Carboxyl-terminal modulator protein induces apoptosis by regulating mitochondrial function in lung cancer cells

  • Authors:
    • Soon-Kyung Hwang
    • Arash Minai-Tehrani
    • Kyeong-Nam Yu
    • Seung-Hee Chang
    • Ji-Eun Kim
    • Kee-Ho Lee
    • Jongsun Park
    • George R. Beck
    • Myung-Haing Cho
  • View Affiliations

  • Published online on: December 23, 2011     https://doi.org/10.3892/ijo.2011.1319
  • Pages: 1515-1524
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Abstract

Serine/threonine protein kinase B (PKB/Akt) is involved in cell survival and growth. Carboxyl-terminal modulator protein (CTMP), a novel Akt binding partner, prevents Akt activation at the plasma membrane in response to various stimuli, and thus possesses a tumor suppressor-like function. In a previous study, we have demonstrated that CTMP inhibits tumor progression by facilitating apoptosis in a mouse lung cancer model. However, the precise mechanism of CTMP-induced apoptosis remains to be elucidated. The present study was performed to examine the role of CTMP in mitochondrial-mediated apoptosis and regulation of mitochondrial function in human lung carcinoma cells. Our results showed that CTMP altered mitochondrial morphology and caused the release of cytochrome c by inhibiting OPA1 expression. Additionally, CTMP facilitated mitochondrial-mediated apoptosis by inhibiting heat-shock protein 27 and preventing cytochrome c interaction with Apaf-1. Our data suggest that CTMP may therefore play a critical role in mitochondrial-mediated apoptosis in lung cancer cells.

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May 2012
Volume 40 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Hwang S, Minai-Tehrani A, Yu K, Chang S, Kim J, Lee K, Park J, Beck GR and Cho M: Carboxyl-terminal modulator protein induces apoptosis by regulating mitochondrial function in lung cancer cells. Int J Oncol 40: 1515-1524, 2012
APA
Hwang, S., Minai-Tehrani, A., Yu, K., Chang, S., Kim, J., Lee, K. ... Cho, M. (2012). Carboxyl-terminal modulator protein induces apoptosis by regulating mitochondrial function in lung cancer cells. International Journal of Oncology, 40, 1515-1524. https://doi.org/10.3892/ijo.2011.1319
MLA
Hwang, S., Minai-Tehrani, A., Yu, K., Chang, S., Kim, J., Lee, K., Park, J., Beck , G. R., Cho, M."Carboxyl-terminal modulator protein induces apoptosis by regulating mitochondrial function in lung cancer cells". International Journal of Oncology 40.5 (2012): 1515-1524.
Chicago
Hwang, S., Minai-Tehrani, A., Yu, K., Chang, S., Kim, J., Lee, K., Park, J., Beck , G. R., Cho, M."Carboxyl-terminal modulator protein induces apoptosis by regulating mitochondrial function in lung cancer cells". International Journal of Oncology 40, no. 5 (2012): 1515-1524. https://doi.org/10.3892/ijo.2011.1319