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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2006 Volume 29 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2006 Volume 29 Issue 1

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Article

Inhibition of transendothelial migration and invasion of human breast cancer cells by preventing geranylgeranylation of Rho

  • Authors:
    • Toshiyuki Kusama
    • Mutsuko Mukai
    • Masaharu Tatsuta
    • Hiroyuki Nakamura
    • Masahiro Inoue

  • View Affiliations / Copyright

    Affiliations: Department of Tumor Biochemistry, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari-ku, Osaka 537-8511, Japan. kusama-to@ mc.pref.osaka.jp
  • Pages: 217-223
    |
    Published online on: July 1, 2006
       https://doi.org/10.3892/ijo.29.1.217
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Abstract

Rho family GTPases are frequently overexpressed in breast cancers, which regulate cancer cell migration and invasion. They require prenylation, a lipid post-translational modification, for full biological functions. We examined the effects of 3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor (fluvastatin), a selective farnesyltransferase inhibitor (FTI-277) and a selective geranylgeranyltransferase type I inhibitor (GGTI-298) on in vitro invasive capacity of MDA-MB-231 human breast cancer cells into the endothelial cell monolayer in a transendothelial migration assay. Although, at a maximal dose of 5 µM, fluvastatin did not affect the integrity of endothelial cell monolayer, the transendothelial migration of MDA-MB-231 cells was inhibited potently by fluvastatin in a dose-dependent manner. The transendothelial migration of MDA-MB-231 cells was also inhibited potently by GGTI-298 in a dose-dependent manner but weakly by FTI-277. The inhibitory effects of fluvastatin, GGTI-298 and FTI-277 on MDA-MB-231 cell invasion were shown to correlate well with inhibition of the membrane localization of RhoA and RhoC, but not with Ras. These results suggest that geranylgeranylation step of RhoA and RhoC could be a good therapeutic target for the prevention of invasion and metastasis of breast cancer cells.

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Copy and paste a formatted citation
Spandidos Publications style
Kusama T, Mukai M, Tatsuta M, Nakamura H and Inoue M: Inhibition of transendothelial migration and invasion of human breast cancer cells by preventing geranylgeranylation of Rho. Int J Oncol 29: 217-223, 2006.
APA
Kusama, T., Mukai, M., Tatsuta, M., Nakamura, H., & Inoue, M. (2006). Inhibition of transendothelial migration and invasion of human breast cancer cells by preventing geranylgeranylation of Rho. International Journal of Oncology, 29, 217-223. https://doi.org/10.3892/ijo.29.1.217
MLA
Kusama, T., Mukai, M., Tatsuta, M., Nakamura, H., Inoue, M."Inhibition of transendothelial migration and invasion of human breast cancer cells by preventing geranylgeranylation of Rho". International Journal of Oncology 29.1 (2006): 217-223.
Chicago
Kusama, T., Mukai, M., Tatsuta, M., Nakamura, H., Inoue, M."Inhibition of transendothelial migration and invasion of human breast cancer cells by preventing geranylgeranylation of Rho". International Journal of Oncology 29, no. 1 (2006): 217-223. https://doi.org/10.3892/ijo.29.1.217
Copy and paste a formatted citation
x
Spandidos Publications style
Kusama T, Mukai M, Tatsuta M, Nakamura H and Inoue M: Inhibition of transendothelial migration and invasion of human breast cancer cells by preventing geranylgeranylation of Rho. Int J Oncol 29: 217-223, 2006.
APA
Kusama, T., Mukai, M., Tatsuta, M., Nakamura, H., & Inoue, M. (2006). Inhibition of transendothelial migration and invasion of human breast cancer cells by preventing geranylgeranylation of Rho. International Journal of Oncology, 29, 217-223. https://doi.org/10.3892/ijo.29.1.217
MLA
Kusama, T., Mukai, M., Tatsuta, M., Nakamura, H., Inoue, M."Inhibition of transendothelial migration and invasion of human breast cancer cells by preventing geranylgeranylation of Rho". International Journal of Oncology 29.1 (2006): 217-223.
Chicago
Kusama, T., Mukai, M., Tatsuta, M., Nakamura, H., Inoue, M."Inhibition of transendothelial migration and invasion of human breast cancer cells by preventing geranylgeranylation of Rho". International Journal of Oncology 29, no. 1 (2006): 217-223. https://doi.org/10.3892/ijo.29.1.217
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