Elevated pleural fluid RCAS1 is a diagnostic marker and outcome predictor in lung cancer patients

  • Authors:
    • Keisuke Aoe
    • Akio Hiraki
    • Koichi Yamazaki
    • Yuichi Nakamura
    • Tomoyuki Murakami
    • Tadashi Maeda
    • Masaharu Nishimura
    • Kazuro Sugi
    • Hiroshi Ueoka
  • View Affiliations

  • Published online on: July 1, 2006     https://doi.org/10.3892/ijo.29.1.65
  • Pages: 65-72
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Abstract

RCAS1, a type II membrane protein also secreted in soluble form, may be important in tumor cell evasion of immune surveillance and contribute to the aggressiveness of human tumors. We examined the implications of elevated pleural fluid RCAS1 at the onset of effusion in lung cancer patients. Of 102 patients presenting with pleural effusion, 59 proved to have a malignant effusion and 43, nonmalignant. Malignant effusions exhibited higher RCAS1 concentrations than nonmalignant effusions (mean ± SD; 36.3 ± 114 vs. 2.7 ± 1.8 U/ml; p=0.014). Lung cancer patients with pleural fluid RCAS1 concentrations below 15 U/ml had a longer mean survival than those with higher concentrations (4.7 vs. 1.7 months; p<0.05). By multivariate analysis, pleural fluid RCAS1 was an independent prognostic factor in lung cancer patients with effusion. In conclusion, RCAS1 determination at onset of pleural effusion is informative for both diagnosis and outcome prediction in lung cancer patients.

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July 2006
Volume 29 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Aoe K, Hiraki A, Yamazaki K, Nakamura Y, Murakami T, Maeda T, Nishimura M, Sugi K and Ueoka H: Elevated pleural fluid RCAS1 is a diagnostic marker and outcome predictor in lung cancer patients. Int J Oncol 29: 65-72, 2006
APA
Aoe, K., Hiraki, A., Yamazaki, K., Nakamura, Y., Murakami, T., Maeda, T. ... Ueoka, H. (2006). Elevated pleural fluid RCAS1 is a diagnostic marker and outcome predictor in lung cancer patients. International Journal of Oncology, 29, 65-72. https://doi.org/10.3892/ijo.29.1.65
MLA
Aoe, K., Hiraki, A., Yamazaki, K., Nakamura, Y., Murakami, T., Maeda, T., Nishimura, M., Sugi, K., Ueoka, H."Elevated pleural fluid RCAS1 is a diagnostic marker and outcome predictor in lung cancer patients". International Journal of Oncology 29.1 (2006): 65-72.
Chicago
Aoe, K., Hiraki, A., Yamazaki, K., Nakamura, Y., Murakami, T., Maeda, T., Nishimura, M., Sugi, K., Ueoka, H."Elevated pleural fluid RCAS1 is a diagnostic marker and outcome predictor in lung cancer patients". International Journal of Oncology 29, no. 1 (2006): 65-72. https://doi.org/10.3892/ijo.29.1.65