Lipogenesis in cancer progression (Review)
- Authors:
- Catherine Mounier
- Lamia Bouraoui
- Eric Rassart
-
Affiliations: Biomed-Biological Sciences Department, UQÀM, Montréal, PQ, Canada - Published online on: May 13, 2014 https://doi.org/10.3892/ijo.2014.2441
- Pages: 485-492
This article is mentioned in:
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Medes G, Thomas A and Weinhouse S: Metabolism of neoplastic tissue. IV A study of lipid synthesis in neoplastic tissue slices in vitro. Cancer Res. 13:27–29. 1953.PubMed/NCBI | |
|
Swinnen JV, Brusselmans K and Verhoeven G: Increased lipogenesis in cancer cells: new players, novel targets. Curr Opin Clin Nutr Metab Care. 9:358–365. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Postic C and Girard J: The role of the lipogenic pathway in the development of hepatic steatosis. Diabetes Metab. 34:643–648. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Ntambi JM: The regulation of stearoyl-CoA desaturase (SCD). Prog Lipid Res. 34:139–150. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Neuschwander-Tetri BA: Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: the central role of nontriglyceride fatty acid metabolites. Hepatology. 52:774–788. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Viollet B, Guigas B, Leclerc J, et al: AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives. Acta Physiol (Oxf). 196:81–98. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Viollet B, Foretz M, Guigas B, et al: Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders. J Physiol. 574:41–53. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Kuhajda FP: Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology. Nutrition. 16:202–208. 2000. View Article : Google Scholar | |
|
Bougnoux P, Chajes V, Lanson M, et al: Prognostic significance of tumor phosphatidylcholine stearic acid level in breast carcinoma. Breast Cancer Res Treat. 20:185–194. 1992. View Article : Google Scholar : PubMed/NCBI | |
|
Guo D, Reinitz F, Youssef M, et al: An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway. Cancer Discov. 1:442–456. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Nieva C, Marro M, Santana-Codina N, Rao S, Petrov D and Sierra A: The lipid phenotype of breast cancer cells characterized by Raman microspectroscopy: towards a stratification of malignancy. PLoS One. 7:e464562012. View Article : Google Scholar | |
|
Pizer ES, Chrest FJ, DiGiuseppe JA and Han WF: Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines. Cancer Res. 58:4611–4615. 1998.PubMed/NCBI | |
|
Horiguchi A, Asano T, Asano T, Ito K, Sumitomo M and Hayakawa M: Pharmacological inhibitor of fatty acid synthase suppresses growth and invasiveness of renal cancer cells. J Urol. 180:729–736. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Ma J, Yan R, Zu X, et al: Aldo-keto reductase family 1 B10 affects fatty acid synthesis by regulating the stability of acetyl-CoA carboxylase-alpha in breast cancer cells. J Biol Chem. 283:3418–3423. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Chajes V, Cambot M, Moreau K, Lenoir GM and Joulin V: Acetyl-CoA carboxylase alpha is essential to breast cancer cell survival. Cancer Res. 66:5287–5294. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Brusselmans K, De Schrijver E, Verhoeven G and Swinnen JV: RNA interference-mediated silencing of the acetyl-CoA-carboxylase-alpha gene induces growth inhibition and apoptosis of prostate cancer cells. Cancer Res. 65:6719–6725. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Zhan Y, Ginanni N, Tota MR, et al: Control of cell growth and survival by enzymes of the fatty acid synthesis pathway in HCT-116 colon cancer cells. Clin Cancer Res. 14:5735–5742. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Scaglia N, Caviglia JM and Igal RA: High stearoyl-CoA desaturase protein and activity levels in simian virus 40 transformed-human lung fibroblasts. Biochim Biophys Acta. 1687:141–151. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Scaglia N, Chisholm JW and Igal RA: Inhibition of stearoylCoA desaturase-1 inactivates acetyl-CoA carboxylase and impairs proliferation in cancer cells: role of AMPK. PloS One. 4:e68122009. View Article : Google Scholar : PubMed/NCBI | |
|
