PI3K-Akt signaling is involved in the regulation of p21WAF/CIP expression and androgen-independent growth in prostate cancer cells

  • Authors:
    • Shan Lu
    • Chengxi Ren
    • Yin Liu
    • Daniel E. Epner
  • View Affiliations

  • Published online on: January 1, 2006     https://doi.org/10.3892/ijo.28.1.245
  • Pages: 245-251
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The purpose of this study is to investigate the role of PI3K-Akt signaling in prostate cancer cell growth and androgen receptor (AR)-mediated gene expression. Androgen-dependent LNCaP cells and their androgen-independent counterpart, LNCaP-AI cells, were used. We found that PI3K-Akt signaling is elevated in LNCaP-AI cells compared to that in LNCaP cells and is involved in androgen-independent growth. More importantly, PI3K-Akt signaling enhances AR activity and is involved in the induction of AR target genes, such as p21WAF/CIP, a gene with anti-apoptosis activity and associated with androgen-independent growth in human prostate cancer. A receptor tyrosine kinase inhibitor also inhibits the PI3K-Akt signaling and compromises AR activity and cell growth. These findings suggest that the PI3K-Akt cell growth survival pathway and its downstream-regulated gene, p21WAF/CIP, are targets for developing novel therapies against prostate cancer, especially those androgen-independent diseases.

Related Articles

Journal Cover

January 2006
Volume 28 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Lu S, Ren C, Liu Y and Epner DE: PI3K-Akt signaling is involved in the regulation of p21WAF/CIP expression and androgen-independent growth in prostate cancer cells. Int J Oncol 28: 245-251, 2006
APA
Lu, S., Ren, C., Liu, Y., & Epner, D.E. (2006). PI3K-Akt signaling is involved in the regulation of p21WAF/CIP expression and androgen-independent growth in prostate cancer cells. International Journal of Oncology, 28, 245-251. https://doi.org/10.3892/ijo.28.1.245
MLA
Lu, S., Ren, C., Liu, Y., Epner, D. E."PI3K-Akt signaling is involved in the regulation of p21WAF/CIP expression and androgen-independent growth in prostate cancer cells". International Journal of Oncology 28.1 (2006): 245-251.
Chicago
Lu, S., Ren, C., Liu, Y., Epner, D. E."PI3K-Akt signaling is involved in the regulation of p21WAF/CIP expression and androgen-independent growth in prostate cancer cells". International Journal of Oncology 28, no. 1 (2006): 245-251. https://doi.org/10.3892/ijo.28.1.245