RhoA is associated with invasion and poor prognosis in colorectal cancer

  • Authors:
    • Dongjun Jeong
    • Soyoung Park
    • Hyungjoo Kim
    • Chang-Jin Kim
    • Tae Sung Ahn
    • Sang Byung Bae
    • Han Jo Kim
    • Tae Hyun Kim
    • Jungkyun Im
    • Moon Soo Lee
    • Hyog Young Kwon
    • Moo Jun Baek
  • View Affiliations

  • Published online on: December 8, 2015     https://doi.org/10.3892/ijo.2015.3281
  • Pages: 714-722
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Abstract

Colorectal cancer is one of the most common cancers and is the fourth leading cause of cancer death in Korea. Mortality of colorectal cancer is strongly associated with the metastatic spread of the disease. As such, it is important to find and characterize signaling pathways involved in colon cancer metastasis. We investigated the functional importance of RhoA using human cell lines as well as 150 colorectal cancer patient-derived samples as it remains unclear whether RhoA functions as either an oncogene or a tumor suppressor in colon cancer. RhoA was highly expressed in metastatic cancer cell lines. Although cancer cell proliferation was only moderately impaired after depletion of RhoA, RhoA-depleted cancer cells exhibited markedly reduced migration and invasion ability in vitro. Furthermore, we found that RhoA is associated with the invasion of lymph nodes and blood vessels in the patient colorectal cancer samples. Most notably, patients with higher RhoA expression had a significantly poorer 5-year survival rate after surgery. These results suggest that RhoA is a marker of poor prognosis in colorectal cancer and may be a promising target for cancer treatment.

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Copy and paste a formatted citation
APA
Jeong, D., Park, S., Kim, H., Kim, C., Ahn, T.S., Bae, S.B. ... Baek, M.J. (2016). RhoA is associated with invasion and poor prognosis in colorectal cancer. International Journal of Oncology, 48, 714-722. https://doi.org/10.3892/ijo.2015.3281
MLA
Jeong, D., Park, S., Kim, H., Kim, C., Ahn, T. S., Bae, S. B., Kim, H. J., Kim, T. H., Im, J., Lee, M. S., Kwon, H. Y., Baek, M. J."RhoA is associated with invasion and poor prognosis in colorectal cancer". International Journal of Oncology 48.2 (2016): 714-722.
Chicago
Jeong, D., Park, S., Kim, H., Kim, C., Ahn, T. S., Bae, S. B., Kim, H. J., Kim, T. H., Im, J., Lee, M. S., Kwon, H. Y., Baek, M. J."RhoA is associated with invasion and poor prognosis in colorectal cancer". International Journal of Oncology 48, no. 2 (2016): 714-722. https://doi.org/10.3892/ijo.2015.3281