Scaglia N and Igal RA: Inhibition of stearoyl-CoA desaturase 1 expression in human lung adenocarcinoma cells impairs tumorigenesis. Int J Oncol. 33:839–850. 2008.PubMed/NCBI | |
|
Morgan-Lappe SE, Tucker LA, Huang X, et al: Identification of Ras-related nuclear protein, targeting protein for xenopus kinesin-like protein 2, and stearoyl-CoA desaturase 1 as promising cancer targets from an RNAi-based screen. Cancer Res. 67:4390–4398. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Guo D, Prins RM, Dang J, et al: EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy. Sci Signal. 2:ra822009.PubMed/NCBI | |
|
Zhang D, Tai LK, Wong LL, Chiu LL, Sethi SK and Koay ES: Proteomic study reveals that proteins involved in metabolic and detoxification pathways are highly expressed in HER-2/neu-positive breast cancer. Mol Cell Proteomics. 4:1686–1696. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Porstmann T, Griffiths B, Chung YL, et al: PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP. Oncogene. 24:6465–6481. 2005.PubMed/NCBI | |
|
Wang HQ, Altomare DA, Skele KL, et al: Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells. Oncogene. 24:3574–3582. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Bandyopadhyay S, Pai SK, Watabe M, et al: FAS expression inversely correlates with PTEN level in prostate cancer and a PI 3-kinase inhibitor synergizes with FAS siRNA to induce apoptosis. Oncogene. 24:5389–5395. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Chang Y, Wang J, Lu X, Thewke DP and Mason RJ: KGF induces lipogenic genes through a PI3K and JNK/SREBP-1 pathway in H292 cells. J Lipid Res. 46:2624–2635. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Swinnen JV, Beckers A, Brusselmans K, et al: Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype. Cancer Res. 65:2441–2448. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Mehes G, Witt A, Kubista E and Ambros PF: Circulating breast cancer cells are frequently apoptotic. Am J Pathol. 159:17–20. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Iwatsuki M, Mimori K, Yokobori T, et al: Epithelial-mesenchymal transition in cancer development and its clinical significance. Cancer Sci. 101:293–299. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Polyak K and Weinberg RA: Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer. 9:265–273. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Thiery JP: Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer. 2:442–454. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Voulgari A and Pintzas A: Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic. Biochim Biophys Acta. 1796:75–90. 2009.PubMed/NCBI | |
|
Yang J, Mani SA, Donaher JL, et al: Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell. 117:927–939. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Batlle E, Sancho E, Franci C, et al: The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol. 2:84–89. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Darnell JE Jr: Transcription factors as targets for cancer therapy. Nature reviews Cancer. 2:740–749. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Moustakas A and Heldin CH: Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression. Cancer Sci. 98:1512–1520. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Blobe GC, Schiemann WP and Lodish HF: Role of transforming growth factor beta in human disease. N Engl J Med. 342:1350–1358. 2000. View Article : Google Scholar | |
|
Stambolic V and Woodgett JR: Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation. Biochem J. 303:701–704. 1994. | |
|
Peinado H, Portillo F and Cano A: Transcriptional regulation of cadherins during development and carcinogenesis. Int J Dev Biol. 48:365–375. 2004. View Article : Google Scholar | |
|
Hamada F and Bienz M: The APC tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF. Dev Cell. 7:677–685. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
He TC, Sparks AB, Rago C, et al: Identification of c-MYC as a target of the APC pathway. Science. 281:1509–1512. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Takeichi M, Nakagawa S, Aono S, Usui T and Uemura T: Patterning of cell assemblies regulated by adhesion receptors of the cadherin superfamily. Philos Trans R Soc Lond B Biol Sci. 355:885–890. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Efstathiou JA and Pignatelli M: Modulation of epithelial cell adhesion in gastrointestinal homeostasis. Am J Pathol. 153:341–347. 1998. View Article : Google Scholar | |
