Fibulin-5 downregulates Ki-67 and inhibits proliferation and invasion of breast cancer cells

  • Authors:
    • Yamina Mohamedi
    • Tania Fontanil
    • Laura Solares
    • Olivia Garcia-Suárez
    • Jorge García-Piqueras
    • Jose A. Vega
    • Santiago Cal
    • Alvaro J. Obaya
  • View Affiliations

  • Published online on: February 17, 2016     https://doi.org/10.3892/ijo.2016.3394
  • Pages: 1447-1456
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Abstract

Fibulins not only function as molecular bridges within the cellular microenvironment but also influence cell behavior. Thus, fibulins may contribute to create a permissive microenvironment for tumor growth but can also stimulate different mechanisms that may impede tumor progression. This is the case with Fibulin-5, which has been shown to display both tumor-promoting and tumor-protective functions by mechanisms that are not totally defined. We show new evidence on the tumor-protective functions displayed by Fibulin-5 in MCF-7, T47D and MDA-MB-231 breast cancer cells including the inhibition of invasion and proliferation capacity and hampering the ability to form mammospheres. Reduction in the level of phosphorylation of Ser residues involved in the nuclear translocation of β-catenin may underlie these antitumor effects. We also found that Fibulin-5 reduces the level of expression of Ki-67, a nuclear protein associated with cell proliferation. Moreover, reduction in Fibulin-5 expression corresponds to an increase of Ki-67 detection in breast tissue samples. Overall, our data provide new insights into the influence of Fibulin-5 to modify breast cancer cell behavior and contribute to better understand the connections between fibulins and cancer.

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April 2016
Volume 48 Issue 4

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Online ISSN:1791-2423

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Copy and paste a formatted citation
APA
Mohamedi, Y., Fontanil, T., Solares, L., Garcia-Suárez, O., García-Piqueras, J., Vega, J.A. ... Obaya, A.J. (2016). Fibulin-5 downregulates Ki-67 and inhibits proliferation and invasion of breast cancer cells. International Journal of Oncology, 48, 1447-1456. https://doi.org/10.3892/ijo.2016.3394
MLA
Mohamedi, Y., Fontanil, T., Solares, L., Garcia-Suárez, O., García-Piqueras, J., Vega, J. A., Cal, S., Obaya, A. J."Fibulin-5 downregulates Ki-67 and inhibits proliferation and invasion of breast cancer cells". International Journal of Oncology 48.4 (2016): 1447-1456.
Chicago
Mohamedi, Y., Fontanil, T., Solares, L., Garcia-Suárez, O., García-Piqueras, J., Vega, J. A., Cal, S., Obaya, A. J."Fibulin-5 downregulates Ki-67 and inhibits proliferation and invasion of breast cancer cells". International Journal of Oncology 48, no. 4 (2016): 1447-1456. https://doi.org/10.3892/ijo.2016.3394