The new iron age.

  • Authors:
    • D Trinder
    • D J Macey
    • J K Olynyk
  • View Affiliations

  • Published online on: December 1, 2000     https://doi.org/10.3892/ijmm.6.6.607
  • Pages: 607-619
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Abstract

In the last four years there has been a major change in the approach to diagnosis of the iron overload disorder hereditary haemochromatosis (HH) following the discovery of the gene that is mutated in HH called HFE. In the first part of this review we will give a concise overview of the disease. Also the current literature on the role of HFE in iron absorption and transport at a molecular level and how mutations in HFE may lead to the break down in the regulation of iron homeostasis is reviewed. The second part of the review focuses on the molecular aspects of iron storage. Different chemical forms of storage iron deposits such as ferrihydrite and geotite are present in the iron storage proteins ferritin and haemosiderin. The type of iron storage deposits is thought to be an important factor in determining the degree of iron toxicity and tissue damage in patients with iron overload. Variations in the form of iron deposits in different types of iron overload disease e.g. HH or beta-thalessemia, the site of iron deposition and the clinical treatment used will be discussed.

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Dec 2000
Volume 6 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Trinder D, Macey D and Olynyk J: The new iron age.. Int J Mol Med 6: 607-619, 2000.
APA
Trinder, D., Macey, D., & Olynyk, J. (2000). The new iron age.. International Journal of Molecular Medicine, 6, 607-619. https://doi.org/10.3892/ijmm.6.6.607
MLA
Trinder, D., Macey, D., Olynyk, J."The new iron age.". International Journal of Molecular Medicine 6.6 (2000): 607-619.
Chicago
Trinder, D., Macey, D., Olynyk, J."The new iron age.". International Journal of Molecular Medicine 6, no. 6 (2000): 607-619. https://doi.org/10.3892/ijmm.6.6.607