

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Research progress on the role of IL‑37 in gynecological and obstetrics‑related diseases (Review)

Hongjing Wang, Renukha Arjune, Weiyu Gan, Na Guo, Nan Yu, Ting Xiong
Article Number: 325
Published online on: 21 September 2026

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Expression of Concern Open Access

[Expression of Concern] PAT protein mRNA expression in primary rat hepatocytes: Effects of exposure to fatty acids

Elena Grasselli, Adriana Voci, Carlo Pesce, Laura Canesi, Emilia Fugassa, Gabriella Gallo, Laura Vergani
Article Number: 324
Published online on: 21 September 2026

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Neutrophil extracellular traps in cardiovascular disease: Mechanisms and therapeutic implications (Review)

Zhao Wang, Mingde Chang, Wenyu Shang, Yunfeng Jia, Xiaoyu Shan, Xinnong Chen, Yingxi Yang, Junping Zhang
Article Number: 323
Published online on: 18 September 2026

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Article Open Access

Sirt1 attenuates calcific aortic valve disease by inhibiting ferroptosis and enhancing mitochondrial function via the activation of the Nrf2/HO‑1/FTH1 axis

Fei Yan, Lei Shi, Yuechan Wang, Ying Zhao, Yuanyuan Wu, Dubiao Xian, Yunheng Liang, Ning Wang, Hongwang Cui, Minni Zhang
Article Number: 322
Published online on: 18 September 2026

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Article Open Access

Ketogenic diet attenuates Müller cell activation and retinal neuroinflammation in autoimmune glaucoma through acetylation‑mediated FOXO signalling

Sisi Tan, Xiaochen Wang, Yunfan Zheng, Zhenni Mou, Lihong Zeng, Jingchang Yuan, Xiao Fan, Miao Wei, Yujia Huo, Ruotong Ouyang, Yanyu Pu, Junqin Lei, Xi Gao, Dangdang Wang, Yang Peng, Hong Li
Article Number: 321
Published online on: 17 September 2026

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ILC3s as central regulators of mucosal homeostasis and disease pathogenesis (Review)

Jingwen Zhang, Lili Bao, Jiaxi Li, Xia Li, Lu Qiao, Jiaxian Cui, Xiaoxia He, Mingyu Zhang, Jingkun Lu, Xuan Zhang, Jing Dong, Gesi Tao, Yaoqing Feng, Yun Peng Tian, Pengwei Zhao, Ya Tuo
Article Number: 320
Published online on: 17 September 2026

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Small extracellular vesicles in osteoarthritis: A double‑edged sword regulating inflammation and cartilage homeostasis (Review)

Yifan Yang, Jiachen Liang, Xiangyu Shi, Anqi Niu, Ruifang Gao, Xiuping Wu, Xiaojuan Guo, Xiaotong Shi, Kejie Cao, Bing Li, Ran Li
Article Number: 319
Published online on: 17 September 2026

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Exosomal circular RNAs in the tumor immune microenvironment: From regulatory mechanisms to therapeutic opportunities and translational hurdles (Review)

Wenlong Zhang, Nuo Chen, Liya Gong, Yu Dong, Hui Shen, Xin Liu, Jie Sun, Luxuan Liu, Zhe Jin, Liaoyuan Wang, Xue Han, Bin Zhang, Shuixing Zhang
Article Number: 318
Published online on: 17 September 2026

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Expression of Concern Open Access

[Expression of Concern] Ginsenoside Rg1 protects against H2O2‑induced neuronal damage due to inhibition of the NLRP1 inflammasome signalling pathway in hippocampal neurons in vitro

Tan-Zhen Xu, Xiao-Yan Shen, Ling-Ling Sun, Ya-Li Chen, Bi-Qiong Zhang, Da-Ke Huang, Wei-Zu Li
Article Number: 317
Published online on: 16 September 2026

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tRNA‑derived RNAs in hepatic diseases: From biological functions to clinical translation (Review)

Yaotian Cai, Yifei Chen, Fuji Yang, Yongmin Yan, Ting Jiang
Article Number: 316
Published online on: 15 September 2026

