Open Access

VEGF-C and VEGF-D expression is correlated with lymphatic vessel density and lymph node metastasis in oral squamous cell carcinoma: Implications for use as a prognostic marker

  • Authors:
    • Tsuyoshi Sugiura
    • Yoshiko Inoue
    • Ryosuke Matsuki
    • Kotaro Ishii
    • Miho Takahashi
    • Masakazu Abe
    • Kanemitsu Shirasuna
  • View Affiliations

  • Published online on: March 1, 2009     https://doi.org/10.3892/ijo_00000193
  • Pages: 673-680
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Abstract

The prognosis of patients with oral squamous cell carcinoma (SCC) is influenced by the presence of lymph node metastasis. In this study, we analyzed the relationship between lymphangiogenesis and the expression of VEGF-C and VEGF-D in association with lymph node metastasis in oral SCC. Oral SCC biopsy specimens (160 cases) were examined for lymphatic vessel density (LVD) and the expression of VEGF-C and VEGF-D immunohistochemically. The levels of VEGF-C and VEGF-D expression and LVD were significantly associated with lymph node metastasis (p<0.001). The expression of VEGF-C and VEGF-D increased the LVD significantly (p<0.001). Multivariate analysis showed that VEGF-C expression and LVD were significantly associated with lymph node metastasis (p<0.001). This study presents clinical evidence for the important roles of VEGF-C and VEGF-D in lymphangiogenesis and lymphatic metastasis of oral SCC, and suggests that VEGF-C or LVD can effectively predict lymphatic metastasis of oral SCC.

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March 2009
Volume 34 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Sugiura T, Inoue Y, Matsuki R, Ishii K, Takahashi M, Abe M and Shirasuna K: VEGF-C and VEGF-D expression is correlated with lymphatic vessel density and lymph node metastasis in oral squamous cell carcinoma: Implications for use as a prognostic marker. Int J Oncol 34: 673-680, 2009.
APA
Sugiura, T., Inoue, Y., Matsuki, R., Ishii, K., Takahashi, M., Abe, M., & Shirasuna, K. (2009). VEGF-C and VEGF-D expression is correlated with lymphatic vessel density and lymph node metastasis in oral squamous cell carcinoma: Implications for use as a prognostic marker. International Journal of Oncology, 34, 673-680. https://doi.org/10.3892/ijo_00000193
MLA
Sugiura, T., Inoue, Y., Matsuki, R., Ishii, K., Takahashi, M., Abe, M., Shirasuna, K."VEGF-C and VEGF-D expression is correlated with lymphatic vessel density and lymph node metastasis in oral squamous cell carcinoma: Implications for use as a prognostic marker". International Journal of Oncology 34.3 (2009): 673-680.
Chicago
Sugiura, T., Inoue, Y., Matsuki, R., Ishii, K., Takahashi, M., Abe, M., Shirasuna, K."VEGF-C and VEGF-D expression is correlated with lymphatic vessel density and lymph node metastasis in oral squamous cell carcinoma: Implications for use as a prognostic marker". International Journal of Oncology 34, no. 3 (2009): 673-680. https://doi.org/10.3892/ijo_00000193