Open Access

The collagen receptor uPARAP/Endo180 in tissue degradation and cancer (Review)

  • Authors:
    • Maria C. Melander
    • Henrik J. Jürgensen
    • Daniel H. Madsen
    • Lars H. Engelholm
    • Niels Behrendt
  • View Affiliations

  • Published online on: August 12, 2015     https://doi.org/10.3892/ijo.2015.3120
  • Pages: 1177-1188
  • Copyright: © Melander et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The collagen receptor uPARAP/Endo180, the product of the MRC2 gene, is a central component in the collagen turnover process governed by various mesenchymal cells. Through the endocytosis of collagen or large collagen fragments, this recycling receptor serves to direct basement membrane collagen as well as interstitial collagen to lysosomal degradation. This capacity, shared only with the mannose receptor from the same protein family, endows uPARAP/Endo180 with a critical role in development and homeostasis, as well as in pathological disruptions of the extracellular matrix structure. Important pathological functions of uPARAP/Endo180 have been identified in various cancers and in several fibrotic conditions. With a particular focus on matrix turnover in cancer, this review presents the necessary background for understanding the function of uPARAP/Endo180 at the molecular and cellular level, followed by an in-depth survey of the available knowledge of the expression and role of this receptor in various types of cancer and other degenerative diseases.
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October-2015
Volume 47 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Melander MC, Jürgensen HJ, Madsen DH, Engelholm LH and Behrendt N: The collagen receptor uPARAP/Endo180 in tissue degradation and cancer (Review). Int J Oncol 47: 1177-1188, 2015.
APA
Melander, M.C., Jürgensen, H.J., Madsen, D.H., Engelholm, L.H., & Behrendt, N. (2015). The collagen receptor uPARAP/Endo180 in tissue degradation and cancer (Review). International Journal of Oncology, 47, 1177-1188. https://doi.org/10.3892/ijo.2015.3120
MLA
Melander, M. C., Jürgensen, H. J., Madsen, D. H., Engelholm, L. H., Behrendt, N."The collagen receptor uPARAP/Endo180 in tissue degradation and cancer (Review)". International Journal of Oncology 47.4 (2015): 1177-1188.
Chicago
Melander, M. C., Jürgensen, H. J., Madsen, D. H., Engelholm, L. H., Behrendt, N."The collagen receptor uPARAP/Endo180 in tissue degradation and cancer (Review)". International Journal of Oncology 47, no. 4 (2015): 1177-1188. https://doi.org/10.3892/ijo.2015.3120