Expression of MAC30 protein is related to survival and biological variables in primary and metastatic colorectal cancers

  • Authors:
    • Satish Babu Moparthi
    • Gunnar Arbman
    • Åsa Wallin
    • Hany Kayed
    • Jörg Kleeff
    • Hanswalter Zentgraf
    • Xiao-Feng Sun
  • View Affiliations

  • Published online on: January 1, 2007     https://doi.org/10.3892/ijo.30.1.91
  • Pages: 91-95
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

AC30 is highly expressed in several types of tumors including colorectal cancers, however, its clinicopathological and biological significance in colorectal cancers is currently not known. The aim of our study was to investigate MAC30 expression in distant normal mucosa, adjacent normal mucosa, primary tumors and metastases of colorectal cancer, and to determine the relationship between MAC30 expression and clinicopathological and biological variables. MAC30 expression was immunohistochemically examined in distant normal mucosa (n=54), adjacent normal mucosa (n=123), primary tumors (n=217) and lymph node metastases (n=56) from colorectal cancer patients. MAC30 cytoplasmic expression was increased from distant normal mucosa to primary tumor and to metastasis (p<0.0001-0.04). Furthermore, 40% primary and 37% metastatic tumors showed stronger cytoplasmic expression of MAC30 at the tumor invasive margins compared to inner tumor areas. Strong cytoplasmic expression of MAC30 in the metastasis was related to a poor prognosis (p=0.04). MAC30 cytoplasmic expression was positively related to expression of proliferating cell nuclear antigen (p=0.04), p53 (p=0.04), nucleoporin 88 (p=0.001), legumain (p=0.004) and particularly interesting new cysteine-histidine rich protein (p=0.004). However, MAC30 expression in the nucleus and stroma did not have any clinicopathological and biological significance (p>0.05). In conclusion, MAC30 protein may play a role in development of colorectal cancer, and can be considered as a prognostic factor.

Related Articles

Journal Cover

January 2007
Volume 30 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
APA
Moparthi, S.B., Arbman, G., Wallin, Å., Kayed, H., Kleeff, J., Zentgraf, H., & Sun, X. (2007). Expression of MAC30 protein is related to survival and biological variables in primary and metastatic colorectal cancers. International Journal of Oncology, 30, 91-95. https://doi.org/10.3892/ijo.30.1.91
MLA
Moparthi, S. B., Arbman, G., Wallin, Å., Kayed, H., Kleeff, J., Zentgraf, H., Sun, X."Expression of MAC30 protein is related to survival and biological variables in primary and metastatic colorectal cancers". International Journal of Oncology 30.1 (2007): 91-95.
Chicago
Moparthi, S. B., Arbman, G., Wallin, Å., Kayed, H., Kleeff, J., Zentgraf, H., Sun, X."Expression of MAC30 protein is related to survival and biological variables in primary and metastatic colorectal cancers". International Journal of Oncology 30, no. 1 (2007): 91-95. https://doi.org/10.3892/ijo.30.1.91