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Monocytes in pneumonia: Functional plasticity and innate memory (Review) 

Run-Ze Li, Zhi-Han Xie, Li Chen, Yun-Xiao Shang, Fei Wang, Wan-Jie Huang, Qi Cheng
Article Number: 315
Published online on: 15 September 2026

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Correction Open Access

[Corrigendum] Integrative transcriptomic analysis unveils FXR as a key regulator of intestinal stemness and inflammation in ulcerative colitis

Hao Lin, Xinran Cheng, Yangyang Ren, Yongmei Zhang, Weixu Chen, Qingyan Lu, Yiqing Tian
Article Number: 314
Published online on: 14 September 2026

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Ferroptosis in heatstroke: Mechanisms and therapeutic perspectives (Review)

Hongguang Gao, Yang Chen, Tianshan Zhang, Yujun Shi, Rong Yao
Article Number: 313
Published online on: 10 September 2026

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Correction Open Access

[Corrigendum] Inactivation of von Hippel‑Lindau increases ovarian cancer cell aggressiveness through the HIF1α/miR‑210/VMP1 signaling pathway

Ting Liu, Le Zhao, Wei Chen, Zhen Li, Huilian Hou, Lu Ding, Xu Li
Article Number: 312
Published online on: 10 September 2026

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Review Open Access

Interferon regulatory factors orchestrate CD8+ T cell function (Review)

Fa-Xi Wang, Chun-Liang Yang, Shan-Jie Rong, Qi-Jie Chen, Xiong-Tao Yue, Fei Sun
Article Number: 311
Published online on: 08 September 2026

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Expression of Concern Open Access

[Expression of Concern] Rapamycin‑induced miR‑30a downregulation inhibits senescence of VSMCs by targeting Beclin1

Pan Tan, Haiqin Wang, Junkun Zhan, Xinyu Ma, Xingjun Cui, Yanjiao Wang, Yi Wang, Jiayu Zhong, Youshuo Liu
Article Number: 310
Published online on: 07 September 2026

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Deciphering the function and mechanism of extracorporeal shock wave therapy in knee osteoarthritis (Review)

Yixuan Chen, Siqi Song, Yuchen Zhu, Shiqi Wang, Jieyuan Hu, Chenxu Liu, Yuchen Cai, Yushi Hu
Article Number: 309
Published online on: 04 September 2026

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Multi‑omics integration in osteoarthritis: Unraveling cell‑type‑specific gene‑metabolite networks for precision medicine (Review)

Ying Yang, Ruichen Zheng, Yun Zhang, Dongmei Ye, Jiale Xie, Changliang Zhu
Article Number: 308
Published online on: 03 September 2026

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Review Open Access

Autophagy determines the fate of immune cells by regulating metabolic remodeling and PANoptosis (Review)

Yanan Guo, Xinyue Zhou, Yixiao Tian, Dan Chen, Xiaofeng Xie, Bin Zhou, Yingxia Tian, Yaqing Zhang
Article Number: 307
Published online on: 03 September 2026

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Review Open Access

Programmed cell death in metabolic syndrome: From molecular mechanisms to therapeutic strategies (Review)

Jialin Zhong, Maofu Zhang, Yafang Zheng, Cuicui Gong, Yasheng Deng, Lisha Sun, Dongqi Zhou, Qian Zhou, Qiu Chen
Article Number: 306
Published online on: 03 September 2026

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Review Open Access

Research progress on lysine acetylation (Review)

Minghui Zhang, Yuqi Zhang, Haoxin Yin, Junyuan Yan, Yingling Dong, Xin Zhao, Tianyi Cui, Bin Lv, Xiumei Gao
Article Number: 305
Published online on: 02 September 2026

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Expression of Concern Open Access

[Expression of Concern] Human ether‑à‑go‑go‑related gene mutation L539fs/47‑hERG leads to cell apoptosis through the endoplasmic reticulum stress pathway

Shuting Ma, Yun Zhao, Miaomiao Cao, Chaofeng Sun
Article Number: 304
Published online on: 02 September 2026

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Review Open Access

Targeting integrated cell death networks in sepsis‑associated acute kidney injury: Shared regulatory nodes and diet‑related small molecule modulation (Review)