|
Wijnhoven BP and Pignatelli M: E-cadherin-catenin: more than a ‘sticky’ molecular complex. Lancet. 354:356–357. 1999. | |
|
Gilles C, Polette M, Mestdagt M, et al: Transactivation of vimentin by beta-catenin in human breast cancer cells. Cancer Res. 63:2658–2664. 2003.PubMed/NCBI | |
|
Takahashi M, Tsunoda T, Seiki M, Nakamura Y and Furukawa Y: Identification of membrane-type matrix metalloproteinase-1 as a target of the beta-catenin/Tcf4 complex in human colorectal cancers. Oncogene. 21:5861–5867. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Rakha EA: Pitfalls in outcome prediction of breast cancer. J Clin Pathol. 66:458–464. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Milgraum LZ, Witters LA, Pasternack GR and Kuhajda FP: Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma. Clin Cancer Res. 3:2115–2120. 1997.PubMed/NCBI | |
|
Epstein JI, Carmichael M and Partin AW: OA-519 (fatty acid synthase) as an independent predictor of pathologic state in adenocarcinoma of the prostate. Urology. 45:81–86. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Lupu R and Menendez JA: Targeting fatty acid synthase in breast and endometrial cancer: An alternative to selective estrogen receptor modulators? Endocrinology. 147:4056–4066. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Davidson B, Smith Y, Nesland JM, Kaern J, Reich R and Trope CG: Defining a prognostic marker panel for patients with ovarian serous carcinoma effusion. Hum Pathol. 44:2449–2460. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Pflug BR, Pecher SM, Brink AW, Nelson JB and Foster BA: Increased fatty acid synthase expression and activity during progression of prostate cancer in the TRAMP model. Prostate. 57:245–254. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Greenberg NM, DeMayo F, Finegold MJ, et al: Prostate cancer in a transgenic mouse. Proc Natl Acad Sci USA. 92:3439–3443. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Migita T, Ruiz S, Fornari A, Fiorentino M, Priolo C, Zadra G, et al: Fatty acid synthase: a metabolic enzyme and candidate oncogene in prostate cancer. J Natl Cancer Inst. 101:519–532. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Swinnen JV, Esquenet M, Goossens K, Heyns W and Verhoeven G: Androgens stimulate fatty acid synthase in the human prostate cancer cell line LNCaP. Cancer Res. 57:1086–1090. 1997.PubMed/NCBI | |
|
Heemers H, Maes B, Foufelle F, Heyns W, Verhoeven G and Swinnen JV: Androgens stimulate lipogenic gene expression in prostate cancer cells by activation of the sterol regulatory element-binding protein cleavage activating protein/sterol regulatory element-binding protein pathway. Mol Endocrinol. 15:1817–1828. 2001. View Article : Google Scholar | |
|
Van de Sande T, De Schrijver E, Heyns W, Verhoeven G and Swinnen JV: Role of the phosphatidylinositol 3′-kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCaP prostate cancer cells. Cancer Res. 62:642–646. 2002. | |
|
Graner E, Tang D, Rossi S, et al: The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer. Cancer Cell. 5:253–261. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Selvendiran K, Ahmed S, Dayton A, et al: HO-3867, a synthetic compound, inhibits the migration and invasion of ovarian carcinoma cells through downregulation of fatty acid synthase and focal adhesion kinase. Mol Cancer Res. 8:1188–1197. 2010. View Article : Google Scholar | |
|
Hsu YC and Liou YM: The anti-cancer effects of (−)-epigallocatechin-3-gallate on the signaling pathways associated with membrane receptors in MCF-7 cells. J Cell Physiol. 226:2721–2730. 2011. | |
|
Menendez JA, Vellon L, Mehmi I, et al: Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells. Proc Natl Acad Sci USA. 101:10715–10720. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Hartkopf AD, Banys M and Fehm T: HER2-positive DTCs/CTCs in breast cancer. Recent Results Cancer Res. 195:203–215. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Lee JS, Yoon IS, Lee MS, et al: Anticancer activity of pristimerin in epidermal growth factor receptor 2-positive SKBR3 human breast cancer cells. Biol Pharm Bull. 36:316–325. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Swinnen JV, Heemers H, Deboel L, Foufelle F, Heyns W and Verhoeven G: Stimulation of tumor-associated fatty acid synthase expression by growth factor activation of the sterol regulatory element-binding protein pathway. Oncogene. 19:5173–5181. 2000. View Article : Google Scholar | |
