Efficacy of oncolytic reovirus against liver metastasis from pancreatic cancer in immunocompetent models

  • Authors:
    • Yoshihisa Himeno
    • Tsuyoshi Etoh
    • Toshifumi Matsumoto
    • Masayuki Ohta
    • Akira Nishizono
    • Seigo Kitano
  • View Affiliations

  • Published online on: October 1, 2005     https://doi.org/10.3892/ijo.27.4.901
  • Pages: 901-906
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Abstract

Liver metastasis is common in pancreatic cancer patients, and the current treatments are insufficient to improve the clinical outcome. Recently, tumor-targeted replication-competent viruses have been developed as cancer therapy. The aim of this study was to clarify the efficacy of oncolytic reovirus against liver metastases from pancreatic cancer in immunocompetent models. Reovirus serotype 3 and three hamster pancreatic cancer cell lines (HPD1NR, HPD2NR, and HaP-T1) were used in this study. The susceptibility of reovirus to these cell lines was examined. The effect of intraportal administration of reovirus against metastatic liver tumors was evaluated in vivo. Reovirus infected all cell lines and propagated via an activated Ras signalling pathway in vitro. In syngeneic hamster models using the HPD2NR cell line, intraportal administration of reovirus significantly decreased the number and size of treated tumors in comparison with non-treated tumors. Immunohistochemical examination revealed reovirus replication within the tumor cells but not in the surrounding normal tissue and organs. There were no reovirus-related toxicities and deaths. Our results indicate that intraportal administration of reovirus is effective and safe in immunocompetent and syngeneic hamster models of liver metastases from pancreatic cancer, suggesting that reovirus can be developed into an effective therapeutic modality in future.

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October 2005
Volume 27 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Himeno Y, Etoh T, Matsumoto T, Ohta M, Nishizono A and Kitano S: Efficacy of oncolytic reovirus against liver metastasis from pancreatic cancer in immunocompetent models. Int J Oncol 27: 901-906, 2005.
APA
Himeno, Y., Etoh, T., Matsumoto, T., Ohta, M., Nishizono, A., & Kitano, S. (2005). Efficacy of oncolytic reovirus against liver metastasis from pancreatic cancer in immunocompetent models. International Journal of Oncology, 27, 901-906. https://doi.org/10.3892/ijo.27.4.901
MLA
Himeno, Y., Etoh, T., Matsumoto, T., Ohta, M., Nishizono, A., Kitano, S."Efficacy of oncolytic reovirus against liver metastasis from pancreatic cancer in immunocompetent models". International Journal of Oncology 27.4 (2005): 901-906.
Chicago
Himeno, Y., Etoh, T., Matsumoto, T., Ohta, M., Nishizono, A., Kitano, S."Efficacy of oncolytic reovirus against liver metastasis from pancreatic cancer in immunocompetent models". International Journal of Oncology 27, no. 4 (2005): 901-906. https://doi.org/10.3892/ijo.27.4.901