Lin Song, Aifeng He, Wei Jiang, Keran Shi, Jing Wang, Lu Xu, Jiangquan Yu, Ruiqiang Zheng
Article Number: 303
Published online on: 31 August 2026

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Article Open Access

Effect of MALT1 inhibition by MI‑2 on the microglial phenotype switch, inflammatory cytokine secretion, neuronal loss and oxidative stress in Alzheimer's disease

Yuanlong Li, Hua Fan, Xiong Han, Ming Ni, Xiaodan Hou, Hailan Xia, Yinzhu Shi, Lin Zhang, Jun Sun
Article Number: 302
Published online on: 31 August 2026

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Review Open Access

Salvianolic acid monomers against metastasis: Decoding the multilayered interception of EMT, angiogenesis and immune evasion (Review)

Shiting Jiang, Dan Liu, Tingting Wei, Qiwei Shi, Haowen Wang, Yidan Gao, Pingsu Mao, Wenli Yang
Article Number: 301
Published online on: 31 August 2026

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Retraction Open Access

[Retracted] Silencing of decoy receptor 3 (DcR3) expression by siRNA in pancreatic carcinoma cells induces Fas ligand‑mediated apoptosis in vitro and in vivo

Jian Zhou, Shiduo Song, Songbin He, Zhenxin Wang, Bing Zhang, Dechun Li, Dongming Zhu
Article Number: 300
Published online on: 31 August 2026

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Review Open Access

Research progress on BTG2 in non‑tumor diseases (Review)

Shuling Li, Xiaomei Liu, Zheng Zhang, Ling Yang, Yuxuan Li, Qiongdan Hu
Article Number: 299
Published online on: 28 August 2026

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Breaking the cycle of fibrosis: Ferroptosis as a therapeutic target (Review)

Xincheng Feng, Jue Zhang, Qinghong Ma, Chao Sun
Article Number: 298
Published online on: 27 August 2026

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Correction Open Access

[Corrigendum] Tumor‑targeting novel manganese complex induces ROS‑mediated apoptotic and autophagic cancer cell death

Jia Liu, Wenjie Guo, Jing Li, Xiang Li, Ji Geng, Qiuyun Chen, Jing Gao
Article Number: 297
Published online on: 26 August 2026

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Advances in sirtuin research in lung diseases (Review)

Shuangyun Xi, Weijun Chen, Xiuli Li, Yudan Wang, Yong Ke
Article Number: 296
Published online on: 25 August 2026

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Article Open Access

lncRNA TUG1 mediates palmitic acid‑induced neuronal lipotoxic injury via the miR‑449a‑5p/caspase‑3 and Akt/GSK‑3β axes

Ya-Dong Wei, Peng-Quan Chen, Xin Zheng, Le-Qi Wu, Xin-Yi Wang, Xin-Ran Gao, Jin-Fang Ge
Article Number: 295
Published online on: 25 August 2026

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Retraction Open Access

[Retracted] Downregulation of LINC00707 promotes osteogenic differentiation of human bone marrow‑derived mesenchymal stem cells by regulating DKK1 via targeting miR‑103a‑3p

Jun Liu, Minfei Wu, Guang Feng, Rui Li, Yang Wang, Jianhang Jiao
Article Number: 294
Published online on: 24 August 2026

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Journal Cover
December-2026 Volume 58 Issue 6

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Anesthetics and cancer biology: Translational evidence from perioperative modulation to drug repurposing (Review)

Ting Yang, Jiao Tang, Muhammad Saqib Mudabbar, Huan Hu, Qiang Fu, Chunlan Pu
Article Number: 336
Published online on: 05 October 2026

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Expression of Concern Open Access

[Expression of Concern] Multiple roles of SOCS proteins: Differential expression of SOCS1 and SOCS3 in atherosclerosis

Xiao Liang, Ming He, Tao Chen, Yan Liu, Yu-Ling Tian, Yu-Liang Wu, Yan Zhao, Yan Shen, Zu-Yi Yuan
Article Number: 335
Published online on: 30 September 2026

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