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EXPRESSION OF CYCLIN D1 IN SQUAMOUS-CELL CARCINOMAS OF THE HEAD AND NECK

  • Authors:
    • JM LUCAS
    • RE MOUNTAIN
    • AW GRAMZA
    • DE SCHULLER
    • NM WILKIE
    • JC LANG

  • View Affiliations

  • Published online on: September 1, 1994     https://doi.org/10.3892/ijo.5.3.469
  • Pages: 469-472
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Abstract

Expression of oncogenes Cyclin D1, FGF-3 and FGF-4 was investigated in eight cases of squamous cell carcinoma of the head and neck (SCCHN) and matched normal controls using the sensitive detection technique of RT-PCR. We demonstrate elevated expression of cyclin D1 in 5/8 SCCHN tumor samples and describe the first report of overexpression of cyclin D1 in tumors of the pyriform sinus. In contrast, we do not detect, under routine conditions, expression of oncogenes FGF-3 and FGF-4 in these tumors and suggest that FGF-3 and FGF-4 are unlikely to play a role in the development of squamous cell carcinomas of the head and neck.

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September 1994
Volume 5 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Impact Factor: 5.2
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  • CiteScore: 11.4
  • CiteScore Rank: Q1: #40/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 1.125
  • SCImago Journal Rank (SJR): 1.105
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Spandidos Publications style
LUCAS J, MOUNTAIN R, GRAMZA A, SCHULLER D, WILKIE N and LANG J: EXPRESSION OF CYCLIN D1 IN SQUAMOUS-CELL CARCINOMAS OF THE HEAD AND NECK. Int J Oncol 5: 469-472, 1994
APA
LUCAS, J., MOUNTAIN, R., GRAMZA, A., SCHULLER, D., WILKIE, N., & LANG, J. (1994). EXPRESSION OF CYCLIN D1 IN SQUAMOUS-CELL CARCINOMAS OF THE HEAD AND NECK. International Journal of Oncology, 5, 469-472. https://doi.org/10.3892/ijo.5.3.469
MLA
LUCAS, J., MOUNTAIN, R., GRAMZA, A., SCHULLER, D., WILKIE, N., LANG, J."EXPRESSION OF CYCLIN D1 IN SQUAMOUS-CELL CARCINOMAS OF THE HEAD AND NECK". International Journal of Oncology 5.3 (1994): 469-472.
Chicago
LUCAS, J., MOUNTAIN, R., GRAMZA, A., SCHULLER, D., WILKIE, N., LANG, J."EXPRESSION OF CYCLIN D1 IN SQUAMOUS-CELL CARCINOMAS OF THE HEAD AND NECK". International Journal of Oncology 5, no. 3 (1994): 469-472. https://doi.org/10.3892/ijo.5.3.469