The role of EVI-1 in normal hematopoiesis and myeloid malignancies (Review)

  • Authors:
    • Xiaofen Yuan
    • Xidi Wang
    • Kehong Bi
    • Guosheng Jiang
  • View Affiliations

  • Published online on: October 15, 2015     https://doi.org/10.3892/ijo.2015.3207
  • Pages: 2028-2036
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Ecotropic virus integration site-1 (EVI-1) gene, locus on chromosome 3 (3q26.2) in the human genome, was first found in the AKXD strain of mice, in a model of retrovirus-induced acute myeloid leukemia (AML) established twenty years ago. Since then, EVI-1 was regarded as one of the most invasive proto-oncogenes in human leukemia. EVI-1 can encode a unique zinc-finger protein of 145 kDa that can bind with DNA, and its overexpression was closely related to human hemopoietic diseases. Furthermore, accumulating research indicates that EVI-1 is involved in the differentiation, apoptosis and proliferation of leukemia cells. The present review focuses on the biochemical properties of EVI-1 which plays a role in myeloid malignancies.
View Figures
View References

Related Articles

Journal Cover

December-2015
Volume 47 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Yuan X, Wang X, Bi K and Jiang G: The role of EVI-1 in normal hematopoiesis and myeloid malignancies (Review). Int J Oncol 47: 2028-2036, 2015
APA
Yuan, X., Wang, X., Bi, K., & Jiang, G. (2015). The role of EVI-1 in normal hematopoiesis and myeloid malignancies (Review). International Journal of Oncology, 47, 2028-2036. https://doi.org/10.3892/ijo.2015.3207
MLA
Yuan, X., Wang, X., Bi, K., Jiang, G."The role of EVI-1 in normal hematopoiesis and myeloid malignancies (Review)". International Journal of Oncology 47.6 (2015): 2028-2036.
Chicago
Yuan, X., Wang, X., Bi, K., Jiang, G."The role of EVI-1 in normal hematopoiesis and myeloid malignancies (Review)". International Journal of Oncology 47, no. 6 (2015): 2028-2036. https://doi.org/10.3892/ijo.2015.3207