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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 2007 Volume 30 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 2007 Volume 30 Issue 4

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Article

Combined effect of green tea and Ganoderma lucidum on invasive behavior of breast cancer cells

  • Authors:
    • Anita Thyagarajan
    • Jiashi Zhu
    • Daniel Sliva

  • View Affiliations / Copyright

    Affiliations: Cancer Research Laboratory, Methodist Research Institute, E504, Indianapolis, IN 46202, USA
  • Pages: 963-969
    |
    Published online on: April 1, 2007
       https://doi.org/10.3892/ijo.30.4.963
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Abstract

Epidemiological studies have suggested that consumption of green tea may decrease the risk of a variety of cancers. In addition, mushroom Ganoderma lucidum has been used for the promotion of health, longevity and treatment of cancer in traditional Chinese medicine. In the present study we show that extract from green tea (GTE) increased the anticancer effect of G. lucidum extract (GLE) on cell proliferation (anchorage-dependent growth) as well as colony formation (anchorage-independent growth) of breast cancer cells. This effect was mediated by the down-regulation of expression of oncogene c-myc in MDA-MB-231 cells. Although individual GTE and GLE independently inhibited adhesion, migration and invasion of MDA-MB-231 cells, their combination demonstrated a synergistic effect, which was mediated by the suppression of secretion of urokinase plasminogen activator (uPA) from breast cancer cells. Our study suggests the potential use of combined green tea and G. lucidum extracts for the suppression of growth and invasiveness of metastatic breast cancers.

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Copy and paste a formatted citation
Spandidos Publications style
Thyagarajan A, Zhu J and Sliva D: Combined effect of green tea and Ganoderma lucidum on invasive behavior of breast cancer cells. Int J Oncol 30: 963-969, 2007.
APA
Thyagarajan, A., Zhu, J., & Sliva, D. (2007). Combined effect of green tea and Ganoderma lucidum on invasive behavior of breast cancer cells. International Journal of Oncology, 30, 963-969. https://doi.org/10.3892/ijo.30.4.963
MLA
Thyagarajan, A., Zhu, J., Sliva, D."Combined effect of green tea and Ganoderma lucidum on invasive behavior of breast cancer cells". International Journal of Oncology 30.4 (2007): 963-969.
Chicago
Thyagarajan, A., Zhu, J., Sliva, D."Combined effect of green tea and Ganoderma lucidum on invasive behavior of breast cancer cells". International Journal of Oncology 30, no. 4 (2007): 963-969. https://doi.org/10.3892/ijo.30.4.963
Copy and paste a formatted citation
x
Spandidos Publications style
Thyagarajan A, Zhu J and Sliva D: Combined effect of green tea and Ganoderma lucidum on invasive behavior of breast cancer cells. Int J Oncol 30: 963-969, 2007.
APA
Thyagarajan, A., Zhu, J., & Sliva, D. (2007). Combined effect of green tea and Ganoderma lucidum on invasive behavior of breast cancer cells. International Journal of Oncology, 30, 963-969. https://doi.org/10.3892/ijo.30.4.963
MLA
Thyagarajan, A., Zhu, J., Sliva, D."Combined effect of green tea and Ganoderma lucidum on invasive behavior of breast cancer cells". International Journal of Oncology 30.4 (2007): 963-969.
Chicago
Thyagarajan, A., Zhu, J., Sliva, D."Combined effect of green tea and Ganoderma lucidum on invasive behavior of breast cancer cells". International Journal of Oncology 30, no. 4 (2007): 963-969. https://doi.org/10.3892/ijo.30.4.963
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