In vivo single voxel 1H MRS of glial brain tumors: correlation with tissue histology and in vitro MRS.

  • Authors:
    • G Barbarella
    • R Ricci
    • G Pirini
    • V Tugnoli
    • M R Tosi
    • A Bertoluzza
    • F Calbucci
    • M Leonardi
    • C Trevisan
    • V Eusebi
  • View Affiliations

  • Published online on: February 1, 1998     https://doi.org/10.3892/ijo.12.2.461
  • Pages: 461-469
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Abstract

Eighteen patients affected by glial brain tumors were examined by localized single voxel magnetic resonance spectroscopy (1H MRS). For all patients histological diagnosis was obtained after stereotactic biopsy or surgical removal of the tumor. Histological nuclear atypia, tumor cellularity, necrosis, vascular proliferation and percentage of Ki-67 positive cells in the total cell populations were evaluated. It was found that some of the in vivo 1H MRS parameters were related to the histological features of the tumor. In particular, the Choi/Cri metabolite ratio obtained from the neoplastic tissues paralleled the Ki-67 cell proliferation index. For some of the patients 1H and 13C in vitro high resolution magnetic spectroscopy of surgical specimens was also carried out. 1H MRS of aqueous extracts from different biopsy specimens of the same tumor furnished fine biochemical information on intratumor heterogeneity. The degree of histological vascular proliferation of the tumor was correlated to the presence of cholesteryl esters in the 13C spectrum of the lipid fraction of surgical specimens.

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Feb 1998
Volume 12 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Barbarella G, Ricci R, Pirini G, Tugnoli V, Tosi M, Bertoluzza A, Calbucci F, Leonardi M, Trevisan C, Eusebi V, Eusebi V, et al: In vivo single voxel 1H MRS of glial brain tumors: correlation with tissue histology and in vitro MRS.. Int J Oncol 12: 461-469, 1998.
APA
Barbarella, G., Ricci, R., Pirini, G., Tugnoli, V., Tosi, M., Bertoluzza, A. ... Eusebi, V. (1998). In vivo single voxel 1H MRS of glial brain tumors: correlation with tissue histology and in vitro MRS.. International Journal of Oncology, 12, 461-469. https://doi.org/10.3892/ijo.12.2.461
MLA
Barbarella, G., Ricci, R., Pirini, G., Tugnoli, V., Tosi, M., Bertoluzza, A., Calbucci, F., Leonardi, M., Trevisan, C., Eusebi, V."In vivo single voxel 1H MRS of glial brain tumors: correlation with tissue histology and in vitro MRS.". International Journal of Oncology 12.2 (1998): 461-469.
Chicago
Barbarella, G., Ricci, R., Pirini, G., Tugnoli, V., Tosi, M., Bertoluzza, A., Calbucci, F., Leonardi, M., Trevisan, C., Eusebi, V."In vivo single voxel 1H MRS of glial brain tumors: correlation with tissue histology and in vitro MRS.". International Journal of Oncology 12, no. 2 (1998): 461-469. https://doi.org/10.3892/ijo.12.2.461