Journal Articles

IL-8, a novel messenger to cross-link inflammation and tumor EMT via autocrine and paracrine pathways (Review)

Xinxin Long, Yingnan Ye, Lijie Zhang, Pengpeng Liu, Wenwen Yu, Feng Wei, Xiubao Ren, Jinpu Yu

Pages: 5-12 Published online on: 06 November 2015
Open Access

Pemetrexed clinical studies in performance status 2 patients with non-small cell lung cancer (Review)

Ralph Zinner, Carla Visseren-Grul, David R. Spigel, Coleman Obasaju

Pages: 13-27 Published online on: 29 October 2015
Open Access

Involvement of cyclic-nucleotide response element-binding family members in the radiation response of Ramos B lymphoma cells

Chiara Di Nisio, Silvia Sancilio, Viviana Di Giacomo, Monica Rapino, Laura Sancillo, Domenico Genovesi, Alessandro Di Siena, Rosa Alba Rana, Amelia Cataldi, Roberta Di Pietro

Pages: 28-36 Published online on: 09 November 2015
Open Access

Apoptosis and antitumor effects induced by the combination of an mTOR inhibitor and an autophagy inhibitor in human osteosarcoma MG63 cells

Ryosuke Horie, Osamu Nakamura, Yoshiki Yamagami, Masaki Mori, Hideki Nishimura, Natsuko Fukuoka, Tetsuji Yamamoto

Pages: 37-44 Published online on: 03 November 2015
Open Access

Macrolides sensitize EGFR-TKI-induced non-apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines

Shuntaro Mukai, Shota Moriya, Masaki Hiramoto, Hiromi Kazama, Hiroko Kokuba, Xiao-Fang Che, Tomohisa Yokoyama, Satoshi Sakamoto, Akihiro Sugawara, Toshiaki Sunazuka, Satoshi Ōmura, Hiroshi Handa, Takao Itoi, Keisuke Miyazawa

Pages: 45-54 Published online on: 09 November 2015
Open Access

Decreased expression of RASSF1A tumor suppressor gene is associated with worse prognosis in clear cell renal cell carcinoma

Jakub Klacz, Piotr M. Wierzbicki, Agata Wronska, Agnieszka Rybarczyk, Marcin Stanislawowski, Tomasz Slebioda, Agata Olejniczak, Marcin Matuszewski, Zbigniew Kmiec

Pages: 55-66 Published online on: 18 November 2015
Open Access

Glucose starvation induces mutation and lineage-dependent adaptive responses in a large collection of cancer cell lines

Ningning He, Nayoung Kim, Euna Jeong, Yiling Lu, Gordon B. Mills, Sukjoon Yoon

Pages: 67-72 Published online on: 11 November 2015
Open Access

Blockade of voltage-gated sodium channels inhibits invasion of endocrine-resistant breast cancer cells

Fatima H. Mohammed, Maitham A. Khajah, Ming Yang, William J. Brackenbury, Yunus A. Luqmani

Pages: 73-83 Published online on: 09 November 2015
Open Access

Epigenetic induction of epithelial to mesenchymal transition by LCN2 mediates metastasis and tumorigenesis, which is abrogated by NF-κB inhibitor BRM270 in a xenograft model of lung adenocarcinoma

Raj Kumar Mongre, Simrinder Singh Sodhi, Neelesh Sharma, Mrinmoy Ghosh, Jeong Hyun Kim, Nameun Kim, Yang Ho Park, Young Gyu Shin, Sung Jin Kim, Zhang Jiao Jiao, Do Luong Huynh, Dong Kee Jeong

Pages: 84-98 Published online on: 13 November 2015
Open Access

CD44v3+/CD24- cells possess cancer stem cell-like properties in human oral squamous cell carcinoma

Keita Todoroki, Sachiko Ogasawara, Jun Akiba, Masamichi Nakayama, Yoshiki Naito, Naoko Seki, Jingo Kusukawa, Hirohisa Yano

Pages: 99-109 Published online on: 20 November 2015

FH535 suppresses the proliferation and motility of hepatocellular carcinoma cells

Minoru Tomizawa, Fuminobu Shinozaki, Yasufumi Motoyoshi, Takao Sugiyama, Shigenori Yamamoto, Naoki Ishige

