The antitumor effect of PLK1 and HSF1 double knockdown on human oral carcinoma cells

  • Authors:
    • Soo-A Kim
    • Seong-Min Kwon
    • Jung-Hoon Yoon
    • Sang-Gun Ahn
  • View Affiliations

  • Published online on: April 1, 2010     https://doi.org/10.3892/ijo_00000564
  • Pages: 867-872
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Abstract

High levels of mitotic progression-associated PLK1 and stress-associated HSF1 have been observed in various human cancers. In the present study, we investigated the effects of PLK1 and HSF1 knockdown on the proliferation of oral cancer cells using small interfering RNA. In human oral squamous cell carcinoma (SCC) tissues, the levels of PLK1 and HSF1 were higher compared to normal tissues. The expression levels of PLK1 and HSF1 were also elevated in the human oral SCC cell lines FaDu and HEp-2. Disruption of PLK1 induced cell cycle arrest at G2/M phase as well as apoptosis in oral cancer cells. Interestingly, knockdown of both PLK1 and HSF1 expression decreased cell proliferation while increasing apoptotic cell death in synergistic fashion. These results establish the potential value of PLK1 and HSF1 as targets for oral cancer therapy.

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April 2010
Volume 36 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Kim S, Kwon S, Yoon J and Ahn S: The antitumor effect of PLK1 and HSF1 double knockdown on human oral carcinoma cells. Int J Oncol 36: 867-872, 2010
APA
Kim, S., Kwon, S., Yoon, J., & Ahn, S. (2010). The antitumor effect of PLK1 and HSF1 double knockdown on human oral carcinoma cells. International Journal of Oncology, 36, 867-872. https://doi.org/10.3892/ijo_00000564
MLA
Kim, S., Kwon, S., Yoon, J., Ahn, S."The antitumor effect of PLK1 and HSF1 double knockdown on human oral carcinoma cells". International Journal of Oncology 36.4 (2010): 867-872.
Chicago
Kim, S., Kwon, S., Yoon, J., Ahn, S."The antitumor effect of PLK1 and HSF1 double knockdown on human oral carcinoma cells". International Journal of Oncology 36, no. 4 (2010): 867-872. https://doi.org/10.3892/ijo_00000564