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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2011 Volume 39 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2011 Volume 39 Issue 6

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Article

Expression of LDL-A module of relaxin receptor in prostate cancer cells inhibits tumorigenesis

  • Authors:
    • Shu Feng
    • Alexander I. Agoulnik

  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA, Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, 11200 SW 8th Street, HLSI 419B, Miami, FL 33199, USA
  • Pages: 1559-1565
    |
    Published online on: August 12, 2011
       https://doi.org/10.3892/ijo.2011.1159
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Abstract

Peptide hormone relaxin produced in normal and cancer prostate cells can stimulate prostate cancer progression. Suppression of relaxin or relaxin receptor RXFP1 expression inhibited prostate cancer both in vitro and in vivo. RXFP1 is a G protein-coupled receptor with the extracellular low density lipoprotein A (LDL-A) module located at the N-terminus. The LDL-A module exhibits a competitive inhibition effect on the RXFP1 function and might be used to suppress relaxin signaling. In this study, we investigated the effect of LDL-A overexpression on prostate cancer cells. PC3 cells expressing the RXFP1-LDL-A module had a decreased proliferation, soft agar colony formation, adhesion, invasion in vitro, and grew at a slower rate than control cells as tumors in xenograft models in mice. Expression analysis revealed that the RXFP1-LDL-A expression in PC3 cells inhibited Akt phosphorylation and MMP2 activation, and led to the down-regulation of several genes previously implicated in tumorigenesis, such as MMP28, S100P, IGFBP2, MUC1 and S100A4. These results indicate that the inhibition of RXFP1 by peptide based on the LDL-A module of this receptor may be a potential approach for prostate cancer suppression.

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Copy and paste a formatted citation
Spandidos Publications style
Feng S and Agoulnik A : Expression of LDL-A module of relaxin receptor in prostate cancer cells inhibits tumorigenesis. Int J Oncol 39: 1559-1565, 2011.
APA
Feng, S., & Agoulnik, A. . (2011). Expression of LDL-A module of relaxin receptor in prostate cancer cells inhibits tumorigenesis. International Journal of Oncology, 39, 1559-1565. https://doi.org/10.3892/ijo.2011.1159
MLA
Feng, S., Agoulnik, A. ."Expression of LDL-A module of relaxin receptor in prostate cancer cells inhibits tumorigenesis". International Journal of Oncology 39.6 (2011): 1559-1565.
Chicago
Feng, S., Agoulnik, A. ."Expression of LDL-A module of relaxin receptor in prostate cancer cells inhibits tumorigenesis". International Journal of Oncology 39, no. 6 (2011): 1559-1565. https://doi.org/10.3892/ijo.2011.1159
Copy and paste a formatted citation
x
Spandidos Publications style
Feng S and Agoulnik A : Expression of LDL-A module of relaxin receptor in prostate cancer cells inhibits tumorigenesis. Int J Oncol 39: 1559-1565, 2011.
APA
Feng, S., & Agoulnik, A. . (2011). Expression of LDL-A module of relaxin receptor in prostate cancer cells inhibits tumorigenesis. International Journal of Oncology, 39, 1559-1565. https://doi.org/10.3892/ijo.2011.1159
MLA
Feng, S., Agoulnik, A. ."Expression of LDL-A module of relaxin receptor in prostate cancer cells inhibits tumorigenesis". International Journal of Oncology 39.6 (2011): 1559-1565.
Chicago
Feng, S., Agoulnik, A. ."Expression of LDL-A module of relaxin receptor in prostate cancer cells inhibits tumorigenesis". International Journal of Oncology 39, no. 6 (2011): 1559-1565. https://doi.org/10.3892/ijo.2011.1159
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