miR-382 inhibits migration and invasion by targeting ROR1 through regulating EMT in ovarian cancer

Tan,Hong; He,Qingnan; Gong,Guanhui; Wang,Yixuan; Li,Juanni; Wang,Junpu; Zhu,Ding; Wu,Xiaoying

doi:10.3892/ijo.2015.3241

miR-382 inhibits migration and invasion by targeting ROR1 through regulating EMT in ovarian cancer

Authors:
- Hong Tan
- Qingnan He
- Guanhui Gong
- Yixuan Wang
- Juanni Li
- Junpu Wang
- Ding Zhu
- Xiaoying Wu
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Affiliations: Department of Pathology, School of Basic Medical Science, Central South University, Changsha, Hunan 410013, P.R. China, Children's Medical Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China, Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China
Published online on: November 9, 2015 https://doi.org/10.3892/ijo.2015.3241
Pages: 181-190

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Abstract

Increasing evidence suggests that microRNAs (miRNAs) play a critical role in tumorigenesis. Decreased expression of miR‑382 has been observed in various types of cancers. However, the biological function of miRNA-382 in ovarian cancer is still largely unknown. Here, we found miR‑382 was downregulated in human ovarian cancer tissues and cell lines. miR‑382 inhibited ovarian cancer cell proliferation, migration, invasion and the epithelial-mesenchymal transition (EMT). Furthermore, we identified receptor tyrosine kinase orphan receptor 1 (ROR1) as a target of miR‑382, and miR‑382 rescued the promotion effect of ROR1 on migration, invasion and EMT process in SKOV3 and COV434 cells. Collectively, these findings revealed that miR‑382 inhibits migration and invision by targeting ROR1 through regulating EMT in ovarian cancer, and might serve as a tumor suppressor in ovarian cancer.

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