Methylsulfonylmethane inhibits HER2 expression through STAT5b in breast cancer cells

  • Authors:
    • Dong Young Kang
    • Pramod Darvin
    • Young Beom Yoo
    • Youn Hee Joung
    • Nipin Sp
    • Hyo Joo Byun
    • Young Mok Yang
  • View Affiliations

  • Published online on: December 7, 2015     https://doi.org/10.3892/ijo.2015.3277
  • Pages: 836-842
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Abstract

Breast cancer is the most common cancer in women globally. The factors that increase risk include: late age at first birth, alcohol, radiation exposure, family history of breast cancer, and postmenopausal hormone therapy. Numerous drugs are being developed to treat breast cancer. Among them, Herceptin is used for the treatment of human epidermal growth factor receptor 2 (HER2)-positive cases and targets HER2 effectively and efficiently, but it is very expensive. Methylsulfonylmethane (MSM) is an organic sulfur-containing natural compound having no reported toxicity. We examined MSM in breast cancer cell lines and found it inhibited the proliferation of estrogen receptor-positive and HER2-positive breast cancer cells in a dose-dependent manner. It also suppressed the activation of STAT5b and expression of HER2 in breast cancer cells. We determined the STAT5b binding site (GAS element) in the HER2 gene. Detailed analysis showed that MSM decreased the ability of STAT5b to bind the promoter of the HER2 gene and a luciferase assay demonstrated reduced activity. We confirmed that MSM can effectively regulate STAT5b, and thereby decrease HER2 expression. Therefore, we recommend the use of MSM as an inhibitor for the management of HER2-positive breast cancers.

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Copy and paste a formatted citation
APA
Kang, D.Y., Darvin, P., Yoo, Y.B., Joung, Y.H., Sp, N., Byun, H.J., & Yang, Y.M. (2016). Methylsulfonylmethane inhibits HER2 expression through STAT5b in breast cancer cells. International Journal of Oncology, 48, 836-842. https://doi.org/10.3892/ijo.2015.3277
MLA
Kang, D. Y., Darvin, P., Yoo, Y. B., Joung, Y. H., Sp, N., Byun, H. J., Yang, Y. M."Methylsulfonylmethane inhibits HER2 expression through STAT5b in breast cancer cells". International Journal of Oncology 48.2 (2016): 836-842.
Chicago
Kang, D. Y., Darvin, P., Yoo, Y. B., Joung, Y. H., Sp, N., Byun, H. J., Yang, Y. M."Methylsulfonylmethane inhibits HER2 expression through STAT5b in breast cancer cells". International Journal of Oncology 48, no. 2 (2016): 836-842. https://doi.org/10.3892/ijo.2015.3277