Pages: 110-114 Published online on: 29 October 2015

Characteristics of carbonic anhydrase 9 expressing cells in human intestinal crypt base

Hidekazu Takahashi, Yozo Suzuki, Junichi Nishimura, Naotsugu Haraguchi, Masahisa Ohtsuka, Susumu Miyazaki, Mamoru Uemura, Taishi Hata, Ichiro Takemasa, Tsunekazu Mizushima, Hirofumi Yamamoto, Yuichiro Doki, Masaki Mori

Pages: 115-122 Published online on: 20 November 2015

Suppression of hepatocellular carcinoma cell proliferation by short hairpin RNA of frizzled 2 with Sonazoid-enhanced irradiation

Minoru Tomizawa, Fuminobu Shinozaki, Yasufumi Motoyoshi, Takao Sugiyama, Shigenori Yamamoto, Naoki Ishige

Pages: 123-129 Published online on: 20 November 2015

Transcriptome sequencing of human breast cancer reveals aberrant intronic transcription in amplicons and dysregulation of alternative splicing with major therapeutic implications

Shiva Seyed Forootan, Joe M. Butler, Derek Gardener, Alison E. Baird, Andrew Dodson, Alistair Darby, John Kenny, Neil Hall, Andrew R. Cossins, Christopher S. Foster, Christine M. Gosden

Pages: 130-144 Published online on: 30 October 2015

A crucial epithelial to mesenchymal transition regulator, Sox4/Ezh2 axis is closely related to the clinical outcome in pancreatic cancer patients

Shinichiro Hasegawa, Hiroaki Nagano, Masamitsu Konno, Hidetoshi Eguchi, Akira Tomokuni, Yoshito Tomimaru, Tadafumi Asaoka, Hiroshi Wada, Naoki Hama, Koichi Kawamoto, Shigeru Marubashi, Naohiro Nishida, Jun Koseki, Masaki Mori, Yuichiro Doki, Hideshi Ishii

Pages: 145-152 Published online on: 20 November 2015

Epigenetic regulation of IQGAP2 promotes ovarian cancer progression via activating Wnt/β-catenin signaling

Zhuo Deng, Lijie Wang, Huilian Hou, Jiancheng Zhou, Xu Li

Pages: 153-160 Published online on: 04 November 2015

miR-21: A gene of dual regulation in breast cancer

Chunfu Zhang, Kui Liu, Tao Li, Jie Fang, Yanling Ding, Lingxian Sun, Tao Tu, Xinyi Jiang, Shanmei Du, Jiabo Hu, Wei Zhu, Huabiao Chen, Xiaochun Sun

Pages: 161-172 Published online on: 05 November 2015

Detection of neuroendocrine tumors using promoter-specific secreted Gaussia luciferase

Alan Wei-Shun Tseng, Victoria Akerstrom, Chiachen Chen, Mary B. Breslin, Michael S. Lan

Pages: 173-180 Published online on: 30 October 2015

miR-382 inhibits migration and invasion by targeting ROR1 through regulating EMT in ovarian cancer

Hong Tan, Qingnan He, Guanhui Gong, Yixuan Wang, Juanni Li, Junpu Wang, Ding Zhu, Xiaoying Wu

Pages: 181-190 Published online on: 09 November 2015

The impact of CDK9 on radiosensitivity, DNA damage repair and cell cycling of HNSCC cancer cells

Katja Storch, Nils Cordes

Pages: 191-198 Published online on: 13 November 2015

TIPE2 functions as a metastasis suppressor via negatively regulating β-catenin through activating GSK3β in gastric cancer

Jie Wu, Haitao Zhang, Chun Xu, Hong Xu, Xiumin Zhou, Yufeng Xie, Min Tao

Pages: 199-206 Published online on: 30 October 2015

IL-8 suppresses E-cadherin expression in nasopharyngeal carcinoma cells by enhancing E-cadherin promoter DNA methylation

Rui-Li Zhang, Li-Xia Peng, Jun-Ping Yang, Li-Sheng Zheng, Ping Xie, Meng-Yao Wang, Bi-Jun Huang, Hua-Rong Zhao, Yong-Xing Bao, Chao-Nan Qian

