Combined effect of green tea and Ganoderma lucidum on invasive behavior of breast cancer cells

  • Authors:
    • Anita Thyagarajan
    • Jiashi Zhu
    • Daniel Sliva
  • View Affiliations

  • Published online on: April 1, 2007     https://doi.org/10.3892/ijo.30.4.963
  • Pages: 963-969
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Abstract

Epidemiological studies have suggested that consumption of green tea may decrease the risk of a variety of cancers. In addition, mushroom Ganoderma lucidum has been used for the promotion of health, longevity and treatment of cancer in traditional Chinese medicine. In the present study we show that extract from green tea (GTE) increased the anticancer effect of G. lucidum extract (GLE) on cell proliferation (anchorage-dependent growth) as well as colony formation (anchorage-independent growth) of breast cancer cells. This effect was mediated by the down-regulation of expression of oncogene c-myc in MDA-MB-231 cells. Although individual GTE and GLE independently inhibited adhesion, migration and invasion of MDA-MB-231 cells, their combination demonstrated a synergistic effect, which was mediated by the suppression of secretion of urokinase plasminogen activator (uPA) from breast cancer cells. Our study suggests the potential use of combined green tea and G. lucidum extracts for the suppression of growth and invasiveness of metastatic breast cancers.

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April 2007
Volume 30 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Thyagarajan, A., Zhu, J., & Sliva, D. (2007). Combined effect of green tea and Ganoderma lucidum on invasive behavior of breast cancer cells. International Journal of Oncology, 30, 963-969. https://doi.org/10.3892/ijo.30.4.963
MLA
Thyagarajan, A., Zhu, J., Sliva, D."Combined effect of green tea and Ganoderma lucidum on invasive behavior of breast cancer cells". International Journal of Oncology 30.4 (2007): 963-969.
Chicago
Thyagarajan, A., Zhu, J., Sliva, D."Combined effect of green tea and Ganoderma lucidum on invasive behavior of breast cancer cells". International Journal of Oncology 30, no. 4 (2007): 963-969. https://doi.org/10.3892/ijo.30.4.963