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17β-estradiol-induced activation of ERK1/2 through endogenous androgen receptor-estradiol receptor α-Src complex in human prostate cells

  • Authors:
    • Paolo Chieffi
    • Annamaria Kisslinger
    • Antonio A. Sinisi
    • Ciro Abbondanza
    • Donatella Tramontano

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  • Published online on: September 1, 2003     https://doi.org/10.3892/ijo.23.3.797
  • Pages: 797-801
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Abstract

We examined the effect of estrogens on mitogen-activated protein kinase (MAPK) in EPN cells, a line of epithelial cells derived from human normal prostate. 17β-estradiol (E2) caused a rapid and transient activation of MAPK (ERK1/2) within 5 min. This effect was counteracted by the anti-estrogen ICI 182-780 and by MEK inhibitor PD098059. The activation of ERK1/2 through 17β-estradiol triggered simultaneous association of endogenous androgen receptor, estrogen receptor α and Src. In addition, E2 stimulated the proliferation of EPN cells, suggesting that the formation of the ternary complex and the consequent activation of ERKs are implicated in the mechanism regulating proliferation of epithelial prostate cells.

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Journal Cover

September 2003
Volume 23 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Journal Metrics
  • Impact Factor: 5.2
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 11.4
  • CiteScore Rank: Q1: #40/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 1.125
  • SCImago Journal Rank (SJR): 1.105
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Spandidos Publications style
Chieffi P, Kisslinger A, Sinisi AA, Abbondanza C and Tramontano D: 17β-estradiol-induced activation of ERK1/2 through endogenous androgen receptor-estradiol receptor α-Src complex in human prostate cells. Int J Oncol 23: 797-801, 2003
APA
Chieffi, P., Kisslinger, A., Sinisi, A.A., Abbondanza, C., & Tramontano, D. (2003). 17β-estradiol-induced activation of ERK1/2 through endogenous androgen receptor-estradiol receptor α-Src complex in human prostate cells. International Journal of Oncology, 23, 797-801. https://doi.org/10.3892/ijo.23.3.797
MLA
Chieffi, P., Kisslinger, A., Sinisi, A. A., Abbondanza, C., Tramontano, D."17β-estradiol-induced activation of ERK1/2 through endogenous androgen receptor-estradiol receptor α-Src complex in human prostate cells". International Journal of Oncology 23.3 (2003): 797-801.
Chicago
Chieffi, P., Kisslinger, A., Sinisi, A. A., Abbondanza, C., Tramontano, D."17β-estradiol-induced activation of ERK1/2 through endogenous androgen receptor-estradiol receptor α-Src complex in human prostate cells". International Journal of Oncology 23, no. 3 (2003): 797-801. https://doi.org/10.3892/ijo.23.3.797