Cetuximab inhibits growth, peritoneal dissemination, and lymph node and lung metastasis of endometrial cancer, and prolongs host survival

  • Authors:
    • Kayoko Takahashi
    • Yasushi Saga
    • Hiroyuki Mizukami
    • Yuji Takei
    • Shizuo Machida
    • Hiroyuki Fujiwara
    • Keiya Ozawa
    • Mitsuaki Suzuki
  • View Affiliations

  • Published online on: October 1, 2009     https://doi.org/10.3892/ijo_00000385
  • Pages: 725-729
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Abstract

The purpose of this study was to explore the possibility of molecular-targeted therapy with anti-epidermal growth factor receptor (EGFR) antibody (cetuximab) for endometrial cancer to develop a new treatment for advanced endometrial cancer. We analyzed EGFR protein expression and gene mutations in the human endometrial cancer cell line HEC1A, and evaluated the in vitro and in vivo effects of cetuximab on HEC1A. EGFR expression was observed in HEC1A cells, but no mutations in the EGFR gene were detected. Cetuximab inhibited HEC1A cell growth and invasion and VEGF-A production in vitro, and HECIA cell tumor growth, its peritoneal dissemination with ascites, and lymph node and lung metastasis in vivo. In addition, the antibody prolonged the survival of a mouse model of systemic metastasis. These results suggest the possibility of molecular-targeted therapy using cetuximab for endometrial cancer.

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October 2009
Volume 35 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Takahashi K, Saga Y, Mizukami H, Takei Y, Machida S, Fujiwara H, Ozawa K and Suzuki M: Cetuximab inhibits growth, peritoneal dissemination, and lymph node and lung metastasis of endometrial cancer, and prolongs host survival. Int J Oncol 35: 725-729, 2009.
APA
Takahashi, K., Saga, Y., Mizukami, H., Takei, Y., Machida, S., Fujiwara, H. ... Suzuki, M. (2009). Cetuximab inhibits growth, peritoneal dissemination, and lymph node and lung metastasis of endometrial cancer, and prolongs host survival. International Journal of Oncology, 35, 725-729. https://doi.org/10.3892/ijo_00000385
MLA
Takahashi, K., Saga, Y., Mizukami, H., Takei, Y., Machida, S., Fujiwara, H., Ozawa, K., Suzuki, M."Cetuximab inhibits growth, peritoneal dissemination, and lymph node and lung metastasis of endometrial cancer, and prolongs host survival". International Journal of Oncology 35.4 (2009): 725-729.
Chicago
Takahashi, K., Saga, Y., Mizukami, H., Takei, Y., Machida, S., Fujiwara, H., Ozawa, K., Suzuki, M."Cetuximab inhibits growth, peritoneal dissemination, and lymph node and lung metastasis of endometrial cancer, and prolongs host survival". International Journal of Oncology 35, no. 4 (2009): 725-729. https://doi.org/10.3892/ijo_00000385