Differential expression of the CCN family member WISP-1, WISP-2 and WISP-3 in human colorectal cancer and the prognostic implications

  • Authors:
    • Simon R. Davies
    • Mansel Leigh Davies
    • Andrew Sanders
    • Chris Parr
    • Jared Torkington
    • Wen G. Jiang
  • View Affiliations

  • Published online on: May 1, 2010     https://doi.org/10.3892/ijo_00000595
  • Pages:1129-1136
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Abstract

The WISPs (Wnt-inducted secreted proteins, WISP-1, WISP-2 and WISP-3) are part of the CCN family. These molecules are known to play a diverse role in cells but their role in cancer cells remains controversial. We analysed the expression of the three WISP molecules at the mRNA and protein levels in a cohort of 94 human colorectal tumours and 80 normal colorectal tissues and correlated the results with the pathological features and clinical outcome of the patients. WISP-1 transcripts were found at higher levels in the tumour samples than in the normal tissue (p=0.0015); higher in patients with Dukes stage B and C compared to Dukes A (p=0.017 and p=0.024, respectively); higher in patients with moderately and poorly differentiated cancers compared to the well differentiated cancers (p=0.020 and p=0.076, respectively and p=0.0035 when combined); higher in node positive tumours compared with the node negative (p=0.11) and in the patients with higher TNM staging (TNM 2, 3 and 4 compared to TNM 1 p=0.037). WISP-2 showed the opposite pattern with lower levels of expression in cancer cells compared to normal (p=0.082). Although no significant differences were found within the cancer group when indices of a more aggressive tumour were compared to the normal tissue a significant reduction in expression was found (Dukes C p=0.044, poorly differentiated p=0.019, TNM 3 p=0.020 and node positive disease p=0.048). WISP-3 transcript levels showed no significant differences between groups. WISPs may play important but contrasting roles in colorectal cancer with WISP-1 appearing to act as a factor stimulating aggressiveness, WISP-2 as a tumour suppressor and WISP-3 having no definable beneficial or detrimental role.

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May 2010
Volume 36 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

2016 Impact Factor: 3.079
Ranked #33/217 Oncology
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APA
Davies, S.R., Davies, M.L., Sanders, A., Parr, C., Torkington, J., & Jiang, W.G. (2010). Differential expression of the CCN family member WISP-1, WISP-2 and WISP-3 in human colorectal cancer and the prognostic implications. International Journal of Oncology, 36, 1129-1136. https://doi.org/10.3892/ijo_00000595
MLA
Davies, S. R., Davies, M. L., Sanders, A., Parr, C., Torkington, J., Jiang, W. G."Differential expression of the CCN family member WISP-1, WISP-2 and WISP-3 in human colorectal cancer and the prognostic implications". International Journal of Oncology 36.5 (2010): 1129-1136.
Chicago
Davies, S. R., Davies, M. L., Sanders, A., Parr, C., Torkington, J., Jiang, W. G."Differential expression of the CCN family member WISP-1, WISP-2 and WISP-3 in human colorectal cancer and the prognostic implications". International Journal of Oncology 36, no. 5 (2010): 1129-1136. https://doi.org/10.3892/ijo_00000595