Journal Articles

Open Access

Epimutation and cancer: a new carcinogenic mechanism of Lynch syndrome (Review)

Kouji Banno, Iori Kisu, Megumi Yanokura, Kosuke Tsuji, Kenta Masuda, Arisa Ueki, Yusuke Kobayashi, Wataru Yamagami, Hiroyuki Nomura, Eiichiro Tominaga, Nobuyuki Susumu, Daisuke Aoki

Pages: 793-797 Published online on: 25 June 2012
Open Access

Tumor suppressive microRNA‑138 contributes to cell migration and invasion through its targeting of vimentin in renal cell carcinoma

Takeshi Yamasaki, Naohiko Seki, Yasutoshi Yamada, Hirofumi Yoshino, Hideo Hidaka, Takeshi Chiyomaru, Nijiro Nohata, Takashi Kinoshita, Masayuki Nakagawa, Hideki Enokida

Pages: 805-817 Published online on: 03 July 2012
Open Access

Artepillin C (3,5-diprenyl-4-hydroxycinnamic acid) sensitizes LNCaP prostate cancer cells to TRAIL-induced apoptosis

Ewelina Szliszka, Grzegorz Zydowicz, Elzbieta Mizgala, Wojciech Krol

Pages: 818-828 Published online on: 25 June 2012
Open Access

Expression of TMPRSS4 in non-small cell lung cancer and its modulation by hypoxia

Tri-Hung Nguyen, William Weber, Evis Havari, Timothy Connors, Rebecca G. Bagley, Rajashree McLaren, Prashant R. Nambiar, Stephen L. Madden, Beverly A. Teicher, Bruce Roberts, Johanne Kaplan, Srinivas Shankara

Pages: 829-838 Published online on: 12 June 2012
Open Access

Tob1 induces apoptosis and inhibits proliferation, migration and invasion of gastric cancer cells by activating Smad4 and inhibiting β‑catenin signaling

Juthika Kundu, S. M. Riajul Wahab, Joydeb Kumar Kundu, Yoon-La Choi, Ozgur Cem Erkin, Hun Seok Lee, Sang Gyu Park, Young Kee Shin

Pages: 839-848 Published online on: 12 June 2012
Open Access

Silibinin, a natural flavonoid, modulates the early expression of chemoprevention biomarkers in a preclinical model of colon carcinogenesis

Henriette Kauntz, Souad Bousserouel, Francine Gosse, Jacques Marescaux, Francis Raul

Pages: 849-854 Published online on: 25 June 2012
Open Access

Aldehyde dehydrogenase 1A1 confers intrinsic and acquired resistance to gemcitabine in human pancreatic adenocarcinoma MIA PaCa-2 cells

Hong-Quan Duong, Jae Seok Hwang, Hee Jeong Kim, Hyo Jin Kang, Yeon-Sun Seong, Insoo Bae

Pages: 855-861 Published online on: 12 June 2012
Open Access

Characterization of cells resistant to the potent histone deacetylase inhibitor spiruchostatin B (SP-B) and effect of overexpressed p21waf1/cip1 on the SP-B resistance or susceptibility of human leukemia cells

Syu-Ichi Kanno, Naoyuki Maeda, Ayako Tomizawa, Shin Yomogida, Tadashi Katoh, Masaaki Ishikawa

Pages: 862-868 Published online on: 06 June 2012
Open Access

MiR-23a regulates TGF-β-induced epithelial-mesenchymal transition by targeting E-cadherin in lung cancer cells

Mengru Cao, Masahiro Seike, Chie Soeno, Hideaki Mizutani, Kazuhiro Kitamura, Yuji Minegishi, Rintaro Noro, Akinobu Yoshimura, Li Cai, Akihiko Gemma

Pages: 869-875 Published online on: 28 June 2012
Open Access

Multiple myeloma cells expressing low levels of CD138 have an immature phenotype and reduced sensitivity to lenalidomide

Yawara Kawano, Shiho Fujiwara, Naoko Wada, Mikiko Izaki, Hiromichi Yuki, Yutaka Okuno, Kenichi Iyama, Hiroshi Yamasaki, Akira Sakai, Hiroaki Mitsuya, Hiroyuki Hata

