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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 2012 Volume 40 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2012 Volume 40 Issue 5

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Article

Aspirin enhances doxorubicin-induced apoptosis and reduces tumor growth in human hepatocellular carcinoma cells in vitro and in vivo

  • Authors:
    • Mohammad Akbar Hossain
    • Dong Hwan Kim
    • Jung Yoon Jang
    • Yong Jung Kang
    • Jeong-Hyun Yoon
    • Jeon-Ok Moon
    • Hae Young Chung
    • Gi-Young Kim
    • Yung Hyun Choi
    • Bryan L. Copple
    • Nam Deuk Kim

  • View Affiliations / Copyright

    Affiliations: Division of Pharmacy, College of Pharmacy, Molecular Inflammation Research Center for Aging Intervention (MRCA), Pusan National University, Busan 609-735, Republic of Korea, Faculty of Applied Marine Science, Cheju National University, Jeju 690-756, Republic of Korea, Department of Biomaterial Control (BK21 Program), Dongeui University Graduate School, Busan 614-052, Republic of Korea, Department of Pharmacology and Toxicology, Μichigan State University, East Lansing, MI 48824, USA
  • Pages: 1636-1642
    |
    Published online on: February 7, 2012
       https://doi.org/10.3892/ijo.2012.1359
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Abstract

Combined therapy with multiple drugs is a common practice in the treatment of cancer, which can achieve better therapeutic effects than a single drug, and can reduce the side effects as well as drug resistance. This study aimed to determine whether aspirin (ASA) shows synergism with doxorubicin (DOX) in HepG2 human hepatocellular carcinoma cells in vitro and in a HepG2 cell xenograft model in BALB/c nude mice. When treated in combination, DOX (0.25 nmol/ml) and ASA (5 µmol/ml) produced strong synergy in growth inhibition, cell cycle arrest and importantly, apoptosis in vitro in comparison to single treatments. Moreover, ASA (100 mg/kg/day orally) and DOX (1.2 mg/kg biweekly ip) induced synergistic antitumor activity in the HepG2 cell xenograft model in nude mice. Therefore, the combination of ASA and DOX could be used as a novel combination regimen which provides a strong anticancer synergy in the treatment of hepatocellular carcinoma.

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Copy and paste a formatted citation
Spandidos Publications style
Hossain MA, Kim DH, Jang JY, Kang YJ, Yoon J, Moon J, Chung HY, Kim G, Choi YH, Copple BL, Copple BL, et al: Aspirin enhances doxorubicin-induced apoptosis and reduces tumor growth in human hepatocellular carcinoma cells in vitro and in vivo. Int J Oncol 40: 1636-1642, 2012.
APA
Hossain, M.A., Kim, D.H., Jang, J.Y., Kang, Y.J., Yoon, J., Moon, J. ... Kim, N.D. (2012). Aspirin enhances doxorubicin-induced apoptosis and reduces tumor growth in human hepatocellular carcinoma cells in vitro and in vivo. International Journal of Oncology, 40, 1636-1642. https://doi.org/10.3892/ijo.2012.1359
MLA
Hossain, M. A., Kim, D. H., Jang, J. Y., Kang, Y. J., Yoon, J., Moon, J., Chung, H. Y., Kim, G., Choi, Y. H., Copple, B. L., Kim, N. D."Aspirin enhances doxorubicin-induced apoptosis and reduces tumor growth in human hepatocellular carcinoma cells in vitro and in vivo". International Journal of Oncology 40.5 (2012): 1636-1642.
Chicago
Hossain, M. A., Kim, D. H., Jang, J. Y., Kang, Y. J., Yoon, J., Moon, J., Chung, H. Y., Kim, G., Choi, Y. H., Copple, B. L., Kim, N. D."Aspirin enhances doxorubicin-induced apoptosis and reduces tumor growth in human hepatocellular carcinoma cells in vitro and in vivo". International Journal of Oncology 40, no. 5 (2012): 1636-1642. https://doi.org/10.3892/ijo.2012.1359
Copy and paste a formatted citation
x
Spandidos Publications style
Hossain MA, Kim DH, Jang JY, Kang YJ, Yoon J, Moon J, Chung HY, Kim G, Choi YH, Copple BL, Copple BL, et al: Aspirin enhances doxorubicin-induced apoptosis and reduces tumor growth in human hepatocellular carcinoma cells in vitro and in vivo. Int J Oncol 40: 1636-1642, 2012.
APA
Hossain, M.A., Kim, D.H., Jang, J.Y., Kang, Y.J., Yoon, J., Moon, J. ... Kim, N.D. (2012). Aspirin enhances doxorubicin-induced apoptosis and reduces tumor growth in human hepatocellular carcinoma cells in vitro and in vivo. International Journal of Oncology, 40, 1636-1642. https://doi.org/10.3892/ijo.2012.1359
MLA
Hossain, M. A., Kim, D. H., Jang, J. Y., Kang, Y. J., Yoon, J., Moon, J., Chung, H. Y., Kim, G., Choi, Y. H., Copple, B. L., Kim, N. D."Aspirin enhances doxorubicin-induced apoptosis and reduces tumor growth in human hepatocellular carcinoma cells in vitro and in vivo". International Journal of Oncology 40.5 (2012): 1636-1642.
Chicago
Hossain, M. A., Kim, D. H., Jang, J. Y., Kang, Y. J., Yoon, J., Moon, J., Chung, H. Y., Kim, G., Choi, Y. H., Copple, B. L., Kim, N. D."Aspirin enhances doxorubicin-induced apoptosis and reduces tumor growth in human hepatocellular carcinoma cells in vitro and in vivo". International Journal of Oncology 40, no. 5 (2012): 1636-1642. https://doi.org/10.3892/ijo.2012.1359
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