|
Oskouian B: Overexpression of fatty acid synthase in SKBR3 breast cancer cell line is mediated via a transcriptional mechanism. Cancer Lett. 149:43–51. 2000. View Article : Google Scholar | |
|
Kumar-Sinha C, Ignatoski KW, Lippman ME, Ethier SP and Chinnaiyan AM: Transcriptome analysis of HER2 reveals a molecular connection to fatty acid synthesis. Cancer Res. 63:132–139. 2003.PubMed/NCBI | |
|
Nicolini A, Giardino R, Carpi A, et al: Metastatic breast cancer: an updating. Biomed Pharmacother. 60:548–556. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Camassei FD, Cozza R, Acquaviva A, et al: Expression of the lipogenic enzyme fatty acid synthase (FAS) in retinoblastoma and its correlation with tumor aggressiveness. Invest Ophthalmol Vis Sci. 44:2399–2403. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Rashid A, Pizer ES, Moga M, et al: Elevated expression of fatty acid synthase and fatty acid synthetic activity in colorectal neoplasia. Am J Pathol. 150:201–208. 1997.PubMed/NCBI | |
|
Kalyankrishna S and Grandis JR: Epidermal growth factor receptor biology in head and neck cancer. J Clin Oncol. 24:2666–2672. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Qiu Z, Huang C, Sun J, et al: RNA interference-mediated signal transducers and activators of transcription 3 gene silencing inhibits invasion and metastasis of human pancreatic cancer cells. Cancer Sci. 98:1099–1106. 2007. View Article : Google Scholar | |
|
Horiguchi A, Asano T, Asano T, Ito K, Sumitomo M and Hayakawa M: Fatty acid synthase over expression is an indicator of tumor aggressiveness and poor prognosis in renal cell carcinoma. J Urol. 180:1137–1140. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Piyathilake CJ, Frost AR, Manne U, Bell WC, Weiss H, Heimburger DC, et al: The expression of fatty acid synthase (FASE) is an early event in the development and progression of squamous cell carcinoma of the lung. Hum Pathol. 31:1068–1073. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Carvalho MA, Zecchin KG, Seguin F, et al: Fatty acid synthase inhibition with Orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model. Int J Cancer. 123:2557–2565. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Murata S, Yanagisawa K, Fukunaga K, et al: Fatty acid synthase inhibitor cerulenin suppresses liver metastasis of colon cancer in mice. Cancer Sci. 101:1861–1865. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Zaytseva YY, Rychahou PG, Gulhati P, et al: Inhibition of fatty acid synthase attenuates CD44-associated signaling and reduces metastasis in colorectal cancer. Cancer Res. 72:1504–1517. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Chajes V, Hulten K, Van Kappel AL, et al: Fatty-acid composition in serum phospholipids and risk of breast cancer: an incident case-control study in Sweden. Int J Cancer. 83:585–590. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Chajes V, Thiebaut AC, Rotival M, et al: Association between serum trans-monounsaturated fatty acids and breast cancer risk in the E3N-EPIC study. Am J Epidemiol. 167:1312–1320. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Pala V, Krogh V, Muti P, et al: Erythrocyte membrane fatty acids and subsequent breast cancer: a prospective Italian study. J Natl Cancer Inst. 93:1088–1095. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Mauvoisin D, Charfi C, Lounis AM, Rassart E and Mounier C: Decreasing stearoyl-CoA desaturase-1 expression inhibits beta-catenin signaling in breast cancer cells. Cancer Sci. 104:36–42. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Goodridge AG: Regulation of the activity of acetyl coenzyme A carboxylase by palmitoyl coenzyme A and citrate. J Biol Chem. 247:6946–6952. 1972.PubMed/NCBI | |
|
Zureik M, Ducimetiere P, Warnet JM and Orssaud G: Fatty acid proportions in cholesterol esters and risk of premature death from cancer in middle aged French men. BMJ. 311:1251–1254. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Petrek JA, Hudgins LC, Ho M, Bajorunas DR and Hirsch J: Fatty acid composition of adipose tissue, an indication of dietary fatty acids, and breast cancer prognosis. J Clin Oncol. 15:1377–1384. 1997.PubMed/NCBI | |