Pages: 876-884 Published online on: 04 July 2012

Cyclooxygenase-2 promotes tumor lymphangiogenesis and lymph node metastasis in oral squamous cell carcinoma

Yoshihiro Morita, Kenji Hata, Masako Nakanishi, Toshihiko Nishisho, Yoshiaki Yura, Toshiyuki Yoneda

Pages: 885-892 Published online on: 25 June 2012

Oncolytic virotherapy for human bone and soft tissue sarcomas using live attenuated poliovirus

Satoru Atsumi, Akihiko Matsumine, Hidemi Toyoda, Rui Niimi, Takahiro Iino, Tomoki Nakamura, Takao Matsubara, Kunihiro Asanuma, Yoshihiro Komada, Atsumasa Uchida, Akihiro Sudo

Pages: 893-902 Published online on: 12 June 2012

Transcatheter arterial infusion chemotherapy prior to radiofrequency thermal ablation for single hepatocellular carcinoma reduces the risk of intrahepatic distant recurrence

Hiroki Nishikawa, Yukio Osaki, Ryuichi Kita, Toru Kimura, Tadashi  Inuzuka, Haruhiko Takeda, Jun Nakajima, Fumihiro Matsuda, Azusa  Sakamoto, Shinichiro Henmi, Keiichi Hatamaru, Sumio Saito, Akihiro Nasu

Pages: 903-909 Published online on: 11 June 2012

Decitabine, a DNA methyltransferase inhibitor, induces apoptosis in human leukemia cells through intracellular reactive oxygen species generation

Dong Yeok Shin, You-Soo Park, Kwangmo Yang, Gi-Young Kim, Wun-Jae Kim, Min Ho Han, Ho Sung Kang, Yung Hyun Choi

Pages: 910-918 Published online on: 05 July 2012

Expression profiling of dipeptidyl peptidase 8 and 9 in breast and ovarian carcinoma cell lines

Claire H. Wilson, Catherine A. Abbott

Pages: 919-932 Published online on: 19 June 2012

Frondoside A has an anti-invasive effect by inhibiting TPA-induced MMP-9 activation via NF-κB and AP-1 signaling in human breast cancer cells

Sun Young Park, Young Hun Kim, YoungHee Kim, Sang-Joon Lee

Pages: 933-940 Published online on: 14 June 2012

Connexin 43 interacts with Bax to regulate apoptosis of pancreatic cancer through a gap junction-independent pathway

Yan Sun, Xiaoping Zhao, Yuting Yao, Xinyi Qi, Yaozong Yuan, Yu Hu

Pages: 941-948 Published online on: 20 June 2012

Oridonin enhances antitumor activity of gemcitabine in pancreatic cancer through MAPK-p38 signaling pathway

He-Qi Bu, Jiang Luo, Hui Chen, Jian-Hong Zhang, Hong-Hai Li, Hong-Chun Guo, Zhao-Hong Wang, Sheng-Zhang Lin

Pages: 949-958 Published online on: 14 June 2012

Mesenchymal stem cells play a potential role in regulating the establishment and maintenance of epithelial-mesenchymal transition in MCF7 human breast cancer cells by paracrine and induced autocrine TGF-β

Qilin Xu, Liang Wang, Hongling Li, Qin Han, Jing  Li, Xuebin  Qu, Shan Huang, Robert Chunhua Zhao

Pages: 959-968 Published online on: 03 July 2012

Preferential inhibition of hepatocellular carcinoma by the flavonoid Baicalein through blocking MEK-ERK signaling

Rong-Rui Liang, Shu Zhang, Jun-An Qi, Zhi-Dong Wang, Jun Li, Pei-Jun Liu, Chen Huang, Xiao-Feng Le, Jun Yang, Zong-Fang Li

Pages: 969-978 Published online on: 06 June 2012

Transcriptomic study of dormant gastrointestinal cancer stem cells

Shimpei Nishikawa, Dyah Laksmi Dewi, Hideshi Ishii, Masamitsu Konno, Naotsugu Haraguchi, Yoshihiro Kano, Takahito Fukusumi, Katsuya Ohta, Yuko Noguchi, Miyuki Ozaki, Daisuke Sakai, Taroh Satoh, Yuichiro Doki, Masaki Mori

