RALBP1/RLIP76 mediates multidrug resistance

  • Authors:
    • Kenneth J. Drake
    • Jyotsana Singhal
    • Sushma Yadav
    • Aalok Nadkar
    • Chirag Pungaliya
    • Sharad S. Singhal
    • Sanjay Awasthi
  • View Affiliations

  • Published online on: January 1, 2007     https://doi.org/10.3892/ijo.30.1.139
  • Pages: 139-144
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

RLIP76/RALBP1 is a multi-specific drug-transporter which can mediate drug-resistance in lung and other cancers, but its ability to mediate multidrug-resistance has not been previously demonstrated in hematological malignancy. Present studies in K562 human myelogenous leukemia show that RALBP1 overexpression confers broad resistance to multiple chemotherapy drugs including cisplatin, melphalan, doxorubicin, daunorubicin, vincristine, vinblastine, vinorelbine, and mitomycin-C. Conversely, inhibition of RALBP1 by polyclonal antibodies causes increased drug-accumulation and increased cytotoxicity. These studies demonstrate the potential utility of targeting RALBP1 in the treatment of leukemia.

Related Articles

Journal Cover

January 2007
Volume 30 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Drake KJ, Singhal J, Yadav S, Nadkar A, Pungaliya C, Singhal SS and Awasthi S: RALBP1/RLIP76 mediates multidrug resistance. Int J Oncol 30: 139-144, 2007.
APA
Drake, K.J., Singhal, J., Yadav, S., Nadkar, A., Pungaliya, C., Singhal, S.S., & Awasthi, S. (2007). RALBP1/RLIP76 mediates multidrug resistance. International Journal of Oncology, 30, 139-144. https://doi.org/10.3892/ijo.30.1.139
MLA
Drake, K. J., Singhal, J., Yadav, S., Nadkar, A., Pungaliya, C., Singhal, S. S., Awasthi, S."RALBP1/RLIP76 mediates multidrug resistance". International Journal of Oncology 30.1 (2007): 139-144.
Chicago
Drake, K. J., Singhal, J., Yadav, S., Nadkar, A., Pungaliya, C., Singhal, S. S., Awasthi, S."RALBP1/RLIP76 mediates multidrug resistance". International Journal of Oncology 30, no. 1 (2007): 139-144. https://doi.org/10.3892/ijo.30.1.139