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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 2006 Volume 28 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 2006 Volume 28 Issue 4

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Article

Oncolytic recombinant herpes simplex virus for treatment of orthotopic liver tumors in nude mice

  • Authors:
    • Young Sik Chung
    • Shin-Ichi Miyatake
    • Akiko Miyamoto
    • Yoshiharu Miyamoto
    • Takehiko Dohi
    • Nobuhiko Tanigawa

  • View Affiliations / Copyright

    Affiliations: Department of General and Gastroenterological Surgery, Osaka Medical College, Takatsuki, Osaka 569-8686, Japan
  • Pages: 793-798
    |
    Published online on: April 1, 2006
       https://doi.org/10.3892/ijo.28.4.793
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Abstract

Cell-specific, replicating viruses are being developed as a new class of oncolytic agents. A novel approach to viral gene therapy with the use of replication-competent herpes simplex virus has been described; G92A is a replication-competent, multimutant oncolytic herpes simplex virus (HSV) that has been evaluated for anticancer effects and selectivity in the treatment of subcutaneous tumors. G92A replicates efficiently in albumin-producing tumor cell lines but not in non-albumin-producing tumor cell lines, whereas both types are equally susceptible to a non-tissue-specific recombinant HSV, hrR3. In this study, we analyzed the antitumoral efficacy of a single intrasplenic G92A or hrR3 injection in nude mice. In vivo, G92A replicated well in liver xenografts of human albumin-producing hepatoma cells (Hep3B) but not in liver xenografts of a non-albumin-producing malignant colon tumor cell line (HT29), whereas hrR3 replicated well in both tumor types. G92A effectively and selectively replicated throughout liver tumors without apparent hepatotoxicity and inhibited tumor growth, leading to a significantly increased survival time. By monitoring lacZ histochemical staining, we determined the oncolytic potential of recombinant HSV against liver tumors. Our results indicate that G92A warrants further investigation as a clinical therapy against malignant liver tumors.

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Copy and paste a formatted citation
Spandidos Publications style
Chung YS, Miyatake S, Miyamoto A, Miyamoto Y, Dohi T and Tanigawa N: Oncolytic recombinant herpes simplex virus for treatment of orthotopic liver tumors in nude mice. Int J Oncol 28: 793-798, 2006.
APA
Chung, Y.S., Miyatake, S., Miyamoto, A., Miyamoto, Y., Dohi, T., & Tanigawa, N. (2006). Oncolytic recombinant herpes simplex virus for treatment of orthotopic liver tumors in nude mice. International Journal of Oncology, 28, 793-798. https://doi.org/10.3892/ijo.28.4.793
MLA
Chung, Y. S., Miyatake, S., Miyamoto, A., Miyamoto, Y., Dohi, T., Tanigawa, N."Oncolytic recombinant herpes simplex virus for treatment of orthotopic liver tumors in nude mice". International Journal of Oncology 28.4 (2006): 793-798.
Chicago
Chung, Y. S., Miyatake, S., Miyamoto, A., Miyamoto, Y., Dohi, T., Tanigawa, N."Oncolytic recombinant herpes simplex virus for treatment of orthotopic liver tumors in nude mice". International Journal of Oncology 28, no. 4 (2006): 793-798. https://doi.org/10.3892/ijo.28.4.793
Copy and paste a formatted citation
x
Spandidos Publications style
Chung YS, Miyatake S, Miyamoto A, Miyamoto Y, Dohi T and Tanigawa N: Oncolytic recombinant herpes simplex virus for treatment of orthotopic liver tumors in nude mice. Int J Oncol 28: 793-798, 2006.
APA
Chung, Y.S., Miyatake, S., Miyamoto, A., Miyamoto, Y., Dohi, T., & Tanigawa, N. (2006). Oncolytic recombinant herpes simplex virus for treatment of orthotopic liver tumors in nude mice. International Journal of Oncology, 28, 793-798. https://doi.org/10.3892/ijo.28.4.793
MLA
Chung, Y. S., Miyatake, S., Miyamoto, A., Miyamoto, Y., Dohi, T., Tanigawa, N."Oncolytic recombinant herpes simplex virus for treatment of orthotopic liver tumors in nude mice". International Journal of Oncology 28.4 (2006): 793-798.
Chicago
Chung, Y. S., Miyatake, S., Miyamoto, A., Miyamoto, Y., Dohi, T., Tanigawa, N."Oncolytic recombinant herpes simplex virus for treatment of orthotopic liver tumors in nude mice". International Journal of Oncology 28, no. 4 (2006): 793-798. https://doi.org/10.3892/ijo.28.4.793
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