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Bone morphogenetic protein 2 (BMP-2) induces in vitro invasion and in vivo hormone independent growth of breast carcinoma cells

  • Authors:
    • Joachim H. Clement
    • Martin Raida
    • Jörg Sänger
    • Roy Bicknell
    • Jingwen Liu
    • Anke Naumann
    • Annette Geyer
    • Anja Waldau
    • Peter Hortschansky
    • Andreas Schmidt
    • Klaus Höffken
    • Stefan Wölft
    • Adrian L. Harris

  • View Affiliations

  • Published online on: August 1, 2005     https://doi.org/10.3892/ijo.27.2.401
  • Pages: 401-407
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Abstract

Breast cancer cell lines migrated towards a BMP-2 source depending on BMP-2 concentration. After a short exposure to BMP-2, the cells were able to migrate through matrigel. MCF-7 cells transfected with the BMP-2 gene also showed enhanced migratory properties and high expression of the metastasis-related gene BCSG1. In a xenograft model without estrogen supplementation MCF-7/BMP-2 cells formed tumors. These tumors were characterised by an enhanced vasculature and the formation of chondroid and osseous structures. In conclusion elevated levels of BMP-2 enhance the tumorigenic properties of breast carcinoma cells and drive the cells towards a more aggressive phenotype with estrogen independent growth.

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Journal Cover

August 2005
Volume 27 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Journal Metrics
  • Impact Factor: 5.2
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 11.4
  • CiteScore Rank: Q1: #40/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 1.125
  • SCImago Journal Rank (SJR): 1.105
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Spandidos Publications style
Clement JH, Raida M, Sänger J, Bicknell R, Liu J, Naumann A, Geyer A, Waldau A, Hortschansky P, Schmidt A, Schmidt A, et al: Bone morphogenetic protein 2 (BMP-2) induces in vitro invasion and in vivo hormone independent growth of breast carcinoma cells. Int J Oncol 27: 401-407, 2005
APA
Clement, J.H., Raida, M., Sänger, J., Bicknell, R., Liu, J., Naumann, A. ... Harris, A.L. (2005). Bone morphogenetic protein 2 (BMP-2) induces in vitro invasion and in vivo hormone independent growth of breast carcinoma cells. International Journal of Oncology, 27, 401-407. https://doi.org/10.3892/ijo.27.2.401
MLA
Clement, J. H., Raida, M., Sänger, J., Bicknell, R., Liu, J., Naumann, A., Geyer, A., Waldau, A., Hortschansky, P., Schmidt, A., Höffken, K., Wölft, S., Harris, A. L."Bone morphogenetic protein 2 (BMP-2) induces in vitro invasion and in vivo hormone independent growth of breast carcinoma cells". International Journal of Oncology 27.2 (2005): 401-407.
Chicago
Clement, J. H., Raida, M., Sänger, J., Bicknell, R., Liu, J., Naumann, A., Geyer, A., Waldau, A., Hortschansky, P., Schmidt, A., Höffken, K., Wölft, S., Harris, A. L."Bone morphogenetic protein 2 (BMP-2) induces in vitro invasion and in vivo hormone independent growth of breast carcinoma cells". International Journal of Oncology 27, no. 2 (2005): 401-407. https://doi.org/10.3892/ijo.27.2.401