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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 2004 Volume 25 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2004 Volume 25 Issue 5

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Article

The ectopeptidases CD10, CD13, CD26, and CD143 are upregulated in gastric cancer

  • Authors:
    • Stacy Carl-McGrath
    • Uwe Lendeckel
    • Matthias Ebert
    • Alexandra-Beatrice Wolter
    • Albert Roessner
    • Christoph Röcken

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Otto-von-Guericke University, Magdeburg, Germany
  • Pages: 1223-1232
    |
    Published online on: November 1, 2004
       https://doi.org/10.3892/ijo.25.5.1223
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Abstract

Due to their extracellular orientation, the ectopeptidases CD10, CD13, CD26, and CD143 have numerous functions, including the post-secretory processing of the neuropeptides and peptide hormones involved in the regulation of growth and differentiation in the gastrointestinal tract. We investigated the transcription and expression pattern of these four ectopeptidases in gastric carcinomas (GC), the corresponding non-neoplastic epithelium, a selection of lymph node metastases (LNM), and the MKN28, AGS, NCI-N87, KATO III gastric cancer cell lines. The gastric foveolar epithelium did not express CD10, CD13, or CD143, but the intestinal metaplasia demonstrated strong immunoreactivity at the brush border for all four ectopeptidases. CD10, CD13, and CD143 were significantly up-regulated in GCs and the lymph node metastases, confirming that they are important for the tumor cell biology. However, there is a lack of correlation between expression in intestinal metaplasia and tumor, as well as in tumor and LNM. Cell proliferation assays were performed with MKN28 and AGS, in which inhibition of CD10 significantly reduced the growth of both cell lines, and inhibition of CD13 significantly increased the proliferation of the AGS cells, indicating that the ability to degrade gastrointestinal peptides may play an important role in the pathobiology of gastric cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Carl-McGrath S, Lendeckel U, Ebert M, Wolter A, Roessner A and Röcken C: The ectopeptidases CD10, CD13, CD26, and CD143 are upregulated in gastric cancer. Int J Oncol 25: 1223-1232, 2004.
APA
Carl-McGrath, S., Lendeckel, U., Ebert, M., Wolter, A., Roessner, A., & Röcken, C. (2004). The ectopeptidases CD10, CD13, CD26, and CD143 are upregulated in gastric cancer. International Journal of Oncology, 25, 1223-1232. https://doi.org/10.3892/ijo.25.5.1223
MLA
Carl-McGrath, S., Lendeckel, U., Ebert, M., Wolter, A., Roessner, A., Röcken, C."The ectopeptidases CD10, CD13, CD26, and CD143 are upregulated in gastric cancer". International Journal of Oncology 25.5 (2004): 1223-1232.
Chicago
Carl-McGrath, S., Lendeckel, U., Ebert, M., Wolter, A., Roessner, A., Röcken, C."The ectopeptidases CD10, CD13, CD26, and CD143 are upregulated in gastric cancer". International Journal of Oncology 25, no. 5 (2004): 1223-1232. https://doi.org/10.3892/ijo.25.5.1223
Copy and paste a formatted citation
x
Spandidos Publications style
Carl-McGrath S, Lendeckel U, Ebert M, Wolter A, Roessner A and Röcken C: The ectopeptidases CD10, CD13, CD26, and CD143 are upregulated in gastric cancer. Int J Oncol 25: 1223-1232, 2004.
APA
Carl-McGrath, S., Lendeckel, U., Ebert, M., Wolter, A., Roessner, A., & Röcken, C. (2004). The ectopeptidases CD10, CD13, CD26, and CD143 are upregulated in gastric cancer. International Journal of Oncology, 25, 1223-1232. https://doi.org/10.3892/ijo.25.5.1223
MLA
Carl-McGrath, S., Lendeckel, U., Ebert, M., Wolter, A., Roessner, A., Röcken, C."The ectopeptidases CD10, CD13, CD26, and CD143 are upregulated in gastric cancer". International Journal of Oncology 25.5 (2004): 1223-1232.
Chicago
Carl-McGrath, S., Lendeckel, U., Ebert, M., Wolter, A., Roessner, A., Röcken, C."The ectopeptidases CD10, CD13, CD26, and CD143 are upregulated in gastric cancer". International Journal of Oncology 25, no. 5 (2004): 1223-1232. https://doi.org/10.3892/ijo.25.5.1223
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