Pages: 979-984 Published online on: 25 June 2012

Identification of novel molecular targets regulated by tumor suppressive miR-375 induced by histone acetylation in esophageal squamous cell carcinoma

Yuka Isozaki, Isamu Hoshino, Nijiro Nohata, Takashi  Kinoshita, Yasunori Akutsu, Naoyuki Hanari, Mikito Mori, Yasuo  Yoneyama, Naoki  Akanuma, Nobuyoshi Takeshita, Tetsuro Maruyama, Naohiko  Seki, Norikazu Nishino, Minoru Yoshida, Hisahiro Matsubara

Pages: 985-994 Published online on: 28 June 2012

RasGRF1 regulates proliferation and metastatic behavior of human alveolar rhabdomyosarcomas

Maciej Tarnowski, Gabriela Schneider, Gabriele Amann, Geoffrey Clark, Peter Houghton, Frederic G. Barr, Lukas Kenner, Mariusz Z. Ratajczak, Magda Kucia

Pages: 995-1004 Published online on: 28 June 2012

Co-inhibition of microRNA-10b and microRNA-21 exerts synergistic inhibition on the proliferation and invasion of human glioma cells

Chang G. Dong, William K.K. Wu, Su Y. Feng, Xiao J. Wang, Jun F. Shao, Jian Qiao

Pages: 1005-1012 Published online on: 03 July 2012

Systemic delivery of lentivirus-mediated secretable TAT-apoptin eradicates hepatocellular carcinoma xenografts in nude mice

Jin-Lu Ma, Su-Xia Han, Jing Zhao, Dan Zhang, Li Wang, Yao-Dong Li, Qing Zhu

Pages: 1013-1020 Published online on: 05 July 2012

Expression and role of the inhibitor of apoptosis protein livin in chemotherapy sensitivity of ovarian carcinoma

Xiaomei Liu, Aiyuan Wang, Hong Gao, Zhengwei Yuan, Yisheng Jiao

Pages: 1021-1028 Published online on: 03 July 2012

Correlation of EGFR, IDH1 and PTEN status with the outcome of patients with recurrent glioblastoma treated in a phase II clinical trial with the EGFR-blocking monoclonal antibody cetuximab

Shasha Lv, Erik Teugels, Jan Sadones, Sylvia De Brakeleer, Johnny Duerinck, Stephanie Du Four, Alex Michotte, Jacques De Grève, Bart Neyns

Pages: 1029-1035 Published online on: 29 June 2012

Prospective impact of 5-FU in the induction of endoplasmic reticulum stress, modulation of GRP78 expression and autophagy in Sk-Hep1 cells

Anandam Kasin Yadunandam, Jin-Soo Yoon, Yeong‑Ae  Seong, Chul-Woong Oh, Gun-Do Kim

Pages: 1036-1042 Published online on: 06 June 2012

Expression of ADAMTS-1, ADAMTS-4, ADAMTS-5 and TIMP3 by hepatocellular carcinoma cell lines

Sharon L. Turner, David Mangnall, Nigel C. Bird, Rowena A.D. Bunning, Maria E. Blair-Zajdel

Pages: 1043-1049 Published online on: 20 June 2012

Norcantharidin triggers cell death and DNA damage through S-phase arrest and ROS-modulated apoptotic pathways in TSGH 8301 human urinary bladder carcinoma cells

Chien-Chih Yu, Fang-Yu Ko, Chun-Shu Yu, Chin-Chung Lin, Yi‑Ping  Huang, Jai-Sing Yang, Jing-Pin Lin, Jing-Gung Chung

Pages: 1050-1060 Published online on: 07 June 2012

Autoantibodies against glucose-regulated protein 78 as serological diagnostic biomarkers in hepatocellular carcinoma

Qing Shao, Pengfei Ren, Yang Li, Bo Peng, Liping Dai, Ningjing  Lei, Wu Yao, Gang Zhao, Linggen Li, Jianying Zhang

Pages: 1061-1067 Published online on: 12 June 2012

Putative tumor metastasis-associated genes in human gastric cancer

Tsung-Fan Tuan, Cheng-Ta Chung, Hsiao-Hui Tsou, Fong-Wen Chen, Heng-Liang  Lin, Yiu-Kay Lai, Wen-Sen Lee, Yu-Sheng Chao, Ling-Ling Hwang, Chiung-Tong Chen

