Open Access

Identification and characterization of early growth response 2, a zinc-finger transcription factor, as a p53-regulated proapoptotic gene

  • Authors:
    • Ikuko Yokota
    • Yasushi Sasaki
    • Lisa Kashima
    • Masashi Idogawa
    • Takashi Tokino
  • View Affiliations

  • Published online on: December 1, 2010     https://doi.org/10.3892/ijo_00000792
  • Pages: 1407-1416
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Abstract

Tumor suppressor p53 is a transcription factor that induces growth arrest and/or apoptosis in response to cellular stress. In recent years, many genes have been identified as p53-regulated genes; however, no single target gene has been shown to be required for the apoptotic effect. Using microarray analysis, we have identified the transcription factor early growth response 2 (EGR2) as a target of the p53 family, specifically p53, p63 and p73. EGR2 expression was up-regulated by DNA damage-induced p53 activity, as well as by overexpression of p53 family genes. Furthermore, we identified a responsive element to p53, TAp63, and TAp73 within the EGR2 gene. This response element is highly conserved between human and rodents. We also found that overexpression of EGR2 induced apoptosis when combined with anticancer agents. Conversely, inactivation of EGR2 attenuated p53-mediated apoptosis. The results presented here suggest that EGR2 is a direct transcriptional target of p53 family that can in part mediate the p53-dependent apoptotic pathway.

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December 2010
Volume 37 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Yokota I, Sasaki Y, Kashima L, Idogawa M and Tokino T: Identification and characterization of early growth response 2, a zinc-finger transcription factor, as a p53-regulated proapoptotic gene. Int J Oncol 37: 1407-1416, 2010
APA
Yokota, I., Sasaki, Y., Kashima, L., Idogawa, M., & Tokino, T. (2010). Identification and characterization of early growth response 2, a zinc-finger transcription factor, as a p53-regulated proapoptotic gene. International Journal of Oncology, 37, 1407-1416. https://doi.org/10.3892/ijo_00000792
MLA
Yokota, I., Sasaki, Y., Kashima, L., Idogawa, M., Tokino, T."Identification and characterization of early growth response 2, a zinc-finger transcription factor, as a p53-regulated proapoptotic gene". International Journal of Oncology 37.6 (2010): 1407-1416.
Chicago
Yokota, I., Sasaki, Y., Kashima, L., Idogawa, M., Tokino, T."Identification and characterization of early growth response 2, a zinc-finger transcription factor, as a p53-regulated proapoptotic gene". International Journal of Oncology 37, no. 6 (2010): 1407-1416. https://doi.org/10.3892/ijo_00000792