Pages: 207-214 Published online on: 02 November 2015

Interleukin-6 stimulates aerobic glycolysis by regulating PFKFB3 at early stage of colorectal cancer

Jun Han, Qingyang Meng, Qiulei Xi, Yongxian Zhang, Qiulin Zhuang, Yusong Han, Yi Jiang, Qiurong Ding, Guohao Wu

Pages: 215-224 Published online on: 02 November 2015

NF-κB signaling plays irreplaceable roles in cisplatin-induced bladder cancer chemoresistance and tumor progression

Yi Sun, Zhenfeng Guan, Liang Liang, Yongyi Cheng, Jiancheng Zhou, Jing Li, Yonggang Xu

Pages: 225-234 Published online on: 20 November 2015

Combination of Hedgehog inhibitors and standard anticancer agents synergistically prevent osteosarcoma growth

Yoshinobu Saitoh, Takao Setoguchi, Masahito Nagata, Arisa Tsuru, Shunsuke Nakamura, Satoshi Nagano, Yasuhiro Ishidou, Hiroko Nagao-Kitamoto, Masahiro Yokouchi, Shingo Maeda, Akihide Tanimoto, Tatsuhiko Furukawa, Setsuro Komiya

Pages: 235-242 Published online on: 06 November 2015

Downregulation of transient receptor potential cation channel, subfamily C, member 1 contributes to drug resistance and high histological grade in ovarian cancer

Xia Liu, Jing Zou, Jie Su, Yi Lu, Jian Zhang, Li Li, Fuqiang Yin

Pages: 243-252 Published online on: 19 November 2015

PF-04691502, a dual PI3K/mTOR inhibitor has potent pre-clinical activity by inducing apoptosis and G1 cell cycle arrest in aggressive B-cell non-Hodgkin lymphomas

Deyu Chen, Chaoming Mao, Yuepeng Zhou, Yuting Su, Shenzha Liu, Wen-Qing Qi

Pages: 253-260 Published online on: 05 November 2015

Ethanol extract of Kalopanax septemlobus leaf induces caspase-dependent apoptosis associated with activation of AMPK in human hepatocellular carcinoma cells

Cheol Park, Ji-Suk Jeong, Jin-Woo Jeong, Yong-Joo Kim, Yeon-Kwon Jung, Geun-Bae Go, Sung Ok Kim, Gi-Young Kim, Su-Hyun Hong, Young Hyun Yoo, Yung Hyun Choi

Pages: 261-270 Published online on: 05 November 2015

CA IX is upregulated in CoCl2-induced hypoxia and associated with cell invasive potential and a poor prognosis of breast cancer

Cheng-Yu Chu, Yi-Ting Jin, Wei Zhang, Juan Yu, Hai-Ping Yang, Hong-Ying Wang, Zi-Jing Zhang, Xiu-Ping Liu, Qiang Zou

Pages: 271-280 Published online on: 19 November 2015

Theaflavin-3, 3'-digallate decreases human ovarian carcinoma OVCAR-3 cell-induced angiogenesis via Akt and Notch-1 pathways, not via MAPK pathways

Ying Gao, Gary O. Rankin, Youying Tu, Yi Charlie Chen

Pages: 281-292 Published online on: 20 November 2015

Diallyl trisulfide induces apoptosis by suppressing NF-κB signaling through destabilization of TRAF6 in primary effusion lymphoma

Zenpei Shigemi, Yoshiki Furukawa, Kohei Hosokawa, Setsuya Minami, Jumpei Matsuhiro, Shiori Nakata, Tadashi Watanabe, Hiroki Kagawa, Koji Nakagawa, Hiroshi Takeda, Masahiro Fujimuro

Pages: 293-304 Published online on: 17 November 2015

Exosomes derived from SW480 colorectal cancer cells promote cell migration in HepG2 hepatocellular cancer cells via the mitogen-activated protein kinase pathway

Mitsuru Chiba, Narumi Watanabe, Miki Watanabe, Maki Sakamoto, Akika Sato, Mizuki Fujisaki, Shiori Kubota, Satoru Monzen, Atsushi Maruyama, Naoki Nanashima, Ikuo Kashiwakura, Toshiya Nakamura