|
Zhu ZR, Agren J, Mannisto S, et al: Fatty acid composition of breast adipose tissue in breast cancer patients and in patients with benign breast disease. Nutr Cancer. 24:151–160. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Simonsen NR, Fernandez-Crehuet Navajas J, Martin-Moreno JM, et al: Tissue stores of individual monounsaturated fatty acids and breast cancer: the EURAMIC study. European Community Multicenter Study on Antioxidants, Myocardial Infarction, and Breast. Cancer Am J Clin Nutr. 68:134–141. 1998.PubMed/NCBI | |
|
Lamouille S and Derynck R: Emergence of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin axis in transforming growth factor-beta-induced epithelial-mesenchymal transition. Cells Tissues Organs. 193:8–22. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Lin SY, Xia W, Wang JC, et al: Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression. Proc Natl Acad Sci USA. 97:4262–4266. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Rios-Esteves J and Resh MD: Stearoyl CoA desaturase is required to produce active, lipid-modified Wnt proteins. Cell Rep. 4:1072–1081. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Samuel W, Nagineni CN, Kutty RK, et al: Transforming growth factor-beta regulates stearoyl coenzyme A desaturase expression through a Smad signaling pathway. J Biol Chem. 277:59–66. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
McIntyre E, Blackburn E, Brown PJ, Johnson CG and Gullick WJ: The complete family of epidermal growth factor receptors and their ligands are co-ordinately expressed in breast cancer. Breast Cancer Res Treat. 122:105–110. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Menendez JA, Vazquez-Martin A, Ropero S, Colomer R and Lupu R: HER2 (erbB-2)-targeted effects of the omega-3 polyunsaturated fatty acid, alpha-linolenic acid (ALA; 18:3n-3), in breast cancer cells: the ‘fat features’ of the ‘Mediterranean diet’ as an ‘anti-HER2 cocktail’. Clin Transl Oncol. 8:812–820. 2006.PubMed/NCBI | |
|
Wells WA, Schwartz GN, Morganelli PM, Cole BF, Gibson JJ and Kinlaw WB: Expression of ‘Spot 14’ (THRSP) predicts disease free survival in invasive breast cancer: immunohistochemical analysis of a new molecular marker. Breast Cancer Res Treat. 98:231–240. 2006. | |
|
Kinlaw WB, Quinn JL, Wells WA, Roser-Jones C and Moncur JT: Spot 14: A marker of aggressive breast cancer and a potential therapeutic target. Endocrinology. 147:4048–4055. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Chin K, DeVries S, Fridlyand J, et al: Genomic and transcriptional aberrations linked to breast cancer pathophysiologies. Cancer Cell. 10:529–541. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Moreau K, Dizin E, Ray H, et al: BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylase. J Biol Chem. 281:3172–3181. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Saxena NK and Sharma D: Metastasis suppression by adiponectin: LKB1 rises up to the challenge. Cell Adh Migr. 4:358–362. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Scott KE, Wheeler FB, Davis AL, Thomas MJ, Ntambi JM, Seals DF, et al: Metabolic regulation of invadopodia and invasion by acetyl-CoA carboxylase 1 and de novo lipogenesis. PloS One. 7:e297612012. View Article : Google Scholar : PubMed/NCBI | |
|
Menendez JA and Lupu R: Mediterranean dietary traditions for the molecular treatment of human cancer: anti-oncogenic actions of the main olive oil’s monounsaturated fatty acid oleic acid (18:1n-9). Curr Pharm Biotechnol. 7:495–502. 2006.PubMed/NCBI | |
|
Swinnen JV, Ulrix W, Heyns W and Verhoeven G: Coordinate regulation of lipogenic gene expression by androgens: evidence for a cascade mechanism involving sterol regulatory element binding proteins. Proc Natl Acad Sci USA. 94:12975–12980. 1997. View Article : Google Scholar | |
|
Huang WC, Li X, Liu J, Lin J and Chung LW: Activation of androgen receptor, lipogenesis, and oxidative stress converged by SREBP-1 is responsible for regulating growth and progression of prostate cancer cells. Mol Cancer Res. 10:133–142. 2012. View Article : Google Scholar | |
|
Bhandary B, Marahatta A, Kim HR and Chae HJ: Mitochondria in relation to cancer metastasis. J Bioenerg Biomembr. 44:623–627. 2012. View Article : Google Scholar : PubMed/NCBI |
