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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 2004 Volume 24 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 2004 Volume 24 Issue 4

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Article

Modulation of Janus kinase 2 by cisplatin in cancer cells

  • Authors:
    • Hui Song
    • Vernon K. Sondak
    • Dwayne L. Barber
    • Thomas J. Reid
    • Jiayuh Lin

  • View Affiliations / Copyright

    Affiliations: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109-0936, USA
  • Pages: 1017-1026
    |
    Published online on: April 1, 2004
       https://doi.org/10.3892/ijo.24.4.1017
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Abstract

Constitutive activation of Janus kinases (JAKs) is frequently detected in various human cancers. The activation of JAKs results in the phosphorylation and activation of signal transducers and activators of transcription (STATs). The constitutive activation of JAK/STAT pathway may play an important role in growth and survival of human cancer cells. In this study, we examined whether a chemotherapeutic agent cisplatin could inhibit the JAK/STAT pathway. In ovarian cancer and sarcoma cells that express constitutively active JAK2, cisplatin significantly inhibited tyrosine phosphorylation and kinase activity of JAK2 in a dose- and time-dependent manner. Meanwhile, cisplatin also inhibited Stat3 tyrosine phosphorylation and down-regulated BcL-XL anti-apoptotic protein in the cancer cells tested. In leukemia cells expressing high level of TEL-JAK2 fusion protein, cisplatin dramatically inhibited tyrosine phosphorylation of TEL-JAK2 as well. Furthermore, our results have shown that down-regulation of JAK2 by cisplatin might be through modulation of a tyrosine phosphatase SHP-1 but not SOCS family members. Taken together, our observations demonstrated that cisplatin down-regulated the JAK/STAT pathway through de-phosphorylation of JAK/STAT in cancer cells.

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Copy and paste a formatted citation
Spandidos Publications style
Song H, Sondak VK, Barber DL, Reid TJ and Lin J: Modulation of Janus kinase 2 by cisplatin in cancer cells. Int J Oncol 24: 1017-1026, 2004.
APA
Song, H., Sondak, V.K., Barber, D.L., Reid, T.J., & Lin, J. (2004). Modulation of Janus kinase 2 by cisplatin in cancer cells. International Journal of Oncology, 24, 1017-1026. https://doi.org/10.3892/ijo.24.4.1017
MLA
Song, H., Sondak, V. K., Barber, D. L., Reid, T. J., Lin, J."Modulation of Janus kinase 2 by cisplatin in cancer cells". International Journal of Oncology 24.4 (2004): 1017-1026.
Chicago
Song, H., Sondak, V. K., Barber, D. L., Reid, T. J., Lin, J."Modulation of Janus kinase 2 by cisplatin in cancer cells". International Journal of Oncology 24, no. 4 (2004): 1017-1026. https://doi.org/10.3892/ijo.24.4.1017
Copy and paste a formatted citation
x
Spandidos Publications style
Song H, Sondak VK, Barber DL, Reid TJ and Lin J: Modulation of Janus kinase 2 by cisplatin in cancer cells. Int J Oncol 24: 1017-1026, 2004.
APA
Song, H., Sondak, V.K., Barber, D.L., Reid, T.J., & Lin, J. (2004). Modulation of Janus kinase 2 by cisplatin in cancer cells. International Journal of Oncology, 24, 1017-1026. https://doi.org/10.3892/ijo.24.4.1017
MLA
Song, H., Sondak, V. K., Barber, D. L., Reid, T. J., Lin, J."Modulation of Janus kinase 2 by cisplatin in cancer cells". International Journal of Oncology 24.4 (2004): 1017-1026.
Chicago
Song, H., Sondak, V. K., Barber, D. L., Reid, T. J., Lin, J."Modulation of Janus kinase 2 by cisplatin in cancer cells". International Journal of Oncology 24, no. 4 (2004): 1017-1026. https://doi.org/10.3892/ijo.24.4.1017
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