Pages: 1068-1084 Published online on: 31 May 2012

Evaluation of MAGE-A expression and grade of dysplasia for predicting malignant progression of oral leukoplakia

Jutta Ries, Abbas Agaimy, Elefterios Vairaktaris, Yeeun Kwon, Friedrich W. Neukam, Lei H. Strassburg, Emeka Nkenke

Pages: 1085-1093 Published online on: 26 June 2012

Cytokine gene expression signature in ovarian clear cell carcinoma

Nozomu Yanaihara, Michael S. Anglesio, Kazunori Ochiai, Yukihiro  Hirata, Misato Saito, Chie Nagata, Yasushi Iida, Satoshi  Takakura, Kyosuke Yamada, Tadao Tanaka, Aikou Okamoto

Pages: 1094-1100 Published online on: 26 June 2012

Sirtinol, a class III HDAC inhibitor, induces apoptotic and autophagic cell death in MCF-7 human breast cancer cells

Jing Wang, Tae Hyung Kim, Mee Young Ahn, Jaewon Lee, Jee H. Jung, Wahn Soo Choi, Byung Mu Lee, Kyuing Sil Yoon, Sungpil Yoon, Hyung Sik Kim

Pages: 1101-1109 Published online on: 26 June 2012

Periostin activates integrin α5β1 through a PI3K/AKT‑dependent pathway in invasion of cholangiocarcinoma

Kusumawadee Utispan, Jumaporn Sonongbua, Peti Thuwajit, Siri Chau-In, Chawalit Pairojkul, Sopit Wongkham, Chanitra Thuwajit

Pages: 1110-1118 Published online on: 25 June 2012

RL71, a second-generation curcumin analog, induces apoptosis and downregulates Akt in ER-negative breast cancer cells

Babasaheb Yadav, Sebastien Taurin, Lesley Larsen, Rhonda J. Rosengren

Pages: 1119-1127 Published online on: 15 June 2012

Androgen-independent prostate cancer cells circumvent EGFR inhibition by overexpression of alternative HER receptors and ligands

Dolors Carrión-Salip, Clara Panosa, Javier A. Menendez, Teresa Puig, Glòria Oliveras, Atanasio Pandiella, Rafael De Llorens, Anna Massaguer

Pages: 1128-1138 Published online on: 06 June 2012

A novel cancer/testis antigen KP-OVA-52 identified by SEREX in human ovarian cancer is regulated by DNA methylation

Kang-Mi Kim, Myung-Ha Song, Min-Ju Kim, Sayeema Daudi, Anthony Miliotto, Lloyd Old, Kunle Odunsi, Sang-Yull Lee

Pages: 1139-1147 Published online on: 06 June 2012

Antitumor efficacy of sequential treatment with docetaxel and 5-fluorouracil against human oral cancer cells

Tetsuya Tamatani, Tarannum Ferdous, Natsumi Takamaru, Kanae Hara, Makoto Kinouchi, Nobuyuki Kuribayashi, Go Ohe, Daisuke Uchida, Hirokazu Nagai, Kenji Fujisawa, Youji Miyamoto

Pages: 1148-1156 Published online on: 04 July 2012

Transactivation and reactivation capabilities of temperature-dependent p53 mutants in yeast and human cells

Jana Jagosova, Lenka Pitrova, Jana Slovackova, Barbora  Ravcukova, Jan Smarda, Jana Smardova

Pages: 1157-1163 Published online on: 15 June 2012

Methanol extract of the ethnopharmaceutical remedy Smilax spinosa exhibits anti-neoplastic activity

Mareike Seelinger, Ruxandra Popescu, Benedikt Giessrigl, Kanokwan  Jarukamjorn, Christine  Unger, Bruno Wallnöfer, Monika Fritzer-Szekeres, Thomas  Szekeres, Rene Diaz, Walter Jäger, Richard Frisch, Brigitte Kopp, Georg Krupitza

Pages: 1164-1172 Published online on: 29 June 2012
Journal Cover

Cover Legend PDF

September 2012
Volume 41 Issue 3

Print ISSN: 1019-6439
Online ISSN: 1791-2423

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