Prevalence and associated survival of high-risk HPV-related adenoid cystic carcinoma of the salivary glands

  • Authors:
    • Xu Qian
    • Andreas M. Kaufmann
    • Chao Chen
    • Georgios Tzamalis
    • Veit M. Hofmann
    • Ulrich Keilholz
    • Michael Hummel
    • Andreas E. Albers
  • View Affiliations

  • Published online on: June 3, 2016     https://doi.org/10.3892/ijo.2016.3563
  • Pages: 803-811
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Abstract

Adenoid cystic carcinoma (SACC) is a rare malignancy, but a frequent subtype in minor and major salivary glands. The molecular alterations or biomarkers that underlie its development and progression as well as therapy outcomes are poorly characterized. The main study goal was to investigate reliable biomarkers and patient-related factors that may have impact on recurrence and long-term survival of SACC. The prevalence of human papilloma virus (HPV) in SACC was determined by HPV-DNA genotyping and p16 immunostaining. Epithelial growth factor receptor (EGFR), p53 and Ki-67 expression were also evaluated. Twenty-eight (42%) of 67 patients were HPV-DNA positive. Kaplan-Meier analysis indicated that SACC patients with metastases (P=0.03) had a poor overall survival (OS) and a shorter recurrence-free survival (P<0.001). Positive resection margins significantly predicted shorter recurrence-free survival (P=0.01). In the multivariate analysis, non-metastatic disease (P=0.033) and p16 positivity (P=0.005) have shown their prediction value for OS while non-metastatic disease (P=0.002), HPV positivity (P=0.041) and negative resection margin predicted a better recurrence-free survival. The present study documents for the first time the positivity for HPV infection and overexpression of certain markers (p16, Ki-67, EGFR and p53) used in diagnostics in SACC as well as characterizes clinical entities. These factors might be exploited in the future as biomarkers for its prognostic value. Using the clinical and pathological basis for predicting different outcomes could significantly facilitate SACC stratification and potentially directing treatment.
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August-2016
Volume 49 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Qian X, Kaufmann AM, Chen C, Tzamalis G, Hofmann VM, Keilholz U, Hummel M and Albers AE: Prevalence and associated survival of high-risk HPV-related adenoid cystic carcinoma of the salivary glands. Int J Oncol 49: 803-811, 2016.
APA
Qian, X., Kaufmann, A.M., Chen, C., Tzamalis, G., Hofmann, V.M., Keilholz, U. ... Albers, A.E. (2016). Prevalence and associated survival of high-risk HPV-related adenoid cystic carcinoma of the salivary glands. International Journal of Oncology, 49, 803-811. https://doi.org/10.3892/ijo.2016.3563
MLA
Qian, X., Kaufmann, A. M., Chen, C., Tzamalis, G., Hofmann, V. M., Keilholz, U., Hummel, M., Albers, A. E."Prevalence and associated survival of high-risk HPV-related adenoid cystic carcinoma of the salivary glands". International Journal of Oncology 49.2 (2016): 803-811.
Chicago
Qian, X., Kaufmann, A. M., Chen, C., Tzamalis, G., Hofmann, V. M., Keilholz, U., Hummel, M., Albers, A. E."Prevalence and associated survival of high-risk HPV-related adenoid cystic carcinoma of the salivary glands". International Journal of Oncology 49, no. 2 (2016): 803-811. https://doi.org/10.3892/ijo.2016.3563