DNA amplification on chromosome 7q in squamous cell carcinoma of the tongue

  • Authors:
    • H. Steinhart
    • J. Bohlender
    • H. Iro
    • Volker Jung
    • J. Constantinidis
    • E. Gebhart
    • S. Pahl
    • S. Urbschat
  • View Affiliations

  • Published online on: October 1, 2001     https://doi.org/10.3892/ijo.19.4.851
  • Pages: 851-855
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Abstract

Squamous cell carcinoma of the head and neck exhibit a highly variable picture of chromosomal aberrations. In the present study the clearly defined anatomical region of the tongue was analyzed for potentially specific patterns of chromosomal alterations. Fresh tumor samples from 18 patients afflicted by squamous cell carcinoma of the tongue constituted the clinical basis of the present investigation. The tumor samples were analyzed on the basis of comparative genomic hybridization (CGH), a molecular cytogenetic FISH-approach. Gains in DNA copy numbers were detected as the predominant imbalance on chromosomes 7q (9/18), 3q (48/18), 16p (7/18) and 20q (7/18). The regions of minimal overlap on these chromosomes were mapped to 7q11.2q11.3 and 3q26. A conspicuous finding was the frequent detection of amplifications in the 7q11 region. Gains in the 7q region have been rarely reported in CGH studies of tumors derived from different regions of the head and neck. Amplifications on 7q could thus be specifically linked with the tongue region and could correlate with specific clinical factors of this tumor entity.

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October 2001
Volume 19 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Steinhart H, Bohlender J, Iro H, Jung V, Constantinidis J, Gebhart E, Pahl S and Urbschat S: DNA amplification on chromosome 7q in squamous cell carcinoma of the tongue. Int J Oncol 19: 851-855, 2001.
APA
Steinhart, H., Bohlender, J., Iro, H., Jung, V., Constantinidis, J., Gebhart, E. ... Urbschat, S. (2001). DNA amplification on chromosome 7q in squamous cell carcinoma of the tongue. International Journal of Oncology, 19, 851-855. https://doi.org/10.3892/ijo.19.4.851
MLA
Steinhart, H., Bohlender, J., Iro, H., Jung, V., Constantinidis, J., Gebhart, E., Pahl, S., Urbschat, S."DNA amplification on chromosome 7q in squamous cell carcinoma of the tongue". International Journal of Oncology 19.4 (2001): 851-855.
Chicago
Steinhart, H., Bohlender, J., Iro, H., Jung, V., Constantinidis, J., Gebhart, E., Pahl, S., Urbschat, S."DNA amplification on chromosome 7q in squamous cell carcinoma of the tongue". International Journal of Oncology 19, no. 4 (2001): 851-855. https://doi.org/10.3892/ijo.19.4.851