Expression of major histocompatibility complex class I-related chain A/B (MICA/B) in pancreatic carcinoma

  • Authors:
    • Zilvinas Dambrauskas
    • Helena Svensson
    • Meghnad Joshi
    • Anders Hyltander
    • Peter Naredi
    • Britt-Marie Iresjö
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  • Published online on: October 31, 2013     https://doi.org/10.3892/ijo.2013.2156
  • Pages: 99-104
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Abstract

Major histocompatibility complex class I-related chain A and B (MICA/B) are two stress-inducible ligands that bind to the immunoreceptor NKG2D and play an important role in mediating cytotoxicity of NK and T cells. Release of MIC molecules from the cell surface is thought to constitute an immune escape mechanism of tumor cells and thus could be associated with more aggressive course of tumor growth. In this study, we investigated the expression of MICA/B in ductal pancreatic carcinoma and serum in relation to tumor stage, differentiation and survival. MICA/B expression in tumor tissues and sera from patients with pancreatic cancer were analyzed by immunohistochemical staining (IHC), western blotting and ELISA, respectively. MICA/B expression was present in 17 of 22 (77%) of the tumors but not in normal pancreatic ductal epithelial cells. Poorly differentiated tumors showed more pronounced MICA/B expression compared to differentiated tumors, but did not correlate significantly to other tumor characteristics. MICA/B-negative tumors displayed significantly lower incidence of lymph node metastases (p<0.01), and less mortality within 3 years following resection (p<0.02). In conclusion, tissue levels of MICA/B expression were elevated in pancreatic cancer cells without elevated levels in serum, despite well-recognized acute phase reactants in serum. Poorly differentiated tumors showed high MICA/B expression, which was related to extended tumor lymph node metastases and less frequent long-term survival.
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2014-January
Volume 44 Issue 1

Print ISSN: 1019-6439
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Spandidos Publications style
Dambrauskas Z, Svensson H, Joshi M, Hyltander A, Naredi P and Iresjö B: Expression of major histocompatibility complex class I-related chain A/B (MICA/B) in pancreatic carcinoma. Int J Oncol 44: 99-104, 2014
APA
Dambrauskas, Z., Svensson, H., Joshi, M., Hyltander, A., Naredi, P., & Iresjö, B. (2014). Expression of major histocompatibility complex class I-related chain A/B (MICA/B) in pancreatic carcinoma. International Journal of Oncology, 44, 99-104. https://doi.org/10.3892/ijo.2013.2156
MLA
Dambrauskas, Z., Svensson, H., Joshi, M., Hyltander, A., Naredi, P., Iresjö, B."Expression of major histocompatibility complex class I-related chain A/B (MICA/B) in pancreatic carcinoma". International Journal of Oncology 44.1 (2014): 99-104.
Chicago
Dambrauskas, Z., Svensson, H., Joshi, M., Hyltander, A., Naredi, P., Iresjö, B."Expression of major histocompatibility complex class I-related chain A/B (MICA/B) in pancreatic carcinoma". International Journal of Oncology 44, no. 1 (2014): 99-104. https://doi.org/10.3892/ijo.2013.2156