Genetic differences between Asian and Caucasian chronic lymphocytic leukemia

Kawamata,Norihiko; Moreilhon,Chimene; Saitoh,Takayuki; Karasawa,Masamitsu; Bernstein,Brian  K.; Sato-Otsubo,Aiko; Ogawa,Seishi; Raynaud,Sophie; Koeffler,H.  Phillip

doi:10.3892/ijo.2013.1966

Genetic differences between Asian and Caucasian chronic lymphocytic leukemia

Authors:
- Norihiko Kawamata
- Chimene Moreilhon
- Takayuki Saitoh
- Masamitsu Karasawa
- Brian K. Bernstein
- Aiko Sato-Otsubo
- Seishi Ogawa
- Sophie Raynaud
- H. Phillip Koeffler
View Affiliations

Affiliations: Hematology/Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, USA, Center Hospital, University of Nice, Nice, France, Gunma University, Maebashi, Gunma, Japan, University of Tokyo, Tokyo, Japan
Published online on: May 27, 2013 https://doi.org/10.3892/ijo.2013.1966
Pages: 561-565

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Chronic lymphocytic leukemia (CLL) is a common hematological malignancy in Western countries. However, this disease is very rare in Asian countries. It is not clear whether the mechanisms of development of CLL in Caucasians and Asians are the same. We compared genetic abnormalities in Asian and Caucasian CLL using 250k GeneChip arrays. Both Asian and Caucasian CLL had four common genetic abnormalities: deletion of 13q14.3, trisomy 12, abnormalities of ATM (11q) and abnormalities of 17p. Interestingly, trisomy 12 and deletion of 13q14.3 were mutually exclusive in both groups. We also found that deletions of miR 34b/34c (11q), caspase 1/4/5 (11q), Rb1 (13q) and DLC1 (8p) are common in both ethnic groups. Asian CLL more frequently had gain of 3q and 18q. These suggest that classic genomic changes in the Asian and Caucasina CLL are same. Further, we found amplification of IRF4 and deletion of the SP140/SP100 genes; these genes have been reported as CLL-associated genes by previous genome-wide-association study. We have found classic genomic abnormalities in Asian CLL as well as novel genomic alteration in CLL.

