Connexin 43 interacts with Bax to regulate apoptosis of pancreatic cancer through a gap junction-independent pathway

  • Authors:
    • Yan Sun
    • Xiaoping Zhao
    • Yuting Yao
    • Xinyi Qi
    • Yaozong Yuan
    • Yu Hu
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  • Published online on: June 20, 2012     https://doi.org/10.3892/ijo.2012.1524
  • Pages: 941-948
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Abstract

Connexins play important roles in many physiological and pathological processes. Although connexins are considered as tumor suppressors in several types of cancer, their roles in pancreatic cancer are unknown. In this study, we found that connexin 43 (Cx43) caused apparent apoptosis and growth inhibition in pancreatic cancer cells. The tumor-suppressive role of Cx43 was independent of the canonical gap junction pathway. In the context of apoptosis, Cx43 translocated to the mitochondria, where it interacted with Bax to initiate the mitochondrial apoptotic pathway. Following further examination of the Cx43 protein, we found that the 241-382aa region of Cx43 was required for interaction with Bax. Furthermore, this region was responsible for permeabilizing mitochondrial membrane potential. The results from the present study elucidate a novel mechanism of the Cx43-mediated regulation of apoptosis in pancreatic cancer.
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September 2012
Volume 41 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Sun Y, Zhao X, Yao Y, Qi X, Yuan Y and Hu Y: Connexin 43 interacts with Bax to regulate apoptosis of pancreatic cancer through a gap junction-independent pathway. Int J Oncol 41: 941-948, 2012.
APA
Sun, Y., Zhao, X., Yao, Y., Qi, X., Yuan, Y., & Hu, Y. (2012). Connexin 43 interacts with Bax to regulate apoptosis of pancreatic cancer through a gap junction-independent pathway. International Journal of Oncology, 41, 941-948. https://doi.org/10.3892/ijo.2012.1524
MLA
Sun, Y., Zhao, X., Yao, Y., Qi, X., Yuan, Y., Hu, Y."Connexin 43 interacts with Bax to regulate apoptosis of pancreatic cancer through a gap junction-independent pathway". International Journal of Oncology 41.3 (2012): 941-948.
Chicago
Sun, Y., Zhao, X., Yao, Y., Qi, X., Yuan, Y., Hu, Y."Connexin 43 interacts with Bax to regulate apoptosis of pancreatic cancer through a gap junction-independent pathway". International Journal of Oncology 41, no. 3 (2012): 941-948. https://doi.org/10.3892/ijo.2012.1524