Expression of vascular cell adhesion molecule-1 (CD 106) in normal and neoplastic human esophageal squamous epithelium

  • Authors:
    • Jan Heidemann
    • Christian Maaser
    • Andreas Lügering
    • Thomas W. Spahn
    • Klaus P. Zimmer
    • Hermann Herbst
    • Parvaneh Rafiee
    • Wolfram Domschke
    • Christian F. Krieglstein
    • David G. Binion
    • Torsten F. Kucharzik
  • View Affiliations

  • Published online on: January 1, 2006     https://doi.org/10.3892/ijo.28.1.77
  • Pages: 77-85
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Abstract

Vascular cell adhesion molecule-1 (VCAM-1), a key receptor for the leukocyte-associated integrin (VLA4), is a crucial mediator of leukocyte adhesion and has co-stimulatory functions in inflammation at various organ sites. Specifically, VCAM-1/VLA4 interactions have been shown to play important roles in the setting of cutaneous immune responses, such as psoriatic lesions in humans and acute Graft-versus-Host-Disease in mice. VCAM-1 is generally expressed on activated endothelial cells in inflamed tissues, mediating endothelium-leukocyte interactions, leading to leukocyte diapedesis to the site of inflammation. We report novel and unexpected membrane expression of VCAM-1 in the basal squamous epithelial strata of the normal human esophagus and distinct patterns of epithelial expression in esophageal pathology. To further delineate the differential expression patterns of VCAM-1 in the esophageal epithelium, we examined specimens from squamous cell carcinoma (SCC), adenocarcinoma, and Barrett's columnar cell metaplasia. VCAM-1 was strongly expressed in squamous cell carcinoma, but not adenocarcinoma nor columnar epithelia in Barrett's esophagus. VCAM-1 expression was focally accentuated at sites characteristic of microscopic tumor invasion in SCC, pointing to a potential role of VCAM-1 in the development of metastasis. In addition, in vitro immunofluorescence studies using OE21 cells, an esophageal squamous epithelial cell line, displayed distinct VCAM-1 immunoreactivity confined to mitotic and dividing cells. Cell cycle arrest caused a significant decrease in VCAM-1 immunoreactivity in OE21 cells. These data suggest a previously unappreciated role for VCAM-1 in esophageal squamous epithelial homeostasis and pathology.

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January 2006
Volume 28 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Heidemann J, Maaser C, Lügering A, Spahn TW, Zimmer KP, Herbst H, Rafiee P, Domschke W, Krieglstein CF, Binion DG, Binion DG, et al: Expression of vascular cell adhesion molecule-1 (CD 106) in normal and neoplastic human esophageal squamous epithelium. Int J Oncol 28: 77-85, 2006
APA
Heidemann, J., Maaser, C., Lügering, A., Spahn, T.W., Zimmer, K.P., Herbst, H. ... Kucharzik, T.F. (2006). Expression of vascular cell adhesion molecule-1 (CD 106) in normal and neoplastic human esophageal squamous epithelium. International Journal of Oncology, 28, 77-85. https://doi.org/10.3892/ijo.28.1.77
MLA
Heidemann, J., Maaser, C., Lügering, A., Spahn, T. W., Zimmer, K. P., Herbst, H., Rafiee, P., Domschke, W., Krieglstein, C. F., Binion, D. G., Kucharzik, T. F."Expression of vascular cell adhesion molecule-1 (CD 106) in normal and neoplastic human esophageal squamous epithelium". International Journal of Oncology 28.1 (2006): 77-85.
Chicago
Heidemann, J., Maaser, C., Lügering, A., Spahn, T. W., Zimmer, K. P., Herbst, H., Rafiee, P., Domschke, W., Krieglstein, C. F., Binion, D. G., Kucharzik, T. F."Expression of vascular cell adhesion molecule-1 (CD 106) in normal and neoplastic human esophageal squamous epithelium". International Journal of Oncology 28, no. 1 (2006): 77-85. https://doi.org/10.3892/ijo.28.1.77