Curcumin analogue GO-Y030 inhibits STAT3 activity and cell growth in breast and pancreatic carcinomas

  • Authors:
    • Brian Hutzen
    • Lauren Friedman
    • Matthew Sobo
    • Li Lin
    • Ling Cen
    • Stephanie De Angelis
    • Hiroyuki Yamakoshi
    • Hiroyuki Shibata
    • Yoshiharu Iwabuchi
    • Jiayuh Lin
  • View Affiliations

  • Published online on: October 1, 2009     https://doi.org/10.3892/ijo_00000401
  • Pages: 867-872
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Abstract

Curcumin has numerous anti-carcinogenic properties, but low bioavailability prevents its use in chemotherapeutic applications. One strategy for circumventing this problem has been the creation of synthetic analogues. We tested the efficacy of an analogue known as GO-Y030 in human breast and pancreatic cancer cells. We compared the impact of curcumin and GO-Y030 on the breast cancer cell line MDA-MB-231 and pancreatic cancer cell lines, PANC-1, HPAC and BXPC-3. Both compounds reduced cell viability and induced apoptosis, but GO-Y030 was substantially more potent. We also demonstrated that GO-Y030 was capable of interfering with STAT3, a persistently activated transcription factor in many cancer types. GO-Y030 inhibited STAT3 phosphorylation and transcriptional activity whereas comparable dosages of curcumin had little or no effect. These results indicate that GO-Y030 is a potent inhibitor of cell viability and STAT3 activation, and may thus have potential as a therapeutic agent for cancers expressing high levels of activated STAT3.

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October 2009
Volume 35 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Hutzen B, Friedman L, Sobo M, Lin L, Cen L, De Angelis S, Yamakoshi H, Shibata H, Iwabuchi Y, Lin J, Lin J, et al: Curcumin analogue GO-Y030 inhibits STAT3 activity and cell growth in breast and pancreatic carcinomas. Int J Oncol 35: 867-872, 2009.
APA
Hutzen, B., Friedman, L., Sobo, M., Lin, L., Cen, L., De Angelis, S. ... Lin, J. (2009). Curcumin analogue GO-Y030 inhibits STAT3 activity and cell growth in breast and pancreatic carcinomas. International Journal of Oncology, 35, 867-872. https://doi.org/10.3892/ijo_00000401
MLA
Hutzen, B., Friedman, L., Sobo, M., Lin, L., Cen, L., De Angelis, S., Yamakoshi, H., Shibata, H., Iwabuchi, Y., Lin, J."Curcumin analogue GO-Y030 inhibits STAT3 activity and cell growth in breast and pancreatic carcinomas". International Journal of Oncology 35.4 (2009): 867-872.
Chicago
Hutzen, B., Friedman, L., Sobo, M., Lin, L., Cen, L., De Angelis, S., Yamakoshi, H., Shibata, H., Iwabuchi, Y., Lin, J."Curcumin analogue GO-Y030 inhibits STAT3 activity and cell growth in breast and pancreatic carcinomas". International Journal of Oncology 35, no. 4 (2009): 867-872. https://doi.org/10.3892/ijo_00000401