Pages: 305-312 Published online on: 19 November 2015

3D matrix-based cell cultures: Automated analysis of tumor cell survival and proliferation

Iris Eke, Stephanie Hehlgans, Veit Sandfort, Nils Cordes

Pages: 313-321 Published online on: 04 November 2015

The antipsychotic drug pimozide inhibits cell growth in prostate cancer through suppression of STAT3 activation

Wei Zhou, Ming-Kun Chen, Hao-Tao Yu, Zhi-Hong Zhong, Nan Cai, Guan-Zhong Chen, Ping Zhang, Jia-Jie Chen

Pages: 322-328 Published online on: 04 November 2015

Hepatitis B virus X protein activates Notch signaling by its effects on Notch1 and Notch4 in human hepatocellular carcinoma

Juan Gao, Yimin Xiong, Yan Wang, Yiming Wang, Guorong Zheng, Hualin Xu

Pages: 329-337 Published online on: 30 October 2015

The effect and mechanism of bufalin on regulating hepatocellular carcinoma cell invasion and metastasis via Wnt/β-catenin signaling pathway

Ji Qin Gai, Xia Sheng, Jian Min Qin, Kang Sun, Wei Zhao, Lei Ni

Pages: 338-348 Published online on: 18 November 2015

All-trans retinoic acid inhibits proliferation, migration, invasion and induces differentiation of hepa1-6 cells through reversing EMT in vitro

Jiejie Cui, Mengjia Gong, Yun He, Qilin Li, Tongchuan He, Yang Bi

Pages: 349-357 Published online on: 06 November 2015

Overexpression of Tyro3 and its implications on hepatocellular carcinoma progression

Yan Duan, Winnie Wong, Sonja Courtney Chua, Hwee Lin Wee, Seng Gee Lim, Boon Tin Chua, Han Kiat Ho

Pages: 358-366 Published online on: 13 November 2015

Differential regulation and synthetic lethality of exclusive RB1 and CDKN2A mutations in lung cancer

Nayoung Kim, Mee Song, Somin Kim, Yujeong Seo, Yonghwan Kim, Sukjoon Yoon

Pages: 367-375 Published online on: 20 November 2015

Gambogic acid induces apoptosis and sensitizes TRAIL-mediated apoptosis through downregulation of cFLIPL in renal carcinoma Caki cells

Ji Hoon Jang, Joo-Young Kim, Eon-Gi Sung, Eun-Ae Kim, Tae-Jin Lee

Pages: 376-384 Published online on: 18 November 2015

A novel curcumin derivative increases the cytotoxicity of raloxifene in estrogen receptor-negative breast cancer cell lines

Sebastien Taurin, Mhairi Nimick, Lesley Larsen, Rhonda J. Rosengren

Pages: 385-398 Published online on: 19 November 2015

Inhibition of glutamine utilization sensitizes lung cancer cells to apigenin-induced apoptosis resulting from metabolic and oxidative stress

Yoon-Mi Lee, Gibok Lee, Taek-In Oh, Byeong Mo Kim, Do-Wan Shim, Kwang-Ho Lee, Young Jun Kim, Beong Ou Lim, Ji-Hong Lim

Pages: 399-408 Published online on: 11 November 2015

Synergistic anticancer effects of cisplatin and histone deacetylase inhibitors (SAHA and TSA) on cholangiocarcinoma cell lines

Md. Ali Asgar, Gulsiri Senawong, Banchob Sripa, Thanaset Senawong

Pages: 409-420 Published online on: 09 November 2015

The mechanism of adenosine-mediated activation of lncRNA MEG3 and its antitumor effects in human hepatoma cells

Li-Xuan Liu, Wei Deng, Xiao-Tao Zhou, Rui-Pei Chen, Meng-Qi Xiang, Yi-Tian Guo, Ze-Jin Pu, Rui Li, Ge-Fei Wang, Ling-Fei Wu

Pages: 421-429 Published online on: 18 November 2015
Journal Cover

Cover Legend PDF

January 2016
Volume 48 Issue 1

Print ISSN: 1019-6439
Online ISSN: 1791-2423

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