Isostrychnopentamine, an indolomonoterpenic alkaloid from Strychnos usambarensis, with potential anti-tumor activity against apoptosis-resistant cancer cells

Corrigendum in: /ijo/36/5/1315

  • Authors:
    • El-Hadj Saidou Balde
    • Véronique Mégalizzi
    • Martine Cao
    • Luc Angenot
    • Robert Kiss
    • Marc Van Damme
    • Michel Frederich
  • View Affiliations

  • Published online on: April 1, 2010     https://doi.org/10.3892/ijo_00000575
  • Pages: 961-965
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Abstract

Isostrychnopentamine (ISP) is an indolomonoter-penic alkaloid that is present in the leaves of Strychnos usambarensis, an East African small tree. We have reported previously pro-apoptotic effects induced in vitro by ISP in the human HCT-116 colon cancer cell line, a model that displays relative sensitivity to apoptosis. In the present study, we observed that the in vitro growth inhibitory activities of ISP are similar in cancer cells that display sensitivity versus resistance to apoptosis. We made use of the U373 glioblastoma and the A549 non-small cell lung cancer (NSCLC) cell lines as models relatively resistant to apoptosis, and the human PC-3 prostate cancer cell line as a model relatively sensitive to apoptosis. While ISP induced transient decreases in [ATP]i and apoptosis in human U373 GBM cells, it did not provoke such features in A549 NSCLC cells. It thus seems that ISP-induced anti-cancer activity can lead to pro-apoptotic effects as a consequence, while apoptosis seems not to be the main cause by which ISP induces cancer cell death. ISP is a compound that merits further investigations in order to: i) identify the mechanism(s) of action by which it kills cancer cells, and ii) hemisynthesize novel ISP derivatives aiming to overcome, at least partly, the resistance of metastatic cancers to apoptosis. Corrigendum in http://www.spandidos-publications.com/10.3892/ijo.2013.2213

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April 2010
Volume 36 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Saidou Balde E, Mégalizzi V, Cao M, Angenot L, Kiss R, Van Damme M and Frederich M: Isostrychnopentamine, an indolomonoterpenic alkaloid from Strychnos usambarensis, with potential anti-tumor activity against apoptosis-resistant cancer cells Corrigendum in /ijo/36/5/1315. Int J Oncol 36: 961-965, 2010.
APA
Saidou Balde, E., Mégalizzi, V., Cao, M., Angenot, L., Kiss, R., Van Damme, M., & Frederich, M. (2010). Isostrychnopentamine, an indolomonoterpenic alkaloid from Strychnos usambarensis, with potential anti-tumor activity against apoptosis-resistant cancer cells Corrigendum in /ijo/36/5/1315. International Journal of Oncology, 36, 961-965. https://doi.org/10.3892/ijo_00000575
MLA
Saidou Balde, E., Mégalizzi, V., Cao, M., Angenot, L., Kiss, R., Van Damme, M., Frederich, M."Isostrychnopentamine, an indolomonoterpenic alkaloid from Strychnos usambarensis, with potential anti-tumor activity against apoptosis-resistant cancer cells Corrigendum in /ijo/36/5/1315". International Journal of Oncology 36.4 (2010): 961-965.
Chicago
Saidou Balde, E., Mégalizzi, V., Cao, M., Angenot, L., Kiss, R., Van Damme, M., Frederich, M."Isostrychnopentamine, an indolomonoterpenic alkaloid from Strychnos usambarensis, with potential anti-tumor activity against apoptosis-resistant cancer cells Corrigendum in /ijo/36/5/1315". International Journal of Oncology 36, no. 4 (2010): 961-965. https://doi.org/10.3892/ijo_00000575