Expression and enzymatic activity of dipeptidyl peptidase-IV in human astrocytic tumours are associated with tumour grade

  • Authors:
    • Jarmila Stremenova
    • Evzen Krepela
    • Vladislav Mares
    • Julie Trim
    • Vladimir Dbaly
    • Josef Marek
    • Zdislava Vanickova
    • Vera Lisa
    • Chris Yea
    • Aleksi Sedo
  • View Affiliations

  • Published online on: October 1, 2007     https://doi.org/10.3892/ijo.31.4.785
  • Pages: 785-792
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Abstract

Alterations in dipeptidyl peptidase-IV (DPP-IV) enzymatic activity are characteristic of malignant transformation. Through its well-characterized functionality in regulating the activity of bioactive peptides by removal of the N-terminal dipeptide, DPP-IV activity may have profound effects upon metastatic potential and cell growth. Although DPP-IV/CD26 (EC 3.4.14.5) is the canonical representative of the group, a number of other proteins including DPP-7, 8, 9, and seprase/fibroblast activation protein-α (FAP-α) have been shown to have similar enzymatic activity. This study was set up to address the relative representation and enzymatic activity of plasma membrane localized DPP-IV/CD26 and FAP-α in human brain and astrocytic tumours. In parallel, expression of CXCR4, receptor for glioma cell growth stimulator chemokine SDF-1α known to be a DPP-IV substrate, was investigated. This is the first report showing that non-malignant brain tissue contains a DPP-IV-like enzymatic activity attributable mostly to DPP-8/9, while the substantial part of the activity in glioma is due to increased DPP-IV/CD26, localized in both the vascular and parenchymal compartments. DPP-IV enzymatic activity increased dramatically with tumour grade severity. A grade-related increase in CXCR4 receptor paralleled the rise in DPP-IV expression and activity. These data might support a role for DPP-IV regulation of the CXCR4-SDF-1α axis in glioma development.

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October 2007
Volume 31 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Stremenova J, Krepela E, Mares V, Trim J, Dbaly V, Marek J, Vanickova Z, Lisa V, Yea C, Sedo A, Sedo A, et al: Expression and enzymatic activity of dipeptidyl peptidase-IV in human astrocytic tumours are associated with tumour grade. Int J Oncol 31: 785-792, 2007
APA
Stremenova, J., Krepela, E., Mares, V., Trim, J., Dbaly, V., Marek, J. ... Sedo, A. (2007). Expression and enzymatic activity of dipeptidyl peptidase-IV in human astrocytic tumours are associated with tumour grade. International Journal of Oncology, 31, 785-792. https://doi.org/10.3892/ijo.31.4.785
MLA
Stremenova, J., Krepela, E., Mares, V., Trim, J., Dbaly, V., Marek, J., Vanickova, Z., Lisa, V., Yea, C., Sedo, A."Expression and enzymatic activity of dipeptidyl peptidase-IV in human astrocytic tumours are associated with tumour grade". International Journal of Oncology 31.4 (2007): 785-792.
Chicago
Stremenova, J., Krepela, E., Mares, V., Trim, J., Dbaly, V., Marek, J., Vanickova, Z., Lisa, V., Yea, C., Sedo, A."Expression and enzymatic activity of dipeptidyl peptidase-IV in human astrocytic tumours are associated with tumour grade". International Journal of Oncology 31, no. 4 (2007): 785-792. https://doi.org/10.3892/ijo.31.4.785