View Figures

View References

1.	DeVita VT, Lawrence TS, Rosenberg SA, DePinho RA and Weinberg RA: DeVita, Hellman, and Rosenberg’s Cancer: Principles and Practice of Oncology. 8th edition. Lippncott: Williams & Wilkins; 2009
2.	Eley JW, Hill HA, Chen VW, et al: Racial differences in survival from breast cancer. Results of the National Cancer Institute Black/White Cancer Survival Study. JAMA. 272. pp. 947–954. 1994, View Article : Google Scholar : PubMed/NCBI
3.	GLOBOCAN 2008/Cancer Incidence and Mortality Worldwide in 2008. International Agency for Research on Cancer. World Health Organization. http://globocan.iarc.fr/.
4.	Tsugane S and Sasazuki S: Diet and the risk of gastric cancer: review of epidemiological evidence. Gastric Cancer. 10:75–83. 2007. View Article : Google Scholar : PubMed/NCBI
5.	Dunn JE: Cancer epidemiology in populations of the United States - with emphasis on Hawaii and California - and Japan. Cancer Res. 35:3240–3245. 1975.PubMed/NCBI
6.	Jänne PA, Engelman JA and Johnson BE: Epidermal growth factor receptor mutations in non-small-cell lung cancer: implications for treatment and tumor biology. J Clin Oncol. 23:3227–3234. 2005.PubMed/NCBI
7.	Bell DW, Lynch TJ, Haserlat SM, et al: Epidermal growth factor receptor mutations and gene amplification in non-small-cell lung cancer: molecular analysis of the IDEAL/INTACT gefitinib trials. J Clin Oncol. 23:8081–8092. 2005. View Article : Google Scholar : PubMed/NCBI
8.	Rai KR and Keating MJ: Chronic Lymphocytic Leukemia Chapter 127 Cancer Medicine. 6th edition. BC Decker; Hamilton, ON: 2000
9.	Redaelli A, Laskin BL, Stephens JM, Botteman MF and Pashos CL: The clinical and epidemiological burden of chronic lymphocytic leukaemia. Eur J Cancer Care. 13:279–287. 2004. View Article : Google Scholar : PubMed/NCBI
10.	SEER Stat Fact Sheets: Chronic Lymphocytic Leukemia Surveillance epidemiology and end of results. National Cancer Institute. http://seer.cancer.gov/statfacts/html/clyl.html.
11.	Gale RP, Cozen W, Goodman MT, Wang FF and Bernstein L: Decreased chronic lymphocytic leukemia incidence in Asians in Los Angeles County. Leuk Res. 24:665–669. 2000. View Article : Google Scholar : PubMed/NCBI
12.	Pan JW, Cook LS, Schwartz SM and Weis NS: Incidence of leukemia in Asian migrants to the United States and their descendants. Cancer Causes Control. 13:791–795. 2002. View Article : Google Scholar : PubMed/NCBI
13.	Hallek M, Cheson BD, Catovsky D, et al: Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood. 111:5446–5456. 2008. View Article : Google Scholar
14.	Nakahashi H, Tsukamoto N, Hashimoto Y, et al: Characterization of immunoglobulin heavy and light chain gene expression in chronic lymphocytic leukemia and related disorders. Cancer Sci. 100:671–677. 2009. View Article : Google Scholar : PubMed/NCBI
15.	Kawamata N, Ogawa S, Gueller S, et al: Identified hidden genomic changes in mantle cell lymphoma using high-resolution single nucleotide polymorphism genomic array. Exp Hematol. 37:937–946. 2009. View Article : Google Scholar : PubMed/NCBI
16.	Yamamoto G, Nannya Y, Kato M, et al: Highly sensitive method for genomewide detection of allelic composition in nonpaired, primary tumor specimens by use of affymetrix single-nucleotide-polymorphism genotyping microarrays. Am J Hum Genet. 81:114–126. 2007. View Article : Google Scholar
17.	Lehmann S, Ogawa S, Raynaud SD, et al: Molecular allelokaryo-typing of early-stage, untreated chronic lymphocytic leukemia. Cancer. 112:1296–1305. 2008. View Article : Google Scholar : PubMed/NCBI
18.	Caporaso N, Goldin L, Plass C, et al: Chronic lymphocytic leukaemia genetics overview. Br J Haematol. 139:630–634. 2007. View Article : Google Scholar : PubMed/NCBI
19.	Di Bernardo MC, Crowther-Swanepoel D, Broderick P, et al: A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia. Nat Genet. 40:1204–1210. 2008.
20.	Kitada S, Andersen J, Akar S, et al: Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with in vitro and in vivo chemoresponses. Blood. 91:3379–3389. 1998.PubMed/NCBI
21.	Majid A, Tsoulakis O, Walewska R, et al: BCL2 expression in chronic lymphocytic leukemia: lack of association with the BCL2 938A>C promoter single nucleotide polymorphism. Blood. 111:874–877. 1998.PubMed/NCBI
22.	Calin GA, Dumitru CD, Shimizu M, et al: Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA. 99:15524–15529. 2002. View Article : Google Scholar : PubMed/NCBI
23.	Calin GA, Ferracin M, Cimmino A, et al: A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N Engl J Med. 353:1793–1801. 2005. View Article : Google Scholar : PubMed/NCBI
24.	Calin GA and Croce CM: Chronic lymphocytic leukemia: interplay between noncoding RNAs and protein-coding genes. Blood. 114:4761–4770. 2009. View Article : Google Scholar : PubMed/NCBI
25.	Cimmino A, Calin GA, Fabbri M, et al: miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci USA. 102:13944–13949. 2006. View Article : Google Scholar : PubMed/NCBI
26.	Abramson JS and Shipp MA: Advances in the biology and therapy of diffuse large B-cell lymphoma: moving toward a molecularly targeted approach. Blood. 106:1164–1174. 2005. View Article : Google Scholar : PubMed/NCBI
27.	Basso K and Dalla-Favera R: BCL6: master regulator of the germinal center reaction and key oncogene in B cell lymphoma-genesis. Adv Immunol. 105:193–210. 2010. View Article : Google Scholar : PubMed/NCBI
28.	Phan RT and Dalla-Favera R: The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells. Nature. 432:635–639. 2004. View Article : Google Scholar : PubMed/NCBI
29.	Ching YP, Wong CM, Chan SF, et al: Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma. J Biol Chem. 278:10824–10830. 2003. View Article : Google Scholar : PubMed/NCBI
30.	Lahoz A and Hall A: DLC1: a significant GAP in the cancer genome. Genes Dev. 22:1724–1730. 2008. View Article : Google Scholar : PubMed/NCBI
31.	Yin XL, Pang JC and Ng HK: Identification of a region of homozygous deletion on 8p22-23.1 in medulloblastoma. Oncogene. 21:1461–1468. 2002. View Article : Google Scholar : PubMed/NCBI
32.	Yuan BZ, Jefferson AM, Baldwin KT, Thorgeirsson SS, Popescu NC and Reynolds SH: DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas. Oncogene. 23:1405–1411. 2004. View Article : Google Scholar : PubMed/NCBI
33.	Zender L, Xue W, Zuber J, et al: An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer. Cell. 135:852–864. 2008. View Article : Google Scholar : PubMed/NCBI
34.	Rinaldi A, Mian M, Chigrinova E, et al: Genome-wide DNA profiling of marginal zone lymphomas identifies subtype-specific lesions with an impact on the clinical outcome. Blood. 117:1595–1604. 2011. View Article : Google Scholar : PubMed/NCBI
35.	Tagawa H, Suguro M, Tsuzuki S, et al: Comparison of genome profiles for identification of distinct subgroups of diffuse large B-cell lymphoma. Blood. 106:1770–1777. 2005. View Article : Google Scholar : PubMed/NCBI
36.	Swerdlow SH, Campo E, Harris NL, et al: WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th edition. World Health Organization; 2008
37.	Martinon F and Tschopp J: Inflammatory caspases and inflammasomes: master switches of inflammation. Cell Death Differ. 14:10–22. 2007. View Article : Google Scholar : PubMed/NCBI
38.	Davis BK, Wen H and Ting JP: The inflammasome NLRs in immunity, inflammation, and associated diseases. Annu Rev Immunol. 29:707–735. 2011. View Article : Google Scholar : PubMed/NCBI
39.	Altshuler D, Daly MJ and Lander ES: Genetic mapping in human disease. Science. 322:881–888. 2008. View Article : Google Scholar : PubMed/NCBI
40.	Clifford RJ, Edmonson MN, Nguyen C, Scherpbier T, Hu Y and Buetow KH: Bioinformatics tools for single nucleotide polymorphism discovery and analysis. Ann NY Acad Sci. 1020:101–109. 2004. View Article : Google Scholar : PubMed/NCBI